Targeted disruption of the β-chemokine receptor CCR1 protects against pancreatitis-associated lung injury

Journal of Clinical Investigation

Volumn 100, Issue 8, 1997, Pages 2022-2027

  Gerard, Craig ^a   Frossard, Jean Louis ^b   Bhatia, Madhav ^b   Saluja, Ashok ^b   Gerard, Norma P ^a   Lu, Bao ^a   Steer, Michael ^b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Caerulein; Gene deletion; MIP1 RANTES receptor; Respiratory distress; Systemic immune response syndrome

Indexed keywords

CHEMOKINE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE TARGETING; HISTOLOGY; LEUKOCYTE ACTIVATION; LUNG INJURY; MOUSE; MYOCARDITIS; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; RESPIRATORY DISTRESS;

EID: 0030783188     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119734     Document Type: Article

References (19)

1. Baggiolini, M., B. Dewald, and B. Moser. 1997. Human chemokines: an update. Annu. Rev. Immunol. 15:675-706.
2. Premark, B.A., and T.J. Schall. 1996. Chemokine receptors: gateway to inflammation and infection. Nat. Med. 11:1174-11178.
3. Cacalano, G., J. Lee, K. Kikly, A.M. Ryan, S. Pitts-Meek, B. Hultgren, W.I. Wood, and M.W. Moore. 1994. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science (Wash. DC). 265:682-684.
4. Cook, D.N., M.A. Beck, T.M. Coffman, S.L. Kirby, J.F. Sheridan, I.B. Pragnell, and O. Smithies. 1995. Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science (Wash. DC). 269:1583-1585.
5. Nagasawa, T., S. Hirota, K. Tachibana, N. Takakura, S. Nishikawa, Y. Kitamura, N. Yoshida, H. Kikutani, and T. Kishimoto. 1996. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature (Lond.). 382:635-638.
6. Bone, R.C. 1996. Immunologic dissonance. Ann. Intern. Med. 125:680-687.
7. Guice, K.S., K. Oldham, K.J. Johnson, R.G. Kunkel, M.L. Morganroth, and P.A. Ward. 1988. Pancreatitis-induced acute lung injury: an ARDS model. Ann. Surg. 208:71-77.
8. 1 on the acute lung injury of caerulein-induced acute pancreatitis in rats. Am. J Physiol. 272:G23-G30.
9. Lampel, M., and H. Kern. 1977. Acute pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virch. Arch. Pathol. Anat. Histol. 373:1007-1117.
10. Guice, K.S., K.T. Oldham, M.G. Caty, K.J. Johnson, and P.A. Ward. 1989. Neutrophil-dependent oxygen radical mediated lung injury associated with acute pancreatitis. Ann. Surg. 210:740-747.
11. Post, T.W., C.R. Bozic, M.E. Rothenberg, A.D. Luster, N.P. Gerard, and C. Gerard. 1995. Molecular characterization of two murine eosinophil beta chemokine receptors. J. Immunol. 155:5299-5305.
12. Hopken, U.E., B. Lu, N.P. Gerard, and C. Gerard. 1996. The C5a chemoattractant receptor mediates mucosal defense to infection. Nature (Lond.). 383:86-89.
13. Pierre, K.J., K.K. Tung, and H. Nadj. 1976. A new enzymatic kinetic method for the determination of alpha amylase. Clin. Chem. 22:1219.
14. Imamura, S., T. Hirayama, T. Arai, K. Takao, and H. Misaka. 1989. An enymatic method using 1,2-diglyceride for pancreatic lipase test in serum. Clin. Chem. 35:1126.
15. Runzi, M., V. Raptopoulos, A.K. Saluja, A.M. Kaiser, H. Nishino, D. Gerdes, and M.L. Steer. 1995. Evaluation of necrotizing pancreatitis in the opossum by dynamic contrast-enhanced computed tomography: correlation between radiographic and morphologic changes. J. Am. Coll. Surg. 180:673-682.
16. Broxmeyer, H., S. Cooper, G. Cacalano, N.L. Hague, E. Bailish, and M.W. Moore. 1996. Involvement of interleukin-8 receptor in negative regulation of myeloid progenitor cells in vivo: evidence from mice lacking the murine IL-8 receptor homologue. J. Exp. Med. 184:1825-1832.
17. Fahey, T.J., III, K.J. Tracy, P. Tekamp-Olson, L.S. Cousens, W.G. Jones, G.T. Shires, A. Cerami, and B. Sherry. 1992. Macrophage inflammatory protein 1 modulates macrophage function. J. Immunol. 148:2764-2769.
18. Worthen, G.S., B. Schwab, E.L. Elson, and G.P. Downey, 1989. Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries. Science (Wash. DC). 245:183-186.
19. Standiford, T.J., S.L. Kunkel, N.W. Lukacs, M.J. Greenberger, J.M. Danforth, R.G. Kunkel, and R.M. Stricter. 1995. Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia. J. Immunol. 155:1515-1524.