메뉴 건너뛰기




Volumn 14, Issue 1, 2004, Pages 13-21

New approaches in identifying drugs to inactivate oncogene products

Author keywords

Cancer therapeutic targets; Chemical microarrays; Combinatorial chemistry; Drug discovery; Inactivate oncogenes

Indexed keywords

BINDING AFFINITY; CANCER CELL DESTRUCTION; CELL ONCOGENE; COMBINATORIAL CHEMISTRY; CRYSTAL STRUCTURE; DNA MICROARRAY; DRUG DESIGN; DRUG INDUSTRY; DRUG SCREENING; DRUG TARGETING; FLUORESCENCE ACTIVATED CELL SORTING; GENE SILENCING; GENETIC DATABASE; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PHAGE DISPLAY; PROTEIN MICROARRAY; PROTEOMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SERIAL ANALYSIS OF GENE EXPRESSION; X RAY ANALYSIS;

EID: 0742269699     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcancer.2003.11.003     Document Type: Article
Times cited : (18)

References (94)
  • 2
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • Nicholson K.M., Anderson N.G. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 14:2002;381-395.
    • (2002) Cell Signal. , vol.14 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 3
    • 0036888335 scopus 로고    scopus 로고
    • Integration of the TGF-beta pathway into the cellular signalling network
    • Lutz M., Knaus P. Integration of the TGF-beta pathway into the cellular signalling network. Cell Signal. 14:2002;977-988.
    • (2002) Cell Signal. , vol.14 , pp. 977-988
    • Lutz, M.1    Knaus, P.2
  • 4
    • 0037152635 scopus 로고    scopus 로고
    • Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer
    • Osada H., Takahashi T. Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. Oncogene. 21:2002;7421-7434.
    • (2002) Oncogene , vol.21 , pp. 7421-7434
    • Osada, H.1    Takahashi, T.2
  • 5
    • 0037370476 scopus 로고    scopus 로고
    • The genetics and genomics of cancer
    • Balmain A. The genetics and genomics of cancer. Nat. Genet. 33(Suppl.):2003;238-244.
    • (2003) Nat. Genet. , vol.33 , Issue.SUPPL. , pp. 238-244
    • Balmain, A.1
  • 8
    • 0031737516 scopus 로고    scopus 로고
    • Antisense RNA: Function and fate of duplex RNA in cells of higher eukaryotes
    • Kumar M., Carmichael G.G. Antisense RNA: function and fate of duplex RNA in cells of higher eukaryotes. Microbiol. Mol. Biol. Rev. 62:1998;1415-1434.
    • (1998) Microbiol. Mol. Biol. Rev. , vol.62 , pp. 1415-1434
    • Kumar, M.1    Carmichael, G.G.2
  • 9
    • 0642307773 scopus 로고    scopus 로고
    • RNA interference: Gene silencing in the fast lane
    • Kittler R., Buchholz F. RNA interference: gene silencing in the fast lane. Semin. Cancer Biol. 13:2003;259-265.
    • (2003) Semin. Cancer Biol. , vol.13 , pp. 259-265
    • Kittler, R.1    Buchholz, F.2
  • 10
    • 0141502041 scopus 로고    scopus 로고
    • SiRNAs and shRNAs: Skeleton keys to the human genome
    • Paddison P.J., Hannon G.J. siRNAs and shRNAs: skeleton keys to the human genome. Curr. Opin. Mol. Ther. 5:2003;217-224.
    • (2003) Curr. Opin. Mol. Ther. , vol.5 , pp. 217-224
    • Paddison, P.J.1    Hannon, G.J.2
  • 12
    • 0037088998 scopus 로고    scopus 로고
    • Transgenic systems in drug discovery: From target identification to humanized mice
    • Tornell J., Snaith M. Transgenic systems in drug discovery: from target identification to humanized mice. Drug Discov. Today. 7:2002;461-470.
    • (2002) Drug Discov. Today , vol.7 , pp. 461-470
    • Tornell, J.1    Snaith, M.2
  • 13
    • 0000577984 scopus 로고    scopus 로고
    • The "one-bead-one-compound" combinatorial library method
    • Lam K.S., Lebl M., Krchnak V. The "one-bead-one-compound" combinatorial library method. Chem. Rev. 97:1997;411-448.
