A role for DNA polymerase V in G → T mutations from the major benzo[a]pyrene N2-dG adduct when studied in a 5′-TGT sequence in E. coli

DNA Repair

Volumn 3, Issue 3, 2004, Pages 323-334

  Yin, Jun ^a   Seo, Kwang Young ^a   Loechler, Edward L ^a  

^a Boston University   (United States)

Author keywords

Adduct site specific mutagenesis; Cancer; Genotoxins; Lesion and sequence context effects; Mutational spectrum; Mutations; Pol II; Pol IV; Pol V; UVM

Indexed keywords

BENZO[A]PYRENE; DNA POLYMERASE;

ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; ESCHERICHIA COLI; GENE MUTATION; MUTAGENESIS; NONHUMAN; PLASMID; PRIORITY JOURNAL; ULTRAVIOLET IRRADIATION;

EID: 0842303308     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2003.11.012     Document Type: Article

References (146)

1. R.G. Harvey, Polycyclic Aromatic Hydrocarbons: Chemistry and Cancer, Wiley-VCH, New York, 1997.
2. Phillips D.H. Fifty years of benzo[a]pyrene. Nature. 303:1983;468-472.
3. B. Singer, D. Grunberger, Molecular Biology of Mutagens and Carcinogens, Plenum Press, New York, 1983.
4. Conney A.H. Induction of microsomal enzymes by foreign chemicals and carcinogens by polycyclic aromatic hydrocarbons. Cancer Res. 42:1982;4875-4917.
5. A. Dipple, Polycyclic aromatic hydrocarbon carcinogens, in: R.G. Harvey (Ed.), Polycyclic Aromatic Hydrocarbons and Carcinogenesis, American Chemical Society Press, Washington, DC, 1985, pp. 1-17.
6. P.W. Jones, Polynuclear aromatic hydrocarbons, in: M.G. Bowman (Ed.), Handbook of Carcinogens and Hazardous Substances, Marcel Dekker, New York, 1982, pp. 573-639.
7. P. Grasso, Carcinogens in food, in: C.E. Searle (Ed.), Chemical Carcinogens, second ed., ACS Monograph 182, American Chemical Society Press, Washington, DC, 1984, pp. 1205-1239.
8. Cheng S.C., Hilton B.D., Roman J.M., Dipple A. DNA adducts from carcinogenic and noncarcinogenic enantiomers of benzo[a]pyrene dihydrodiol epoxide. Chem. Res. Toxicol. 2:1989;334-340.
9. Sayer J.M., Chadha A., Agarwal H.S.K., Yeh H.J.C., Yagi H., Jerina D.M. Covalent nucleoside adducts of benzo[a]pyrene 7,8-diol 9,10-epoxides: structural reinvestigation and characterization of a novel adenosine adduct on the ribose moiety. J. Org. Chem. 56:1991;20-29.
10. Phillips D.H., Hewer A., Grover P.L. Aberrant activation of benzo[a]pyrene in cultured rat mammary cells in vitro and following direct application to rat mammary glands in vivo. Cancer Res. 45:1985;4167-4174.
11. Marnett L.J. Peroxyl free radicals: potential mediators of tumor initiation and promotion. Carcinogenesis. 8:1987;1365-1373.
12. Devanesan P.D., RamaKrishna N.V.S., Todorovic R., Rogan E.G., Cavalieri E.L., Jeong H., Jankowiak R., Small G.J. Identification and quantitation of benzo[a]pyrene-DNA adducts formed by rat liver microsomes. Chem. Res. Toxicol. 5:1992;302-309.
13. Chakravarti D., Mailander P.C., Cavalieri E.L., Rogan E.G. Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia. Mutat. Res. 456:2000;17-32.
14. Chakravarti D., Pelling J., Cavalieri E.L., Rogan E.G. Relating aromatic hydrocarbon-induced DNA adducts and the c-H-ras mutations in mouse skin papillomas: The role of apurinic sites. Proc. Natl. Acad. Sci. U.S.A. 92:1995;10422-10426.
15. Chen L., Devanesan R., Higginbotham S., Ariese F., Jankowiak R., Small G.J., Rogan E.G., Cavalieri E. Expanded analysis of benzo[a]pyrene-DNA adducts formed in vitro and in mouse skin: their significance in tumor initiation. Chem. Res. Toxicol. 9:1996;897-903.
