Modification with SUMO. A role in transcriptional regulation

EMBO Reports

Volumn 4, Issue 2, 2003, Pages 137-142

  Verger, Alexis ^a   Perdomo, José ^a   Crossley, Merlin ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; LYSINE; PROTEIN C JUN; PROTEIN C MYB; SUMO PROTEIN; TRANSCRIPTION FACTOR SP3; UNCLASSIFIED DRUG;

CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOLOGY; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVIEW; TRANSCRIPTION REGULATION; CONJUGATION; DNA BINDING; NONHUMAN; NUCLEAR PORE COMPLEX; SUMOYLATION; UBIQUITINATION;

GENE EXPRESSION REGULATION; HUMANS; PROTEIN STRUCTURE, TERTIARY; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; TRANSCRIPTION, GENETIC;

EID: 0037295721     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.embor738     Document Type: Review

References (47)

1. Abdel-Hafiz, H.A.,Takimoto, G.S., Tung, L. & Horwitz, K.B. (2002) The inhibitory function (IF) in human progesterone receptor N-termini binds small ubiquitin-like modifier (SUMO-1) protein to regulate autoinhibition and transrepression. J. Biol. Chem., 277, 33950-33956.
2. Best, J.L. et al. (2002) SUMO-1 protease-1 regulates gene transcription through PML. Mol. Cell, 10, 843-855.
3. Bies, J., Markus, J. & Wolff, L. (2002) Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity. J. Biol. Chem., 277, 8999-9009.
4. Braun, H., Koop, R., Ertmer, A., Nacht, S. & Suske, G. (2001) Transcription factor Sp3 is regulated by acetylation. Nucleic Acids Res., 29, 4994-5000.
5. Chakrabarti, S.R. et al. (1999) Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9. Proc. Natl Acad. Sci. USA, 96, 7467-7472.
6. David, G., Neptune, M.A. & DePinho, R.A. (2002) SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities. J. Biol Chem., 277, 23658-23663.
7. Desterro, J.M., Rodriguez, M.S. & Hay, R.T. (1998) SUMO-1 modification of IκBα inhibits NF-κB activation. Mol. Cell, 2, 233-239.
8. Eloranta, J.J. & Hurst, H.C. (2002) Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. J. Biol. Chem., 277, 30798-30804.
9. Gong, L., Kamitani, T., Fujise, K., Caskey, L.S. & Yeh, E.T. (1997) Preferential interaction of sentrin with a ubiquitin-conjugating enzyme, Ubc9. J. Biol. Chem., 272, 28198-28201.
10. Goodson, M.L. et al. (2001) Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor. J. Biol. Chem., 276, 18513-18518.
11. Hardeland, U., Steinacher, R., Jiricny, J. & Schar, P. (2002) Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. EMBO J., 21, 1456-1464.
12. Hochstrasser, M. (2000) Biochemistry. All in the ubiquitin family. Science, 289, 563-564.
13. Hoege, C., Pfander, B., Moldovan, G.L., Pyrowolakis, G. & Jentsch, S. (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature, 419, 135-141.
14. Hofmann, H., Floss, S. & Stamminger, T. (2000) Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b. J. Virol., 74, 2510-2524.
15. Hong, Y. et al. (2001) Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification. J. Biol. Chem., 276, 40263-40267.
16. Iniguez-Lluhi, J.A. & Pearce, D. (2000) A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol. Cell. Biol., 20, 6040-6050.
17. Johnson, E.S. & Gupta, A.A. (2001) An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell, 106, 735-744.
18. Kahyo, T., Nishida, T. & Yasuda, H. (2001) Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Mol. Cell, 8, 713-718.
19. Kim, J., Cantwell, C.A., Johnson, P.F., Pfarr, C.M. & Williams, S.C. (2002a) Transcriptional activity of CCAAT/enhancer binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation. J. Biol. Chem., 277, 38037-38044.
20. Kim, K.I., Baek, S.H. & Chung, C.H. (2002b) Versatile protein tag, SUMO: its enzymology and biological function. J. Cell Physiol., 191, 257-268.
21. Kirsh, O. et al. (2002) The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J., 21, 2682-2691.