    • (1997) Chem. Rev. , vol.97 , pp. 411-448
    • Lam, K.S.1    Lebl, M.2    Krchnak, V.3
  • 14
    • 84955072980 scopus 로고    scopus 로고
    • Combinatorial chemistry
    • Jung G, editor Weinheim: Wiley-VCH
    • Tiebes D. Combinatorial chemistry. In: Jung G, editor. Combinatorial chemistry. Weinheim: Wiley-VCH; 1999. p. 1-34.
    • (1999) Combinatorial Chemistry , pp. 1-34
    • Tiebes, D.1
  • 16
    • 0742272229 scopus 로고    scopus 로고
    • Developments in combinatorial chemistry
    • Weber L. Developments in combinatorial chemistry. Pharm Manuf Int 2000;45-6,48,50.
    • (2000) Pharm Manuf Int , vol.45 , Issue.6 , pp. 48
    • Weber, L.1
  • 17
    • 79959571835 scopus 로고    scopus 로고
    • Combinatorial chemistry and high-throughput screening in drug discovery and development
    • San Diego, CA, USA. Sep Sci Technol
    • Appell K, Baldwin JJ, Egan WJ. Combinatorial chemistry and high-throughput screening in drug discovery and development. Handbook of modern pharmaceutical analysis, San Diego, CA, USA. Sep Sci Technol 2001;3:23-56.
    • (2001) Handbook of modern pharmaceutical analysis , vol.3 , pp. 23-56
    • Appell, K.1    Baldwin, J.J.2    Egan, W.J.3
  • 19
    • 0036510961 scopus 로고    scopus 로고
    • Identification and mapping of small-molecule binding sites in proteins: Computational tools for structure-based drug design
    • Sotriffer C., Klebe G. Identification and mapping of small-molecule binding sites in proteins: computational tools for structure-based drug design. Farmaco. 57:2002;243-251.
    • (2002) Farmaco , vol.57 , pp. 243-251
    • Sotriffer, C.1    Klebe, G.2
  • 20
    • 0036589881 scopus 로고    scopus 로고
    • Structural genomics: Bridging functional genomics and structure-based drug design
    • Buchanan S.G. Structural genomics: bridging functional genomics and structure-based drug design. Curr. Opin. Drug Discov. Dev. 5:2002;367-381.
    • (2002) Curr. Opin. Drug Discov. Dev. , vol.5 , pp. 367-381
    • Buchanan, S.G.1
  • 21
    • 0742307009 scopus 로고    scopus 로고
    • HIV-1 protease: Structure-based drug design using the free energy perturbation approach
    • Reddy MR, Appelt K. HIV-1 protease: structure-based drug design using the free energy perturbation approach. Free Energy Calc Rational Drug Design 2001;1:317-34.
    • (2001) Free Energy Calc Rational Drug Design , vol.1 , pp. 317-334
    • Reddy, M.R.1    Appelt, K.2
  • 22
    • 0036066481 scopus 로고    scopus 로고
    • Affinity NMR: A powerful method for drug discovery
    • Shapiro M.J. Affinity NMR: a powerful method for drug discovery. Am. Pharm. Rev. 5:2002;96-97.
    • (2002) Am. Pharm. Rev. , vol.5 , pp. 96-97
    • Shapiro, M.J.1
  • 23
    • 0036138731 scopus 로고    scopus 로고
    • Strategic use of affinity-based mass spectrometry techniques in the drug discovery process
    • Kelly M.A., McLellan T.J., Rosner P.J. Strategic use of affinity-based mass spectrometry techniques in the drug discovery process. Anal Chem. 74:2002;1-9.
    • (2002) Anal Chem. , vol.74 , pp. 1-9
    • Kelly, M.A.1    McLellan, T.J.2    Rosner, P.J.3
  • 24
    • 0028806048 scopus 로고
    • Quantitative monitoring of gene expression patterns with a complementary DNA microarray
    • Schena M., Shalon D., Davis R.W., Brown P.O. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science. 270:1995;467-470.
    • (1995) Science , vol.270 , pp. 467-470
    • Schena, M.1    Shalon, D.2    Davis, R.W.3    Brown, P.O.4
  • 25
    • 0033542378 scopus 로고    scopus 로고
    • Identification and temporal expression pattern of genes modulated during irreversible growth arrest and terminal differentiation in human melanoma cells
    • Huang F., Adelman J., Jiang H., Goldstein N.I., Fisher P.B. Identification and temporal expression pattern of genes modulated during irreversible growth arrest and terminal differentiation in human melanoma cells. Oncogene. 18:1999;3546-3552.