16. Balmain A., Brown K. Oncogene activation in chemical carcinogenesis. Adv. Cancer Res. 51:1988;147-182.
17. Ruggeri B.A., Bauer B., Zhang S.-Y., Klein-Szanto A.J.P. Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl1/cyclin D1 abnormalities. Carcinogenesis. 15:1994;6113-6119.
18. M. Hall, P.L. Grover, Polycyclic aromatic hydrocarbons: metabolism, activation and tumour initiation, in: G.S. Cooper, P.L. Grover, (Eds.), Handbook of Experimental Pharmacology, vol. 94/1, Chemical Carcinogenesis and Mutagenesis, Springer-Verlag, Heidelberg, 1990, pp. 327-372.
19. Denissenko M.F., Pao A., Tang M., Pfeifer G.P. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in p53. Science. 274:1996;430-432.
20. Denissenko M.F., Pao A., Pfeifer G.P., Tang M.-S. Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers. Oncogene. 16:1998;1241-1247.
21. Eisenstadt E., Warren A.J., Porter J., Atkins D., Miller J.H. Carcinogenic epoxides of benzo[a]pyrene and cyclopenta[cd]pyrene induce base substitutions via specific transversions. Proc. Natl. Acad. Sci. U.S.A. 82:1982;1945-1949.
22. Bernelot-Moens C., Glickman B.W., Gordon A.J.E. Induction of specific frameshift and base substitution events by benzo[a]pyrene diol epoxide in excision-repair-deficient Escherichia coli. Carcinogenesis. 11:1990;781-785.
23. Yang J.L., Maher V.M., McCormick J.J. Kinds of mutations formed when a human shuttle vector containing adducts of (+/-)-7β,8α-dihydroxy-9 α,10 α-epoxy-7,8,9,10- dihydrobenzo[a]pyrene replicates in human cells. Proc. Natl. Acad. Sci. U.S.A. 84:1987;3787-3791.
24. Yang J.-L., Chen R.-H., Maher V.M., McCormick J.J. Kinds and locations of mutations induced by (+/-)-7β,8α-dihydroxy-9α,10α- epoxy-7,8,9,10-dihydrobenzo[a]pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in diploid human fibroblasts. Carcinogenesis. 12:1990;71-75.
25. Carothers A.M., Grunberger D. DNA base changes in benzo[a]pyrene diol epoxide-induced dihydrofolate reductase mutants of Chinese hampster ovary cells. Carcinogenesis. 11:1990;189-192.
26. Rodriguez H., Loechler E.L. Mutational spectra of the (+)-anti-diol epoxide of benzo[a]pyrene in a supF gene of an Escherichia coli plasmid: DNA sequence context influences hotspots, mutational specificity and the extent of SOS enhancement of mutagenesis. Carcinogenesis. 14:1993;373-383.
27. Rodriguez H., Loechler E.L. Mutagenesis by the (+)-anti-diol epoxide of benzo[a]pyrene: what controls mutagenic specificity? Biochemistry. 32:1993;373-383.
28. Rodriguez H., Loechler E.L. Are base substitution and frameshift mutagenesis pathways interrelated? An analysis based upon studies of mutagenesis by the (+)-anti diol epoxide of benzo[a]pyrene. Mutat. Res. 326:1995;29-37.
29. Wei S.-J.C., Chang R.L., Wong C.-Q., Bhachech N., Cui X.X., Hennig E., Yagi H., Sayer J.M., Jerina D.M., Preston B.D., Conney A.H. Dose-dependent differences in the profile of mutations induced by an ultimate carcinogen from benzo[a]pyrene. Proc. Natl. Acad. Sci. U.S.A. 88:1991;11227-11230.
30. Wei S.J., Chang R.L., Hennig E., Cui X.X., Merkler K.A., Wong C.Q., Yagi H., Jerina D.M., Conney A.H. Mutagenic selectivity at the HPRT locus in V-79 cells: comparison of mutations caused by bay-region benzo[a]pyrene 7,8-diol-9,10-opxide enantiomers with high and low carcinogenic activity. Carcinogenesis. 15:1995;1729-1735.