22. Kotaja, N., Karvonen, U., Janne, O.A. & Palvimo, J.J. (2002a) The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1. J. Biol. Chem., 277, 30283-30288.
23. Kotaja, N., Karvonen, U., Janne, O.A. & Palvimo, J.J. (2002b) PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases. Mol. Cell. Biol., 22, 5222-5234.
24. Matunis, M.J., Wu, J. & Blobel, G. (1998) SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J. Cell Biol., 140, 499-509.
25. Megidish, T., Xu, J.H. & Xu, C.W. (2002) Activation of p53 by protein inhibitor of activated Stat1 (PIAS1). J. Biol. Chem., 277, 8255-8259.
26. Melchior, F. (2000) SUMO - nonclassical ubiquitin. Annu. Rev. Cell Dev. Biol., 16, 591-626.
27. Minty, A., Dumont, X., Kaghad, M. & Caput, D. (2000) Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif. J. Biol. Chem., 275, 36316-36323.
28. Muller, S. et al. (2000) c-Jun and p53 activity is modulated by SUMO-1 modification. J. Biol. Chem., 275, 13321-13329.
29. Muller, S., Hoege, C., Pyrowolakis, G. & Jentsch, S. (2001) SUMO, ubiquitin's mysterious cousin. Nature Rev. Mol. Cell Biol., 2, 202-210.
30. Nishida, T. & Yasuda, H. (2002) PIAS1 and PIASxa function as SUMO-E3 ligases toward androgen receptor, and repress androgen receptor-dependent transcription. J. Biol. Chem., 277, 41311-41317.
31. Pichler, A., Gast, A., Seeler, J.S., Dejean, A. & Melchior, F. (2002) The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell, 108, 109-120.
32. Pichler, A. & Melchior, F. (2002) Ubiquitin-related modifier SUMO1 and nucleocytoplasmic transport. Traffic, 3, 381-387.
33. Poukka, H., Aarnisalo, R, Karvonen, U., Palvimo, J.J. & Janne, O.A. (1999) Ubc9 interacts with the androgen receptor and activates receptor-dependent transcription. J. Biol. Chem., 274, 19441-19446.
34. Poukka, H., Karvonen, U., Janne, O.A. & Palvimo, J.J. (2000) Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1). Proc. Natl Acad. Sci. USA, 97, 14145-14150.
35. Ross, S., Best, J.L., Zon, L.I. & Gill, G. (2002) SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol. Cell, 10, 831-842.
36. Sachdev, S. et al. (2001) PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev., 15, 3088-3103.
37. Saitoh, H. & Hinchey, J. (2000) Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J. Biol. Chem., 275, 6252-6258.
38. Salghetti, S.E., Caudy, A.A., Chenoweth, J.G. & Tansey, W.P. (2001) Regulation of transcriptional activation domain function by ubiquitin. Science, 293, 1651-1653.
39. Sampson, D.A., Wang, M. & Matunis, M.J. (2001) The small ubiquitin-like modifier-1 (SUMO-1) consensus sequence mediates Ubc9 binding and is essential for SUMO-1 modification. J. Biol. Chem., 276, 21664-21669.
40. Sapetschnig, A. et al. (2002) Transcription factor Sp3 is silenced through SUMO modification by PIAS1. EMBOJ., 21, 5206-5215.
41. Schmidt, D. & Muller, S. (2002) Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. Proc. Natl Acad. Sci. USA, 99, 2872-2877.
42. Seeler, J.S. & Dejean, A. (2001) SUMO: of branched proteins and nuclear bodies. Oncogene, 20, 7243-7249.
43. Snowden, A.W., Anderson, L.A., Webster, G.A. & Perkins, N.D. (2000) A novel transcriptional repression domain mediates p21 (WAF1/CIP1) induction of p300 transactivation. Mol. Cell. Biol., 20, 2676-2686.
44. Tatham, M.H. et al. (2001) Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J. Biol. Chem., 276, 35368-35374.
45. Tian, S., Poukka, H., Palvimo, J.J. & Janne, O.A. (2002) SUMO-1 modification of the glucocorticoid receptor. Biochem. J., 367, 907-911.
46. Weissman, A.M. (2001) Themes and variations on ubiquitylation. Nature Rev. Mol. Cell. Biol., 2, 169-178.
47. Yang, S.H., Bumpass, D.C., Perkins, N.D. & Sharrocks, A.D. (2002) The ETS domain transcription factor Elk-1 contains a novel class of repression domain. Mol. Cell. Biol., 22, 5036-5046.