    • (1999) Oncogene , vol.18 , pp. 3546-3552
    • Huang, F.1    Adelman, J.2    Jiang, H.3    Goldstein, N.I.4    Fisher, P.B.5
  • 27
    • 0026674886 scopus 로고
    • Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction
    • Liang P., Pardee A.B. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science. 257:1992;967-971.
    • (1992) Science , vol.257 , pp. 967-971
    • Liang, P.1    Pardee, A.B.2
  • 28
    • 0029148619 scopus 로고
    • Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display
    • Shen R., Su Z.Z., Olsson C.A., Fisher P.B. Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display. Proc. Natl. Acad. Sci. U.S.A. 92:1995;6778-6782.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 6778-6782
    • Shen, R.1    Su, Z.Z.2    Olsson, C.A.3    Fisher, P.B.4
  • 29
    • 0032506148 scopus 로고    scopus 로고
    • Reciprocal subtraction differential RNA display: An efficient and rapid procedure for isolating differentially expressed gene sequences
    • Kang D.C., LaFrance R., Su Z.Z., Fisher P.B. Reciprocal subtraction differential RNA display: an efficient and rapid procedure for isolating differentially expressed gene sequences. Proc. Natl. Acad. Sci. U.S.A. 95:1998;13788-13793.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 13788-13793
    • Kang, D.C.1    Lafrance, R.2    Su, Z.Z.3    Fisher, P.B.4
  • 31
    • 0033748034 scopus 로고    scopus 로고
    • RaSH, a rapid subtraction hybridization approach for identifying and cloning differentially expressed genes
    • Jiang H., Kang D.C., Alexandre D., Fisher P.B. RaSH, a rapid subtraction hybridization approach for identifying and cloning differentially expressed genes. Proc. Natl. Acad. Sci. U.S.A. 97:2000;12684-12689.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 12684-12689
    • Jiang, H.1    Kang, D.C.2    Alexandre, D.3    Fisher, P.B.4
  • 32
    • 0034457801 scopus 로고    scopus 로고
    • Subtractive hybridization - Genetic takeaways and the search for meaning
    • Byers R.J., Hoyland J.A., Dixon J., Freemont A.J. Subtractive hybridization - genetic takeaways and the search for meaning. Int. J. Exp. Pathol. 81:2000;391-404.
    • (2000) Int. J. Exp. Pathol. , vol.81 , pp. 391-404
    • Byers, R.J.1    Hoyland, J.A.2    Dixon, J.3    Freemont, A.J.4
  • 33
    • 0035798433 scopus 로고    scopus 로고
    • Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization
    • Stassar M.J., Devitt G., Brosius M., Rinnab L., Prang J., Schradin T.et al. Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization. Br. J. Cancer. 85:2001;1372-1382.
    • (2001) Br. J. Cancer , vol.85 , pp. 1372-1382
    • Stassar, M.J.1    Devitt, G.2    Brosius, M.3    Rinnab, L.4    Prang, J.5    Schradin, T.6
  • 35
    • 0028577898 scopus 로고
    • Identifying differences in mRNA expression by representational difference analysis of cDNA
    • Hubank M., Schatz D.G. Identifying differences in mRNA expression by representational difference analysis of cDNA. Nucleic Acids Res. 22:1994;5640-5648.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 5640-5648
    • Hubank, M.1    Schatz, D.G.2
  • 36
    • 0034622925 scopus 로고    scopus 로고
    • Printing proteins as microarrays for high-throughput function determination
    • MacBeath G., Schreiber S.L. Printing proteins as microarrays for high-throughput function determination. Science. 289:2000;1760-1763.
    • (2000) Science , vol.289 , pp. 1760-1763
    • MacBeath, G.1    Schreiber, S.L.2
  • 37
    • 0041663988 scopus 로고    scopus 로고
    • In vitro protein microarrays for detecting protein-protein interactions: Application of a new method for fluorescence labeling of proteins
    • Kawahashi Y., Doi N., Takashima H., Tsuda C., Oishi Y., Oyama R.et al. In vitro protein microarrays for detecting protein-protein interactions: application of a new method for fluorescence labeling of proteins. Proteomics. 3:2003;1236-1243.
