The SOS response: Recent insights into umuDC-dependent mutagenesis and DNA damage tolerance

Annual Review of Genetics

Volumn 34, Issue , 2000, Pages 479-497

  Sutton, M D ^a   Smith, B T ^a   Godoy, V G ^a   Walker, G C ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; PROTEIN UMUDC; UNCLASSIFIED DRUG;

CELL CYCLE; DNA REPAIR; DNA SYNTHESIS; ESCHERICHIA COLI; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ADAPTATION, PHYSIOLOGICAL; BACTERIAL PROTEINS; DNA DAMAGE; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI PROTEINS; MUTAGENESIS; SOS RESPONSE (GENETICS);

ESCHERICHIA COLI; EUKARYOTA; NEGIBACTERIA; PROKARYOTA;

EID: 0034513411     PISSN: 00664197     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.genet.34.1.479     Document Type: Review

References (99)

1. Reconstitution of an SOS response pathway: Derepression of transcription in response to DNA breaks
2. Dominant negative umuD mutations decreasing RecA-mediated cleavage suggest roles for intact UmuD in modulation of SOS mutagenesis
3. Mechanism of action of the lexA gene product
4. Mutagenic DNA repair in Escherichia coli. III. Requirement for a function of DNA polymerase III in ultraviolet-light mutagenesis
5. Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: Evidence for the requirement for the dinB gene
6. Involvement of DNA polymerase III in UV-induced mutagenesis of bacteriophage lambda
7. Purification of a soluble UmuD'C complex from Escherichia coli. Cooperative binding of UmuD'C to single-stranded DNA
8. UmuD mutagenesis protein of Escherichia coli: Overproduction, purification, and cleavage by RecA
9. Nature of the SOS mutator activity: Genetic characterization of untargeted mutagenesis in Escherichia coli
10. Relationship between cellular RecA protein concentration and untargeted mutagenesis in Escherichia coli
11. Plasmid pKM101-mediated mutagenesis in Escherichia coli is inducible
12. recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli
13. Recovery of DNA replication in UV-irradiated Escherichia coli requires both excision repair and recF protein function
14. The importance of repairing stalled replication forks
15. Function of nucleoside triphosphate and polynucleotide in Escherichia coli recA protein-directed cleavage of phage lambda repressor
16. Ultraviolet reactivation and ultraviolet mutagenesis of lambda in different genetic systems
17. New recA mutations that dissociate the various RecA protein activities in Escherichia coli provide evidence for an additional role for RecA protein in UV mutagenesis
18. Fidelity mechanisms in DNA replication
19. Identification of additional genes belonging to the LexA regulon in Escherichia coli
20. Genetic requirements and mutational specificity of the Escherichia coli SOS mutator activity
21. Interactions between epsilon, the proofreading subunit of DNA polymerase III, and proteins involved in the SOS response of Escherichia coli
22. Presence of the dnaQ-rnh divergent transcriptional unit on a multicopy plasmid inhibits induced mutagenesis in Escherichia coli
23. Targeting of the UmuD, UmuD', and MucA' mutagenesis proteins to DNA by RecA protein
24. "Activated"-RecA protein affinity chromatography of LexA repressor and other SOS-regulated proteins
25. Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily
26. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta
27. Interaction of Escherichia coli RecA protein with LexA repressor. II. Inhibition of DNA strand exchange by the uncleavable LexA S119A repressor argues that recombination and SOS induction are competitive processes
28. hRAD30 mutations in the variant form of Xeroderma pigmentosum
29. Requirement of DNA polymerase activity of yeast Rad30 protein for its biological function
30. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta
31. The antimutagenic effect of a truncated epsilon subunit of DNA polymerase III in Escherichia coli cells irradiated with UV light
32. Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet light
33. DNA polymerase III holoenzyme: Structure and function of a chromosomal replicating machine
34. DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli
35. Mechanism of transient inhibition of DNA synthesis in ultraviolet-irradiated E. coli: Inhibition is independent of recA whilst recovery requires RecA protein itself and an additional, inducible SOS function
36. Multiple pathways for SOS-induced mutagenesis in Escherichia coli: An overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA
37. Identification of a DinB/UmuC homolog in the archeon Sulfolobus solfataricus
38. The REV1 gene of Saccharomyces cerevisiae: Isolation, sequence, and functional analysis
39. Interactions of Escherichia coli UmuD with activated RecA analyzed by cross-linking UmuD monocysteine derivatives
40. Localization of bacterial DNA polymerase: Evidence for a factory model of replication
41. Pathways of ultraviolet mutability in Saccharomyces cerevisiae. I. Some properties of double mutants involving uvs9 and rev
42. The human REV1 gene codes for a DNA template-dependent dCMP transferase
43. Autodigestion of lexA and phage lambda repressors
44. LexA cleavage and other self-processing reactions
