Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression

European Journal of Immunology

Volumn 32, Issue 4, 2002, Pages 1052-1058

  Auger, Graham A ^a   Pease, James E ^b   Shen, Xiaoyun ^a   Xanthou, Georgina ^b   Barker, Michael D ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Chemokine; Eotaxin; Inflammation; Receptor; Signaling

Indexed keywords

ALANINE; CHEMOKINE RECEPTOR CCR3; EOTAXIN; GUANINE NUCLEOTIDE BINDING PROTEIN;

ALLERGIC DISEASE; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CELL SURFACE; CHEMOTAXIS; CONTROLLED STUDY; EOSINOPHIL; GENE EXPRESSION; GENE MUTATION; GENETIC CONSERVATION; MOUSE; MUTAGENESIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; B-LYMPHOCYTES; BINDING SITES; CELL LINE; CHEMOKINES, CC; CHEMOTAXIS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECEPTORS, CHEMOKINE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0036236992     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200204)32:4<1052::AID-IMMU1052>3.0.CO;2-L     Document Type: Article

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