Chronic inhibition of endothelial nitric oxide synthase activity in nucleus tractus solitarii enhances baroreceptor reflex in conscious rats

Journal of Physiology

Volumn 546, Issue 1, 2003, Pages 233-242

  Waki, Hidefumi ^a,b   Kasparov, Sergey ^a   Wong, Liang Fong ^a   Murphy, David ^a   Shimizu, Tsuyoshi ^b   Paton, Julian F R ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; GREEN FLUORESCENT PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENHANCED GREEN FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; CONSCIOUSNESS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE TRANSFER; HEART RATE; MALE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; REVIEW; SOLITARY TRACT NUCLEUS; TELEMETRY; ANIMAL TISSUE; ARTICLE; PROTEIN EXPRESSION;

ANGIOTENSIN II; ANIMALS; BAROREFLEX; BLOOD PRESSURE; CARDIOVASCULAR AGENTS; GENE TRANSFER TECHNIQUES; HEART RATE; MALE; MICROINJECTIONS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, WISTAR; SOLITARY NUCLEUS; TIME FACTORS; TRANSFECTION;

EID: 0037232698     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.030270     Document Type: Review

References (42)

1. Bains JS & Ferguson AV (1997). Nitric oxide regulates NMDA-driven GABAergic inputs to type I neurones of the rat paraventricular nucleus. J Physiol 499, 733-746.
2. Batten TFC, Atkinson L & Deuchars J (2000). Nitric oxide systems in the medulla oblongata and their involvement in autonomic control. In Handbook of Chemical Neuroanatomy, vol. XIV, Functional Neuroanatomy of the Nitric Oxide System, ed. Steinbusch, HWM & De Vente, J, pp. 177-213. Elsevier, Amsterdam.
3. Bertinieri G, Di Rienzo M, Cavallazzi A, Ferrari AU, Pedotti A & Mancia G (1988). Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats. Am J Physiol 254, H377-383.
4. Blessing, WW (1997). Anatomy of the lower brainstem. In The Lower Brainstem and Bodily Homeostasis, pp. 29-99. Oxford University Press, New York.
5. Busconi L & Michel T (1993). Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization. J Biol Chem 268, 8410-8413.
6. Casto R & Phillips MI (1986). Angiotensin II attenuates baroreflexes at nucleus tractus solitarius of rats. Am J Physiol 250, R193-198.
7. Dickinson CJ & Sleight P (2001). The baroreflex bandwagon: time to get off? J Hypertens 19, 157-161.
8. Ferguson AV & Latchford K. J (2000). Local circuitry regulates the excitability of rat neurohypophysial neurones. Exp Physiol 85S, 153S-161S.
9. Forstermann U, Boissel JP & Kleinert H (1998). Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J 12, 773-790.
10. Frankel RA, Metting PJ & Britton SL (1993). Evaluation of spontaneous baroreflex sensitivity in conscious dogs. J Physiol 462, 31-45.
11. Fuxe K, Aganti LF, Covenas R, Norvaez JA, Bunnemann B & Bjelke B (1994). Volume transmission in transmitter peptide co-storing neurons in the medulla oblongata. In Nucleus of the Solitary Tract, ed. Barraco IRA, pp. 75-89. CRC Press, London.
12. Harada S, Tokunaga S, Momohara M, Masaki H, Tagawa T, Imaizumi T & Takeshita A (1993). Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits. Circulation Res 72, 511-516.
13. Iellamo F (2001). Neural mechanisms of cardiovascular regulation during exercise. Auton Neurosci 90, 66-75.
14. Kano T, Shimizu-Sasamata M, Huang P L, Moskowitz M A & Lo EH (1998). Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo. Neuroscience 86, 695-699.
15. Kantor DB, Lanzrein M, Stary SJ, Sandoval GM, Smith WB, Sullivan BM, Davidson N & Schuman EM (1996). A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue. Science 274, 1744-1748.
16. Kasparov S & Paton JFR (1999). Differential effects of angiotensin II in the nucleus tractus solitarii of the rat - plausible neuronal mechanisms. J Physiol 521, 227-238.
17. Lawrence AJ, Castillo-Melendez M, McLean K & Jarrott B(1998). The distribution of nitric oxide synthase-, adenosine deaminase- and neuropeptide Y-immunoreactivity through the entire rat nucleus tractus solitarius. Effects of unilateral nodose ganglionectomy. J Chem Neuroanat 15, 27-40.
18. Lee CM, Robinson LJ & Michel T (1995). Oligomerization of endothelial nitric oxide synthase. Evidence for a dominant negative effect of truncation mutants. J Biol Chem 270, 27 403-27 406.
19. Lewis SJ, Ohta H, Machado B, Bates JN & Talman WT (1991). Microinjection of S-nitrosocysteine into the nucleus tractus solitarii decreases arterial pressure and heart rate via activation of soluble guanylate cyclase. Eur J Pharmacol 202, 135-136.