31. Wei S.J., Chang R.L., Wong C.Q., Cui X.X., Dandamudi N., Lu Y.P., Merkler K.A., Sayer J.M., Conney A.H., Jerina D.M. The ratio of deoxyadenosine to deoxyguanosine adducts formed by (+)-(7R, 8S, 9S, 10R)-7,8-dihydroxy-9,10- epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in purified calf thymus DNA and DNA in V-79 cells is independent of dose. Int. J. Oncol. 14:1999;509-513.
32. Schiltz M., Cui X.X., Lu Y.P., Yagi H., Jerina D.M., Zdzienicka M.Z., Chang R.L., Conney A.H., Wei S.J. Characterization of the mutational profile of (+)-7R, 8S-dihydroxy-9S, 10R-epoxy-7, 8, 9, 10-tetrahydrobenzo[a]pyrene at the hypoxanthine (guanine) phosphoribosyltransferase gene in repair-deficient Chinese hamster V-H1 cells. Carcinogenesis. 20:1999;2279-2286.
33. 2-Gua, when studied in an Escherichia coli plasmid using site-directed methods. Carcinogenesis. 13:1992;1415-1425.
34. 2-dG adduct of (+)-anti-B[a]PDE induces. G→A mutations in a 5′-AGA- 3′ sequence context Carcinogenesis. 20:1999;261-268.
35. Napolitano R., Janel-Bintz R., Wagner J., Fuchs R.P. All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis. EMBO J. 19:2000;6259-6265.
36. Lenne-Samuel N., Janel-Bintz R., Kolbanovskiy A., Geacintov N.E., Fuchs R.P. The processing of a benzo(a)pyrene adduct into a frameshift or a base substitution mutation requires a different set of genes in Escherichia coli. Mol. Microbiol. 38:2000;299-307.
37. 2-dG adduct of (+)-anti-B[a]PDE shows a dramatically different mutagenic specificity (predominantly, G→A ) in a 5′-CGT-3′ sequence context Biochemistry. 36:1997;10256-10261.
38. 2-dG adducts of B[a]PDE: configuration of the adduct bond is more important than of the hydroxyl groups. Biochemistry. 36:1997;13263-13269.
39. 2-Gua adduct of the (+)-anti-benzo[a]pyrene diol epoxide is capable of inducing. G→A and G → C, in addition to G→T , mutations Biochemistry. 34:1995;13545-13553.
40. Hanrahan C.J., Bacolod M.D., Vyas R.R., Liu T., Geacintov N.E., Loechler E.L., Basu A.K. Sequence specific mutagenesis of the major (+)-anti-benzo[a] pyrene diol epoxide-DNA adduct at a mutational hotspot in vitro and in Escherichia coli cells. Chem. Res. Toxicol. 10:1997;369-377.
41. Moriya M., Spiegel S., Fernandes A., Amin S., Liu T.-M., Geacintov N.E., Grollman A.P. Fidelity of translesion synthesis past benzo[a]pyrene diol epoxide-2′-deoxyguanosine DNA adducts: marked effects of host cell, sequence context, and chirality. Biochemistry. 35:1996;16646-16651.
42. 2-2'-deoxyguanosine adducts in Escherichia coli and simian kidney cells. Biochemistry. 37:1998;10164-10172.
43. Page J.E., Zajc B., Oh-hara T., Lakshman M.K., Sayer J.M., Jerina D.M., Dipple A. Sequence context profoundly influences the mutagenic potency of trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-purine nucleoside adducts in site-specific mutation studies. Biochemistry. 37:1998;9127-9137.
44. Ponten I., Kroth H., Sayer J.M., Dipple A., Jerina D.M. Differences between the mutational consequences of replication of cis- and trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-deoxyguanosine adducts in M13mp7L2 constructs. Chem. Res. Toxicol. 14:2001;720-726.
45. Min Z., Gill R.G., Cortez C., Harvey R.G., Loechler E.L., DiGiovanni J. Targeted. A→T , and G→T mutations induced by site-specific deoxyadenosine and deoxyguanosine adducts, respectively, from the (+)-anti-diol-epoxide of dibenz[a,j]anthracene in M13mp7L2 Biochemistry. 35:1996;4128-4138.
46. 6 at the second position of N-ras codon 61. J. Biol. Chem. 270:1995;4990-5000.
47. 6 is dependent on both chirality of the lesion and the local sequence context. J. Biol. Chem. 268:1993;23427-23434.
48. Page J.E., Pilcher A.S., Yagi H., Sayer J.M., Jerina D.M., Dipple A. Mutational consequences of replication of M13mp7L2 constructs containing cis-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-deoxyadenosine adducts. Chem. Res. Toxicol. 12:1999;258-263.
49. 2-deoxyguanosine adducts derived from the highly carcinogenic fjord-region benzo[c]phenanthrene 3,4-diol 1,2-epoxides. Chem. Res. Toxicol. 15:2002;1619-1626.
50. Ponten I., Sayer J.M., Pilcher A.S., Yagi H., Kumar S., Jerina D.M., Dipple A. Factors determining mutagenic potential for individual cis and trans opened benzo[c]phenanthrene diol epoxide-deoxyadenosine adducts. Biochemistry. 39:2000;4136-4144.
51. Ponten I., Sayer J.M., Pilcher A.S., Yagi H., Kumar S., Jerina D.M., Dipple A. Sequence context effects on mutational properties of cis-opened benzo[c]phenanthrene diol epoxide-deoxyadenosine adducts in site-specific mutation studies. Biochemistry. 38:1999;1144-1152.
52. 6 at the second position of N-ras codon 61. J. Biol. Chem. 10:1995;4990-5000.
53. 2-deoxyguanosine adduct induces mutations at multiple sites in DNA. J. Biol. Chem. 278:2003;9905-9911.
54. Napolitano R.L., Lambert I.B., Fuchs R.P. SOS factors involved in translesion synthesis. Proc. Natl. Acad. Sci. U.S.A. 94:1997;5733-5738.
55. Becherel O.J., Fuchs R.P. Mechanism of DNA polymerase II-mediated frameshift mutagenesis. Proc. Natl. Acad. Sci. U.S.A. 98:2001;8566-8571.
56. Wagner J., Etienne H., Janel-Bintz R., Fuchs R.P. Genetics of mutagenesis in E. coli: various combinations of translesion polymerases (Pol II, IV and V) deal with lesion/sequence context diversity. DNA Repair. 1:2002;159-167.
57. Berardini M., Foster P., Loechler E.L. DNA polymerase II (polB) is involved in a new DNA repair pathway for DNA Interstrand Cross-Links in Escherichia coli. J. Bact. 181:1999;2878-2882.
58. Goodman M.F. Error-prone repair DNA polymerases in prokaryotes and eukaryotes. Annu. Rev. Biochem. 71:2002;17-50.
59. Ohmori H., Friedberg E.C., Fuchs R.P., Goodman M.F., Hanaoka F., Hinkle D., Kunkel T.A., Lawrence C.W., Livneh Z., Nohmi T., Prakash L., Prakash S., Todo T., Walker G.C., Wang Z., Woodgate R. The Y-family of DNA polymerases. Mol. Cell. 8:2001;7-8.
60. Boudsocq F., Ling H., Yang W., Woodgate R. Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass. DNA Repair (Amst.). 30:2002;343-358.
61. Friedberg E.C., Wagner R., Radman M. Specialized DNA polymerases, cellular survival, and the genesis of mutations. Science. 296:2002;1627-1630.
62. Friedberg E.C. Why do cells have multiple error-prone DNA polymerases? Environ. Mol. Mutagen. 38:2001;105-110.
63. Wang Z. Translesion synthesis by the UmuC family of DNA polymerases. Mutat. Res. 486:2001;59-70.
64. Johnson R.E., Washington M.T., Prakash S., Prakash L. Bridging the gap: a family of novel DNA polymerases that replicate faulty DNA. Proc. Natl. Acad. Sci. U.S.A. 96:1999;12224-12226.
65. Pages V., Fuchs R.P. How DNA lesions are turned into mutations within cells? Oncogene. 21:2002;8957-8966.
66. Yang W. Damage repair DNA polymerases Y. Curr. Opin. Struct. Biol. 13:2003;23-30.
67. Burgers P.M., Koonin E.V., Bruford E., Blanco L., Burtis K.C., Christman M.F., Copeland W.C., Friedberg E.C., Hanaoka F., Hinkle D.C., Lawrence C.W., Nakanishi M., Ohmori H., Prakash L., Prakash S., Reynaud C.A., Sugino A., Todo T., Wang Z., Weill J.C., Woodgate R. Eukaryotic DNA polymerases: proposal for a revised nomenclature. J. Biol. Chem. 276:2001;43487-43490.
