Insulin-degrading enzyme in brain microvessels: Proteolysis of amyloid β vasculotropic variants and reduced activity in cerebral amyloid angiopathy

Journal of Biological Chemistry

Volumn 279, Issue 53, 2004, Pages 56004-56013

  Morelli, Laura ^a   Llovera, Ramiro E ^a   Mathov, Irina ^a   Lue, Lih Fen ^b   Frangione, Blas ^c   Ghiso, Jorge ^c   Castaño, Eduardo M ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b SUN HEALTH RESEARCH INSTITUTE   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BLOOD VESSELS; BRAIN; DISEASES; IMMUNOLOGY; INSULIN; MASS SPECTROMETRY; PRECIPITATION (CHEMICAL);

ALZHEIMER'S DISEASE; BRAIN MICROVESSELS; CEREBRAL AMYLOID ANGIOPATHY (CAA); PROTEOLYSIS;

ENZYMES;

AMYLOID BETA PROTEIN; INSULIN; IODINE 125;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; BRAIN MICROCIRCULATION; CONTROLLED STUDY; DOWN SYNDROME; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; ISOTOPE LABELING; MASS SPECTROMETRY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RACE DIFFERENCE; RAT; STROKE; VASCULAR AMYLOIDOSIS; WESTERN BLOTTING;

ADULT; AMYLOID BETA-PROTEIN; ANIMALS; BLOTTING, WESTERN; BRAIN; CEREBRAL AMYLOID ANGIOPATHY; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INSULIN; INSULYSIN; KINETICS; MASS SPECTROMETRY; MICROCIRCULATION; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MUTATION; PEPTIDES; PROTEIN BINDING; RATS; RECOMBINANT PROTEINS; TIME FACTORS;

LEUCISCUS IDUS;

EID: 11244276934     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M407283200     Document Type: Article

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