Purified recombinant insulin-degrading enzyme degrades amyloid β-protein but does not promote its oligomerization

Biochemical Journal

Volumn 351, Issue 2, 2000, Pages 509-516

  Chesneau, V ^a   Vekrellis, K ^a   Rosner, M R ^a   Selkoe, D J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

A proteolysis; Alzheimer's disease; Metalloendopeptidase; Oligomer

Indexed keywords

AMYLOID BETA PROTEIN; INSULINASE; IODINE 125; METALLOPROTEINASE; RECOMBINANT ENZYME; SULFUR 35;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENETIC RECOMBINATION; HUMAN; IODINATION; MICROGLIA; MOLECULAR WEIGHT; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMYLOID BETA-PROTEIN; BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INSULYSIN; PROTEIN BINDING; RECOMBINANT PROTEINS; TIME FACTORS;

LEUCISCUS IDUS;

EID: 0034667518     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3510509     Document Type: Article

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