Viral vectors as tools for studies of central cardiovascular control

Progress in Biophysics and Molecular Biology

Volumn 84, Issue 2-3, 2004, Pages 251-277

  Kasparov, S ^a   Teschemacher, A G ^a   Hwang, D Y ^b   Kim, K S ^b   Lonergan, T ^a   Paton, J F R ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b MCLEAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 1242344045     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbiomolbio.2003.11.011     Document Type: Review

References (103)

1. Akli S., Caillaud C., Vigne E., Stratford-Perricaudet L.D., Poenaru L., Perricaudet M., Kahn A., Peschanski M.R. Transfer of a foreign gene into the brain using adenovirus vectors. Nat. Genet. 3:1993;224-228.
2. Arnolda L., Minson J., Kapoor V., Pilowsky P., Llewellyn-Smith I., Chalmers Amino acid neurotransmitters in hypertension. Kidney Int. 37(Suppl):1992;S2-S7.
3. Bienemann A.S., Martin-Rendon E., Cosgrave A.S., Glover C.P., Wong L.F., Kingsman S.M., Mitrophanous K.A., Mazarakis N.D., Uney J.B. Long-term replacement of a mutated nonfunctional CNS gene. reversal of hypothalamic diabetes insipidus using an EIAV-based lentiviral vector expressing arginine vasopressin Mol. Ther. 7:2003;588-596.
4. Bilang-Bleuel A., Revah F., Colin P., Locquet I., Robert J.-J., Mallet J., Horellou P. Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. Proc. Natl. Acad. Sci. USA. 94:1997;8818-8823.
5. Busche S., Gallinat S., Fleegal M.A., Raizada M.K., Sumners C. Novel role of macrophage migration inhibitory factor in angiotensin II regulation of neuromodulation in rat brain. Endocrinology. 142:2001;4623-4630.
6. Casto R., Phillips M.I. Baroreflex resetting by infusions of angiotensin II into the nucleus tractus solitarius. Fed. Proc. 44:1985;3645.
7. Casto R., Phillips M.I. Angiotensin II attenuates baroreflexes at nucleus tractus solitarius of rats. Am. J. Physiol. - Regulatory Integrative Comparative Physiol. 250:1986;R193-R198.
8. Chalmers J. Brain, blood pressure and stroke. J. Hypertension. 16:1998;1849-1858.
9. Chillon M., Bosch A., Zabner J., Law L., Armentano D., Welsh M.J., Davidson B.L. Group D adenoviruses infect primary central nervous system cells more efficiently than those from group C. J. Virol. 73:1999;2537-2540.
10. Clackson T. Regulated gene expression systems. Gene Thera. 7:2000;120-125.
11. Coleman J.E., Huentelman M.J., Kasparov S., Metcalfe B.L., Paton J.F.R., Katovich M.J., Semple-Rowland S.L., Raizada M.K. Efficient Large-Scale Production and Concentration of HIV-1-Based Lentiviral Vectors For Use In vivo. Physiolog. Genomics. 12:2003;221-228.
12. Cousin M.A. Synaptic vesicle endocytosis. calcium works overtime in the nerve terminal Mol. Neurobiol. 22:2000;115-128.
13. Cucchiarini M., Ren X.L., Perides G., Terwilliger E.F. Selective gene expression in brain microglia mediated via adeno-associated virus type 2 and type 5 vectors. Gene Thera. 10:2003;657-667.
14. Dampney R.A.L. Functional organization of central pathways regulating the cardiovascular system. Physiolog. Rev. 74:1994;323-364.
15. Dampney R.A.L., Goodchild A.K., Tan E. Identification of cardiovascular cell groups in the brain stem. Clinical & Experimental Hypertension. 6:1984;205-220.
16. Davidson B.L., Chiorini J.A. Recombinant adeno-associated viral vector types 4 and 5. Preparation and application for CNS gene transfer. Methods Mol. Med. 76:2003;269-285.
17. Davidson B.L., Allen E.D., Kozarsky K.F., Wilson J.M., Roessler B.J. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat. Genet. 3:1993;219-223.
18. de Wardener H.E. The hypothalamus and hypertension. Physiolog. Rev. 81:2001;1599-1658.
19. Francis N.J., Landis S.C. Cellular and molecular determinants of sympathetic neuron development. Annu. Rev. Neurosci. 22:1999;541-566.
20. Glover C.P., Bienemann A.S., Heywood D.J., Cosgrave A.S., Uney J.B. Adenoviral-mediated, high-level, cell-specific transgene expression. a SYN1-WPRE cassette mediates increased transgene expression with no loss of neuron specificity Mol. Thera. 5:2002;509-516.
21. Glover C.P., Bienemann A.S., Hopton M., Harding T.C., Kew J.N., Uney J.B. Long-term transgene expression can be mediated in the brain by adenoviral vectors when powerful neuron-specific promoters are used. J. Gene Med. 5:2003;554-559.
22. Gossen M., Freundlieb S., Bender G., Muller G., Hillen W., Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science. 268:1995;1766-1769.
23. Griesbeck O., Korte M., Gravel C., Bonhoeffer T., Thoenen H. Rapid gene transfer into cultured hippocampal neurons and acute hippocampal slices using adenoviral vectors. Mol. Brain Res. 44:1997;171-177.
24. Harding T.C., Geddes B.J., Murphy D., Knight D., Uney J.B. Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system. Nat. Biotechnol. 16:1998;553-555.
25. A function and binding in the paraventricular nucleus of the hypothalamus in chronic renal-wrap hypertension. Hypertension. 37:2001;614-618.
26. Hirooka Y., Sakai K., Kishi T., Takeshita A. Adenovirus-mediated gene transfer into the NTS in conscious rats. A new approach to examining the central control of cardiovascular regulation. Ann. NY Acad. Sci. 940:2001;197-205.
27. Huang C.J., Spinella F., Nazarian R., Lee M.M., Dopp J.M., De Vellis J. Expression of green fluorescent protein in oligodendrocytes in a time- and level-controllable fashion with a tetracycline regulated system. J. Mol. Med. 5:1999;129-137.
28. Hwang D.-Y., Carlezon W.A. Jr., Isacson O., Kim K.-S. A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons. Human Gene Thera. 12:2001;1731-1740.
29. A. ε subunit Anesthesiology. 97:2002;717-724.
30. Iwakuma T., Cui Y., Chang L.-J. Self-inactivating lentiviral vectors with U3 and U5 modifications. Virology. 261:1999;120-132.
31. Jaffe E.H., Marty A., Schulte A., Chow R.H. Extrasynaptic vesicular transmitter release from the somata of substantia nigra neurons in rat midbrain slices. J. Neurosci. 18:1998;3548-3553.
32. Jenkins T.A., Allen A.M., Chai S.Y., Mendelsohn F.A.O. Interactions of angiotensin II with central catecholamines. Clin. Exp. Hypertension. 17:1995;267-280.
33. Jin X., Mathers P.H., Szabo G., Katarova Z., Agmon A. Vertical bias in dendritic trees of non-pyramidal neocortical neurons expressing GAD67-GFP in vitro. Cerebral Cortex. 11:2001;666-678.
34. Junier M.P., Suzuki F., Onteniente B., Peschanski M. Target-deprived CNS neurons express the NGF gene while reactive glia around their axonal terminals contain low and high affinity NGF receptors. Brain Res. Mol. Brain Res. 24:1994;247-260.
35. Kantor D.B., Lanzrein M., Stary S.J., Sandoval G.M., Smith W.B., Sullivan B.M., Davidson N., Schuman E.M. A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue. Science. 274:1996;1744-1748.
36. Kasparov S., Paton J.F.R. Somatic gene transfer. implications for cardiovascular control Exp. Physiol. 85:2000;747-755.
37. Kasparov S., Teschemacher A., Paton J.F.R. Dynamic confocal imaging in acute brain slices and organotypic slice cultures using a spectral confocal microscope with single photon excitation. Exp. Physiol. 87:2002;715-724.
38. Kasparov, S., Waki, H., Okwuadigbo, E., Murphy, D., Paton, J.F.R., 2002b. Endothelial nitric oxide synthase in the nucleus tractus solitarii (NTS) attenuates baroreflex and increases blood pressure in spontaneously hypertensive rat (SHR): evidence from in vivo gene transfer. Society for Neuroscience Abstracts 28, 861.1.
39. Katovich M.J., Reaves P.Y., Francis S.C., Pachori A.S., Wang H.W., Raizada M.K. Gene therapy attenuates the elevated blood pressure and glucose intolerance in an insulin-resistant model of hypertension. J. Hypertension. 19:2001;1553-1558.
40. Kishi T., Hirooka Y., Ito K., Sakai K., Shimokawa H., Takeshita A. Cardiovascular effects of overexpression of endothelial nitric oxide synthase in the rostral ventrolateral medulla in stroke-prone spontaneously hypertensive rats. Hypertension. 39:2002;264-268.