68. Shcherbakova P.V., Bebenek K., Kunkel T.A. Function of eukaryotic DNA polymerases. Science. 299:2003;1275. (On-line review at: http://www.sageke. sciencemag.org/cgi/content/full/sage;2003/8/re3 ).
69. Zhou B.L., Pata J.D., Steitz T.A. Crystal structure of a DinB lesion bypass DNA polymerase catalytic fragment reveals a classic polymerase catalytic domain. Mol. Cell. 8:2001;427-437.
70. Trincao J., Johnson R.E., Escalante C.R., Prakash S., Prakash L., Aggarwal A.K. Structure of the catalytic core of S. cerevisiae DNA polymerase η: implications for translesion DNA synthesis. Mol. Cell. 8:2001;417-426.
71. Ling H., Boudsocq F., Woodgate R., Yang W. Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication. Cell. 107:2001;91-102.
72. Shen X., Sayer J.M., Kroth H., Ponten I., O'Donnell M., Woodgate R., Jerina D.M., Goodman M.F. Efficiency and accuracy of SOS-induced DNA polymerases replicating benzo[a]pyrene-7,8-diol 9,10-epoxide A and G adducts. J. Biol. Chem. 277:2002;5265-5274.
73. Frank E.G., Sayerm J.M., Krothm H., Ohashi E., Ohmori H., Jerina D.M., Woodgate R. Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by human DNA polymerase ι Nucl. Acids Res. 30:2002;5284-5292.
74. Simhadri S., Kramata P., Zajc B., Sayer J.M., Jerina D.M., Hinkle D.C., Wei C.S. Benzo[a]pyrene diol epoxide-deoxyguanosine adducts are accurately bypassed by yeast DNA polymerase ζ in vitro. Mutat. Res. 508:2002;137-145.
75. Chiapperino D., Kroth H., Kramarczuk I.H., Sayer J.M., Masutani C., Hanaoka F., Jerina D.M., Cheh A.M. Preferential misincorporation of purine nucleotides by human DNA polymerase η opposite benzo[a]pyrene 7,8-diol, 9,10-epoxide deoxyguanosine adducts. J. Biol. Chem. 277:2002;11765-11771.
76. Zhang Y., Wu X., Guo D., Rechkoblit O., Geacintov N.E., Wang Z. Two-step error-prone bypass of the (+)- and (-)-trans-anti-BPDE-N(2)-dG adducts by human DNA polymerases η and κ Mutat. Res. 510:2002;23-35.
77. Zhang Y., Wu X., Guo D., Rechkoblit O., Taylor J.S., Geacintov N.E., Wang Z. Lesion bypass activities of human DNA polymerase μ J. Biol. Chem. 277:2002;44582-44587.
78. 6-dA lesions catalyzed by DNA bypass polymerases. J. Biol. Chem. 277:2002;30488-30494.
79. Suzuki N., Ohashi E., Kolbanovskiy A., Geacintov N.E., Grollman A.P., Ohmori H., Shibutani S. Translesion synthesis by human DNA polymerase κ on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a] pyrene). Biochemistry. 41:2002;6100-6106.
80. Zhang Y., Wu X., Rechkoblit O., Geacintov N.E., Taylor J.S., Wang Z. Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion. Nucl. Acids Res. 30:2002;1630-1638.
81. Zhang Y., Yuan F., Wu X., Rechkoblit O., Taylor J.S., Geacintov N.E., Wang Z. Error-prone lesion bypass by human DNA polymerase η Nucl. Acids Res. 28:2000;4717-4724.
82. 2-dG lesion catalyzed by the Y-family polymerase pol κ Biochemistry. 42:2003;2456-2466.
83. Zhang Y., Wu X., Guo D., Rechkoblit O., Wang Z. Activities of human DNA polymerase κ in response to the major benzo[a]pyrene DNA adduct: error-free lesion bypass and extension synthesis from opposite the lesion. DNA Repair (Amst.). 1:2002;559-569.
84. Ogi T., Shinkai Y., Tanaka K., Ohmori H. Pol κ protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene. Proc. Natl. Acad. Sci. U.S.A. 99:2002;15548-15553.
85. Xie Z., Braithwaite E., Guo D., Zhao B., Geacintov N.E., Wang Z. Mutagenesis of benzo[a]pyrene diol epoxide in yeast: requirement for DNA polymerase zeta and involvement of DNA polymerase η Biochemistry. 42:2003;11253-11262.
86. Johnson R.E., Washington M.T., Haracska L., Prakash S., Prakash L. Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions. Nature. 406:2000;1015-1019.
87. Haracska L., Washington M.T., Prakash S., Prakash L. Inefficient bypass of an abasic site by DNA polymerase η J. Biol. Chem. 276:2001;6861-6866.
88. Masutani C., Kusumoto R., Yamada A., Dohmae N., Yokoi M., Yuasa M., Araki M., Iwai S., Takio K., Hanaoka F. The xeroderma pigmentosum variant (XPV) gene encodes human DNA polymerase η Nature. 399:1999;700-704.
89. Johnson R.E., Prakash S., Prakash L. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Pol η Science. 283:1999;1001-1004.
90. Johnson R.E., Kondratick C.M., Prakash S., Prakash L. hRAD30 mutations in the variant form of xeroderma pigmentosum. Science. 285:1999;263-265.
91. Washington M.T., Johnson R.E., Prakash S., Prakash L. Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase η J. Biol. Chem. 274:1999;36835-36838.
92. Washington M.T., Johnson R.E., Prakash S., Prakash L. Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase η Proc. Natl. Acad. Sci. U.S.A. 97:2000;3094-3099.
93. Johnson R.E., Washington M.T., Prakash S., Prakash L. Fidelity of human DNA polymerase η J. Biol. Chem. 275:2000;7447-7450.
94. Yu S.L., Johnson R.E., Prakash S., Prakash L. Requirement of DNA polymerase η for error-free bypass of UV-induced CC and TC photoproducts. Mol. Cell Biol. 21:2001;185-188.
95. Yuan F., Zhang Y., Rajpal D.K., Wu X., Guo D., Wang M., Taylor J.S., Wang Z. Specificity of DNA lesion bypass by the yeast DNA polymerase η J. Biol. Chem. 275:2000;8233-8239.
96. Washington M.T., Helquist S.A., Kool E.T., Prakash L., Prakash S. Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase η Mol. Cell Biol. 23:2003;5107-5112.
97. Prakash S., Prakash L. Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affair. Genes Dev. 16:2002;1872-1883.
98. 2-dG adducts by human DNA polymerases η and κ Mutat. Res. 510:2002;23-35.
99. Guo D., Wu X., Rajpal D.K., Taylor J.S., Wang Z. Translesion synthesis by yeast DNA polymerase ζ from templates containing lesions of ultraviolet radiation and acetylaminofluorene. Nucl. Acids Res. 29:2001;2875-2883.
100. Bresson A., Fuchs R.P. Lesion bypass in yeast cells: Pol η participates in a multi-DNA polymerase process. EMBO J. 21:2002;3881-3887.
101. Becherel O.J., Fuchs R.P., Wagner J. Pivotal role of the β-clamp in translesion DNA synthesis and mutagenesis in E. coli cells. DNA Repair (Amst.). 1:2002;703-708.
102. Lenne-Samuel N., Wagner J., Etienne H., Fuchs R.P. The processivity factor β controls DNA polymerase IV traffic during spontaneous mutagenesis and translesion synthesis in vivo. EMBO Rep. 3:2002;45-49.
103. Sutton M.D., Narumi I., Walker G.C. Posttranslational modification of the umuD-encoded subunit of Escherichia coli DNA polymerase V regulates its interactions with the β processivity clamp. Proc. Natl. Acad. Sci. U.S.A. 99:2002;5307-5312.
104. Haracska L., Unk I., Johnson R.E., Phillips B.B., Hurwitz J., Prakash L., Prakash S. Stimulation of DNA synthesis activity of human DNA polymerase κ by PCNA. Mol. Cell Biol. 22:2002;784-791.
105. Haracska L., Johnson R.E., Unk I., Phillips B.B., Hurwitz J., Prakash L., Prakash S. Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA. Proc. Natl. Acad. Sci. U.S.A. 98:2001;14256-14261.