    • (2003) Proteomics , vol.3 , pp. 1236-1243
    • Kawahashi, Y.1    Doi, N.2    Takashima, H.3    Tsuda, C.4    Oishi, Y.5    Oyama, R.6
  • 38
    • 0036603953 scopus 로고    scopus 로고
    • From combinatorial chemistry to chemical microarray
    • Lam K.S., Renil M. From combinatorial chemistry to chemical microarray. Curr. Opin. Chem. Biol. 6:2002;353-358.
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 353-358
    • Lam, K.S.1    Renil, M.2
  • 39
    • 0037294003 scopus 로고    scopus 로고
    • Affinity purification-mass spectrometry. Powerful tools for the characterization of protein complexes
    • Bauer A., Kuster B. Affinity purification-mass spectrometry. Powerful tools for the characterization of protein complexes. Eur. J. Biochem. 70:2003;570-578.
    • (2003) Eur. J. Biochem. , vol.70 , pp. 570-578
    • Bauer, A.1    Kuster, B.2
  • 40
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore P.D., Tuschl T., Sharp P.A., Bartel D.P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 101:2000;25-33.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 41
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir S.M., Lendeckel W., Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15:2001;188-200.
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 42
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 45
    • 0036727416 scopus 로고    scopus 로고
    • Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
    • Lewis D.L., Hagstrom J.E., Loomis A.G., Wolff J.A., Herweijer H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat. Genet. 32:2002;107-108.
    • (2002) Nat. Genet. , vol.32 , pp. 107-108
    • Lewis, D.L.1    Hagstrom, J.E.2    Loomis, A.G.3    Wolff, J.A.4    Herweijer, H.5
  • 47
  • 48
    • 0038380750 scopus 로고    scopus 로고
    • High-content assays for ligand regulation of G-protein-coupled receptors
    • Milligan G. High-content assays for ligand regulation of G-protein-coupled receptors. Drug Discov. Today. 8:2003;579-585.
    • (2003) Drug Discov. Today , vol.8 , pp. 579-585
    • Milligan, G.1
  • 49
    • 0000951677 scopus 로고
    • Use of peptide synthesis to pobe viral antigens for epitopes to a resolution of a single amino acid
    • Geysen H.M., Meloen R.H., Barteling S.J. Use of peptide synthesis to pobe viral antigens for epitopes to a resolution of a single amino acid. Proc. Natl. Acad. Sci. U.S.A. 81:1984;3998-4002.
    • (1984) Proc. Natl. Acad. Sci. U.S.A. , vol.81 , pp. 3998-4002
    • Geysen, H.M.1    Meloen, R.H.2    Barteling, S.J.3
  • 50
    • 0034699864 scopus 로고    scopus 로고
    • Efficient solid-phase synthesis of quinazoline-2-thioxo-4-ones with SynPhase lanterns
    • Makino S., Suzuki N., Nakanishi E., Tsuji T. Efficient solid-phase synthesis of quinazoline-2-thioxo-4-ones with SynPhase lanterns. Tetrahedron Lett. 41:2000;8333-8337.
    • (2000) Tetrahedron Lett. , vol.41 , pp. 8333-8337
    • Makino, S.1    Suzuki, N.2    Nakanishi, E.3    Tsuji, T.4
  • 51
    • 0141546762 scopus 로고    scopus 로고
    • Traceless synthesis of urea, semicarbazide and carbamate derivatives using bromo-Wang resin and bromo-Wang SynPhase Lantern
    • Phoon C.W., Sim M.M. Traceless synthesis of urea, semicarbazide and carbamate derivatives using bromo-Wang resin and bromo-Wang SynPhase Lantern. Synlett. 5:2001;697-699.
    • (2001) Synlett , vol.5 , pp. 697-699
    • Phoon, C.W.1    Sim, M.M.2
  • 52
    • 0026656122 scopus 로고
    • Spot-synthesis - An easy technique for the positionally addressable, parallel chemical synthesis on a membrane support
    • Frank R. Spot-synthesis - an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron. 48:1992;9217-9232.
    • (1992) Tetrahedron , vol.48 , pp. 9217-9232
    • Frank, R.1
  • 54
    • 0028815228 scopus 로고
    • Radio frequency tag encoded combinatorial library method for the discovery of tripeptide-substituted cinnamic acid inhibitors of the protein tyrosine phosphatase Ptp1b
    • Moran E.J., Sarshar S., Cargill J.F., Shahbaz M.M., Lio A., Mjalli A.M.M.et al. Radio frequency tag encoded combinatorial library method for the discovery of tripeptide-substituted cinnamic acid inhibitors of the protein tyrosine phosphatase Ptp1b. J. Am. Chem. Soc. 117:1995;10787-10788.