20. Li J, Smith SA & Mitchell JH (2002). The arterial baroreflex attenuates the pressor response to exercise by increasing nitric oxide formation within the nucleus tractus solitarius. Proceedings of the Experimental Biology 2002 Meeting, 131.4.
21. Lind RW, Swanson LW & Ganten D (1985). Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. An immunohistochemical study. Neuroendocrinology 40, 2-24.
22. Liu J & Sessa WC (1994). Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase. J Biol Chem 269, 11 691-11 694.
23. Liu J-L, Murakami H & Zucker IH (1996). Effects of NO on baroreflex control of heart rate and renal nerve activity in conscious rabbits. Am J Physiol 270, R1361-1370.
24. Luoh HF & Chan SHH (1998). Participation of AT1 and AT2 receptor subtypes in the tonic inhibitory modulation of baroreceptor reflex response by endogenous angiotensins at the nucleus tractus solitarii in the rat. Brain Res 782, 73-83.
25. Michelini LC & Bonagamba LH (1990). Angiotensin II as a modulator of baroreceptor reflexes in the brainstem of conscious rats. Hypertension 15, 145-150.
26. Millatt LJ, Abdel-Rahman EM & Siragy HM (1999). Angiotensin II and nitric oxide: a question of balance. Regul Pep 81, 1-10.
27. Miyajima E, Shigemasa T, Yamada Y, Tochikubo O & Ishii M (1999). Angiotensin II blunts, while an angiotensin-converting enzyme inhibitor augments, reflex sympathetic inhibition in humans. Clin Exp Pharmacol Physiol 26, 797-802.
28. Murasato Y, Hirakawa H, Harada Y, Nakamura T & Hayashida, Y (1998). Effects of systemic hypoxia on R-R interval and blood pressure variabilities in conscious rats. Am J Physiol 275, H797-804.
29. Oosting J, Janssen BJA & Struijker-Boudier HAJ (1997a). Autonomic control of ultradian and circadian rhythms of blood pressure, heart rate, and baroreflex sensitivity in SHR. J Hypertens 15, 401-410.
30. Oosting J, Struijker-Boudier HAJ & Janssen BJA (1997b). Validation of a continuous baroreceptor reflex sensitivity index calculated from spontaneous fluctuations of blood pressure and pulse interval in rats. J Hypertens 15, 391-399.
31. Ozaki M, Shibuya N, Kabashima T, Isse T, Noguchi J, Ueta Y, Inoue Y, Shigematsu A & Yamashita H (2000). Preferential potentiation by nitric oxide of spontaneous inhibitory postsynaptic currents in rat supraoptic neurones. J Neuroendocrinol 12, 273-281.
32. Paton JFR, Boscan P, Murphy D & Kasparov S (2001a). Unravelling mechanisms of action of angiotensin II on cardiorespiratory function using in vivo gene transfer. Acta Physiol Scand 173, 127-137.
33. Paton JFR, Deuchars J, Ahmad Z, Wong L-F, Murphy D & Kasparov S (2001b). Adenoviral vector demonstrates that angiotensin II-induced depression of the cardiac baroreflex is mediated by endothelial nitric oxide synthase in the nucleus tractus solitarii of the rat. J Physiol 531, 445-458.
34. Paton JFR & Kasparov S (1999). Differential effects of angiotensin II on cardiorespiratory reflexes mediated by nucleus tractus solitarii - a microinjection study in the rat. J Physiol 521, 213-225.
35. Paton JFR & Kasparov S (2000). Sensory channel specific modulation in the nucleus of the solitary tract. J Auton Nerv Syst 80, 117-129.
36. Pontieri V, Venezuela MK, Scavone C & Michelini LC (1998). Role of endogenous nitric oxide in the nucleus tractus solitarii on baroreflex control of heart rate in spontaneously hypertensive rats. J Hypertens 16, 1993-1999.
37. Ruggiero DA, Mtui EP, Otake K & Anwar M (1996). Central and primary visceral afferents to nucleus tractus solitarii may generate nitric oxide as a membrane-permeant neuronal messenger. J Comp Neurol 361, 51-67.
38. Sakai K, Hirooka Y, Matsuo I, Eshima K, Shigematsu H, Shimokawa H & Takeshita A (2000). Overexpression of eNOS in NTS causes hypotension and bradycardia in vivo. Hypertension 36, 1023-1028.
39. Struyker-Boudier HAJ, Evenwel RT, Smits JFM & Van Essen H (1982). Baroreflex sensitivity during the development of spontaneous hypertension in rats. Clin Sci 56, 163-167.
40. Thrasher, T. N (2002). Unloading arterial baroreceptors causes neurogenic hypertension. Am JPhysiol 282, R1044-1053.
41. Vasquez EC, Cunha RS & Cabral AM (1994). Baroreceptor reflex function in rats submitted to chronic inhibition of nitric oxide synthesis. Brazilian J Med Biol Res 27, 767-774.
42. Zanzinger J, Czachurski J & Seller H (1995). Effects of nitric oxide on sympathetic baroreflex transmission in the nucleus tractus solitarii and caudal ventrolateral medulla in cats. Neurosci Lett 197, 199-202.