106. Haracska L., Johnson R.E., Unk I., Phillips B., Hurwitz J., Prakash L., Prakash S. Physical and functional interactions of human DNA polymerase η with PCNA. Mol. Cell Biol. 21:2001;7199-7206.
107. Haracska L., Kondratick C.M., Unk I., Prakash S., Prakash L. Interaction with PCNA is essential for yeast DNA polymerase η function. Mol. Cell. 8:2001;407-415.
108. Palejwala V.A., Wang G.E., Murphy H.S., Humayun M.Z. Functional recA, lexA, umuD, umuC, polA, and polB genes are not required for the Escherichia coli UVM response. J. Bacteriol. 177:1995;6041-6048.
109. Humayun M.Z. SOS and Mayday: multiple inducible mutagenic pathways in Escherichia coli. Mol. Microbiol. 30:1998;905-910.
110. Rahman M.S., Humayun M.Z. SOS and UVM pathways have lesion-specific additive and competing effects on mutation fixation at replication-blocking DNA lesions. J. Bacteriol. 181:1999;1515-1523.
111. Al Mamun A.A., Yadava R.S., Ren L., Humayun M.Z. The Escherichia coli UVM response is accompanied by an SOS-independent error-prone DNA replication activity demonstrable in vitro. Mol. Microbiol. 38:2000;368-380.
112. Seo K.-Y., Jelinsky S.A., Loechler E.L. Adduct conformational complexity causes adduct mutational complexity: Evidence from mutagenic studies of the potent environmental carcinogen benzo[a]pyrene. Mutation Res. 463:2000;215-245.
113. Koffel-Schwartz N., Maenhaut-Michel G., Fuchs R.P.P. Specific strand loss in N-2-acetylaminofluorene-modified DNA. J. Mol. Biol. 193:1987;651-659.
114. Rodriguez H., Bhatt U., Snow E.T., Loechler E.L. An Escherichia coli plasmid-based, mutational system in which supF mutants are selectable: insertion elements dominate the spontaneous spectra. Mutat. Res. 270:1992;219-231.
115. Escarceller M., Hicks J., Gudmundsson G., Trump G., Touati D., Lovett S., Foster P.L., McEntee K., Goodman M.F. Involvement of Escherichia coli DNA polymerase II in response to oxidative damage and adaptive mutation. J. Bacteriol. 176:1994;6221-6228.
116. Kim S.R., Maenhaut-Michel G., Yamada M., Yamamoto Y., Matsui K., Sofuni T., Nohmi T., Ohmori H. Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA. Proc. Natl. Acad. Sci. U.S.A. 94:1997;13792-13797.
117. 2′C mutagenic complex and RecA protein Proc. Natl. Acad. Sci. U.S.A. 95:1998;9755-9760.
118. Tang M., Shen X., Frank E.G., O'Donnell M., Woodgate R., Goodman M.F. UmuD′(2)C is an error-prone DNA polymerase, Escherichia coli pol V. Proc. Natl. Acad. Sci. U.S.A. 96:1999;8919-8924.
119. Reuven N.B., Tomer G., Livneh Z. The mutagenesis proteins UmuD′ and UmuC prevent lethal frameshifts while increasing base substitution mutations. Mol. Cell. 2:1998;191-199.
120. Reuven N.B., Arad G., Maor-Shoshani A., Livneh Z. The mutagenesis protein UmuC is a DNA polymerase activated by UmuD′, RecA, and SSB and is specialized for translesion replication. J. Biol. Chem. 274:1999;31763-31766.
121. Pham P., Seitz E.M., Saveliev S., Shen X., Woodgate R., Cox M.M., Goodman M.F. Two distinct modes of RecA action are required for DNA polymerase V-catalyzed translesion synthesis. Proc. Natl. Acad. Sci. U.S.A. 99:2002;11061-11066.
122. Pham P., Bertram J.G., O'Donnell M., Woodgate R., Goodman M.F. A model for SOS-lesion-targeted mutations in Escherichia coli. Nature. 409:2001;366-370.
123. Reuven N.B., Arad G., Stasiak A.Z., Stasiak A., Livneh Z. Lesion bypass by the Escherichia coli DNA polymerase V requires assembly of a RecA nucleoprotein filament. J. Biol. Chem. 276:2001;5511-5517.
124. Sutton M.D., Murli S., Opperman T., Klein C., Walker G.C. umuDC-dnaQ Interaction and its implications for cell cycle regulation and SOS mutagenesis in Escherichia coli. J. Bacteriol. 183:2001;1085-1089.
125. Sutton M.D., Walker G.C. Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination. Proc. Natl. Acad. Sci. U.S.A. 98:2001;8342-8349.
126. Sutton M.D., Smith B.T., Godoy V.G., Walker G.C. The SOS response: recent insights into umuDC-dependent mutagenesis and DNA damage tolerance. Annu. Rev. Genet. 34:2000;479-497.
127. Opperman T., Murli S., Smith B.T., Walker G.C. A model for a umuDC-dependent prokaryotic DNA damage checkpoint. Proc. Natl. Acad. Sci. U.S.A. 96:1999;9218-9223.
128. Tang M., Pham P., Shen X., Taylor J.S., O'Donnell M., Woodgate R., Goodman M.F. Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis. Nature. 404:2000;1014-1018.
129. Strauss B.S., Roberts R., Francis L., Pouryazdanparast P. Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymerase. J. Bacteriol. 182:2000;6742-6750.
130. E.L. Loechler, 1994. Mechanism by which aflatoxins and other bulky carcinogens induce mutations, in: The Toxicology of Aflatoxins: Human Health, Veterinary, and Agricultural Significance (Eaton and Groopman), Academic Press, Orlando. Chapter 8, pp. 149-178.
131. Strauss B.S. The "A" rule revisited: polymerases as determinants of mutational specificity. DNA Repair. 1:2002;125-135.
132. 2-substitution of guanine in DNA. Chem.-Biol. Interact. 31:1980;255-263.
133. Perlow R., Broyde S. Toward understanding the mutagenicity of an environmental carcinogen: structural insights into nucleotide incorporation preferences. J. Mol. Biol. 322:2002;291.
134. Gu Z., Gorin A., Hingerty B.E., Broyde S., Patel D.J. Solution structures of aminofluorene [AF]-stacked conformers of the syn [AF]-C8-dG adduct positioned opposite dC or dA at a template-primer junction. Biochemistry. 38:1999;10855-10870.
135. Loechler E.L. Adduct-induced base-shifts: a mechanism by which the adducts of bulky carcinogens might induce mutations. Biopolymers. 28:1989;909-927.
136. 2-dG) causes. G→T versus G→A mutations based upon a correlation between mutagenesis and molecular modeling results Carcinogenesis. 20:1999;95-104.
137. 2-dG) of the potent environmental carcinogen, benzo[a]pyrene. Mutat. Res. 450:2000;41-59.
138. Ripley L.S. Predictability of mutant sequences. Relationships between mutational mechanisms and mutant specificity. Ann. N. Y. Acad. Sci. 870:1999;159-172.
139. Papanicolaou C., Ripley L.S. An in vitro approach to identifying specificity determinants of mutagenesis mediated by DNA misalignments. J. Mol. Biol. 221:1991;805-821.
140. Ripley L.S. Frameshift mutation: determinants of specificity. Annu. Rev. Genet. 24:1990;189-213.
141. de Boer J.G., Ripley L.S. Demonstration of the production of frameshift and base-substitution mutations by quasipalindromic DNA sequences. Proc. Natl. Acad. Sci. U.S.A. 81:1984;5528-5531.
142. Ripley L.S. Model for the participation of quasi-palindromic DNA sequences in frameshift mutation. Proc. Natl. Acad. Sci. U.S.A. 79:1982;4128-4132.
143. Bebenek K., Kunkel T.A. Frameshift errors initiated by nucleotide misincorporation. Proc. Natl. Acad. Sci. U.S.A. 87:1990;4946-4950.
144. Boosalis M.S., Mosbaugh D.W., Hamatake R., Sugino A., Kunkel T.A., Goodman M.F. Kinetic analysis of base substitution mutagenesis by transient misalignment of DNA and by miscoding. J. Biol. Chem. 264:1989;11360-11366.
145. Kunkel T.A., Soni A. Mutagenesis by transient misalignment. J. Biol. Chem. 263:1988;14784-14789.
146. Kunkel T.A., Alexander P.S. The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitution by dislocation. J. Biol. Chem. 261:1986;160-166.