Toward an understanding of the role of DNA adduct conformation in defining mutagenic mechanism based on studies of the major adduct (formed at N2-dG) of the potent environmental carcinogen, benzo[a]pyrene

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 450, Issue 1-2, 2000, Pages 41-59

  Kozack, Richard ^a   Seo, Kwang Young ^a   Jelinsky, Scott A ^a   Loechler, Edward L ^a  

^a Boston University   (United States)

Author keywords

Adduct conformation; Cancer; Genotoxins; Mutational spectrum; Mutations; Site specific mutagenesis

Indexed keywords

2 AMINOPURINE; BENZO[A]PYRENE; CARCINOGEN; DNA BASE; DNA POLYMERASE; DOUBLE STRANDED DNA; SINGLE STRANDED DNA;

ARTICLE; CHEMICAL CARCINOGENESIS; DNA ADDUCT; DNA CONFORMATION; DNA DAMAGE; DNA REPLICATION; DNA SEQUENCE; FRAMESHIFT MUTATION; HYPOTHESIS; MOLECULAR MODEL; MUTAGENESIS; NUCLEIC ACID BASE SUBSTITUTION; POLLUTANT; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

BASE SEQUENCE; BENZO(A)PYRENE; BINDING SITES; CARCINOGENS, ENVIRONMENTAL; DEOXYGUANOSINE; DNA ADDUCTS; FRAMESHIFT MUTATION; MODELS, GENETIC; MUTATION; NUCLEIC ACID CONFORMATION; POINT MUTATION; THERMODYNAMICS;

EID: 0034732879     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(00)00015-4     Document Type: Article

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