A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading

Journal of Cell Biology

Volumn 152, Issue 3, 2001, Pages 585-598

  Tu, Yizeng ^a   Huang, Yao ^a   Zhang, Yongjun ^a   Hua, Yun ^a   Wu, Chuanyue ^a   Wu, Cary ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Calponin homology; Cell adhesion; Focal adhesion; Integrin linked kinase; Integrins

Indexed keywords

CALPONIN HOMOLOGY DOMAIN CONTAINING INTEGRIN LINKED KINASE BINDING PROTEIN; CELL ADHESION MOLECULE; GREEN FLUORESCENT PROTEIN; INTEGRIN LINKED KINASE; MONOCLONAL ANTIBODY; PHOSPHOTRANSFERASE; PROTEIN PINCH; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; ACTININ; CALCIUM BINDING PROTEIN; CALPONIN; CARRIER PROTEIN; DNA BINDING PROTEIN; INTEGRIN-LINKED KINASE; LIMS1 PROTEIN, HUMAN; PARVA PROTEIN, HUMAN; PARVB PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL SPREADING; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSKELETON; FOCAL ADHESION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REGULATORY MECHANISM; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CELL COMPARTMENTALIZATION; CELL SIZE; CHEMISTRY; CHO CELL; GENETICS; HAMSTER; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; TWO HYBRID SYSTEM;

ANIMALIA; NEMATODA;

ACTININ; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CELL ADHESION; CELL COMPARTMENTATION; CELL SIZE; CHO CELLS; CRICETINAE; CYTOSKELETON; DNA-BINDING PROTEINS; FOCAL ADHESIONS; HUMANS; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE HOMOLOGY, AMINO ACID; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0035972170     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.3.585     Document Type: Article

References (35)

1. Focal adhesions, contractility, and signaling
2. Integrins and actin filaments: Reciprocal regulation of cell adhesion and signaling
3. Integrins and signal transduction pathways: The road taken
4. Integrin cytoplasmic interactions and bidirectional transmembrane signalling
5. Integrin linked kinase (ILK): A regulator of integrin and growth-factor signaling
6. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
7. Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src
8. Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans
9. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase
10. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans
11. The roles of integrin-linked kinase in the regulation of myogenic differentiation
12. Integrins: Versatility, modulation, and signaling in cell adhesion
13. The evolution of cell adhesion
14. Focal adhesion kinase: At the crossroads of signal transduction
15. The molecular architecture of focal adhesions
16. The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine
17. Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens
18. Integrin-linked kinase is localized to cellmatrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats
19. Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion
20. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways
21. Focal adhesion kinase: Structure and signalling
22. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
23. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression
24. Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: A role for paxillin tyrosine phosphorylation
25. Adhesion-growth factor interactions during differentiation: An integrated biological response
26. Integrins: Emerging paradigms of signal transduction
27. Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase sigr aling pathways
28. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells
29. Paxillin
30. Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations
31. Integrin-linked kinase and PINCH: Partners in regulation of cell-extracellular matrix interaction and signal transduction
32. The role of alpha 4 beta 1 integrin in cell motility and fibronectin matrix assembly
33. Integrin-linked protein kinase regulates fibronectin matrix assembly E-cadherin expression, and tumorigenicity
34. Epidermal grwoth factor-induced activation and translocation of phospholipase C-yl to the cytoskeleton in rat hepatocytes
35. Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane