Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7-/- mice

Journal of Experimental Medicine

Volumn 194, Issue 8, 2001, Pages 1141-1150

  Carvalho, T L ^a   Mota Santos, T ^a   Cumano, A ^a   Demengeot, J ^a   Vieira, P ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

B cell development; B lymphocyte; B1 cells; Interleukin 7; Marginal zone B cells

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 7;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL MATURATION; CONTROLLED STUDY; FETUS DEVELOPMENT; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOPOIESIS; MOUSE; NONHUMAN; PERINATAL DEVELOPMENT; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

AGING; ANIMALS; B-LYMPHOCYTES; BIOLOGICAL MARKERS; BONE MARROW CELLS; CELL DIFFERENTIATION; FEMALE; HEMATOPOIESIS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOPHENOTYPING; INTERLEUKIN-7; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; PLASMA CELLS; SPLEEN;

EID: 0035886939     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.8.1141     Document Type: Article

References (43)

1. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
2. Interleukin 7 production and function in stromal cell-dependent B cell development
3. Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily
4. Interleukin-2 receptor gamma chain: A functional component of the interleukin-7 receptor
5. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
6. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
7. Autonomous activation of B and T cells in antigen-free mice
8. IgMhighCD21high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells
9. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk
10. Progenitors for Ly-1 B cells are distinct from progenitors for other B cells
11. Development and function of B-1 cells
12. Sequence homologies, N sequence insertion and JH gene utilization in VH-DJH joining: Implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation
13. B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures
14. The peritoneal Ly-1 (CD5) B cell repertoire is unique among murine B cell repertoires
15. Emergence of multipotent hemopoietic cells in the yolk sac and paraaortic splanchnopleura in mouse embryos, beginning at 8.5 days postcoitus (published erratum at 92:10815)
16. Reactions among IgM antibodies derived from normal, neonatal mice
17. Identification of the earliest B lineage stage in mouse bone marrow
18. + cells in murine bone marrow does not express CD19 and contains natural killer cell progenitors
19. A novel cell surface molecule on early B-lineage cells
20. Genetic basis of the neonatal antibody repertoire: Germline V-gene expression and limited N-region diversity
21. Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences
22. Ontogeny of terminal deoxynucleotidyl transferase-positive cells in lymphohemopoietic tissues of rat and mouse
23. B-1 cells: The lineage question revisited
24. + B cells
25. Characteristics and development of the murine B-1b (Ly-1 B sister) cell population
26. Further evidence for coelomic-associated B lymphocytes
27. CD43 (S7) expression identifies peripheral B cell subsets
28. Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population
29. A critical role of lambda 5 protein in B cell development
30. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses
31. Commitment to the B lymphoid lineage occurs before DH-JH recombination
32. Interleukin-3 and interleukin-7 are alternative growth factors for the same B-cell precursors in the mouse
33. Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro
34. Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL7R alpha, terminal deoxynucleotidyltransferase, and c mu expression
35. Regulation of cell survival during B lymphopoiesis: Apoptosis and Bcl-2/ Bax content of precursor B cells in bone marrow of mice with altered expression of IL-7 and recombinase-activating gene-2
36. Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor-deficient mice but can enhance survival of mature B cells
37. Common cytokine receptor gamma chain (gammac)-deficient B cells persist in T cell-deficient gammac-mice and respond to a T-independent antigen
38. Type I IFN sets the stringency of B cell repertoire selection in the bone marrow
39. Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow
40. Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity
41. Positive and negative selection of antibody repertoires during B-cell differentiation
42. Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors
43. Toward a layered immune system