45. Purified lexA protein is a repressor of the recA and lexA genes
46. Capacity of RecA protein to bind preferentially to UV lesions and inhibit the editing subunit (epsilon) of DNA polymerase III: A possible mechanism for SOS-induced targeted mutagenesis
47. Mechanism of SOS-induced targeted and untargeted mutagenesis in E. coli
48. Genetic control of the UV-induced SOS mutator effect in single- and double-stranded DNA phages
49. Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis
50. Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
51. The XPV (Xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
52. Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta
53. Specificity of mutagenesis resulting from the induction of the SOS system in the absence of mutagenic treatment
54. Studies on radiation-sensitive mutants of E. coli. 3. Participation of the rec system in induction of mutation by ultraviolet irradiation
55. Fidelity and error specificity of the alpha catalytic subunit of Escherichia coli DNA polymerase III
56. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2
57. A role for the umuDC gene products of Escherichia coli in increasing resistance to DNA damage in stationary phase by inhibiting the transition to exponential growth
58. Deoxycytidyl transferase activity of yeast REV1 protein
59. Thymine-thymine dimer bypass by yeast DNA polymerase zeta
60. RecA-mediated cleavage activates UmuD for mutagenesis: Mechanistic relationship between transcriptional derepression and posttranslational activation
61. Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB
62. A model for a umuDC-dependent prokaryotic DNA damage checkpoint
63. The base substitution and frameshift fidelity of Escherichia coli DNA polymerase III holoenzyme in vitro
64. Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III
65. A phenotype for enigmatic DNA polymerase II: A pivotal role for pol II in replication restart in UV-irradiated Escherichia coli
66. Interaction of Escherichia coli RecA protein with LexA repressor. I. LexA repressor cleavage is competitive with binding of a secondary DNA molecule
67. The mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA, and SSB and is specialized for translesion replication
68. The mutagenesis proteins UmuD' and UmuC prevent lethal frameshifts while increasing base substitution mutations
69. Role of PriA in replication fork reactivation in Escherichia coli
70. Differential suppression of priA2::kan phenotypes in Escherichia coli K-12 by mutations in priA, lexA, and dnaC
71. Nature of the SOS-inducing signal in Escherichia coli. The involvement of DNA replication
72. Identification of the epsilon-subunit of Escherichia coli DNA polymerase III holoenzyme as the dnaQ gene product: A fidelity subunit for DNA replication
73. A separate editing exonuclease for DNA replication: The epsilon subunit of Escherichia coli DNA polymerase III holoenzyme
74. RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis
75. Mutagenesis and more: umuDC and the Escherichia coli SOS response
76. Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis. I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesis
77. The structure of the E. coli recA protein monomer and polymer
78. The Escherichia coli SOS mutagenesis proteins UmuD and UmuD' interact physically with the replicative DNA polymerase
79. RecA protein of Escherichia coli has a third essential role in SOS mutator activity
80. Overproduction of the beta subunit of DNA polymerase III holoenzyme reduces UV mutagenesis in Escherichia coli
81. Biochemical basis of SOS-induced mutagenesis in Escherichia coli: Reconstitution of in vitro lesion bypass dependent on the UmuD'2C mutagenic complex and RecA protein
82. Roles of E. coli DNA polymerase IV and V in lesion-targeted and untargeted SOS mutagenesis
83. UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.
84. Mechanism of ultraviolet-induced mutagenesis: Extent and fidelity of in vitro DNA synthesis on irradiated templates
85. The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesis
86. Skiing the black diamond slope: Progress on the biochemistry of translesion DNA synthesis
87. Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase eta
88. Thermal enhancement of ultraviolet mutability in a tif-1 uvrA derivative of Escherichia coli B-r: Evidence that ultraviolet mutagenesis depends upon an inducible function
89. Recovery from ultraviolet light-induced inhibition of DNA synthesis requires umuDC gene products in recA718 mutant strains but not in recA+ strains of Escherichia coli
90. Targeted and untargeted mutagenesis by various inducers of SOS functions in Escherichia coli
91. Damage inducible mutagenesis: Recent insights into the activities of the Umu family of mutagenesis proteins
92. UmuC mutagenesis protein of Escherichia coli: Purification and interaction with UmuD and UmuD'
93. Inhibition of Escherichia coli RecA coprotease activities by DinI
94. Specificity of recA441-mediated (tif-1) mutational events
95. The LexA repressor binds within the deep helical groove of the activated RecA filament
96. Specificity of DNA lesion bypass by the yeast DNA polymerase eta