Efficient gene transfer and long-term expression in neurons using a recombinant adenovirus with a neuron-specific promoter

Gene Therapy

Volumn 6, Issue 11, 1999, Pages 1884-1892

  Navarro, V ^a   Millecamps, S ^a   Geoffroy, M C ^a   Robert, J J ^a   Valin, A ^b   Mallet, J ^a   Le Gal La Salle, G ^b,c  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b CNRS   (France)

^c UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Adenoviral vector; Gene therapy; Hippocampus; Neuron specific enolase promoter; Neurons

Indexed keywords

BETA GALACTOSIDASE; NEURON SPECIFIC ENOLASE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL SPECIFICITY; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; ESCHERICHIA COLI; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSDUCTION; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPORTER GENE; ROUS SARCOMA ONCOVIRUS; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALIA; ESCHERICHIA COLI; ONCOVIRINAE; RICE STRIPE VIRUS; RNA VIRUSES; ROUS SARCOMA VIRUS;

EID: 0032758671     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301008     Document Type: Article

References (25)

1. Anderson WF. Human gene therapy. Nature 1998; 392: 25-30.
2. Le Gal La Salle G et al. An adenovirus vector for gene transfer into neurons and glia in the brain. Science 1993; 259: 988-990.
3. Akli S et al. Transfer of foreign genes into the brain using adenovirus vectors. Nat Genet 1993; 3: 224-228.
4. Hashimoto M et al. A neural cell-type-specific expression system using recombinant adenovirus vectors. Hum Gene Ther 1996; 7: 149-158.
5. Marangos PJ. Neuron-specific enolase, a clinically useful marker for neurons and neuroendocrine cells. Ann Rev Neurosci 1987; 10: 269-295.
6. Sakimura K et al. Upstream and intron regulatory regions for expression of the rat neuron-specific enolase gene. Mol Brain Res 1995; 28: 19-28.
7. Forss-Petter S et al. Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron 1990; 5: 187-197.
8. Martinou JC et al. Overexpression of BCL-2 in transgenic mice protects from naturally occurring cell death and experimental ischemia. Neuron 1994; 13: 1017-1030.
9. Babiss LE, Friedman JM, Darnell JE. Cellular promoters incorporated into the adenovirus genome: effects of viral regulatory elements on transcription rates and cell specificity of albumin and β-globin promoters. Mol Cell Biol 1986; 6: 3798-3806.
10. Sakimura K, Kushiya E, Takahashi Y, Suzuki Y. The structure and expression of neuron-specific enolase gene. Gene 1987; 60: 103-113.
11. Hannas-Djebbara Z et al. Transgene expression of plasmid DNAs directed by viral or neural promoters in the rat brain. Mol Brain Res 1997; 46: 91-99.
12. Klein RL et al. Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors. Exp Neurol 1998; 150: 183-194.
13. Byrnes AP, Wood MJA, Charlton HM. Role of T cells in inflammation caused by adenovirus vectors in the brain. Gene Therapy 1996; 3: 644-651.
14. Palmer TD, Rosman GJ, Osborne WRA, Miller AD. Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes. Proc Natl Acad Sci USA 1991; 88: 1330-1334.
15. Davidson BL et al. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat Genet 1993; 3: 219-223.
16. Andersen JK, Frim DM, Isacson O, Breakefield XO. Herpes virus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter. Cell Mol Neurobiol 1993; 13: 503-515.
17. Dedieu JF et al. Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenoviruses. J Virol 1997; 71: 4626-4637.
18. Kochaneck S et al. A new adenoviral vector: replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and β-galactosidase. Proc Natl Acad Sci USA 1996; 93: 5731-5736.
19. Barkats M et al. An adenovirus encoding CuZnSOD protects cultured striatal neurons against glutamate toxicity. NeuroReport 1996; 7: 497-501.
20. Robert JJ et al. Adenovirus-mediated transfer of a functional GAD gene into nerve cells: potential for the treatment of neurological diseases. Gene Therapy 1997; 4: 1237-1245.
21. Stratford-Perricaudet LD, Makeh I, Perricaudet M, Briand P. Widespread long-term gene transfer to mouse skeletal muscles and heart. J Clin Invest 1992; 90: 626-630.
22. Maizel JV, White DO, Scharff MD. The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12. Virology 1968; 36: 115-125.
23. Mittereder N, March KL, Trapnell BC. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J Virol 1996; 70: 7498-7509.
24. Hawrot E, Patterson PH. Long-term culture of dissociated sympathetic neurons. Meth Enzymol 1979; 58: 574-584.
25. Albe-Fessard D, Stutinsky F, Libouban S. Atlas Stéréotaxique du Diencéphale du Rat Blanc. CNRS: Paris, 1971.