Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist

Journal of Biological Chemistry

Volumn 280, Issue 6, 2005, Pages 4808-4816

  Lopes De Mendonça, Filipa ^a   Da Fonseca, Paula C A ^a   Phillips, Rhian M ^a   Saldanha, José W ^b   Williams, Timothy J ^a   Pease, James E ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DISEASE CONTROL; PATHOLOGY;

ASTHMA; CHEMOKINE RECEPTORS; MULTIPLE SCLEROSIS; RHEUMATOID ARTHRITIS;

MUTAGENESIS;

ANTIINFLAMMATORY AGENT; BETA CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR1; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MUTANT PROTEIN; UCB 35625; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL MIGRATION; DRUG MECHANISM; DRUG RESPONSE; DRUG SCREENING; DRUG STRUCTURE; INFLAMMATION; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; CELL MEMBRANE; CELL MOVEMENT; CHEMOTAXIS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; HUMANS; INFLAMMATION; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CHEMOKINE; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SOFTWARE; STEREOISOMERISM; TRANSFECTION; XANTHENES;

EID: 14244254079     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412267200     Document Type: Article

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