    • (1995) J. Am. Chem. Soc. , vol.117 , pp. 10787-10788
    • Moran, E.J.1    Sarshar, S.2    Cargill, J.F.3    Shahbaz, M.M.4    Lio, A.5    Mjalli, A.M.M.6
  • 55
    • 0037238058 scopus 로고    scopus 로고
    • Combinatorial peptide library methods for immunobiology research
    • Liu R., Enstrom A.M., Lam K.S. Combinatorial peptide library methods for immunobiology research. Exp. Hematol. 31:2003;11-30.
    • (2003) Exp. Hematol. , vol.31 , pp. 11-30
    • Liu, R.1    Enstrom, A.M.2    Lam, K.S.3
  • 56
    • 0030904387 scopus 로고    scopus 로고
    • Application of combinatorial library methods in cancer research and drug discovery
    • Lam K.S. Application of combinatorial library methods in cancer research and drug discovery. Anti-Cancer Drug Design. 12:1997;145-167.
    • (1997) Anti-Cancer Drug Design , vol.12 , pp. 145-167
    • Lam, K.S.1
  • 58
    • 0026419328 scopus 로고
    • A new type of synthetic peptide library for identifying ligand-binding activity
    • Lam K.S., Salmon S.E., Hersh E.M., Hruby V.J., Kazmierski W.M., Knapp R.J. A new type of synthetic peptide library for identifying ligand-binding activity. Nature. 354:1991;82-84.
    • (1991) Nature , vol.354 , pp. 82-84
    • Lam, K.S.1    Salmon, S.E.2    Hersh, E.M.3    Hruby, V.J.4    Kazmierski, W.M.5    Knapp, R.J.6
  • 59
    • 0031151959 scopus 로고    scopus 로고
    • Encoding methods for combinatorial chemistry
    • Czarnik A.W. Encoding methods for combinatorial chemistry. Curr. Opin. Chem. Biol. 1:1997;60-66.
    • (1997) Curr. Opin. Chem. Biol. , vol.1 , pp. 60-66
    • Czarnik, A.W.1
  • 60
    • 0034115097 scopus 로고    scopus 로고
    • Recent developments in the encoding and deconvolution of combinatorial libraries
    • Barnes C., Balasubramanian S. Recent developments in the encoding and deconvolution of combinatorial libraries. Curr. Opin. Chem. Biol. 4:2000;346-350.
    • (2000) Curr. Opin. Chem. Biol. , vol.4 , pp. 346-350
    • Barnes, C.1    Balasubramanian, S.2
  • 61
    • 0035358555 scopus 로고    scopus 로고
    • Solutions for library encoding to create collections of discrete compounds
    • Affleck R.L. Solutions for library encoding to create collections of discrete compounds. Curr. Opin. Chem. Biol. 5:2001;257-263.
    • (2001) Curr. Opin. Chem. Biol. , vol.5 , pp. 257-263
    • Affleck, R.L.1
  • 62
    • 0037014692 scopus 로고    scopus 로고
    • A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries
    • Liu R., Marik J., Lam K.S. A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries. J. Am. Chem. Soc. 124:2002;7678-7680.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 7678-7680
    • Liu, R.1    Marik, J.2    Lam, K.S.3
  • 63
    • 0037951325 scopus 로고    scopus 로고
    • A novel and rapid encoding method based on mass spectrometry for "one-bead-one-compound" small molecule combinatorial libraries
    • Song A., Zhang J., Lebrilla C.B., Lam K.S. A novel and rapid encoding method based on mass spectrometry for "one-bead-one-compound" small molecule combinatorial libraries. J. Am. Chem. Soc. 125:2003;6180-6188.
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 6180-6188
    • Song, A.1    Zhang, J.2    Lebrilla, C.B.3    Lam, K.S.4
  • 64
    • 0035903710 scopus 로고    scopus 로고
    • Decoding products of diversity pathways from stock solutions derived from single polymeric macrobeads
    • Blackwell H.E., Perez L., Schreiber S.L. Decoding products of diversity pathways from stock solutions derived from single polymeric macrobeads. Angew. Chem. Intl. Ed. 40:2001;3421-3425.