41. Kishi T., Hirooka Y., Kimura Y., Sakai K., Ito K., Shimokawa H., Takeshita A. Overexpression of eNOS in RVLM improves impaired baroreflex control of heart rate in SHRSP. Rostral ventrolateral medulla. Stroke-prone spontaneously hypertensive rats. Hypertension. 41:2003;255-260.
42. Klein R.L., Hamby M.E., Gong Y., Hirko A.C., Wang S., Hughes J.A., King M.A., Meyer E.M. Dose and promoter effects of adeno-associated viral vector for green fluorescent protein expression in the rat brain. Exp. Neurol. 176:2002;66-74.
43. Krasnykh V.N., Douglas J.T., van Beusechem V.W. Genetic targeting of adenoviral vectors. Mol. Thera. 1:2000;391-405.
44. Kugler S., Meyn L., Holzmuller H., Gerhardt E., Isenmann S., Schulz J.B., Bahr M. Neuron-specific expression of therapeutic proteins. evaluation of different cellular promoters in recombinant adenoviral vectors Mol. Cellular Neurosci. 17:2001;78-96.
45. Kugler S., Kilic E., Bahr M. Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area. Gene Thera. 10:2003;337-347.
46. Lee C.M., Robinson L.J., Michel T. Oligomerization of endothelial nitric oxide synthase. Evidence for a dominant negative effect of truncation mutants. J. Biol. Chem. 270:1995;27403-27406.
47. Lu D., Yu K., Raizada M.K. Retrovirus-mediated transfer of an angiotensin type I receptor (AT1- R) antisense sequence decreases AT1-Rs and angiotensin II action in astroglial and neuronal cells in primary cultures from the brain. Proc. Natl. Acad. Sci. USA. 92:1995;1162-1166.
48. Lu D., Yu K., Paddy M.R., Rowland N.E., Raizada M.K. Regulation of norepinephrine transport system by angiotensin II in neuronal cultures of normotensive and spontaneously hypertensive rat brains. Endocrinology. 137:1996;763-772.
49. MacLean M.R., Phillips M.I., Summers C., Raizada M.K. Alpha1-Adrenergic receptors in the nucleus tractus solitarii region of rats with experimental and genetic hypertension. Brain Res. 519:1990;261-265.
50. MacLean M.R., Raizada M.K., Sumners C. The influence of angiotensin II on catecholamine synthesis in neuronal cultures from rat brain. Biochem. Biophys. Res. Commun. 167:1990;492-497.
51. Mazarakis N.D., Azzouz M., Rohll J.B., Ellard F.M., Wilkes F.J., Olsen A.L., Carter E.E., Barber R.D., Baban D.F., Kingsman S.M., Kingsman A.J., O'Malley K., Mitrophanous K.A. Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery. Human Mol. Genet. 10:2001;2109-2121.
52. Mitrophanous K.A., Yoon S., Rohll J.B., Patil D., Wilkes F.J., Kim V.N., Kingsman S.M., Kingsman A.J., Mazarakis N.D. Stable gene transfer to the nervous system using a non-primate lentiviral vector. Human Gene Thera. 6:1999;1808-1818.
53. Navarro V., Millecamps S., Geoffroy M.-C., Robert J.-J., Valin A., Mallet J., Le Gal L.S. Efficient gene transfer and long-term expression in neurons using a recombinant adenovirus with a neuron-specific promoter. Gene Thera. 6:1999;1884-1892.
54. Nicklin S.A., Von Seggern D.J., Work L.M., Pek D.C., Dominiczak A.F., Nemerow G.R., Baker A.H. Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus. Mol. Thera. 4:2001;534-542.
55. Nishimura I., Uetsuki T., Dani S.U., Ohsawa Y., Saito I., Okamura H., Uchiyama Y., Yoshikawa K. Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer. J. Neurosci. 18:1998;2387-2398.
56. Niwa H., Yamamura K., Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene. 108:1991;193-199.
57. Nolte C., Matyash M., Pivneva T., Schipke C.G., Ohlemeyer C., Hanisch U.K., Kirchhoff F., Kettenmann H. GFAP promoter-controlled EGFP-expressing transgenic mice. A tool to visualize astrocytes and astrogliosis in living brain tissue Glia. 33:2001;72-86.
58. Oliva A.A. Jr., Jiang M., Lam T., Smith K.L., Swann J.W. Novel hippocampal interneuronal subtypes identified using transgenic mice that express green fluorescent protein in GABAergic interneurones. J. Neurosci. 20:2000;3354-3368.
59. Omori N., Mizuguchi H., Ohsawa K., Kohsaka S., Hayakawa T., Abe K., Shibasaki F. Modification of a fiber protein in an adenovirus vector improves in vitro gene transfer efficiency to the mouse microglial cell line. Neurosci. Lett. 324:2002;145-148.
60. Owens G.C., Boyd C.J. Expressing antisense P0 RNA in Schwann cells perturbs myelination. Development. 112:1991;639-649.
61. Owens G.C., Bunge R.P. Schwann cells infected with a recombinant retrovirus expressing myelin-associated glycoprotein antisense RNA do not form myelin. Neuron. 7:1991;565-575.
62. Pachori A.S., Huentelman M.J., Francis S.C., Gelband C.H., Katovich M.J., Raizada M.K. The future of hypertension therapy. sense, antisense, or nonsense? Hypertension. 37:2001;357-364.
63. Paton J.F.R., Deuchars J., Ahmad Z., Wong L.-F., Murphy D., Kasparov S. Adenoviral vector demonstrates that angiotensin II-induced depression of the cardiac baroreflex is mediated by endothelial nitric oxide synthase in the nucleus tractus solitarii of the rat. J. Physiol. 531:2001;445-458.
64. Paton J.F.R., Kasparov S., Paterson D.J. Nitric oxide and autonomic control of heart rate. a question of specificity Trends Neurosci. 25:2002;626-631. [Review] [65 refs].
65. Paton J.F., Waki H., Kasparov S. In vivo gene transfer to dissect neuronal mechanisms regulating cardiorespiratory function. Can. J. Physiol. Pharmacol. 81:2003;311-316.
66. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, London.
67. Peel A.L., Klein R.L. Adeno-associated virus vectors. activity and applications in the CNS J. Neurosci. Methods. 98:2000;95-104.
68. Phillips M.I. Gene therapy for hypertension. sense and antisense strategies Expert Opin. Biol. Thera. 1:2001;655-662.
69. Phillips M.I. Gene therapy for hypertension. the preclinical data Hypertension. 38:2001;543-548.
70. Phillips M.I., Tang Y., Schmidt-Ott K., Qian K., Kagiyama S. Vigilant vector. heart-specific promoter in an adeno-associated virus vector for cardioprotection Hypertension. 39:2002;651-655.
71. Pollock R., Clackson T. Dimerizer-regulated gene expression. Curr. Opin. Biotechnol. 13:2002;459-467. [Review] [40 refs].
72. 2+ signalling in epithelial cells. Cell Calcium. 24:1998;97-103.
73. Qualmann B., Kessels M.M. Endocytosis and the cytoskeleton. Int. Rev. Cytol. 220:2002;93-144.
74. Raizada M.K., Francis S.C., Wang H., Gelband C.H., Reaves P.Y., Katovich M.J. Targeting of the renin-angiotensin system by antisense gene therapy. a possible strategy for the long-term control of hypertension J. Hypertension. 18:2000;353-362.
75. Ralph G.S., Bienemann A., Harding T.C., Hopton M., Henley J., Uney J.B. Targeting of tetracycline-regulatable transgene expression specifically to neuronal and glial cell populations using adenoviral vectors. NeuroReport. 11:2000;2051-2055.
76. Riis B., Rattan S.I., Clark B.F., Merrick W.C. Eukaryotic protein elongation factors. Trends Biochem. Sci. 15:1990;420-424.
77. Sakai K., Hirooka Y., Matsuo I., Eshima K., Shigematsu H., Shimokawa H., Takeshita A. Overexpression of eNOS in NTS causes hypotension and bradycardia in vivo. Hypertension. 36:2000;1023-1028.
78. Sanders J., Brandsma M., Janssen G.M., Dijk J., Moller W. Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. J. Cell Sci. 109:1996;1113-1117.
79. Shen C., Buck A.K., Liu X., Winkler M., Reske S.N. Gene silencing by adenovirus-delivered siRNA. FEBS Lett. 539:2003;111-114.
80. Sinnayah P., Lindley T.E., Staber P.D., Cassell M.D., Davidson B.L., Davisson R.L. Selective gene transfer to key cardiovascular regions of the brain. comparison of two viral vector systems Hypertension. 39:2002;603-608.
81. Stec D.E., Davisson R.L., Haskell R.E., Davidson B.L., Sigmund C.D. Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo. J. Biol. Chem. 274:1999;21285-21290.
82. Stokes C.E.L., Murphy D., Paton J.F.R., Kasparov S. Dynamics of a transgene expression in acute rat brain slices transfected with adenoviral vectors. Exp. Physiol. 88:2003;459-466.
83. Stokes, C.E.L., Murphy, D., Paton, J.F.R., Teschemacher, A., Kasparov, S., 2003b. Visualising c-fos expression in physiologically viable cells using enhanced green fluorescent protein (EGFP). J. Physiol. 547P, C80 (online).
84. Stoppini L., Buchs P.A., Muller D. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods. 37:1991;173-182.
85. Sumners C., Shalit S.L., Kalberg C.J., Raizada M.K. Norepinephrine metabolism in neuronal cultures is increased by angiotensin II. Am. J. Physiol. - Cell Physiol. 252(21-6):1987;C650-C656.
86. Teschemacher A.G., Seward E.P. Bidirectional modulation of exocytosis by angiotensin II involves multiple G-protein-regulated transduction pathways in chromaffin cells. J. Neurosci. 20:2000;4776-4785.
87. Titeux M., Galou M., Gomes F.C., Dormont D., Neto V.M., Paulin D. Differences in the activation of the GFAP gene promoter by prion and viral infections. Brain Res. Mol Brain Res. 109:2002;119-127.
88. Tiveron M.C., Hirsch M.R., Brunet J.F. The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system. J. Neurosci. 16:1996;7649-7660.
89. Tsuchiya R., Yoshiki F., Kudo Y., Morita M. Cell type-selective expression of green fluorescent protein and the calcium indicating protein, yellow cameleon, in rat cortical primary cultures. Brain Res. 956:2002;221-229.
90. Ullrich B., Sudhof T.C. Differential distributions of novel synaptotagmins. comparison to synapsins Neuropharmacology. 34:1995;1371-1377.
91. Waki H., Kasparov S., Wong L.-F., Murphy D., Shimizu T., Paton J.F.R. Chronic inhibition of eNOS activity in NTS enhances baroreceptor reflex in conscious rats. J. Physiol. 546:2003;233-242.
92. Wang H., Lu D., Reaves P.Y., Katovich M.J., Raizada M.K. Retrovirally mediated delivery of angiotensin II type 1 receptor antisense in vitro and in vivo. Methods Enzymol. 314:1999;581-590.
93. Wang X., Yang H., Raizada M.K. Angiotensin II increases vesicular trafficking in brain neurons. Hypertension. 37:2001;677-682.
94. Wheeler D.G., Cooper E. Depolarization strongly induces human cytomegalovirus major immediate-early promoter/enhancer activity in neurons. J. Biol. Chem. 276:2001;31978-31985.
95. White S.J., Nicklin S.A., Sawamura T., Baker A.H. Identification of peptides that target the endothelial cell-specific LOX-1 receptor. Hypertension. 37:2001;449-455.
96. Wickham T.J. Targeting adenovirus. Gene Thera. 7:2000;110-114.
97. Wilkinson G.W., Akrigg A. Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector. Nucl. Acids Res. 20:1992;2233-2239.
98. Wong, L.-F., Kasparov, S., Murphy, D., Paton, J.F.R., 2001. Angiotensin II-mediated signal transduction mechanisms in the nucleus of the solitary tract (NTS) that depress the baroreflex. Society for Neurocience Abstracts 27, 837.4.
99. Wong L.F., Polson J.W., Murphy D., Paton J.F., Kasparov S. Genetic and pharmacological dissection of pathways involved in the angiotensin II-mediated depression of baroreflex function. FASEB J. Online. 16:2002;1595-1601.
100. Xia H., Mao Q., Paulson H.L., Davidson B.L. SiRNA-mediated gene silencing in vitro and in vivo. Nat. Biotechnol. 20:2002;1006-1010.
101. Yamada K., Moriguchi A., Mikami H., Okuda N., Higaki J., Ogihara T. The effect of central amino acid neurotransmitters on the antihypertensive response to angiotensin blockade in spontaneous hypertension. J. Hypertension. 13:1995;1624-1630.
102. Zimmerman M.C., Lazartigues E., Lang J.A., Sinnayah P., Ahmad I.M., Spitz D.R., Davisson R.L. Superoxide mediates the actions of angiotensin II in the central nervous system. Cir. Res. 91:2002;1038-1045. (comment).
103. Zonta M., Angulo M.C., Gobbo S., Rosengarten B., Hossmann K.A., Pozzan T., Carmignoto G. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat. Neurosci. 6:2003;43-50. [comment].