    • (2001) Angew. Chem. Intl. Ed. , vol.40 , pp. 3421-3425
    • Blackwell, H.E.1    Perez, L.2    Schreiber, S.L.3
  • 67
    • 0035937468 scopus 로고    scopus 로고
    • Dynamic combinatorial chemistry
    • Lehn J.M., Eliseev A.V. Dynamic combinatorial chemistry. Science. 291:2001;2331-2332.
    • (2001) Science , vol.291 , pp. 2331-2332
    • Lehn, J.M.1    Eliseev, A.V.2
  • 69
    • 0036047069 scopus 로고    scopus 로고
    • Drug discovery by dynamic combinatorial libraries
    • Ramstrom O., Lehn J.-M. Drug discovery by dynamic combinatorial libraries. Nat. Rev. Drug Discov. 1:2002;26-36.
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 26-36
    • Ramstrom, O.1    Lehn, J.-M.2
  • 71
    • 0035017737 scopus 로고    scopus 로고
    • Peptide and small molecule microarray for high throughput cell adhesion and functional assays
    • Falsey J.R., Renil M., Park S., Li S., Lam K.S. Peptide and small molecule microarray for high throughput cell adhesion and functional assays. Bioconjugate Chem. 12:2001;346-353.
    • (2001) Bioconjugate Chem. , vol.12 , pp. 346-353
    • Falsey, J.R.1    Renil, M.2    Park, S.3    Li, S.4    Lam, K.S.5
  • 72
    • 0038679485 scopus 로고    scopus 로고
    • Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research
    • Lam K.S., Liu R., Miyamoto S., Lehman A.L., Tuscano J.M. Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research. Acc. Chem. Res. 36:2003;370-377.
    • (2003) Acc. Chem. Res. , vol.36 , pp. 370-377
    • Lam, K.S.1    Liu, R.2    Miyamoto, S.3    Lehman, A.L.4    Tuscano, J.M.5
  • 73
    • 0036603953 scopus 로고    scopus 로고
    • From combinatorial chemistry to chemical microarray
    • Lam K.S., Renil M. From combinatorial chemistry to chemical microarray. Curr. Opin. Chem. Biol. 6:2002;353-358.
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 353-358
    • Lam, K.S.1    Renil, M.2
  • 75
    • 0037394124 scopus 로고    scopus 로고
    • Designing screens: How to make your hits a hit
    • Walters W.P., Namchuk M. Designing screens: how to make your hits a hit. Nat. Rev. Drug Discov. 2:2003;259-266.
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 259-266
    • Walters, W.P.1    Namchuk, M.2
  • 76
    • 0036877067 scopus 로고    scopus 로고
    • An automated quantitative high content sscreening assay for neurite outgrowth
    • Arden S.R., Janardhan P., Debiasio R., Arnold B., Ghosh R.N. An automated quantitative high content sscreening assay for neurite outgrowth. Chimica Oggi. 20:2002;64-67.
    • (2002) Chimica Oggi. , vol.20 , pp. 64-67
    • Arden, S.R.1    Janardhan, P.2    Debiasio, R.3    Arnold, B.4    Ghosh, R.N.5
  • 78
    • 0029873825 scopus 로고    scopus 로고
    • Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags
    • Ni Z.J., Maclean D., Holmes C.P., Murphy M.M., Ruhland B., Jacobs J.W.et al. Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags. J. Med. Chem. 39:1996;1601-1608.
    • (1996) J. Med. Chem. , vol.39 , pp. 1601-1608
    • Ni, Z.J.1    MacLean, D.2    Holmes, C.P.3    Murphy, M.M.4    Ruhland, B.5    Jacobs, J.W.6
  • 79
    • 0001117151 scopus 로고    scopus 로고
    • Improved methods for encoding and decoding dialkylamine-encoded combinatorial libraries
    • Fitch W.L., Baer T.A., Chen W., Holden F., Holmes C.P., Maclean D.et al. Improved methods for encoding and decoding dialkylamine-encoded combinatorial libraries. J. Comb. Chem. 1:1999;188-194.
    • (1999) J. Comb. Chem. , vol.1 , pp. 188-194
    • Fitch, W.L.1    Baer, T.A.2    Chen, W.3    Holden, F.4    Holmes, C.P.5    MacLean, D.6
  • 80
    • 0034697160 scopus 로고    scopus 로고
    • Trityl tags for encoding in combinatorial synthesis
    • Shchepinov M.S., Chalk R., Southern E.M. Trityl tags for encoding in combinatorial synthesis. Tetrahedron. 56:2000;2712-2724.
    • (2000) Tetrahedron , vol.56 , pp. 2712-2724
    • Shchepinov, M.S.1    Chalk, R.2    Southern, E.M.3
  • 81
    • 0030252966 scopus 로고    scopus 로고
    • High-volume cellular screening for anticancer agents with combinatorial chemical libraries - A new methodology
    • Salmon S.E., Liu-Stevens R.H., Zhao Y., Michal L., Viktor K., Ken W.et al. High-volume cellular screening for anticancer agents with combinatorial chemical libraries - a new methodology. Mol. Diversity. 2:1996;57-63.
    • (1996) Mol. Diversity , vol.2 , pp. 57-63
    • Salmon, S.E.1    Liu-Stevens, R.H.2    Zhao, Y.3    Michal, L.4    Viktor, K.5    Ken, W.6
  • 82
    • 0037523452 scopus 로고    scopus 로고
    • Going to the well no more: Lawn format assays for ultra-high-throughput screening
    • Marron B., Jayawickreme C.K. Going to the well no more: lawn format assays for ultra-high-throughput screening. Curr. Opin. Chem. Biol. 7:2003;395-401.
    • (2003) Curr. Opin. Chem. Biol. , vol.7 , pp. 395-401
    • Marron, B.1    Jayawickreme, C.K.2
  • 83
    • 0031127997 scopus 로고    scopus 로고
    • Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D
    • Kick E.K., Roe D.C., Skillman A.G., Liu G., Ewing T.J.A., Sun Y.et al. Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D. Chem. Biol. 4:1997;297-307.
    • (1997) Chem. Biol. , vol.4 , pp. 297-307
    • Kick, E.K.1    Roe, D.C.2    Skillman, A.G.3    Liu, G.4    Ewing, T.J.A.5    Sun, Y.6
  • 86
    • 0036051992 scopus 로고    scopus 로고
    • High-throughput crystallography for lead discovery in drug design
    • Blundell T.L., Jhoti H., Abell C. High-throughput crystallography for lead discovery in drug design. Nat. Rev. Drug. Discov. 1:2002;45-54.
    • (2002) Nat. Rev. Drug. Discov. , vol.1 , pp. 45-54
    • Blundell, T.L.1    Jhoti, H.2    Abell, C.3
  • 87
    • 0036462475 scopus 로고    scopus 로고
    • High-throughput crystallization and structure determination in drug discovery
    • Stewart L., Clark P., Behnke C. High-throughput crystallization and structure determination in drug discovery. Drug Discov. Today. 7:2002;187-196.
    • (2002) Drug Discov. Today , vol.7 , pp. 187-196
    • Stewart, L.1    Clark, P.2    Behnke, C.3
  • 88
    • 0001011919 scopus 로고    scopus 로고
    • High-throughput X-ray crystallography for structure-based drug design
    • Goodwill K.E., Tennant M.G., Stevens R.C. High-throughput X-ray crystallography for structure-based drug design. Drug Discov. Today. 6:2001;S113-S118.
    • (2001) Drug Discov. Today , vol.6
    • Goodwill, K.E.1    Tennant, M.G.2    Stevens, R.C.3
  • 91
    • 0036066481 scopus 로고    scopus 로고
    • Affinity NMR: A powerful method for drug discovery
    • Shapiro M.J. Affinity NMR: a powerful method for drug discovery. Am. Pharma. Rev. 5:2002;9496-9497.
    • (2002) Am. Pharma. Rev. , vol.5 , pp. 9496-9497
    • Shapiro, M.J.1
  • 92
    • 0038520161 scopus 로고    scopus 로고
    • NMR-based screening methods for lead discovery
    • Martin V., Klaus F. NMR-based screening methods for lead discovery. EXS. 93:2003;183-202.
    • (2003) EXS , vol.93 , pp. 183-202
    • Martin, V.1    Klaus, F.2
  • 94
    • 0031962612 scopus 로고    scopus 로고
    • Mass spectrometry and the age of the proteome
    • Yates J.R. III Mass spectrometry and the age of the proteome. J. Mass Spectrom. 33:1998;1-19.
    • (1998) J. Mass Spectrom. , vol.33 , pp. 1-19
    • Yates III, J.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.