-
2
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
Nicholson K.M., Anderson N.G. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 14:2002;381-395.
-
(2002)
Cell Signal.
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
3
-
-
0036888335
-
Integration of the TGF-beta pathway into the cellular signalling network
-
Lutz M., Knaus P. Integration of the TGF-beta pathway into the cellular signalling network. Cell Signal. 14:2002;977-988.
-
(2002)
Cell Signal.
, vol.14
, pp. 977-988
-
-
Lutz, M.1
Knaus, P.2
-
4
-
-
0037152635
-
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer
-
Osada H., Takahashi T. Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. Oncogene. 21:2002;7421-7434.
-
(2002)
Oncogene
, vol.21
, pp. 7421-7434
-
-
Osada, H.1
Takahashi, T.2
-
5
-
-
0037370476
-
The genetics and genomics of cancer
-
Balmain A. The genetics and genomics of cancer. Nat. Genet. 33(Suppl.):2003;238-244.
-
(2003)
Nat. Genet.
, vol.33
, Issue.SUPPL.
, pp. 238-244
-
-
Balmain, A.1
-
7
-
-
0035993393
-
ETS proteins and MMPs: Partners in invasion and metastasis
-
Singh S., Barrett J., Sakata K., Tozer R.G., Singh G. ETS proteins and MMPs: partners in invasion and metastasis. Curr. Drug Targets. 3:2002;359-367.
-
(2002)
Curr. Drug Targets
, vol.3
, pp. 359-367
-
-
Singh, S.1
Barrett, J.2
Sakata, K.3
Tozer, R.G.4
Singh, G.5
-
8
-
-
0031737516
-
Antisense RNA: Function and fate of duplex RNA in cells of higher eukaryotes
-
Kumar M., Carmichael G.G. Antisense RNA: function and fate of duplex RNA in cells of higher eukaryotes. Microbiol. Mol. Biol. Rev. 62:1998;1415-1434.
-
(1998)
Microbiol. Mol. Biol. Rev.
, vol.62
, pp. 1415-1434
-
-
Kumar, M.1
Carmichael, G.G.2
-
9
-
-
0642307773
-
RNA interference: Gene silencing in the fast lane
-
Kittler R., Buchholz F. RNA interference: gene silencing in the fast lane. Semin. Cancer Biol. 13:2003;259-265.
-
(2003)
Semin. Cancer Biol.
, vol.13
, pp. 259-265
-
-
Kittler, R.1
Buchholz, F.2
-
10
-
-
0141502041
-
SiRNAs and shRNAs: Skeleton keys to the human genome
-
Paddison P.J., Hannon G.J. siRNAs and shRNAs: skeleton keys to the human genome. Curr. Opin. Mol. Ther. 5:2003;217-224.
-
(2003)
Curr. Opin. Mol. Ther.
, vol.5
, pp. 217-224
-
-
Paddison, P.J.1
Hannon, G.J.2
-
12
-
-
0037088998
-
Transgenic systems in drug discovery: From target identification to humanized mice
-
Tornell J., Snaith M. Transgenic systems in drug discovery: from target identification to humanized mice. Drug Discov. Today. 7:2002;461-470.
-
(2002)
Drug Discov. Today
, vol.7
, pp. 461-470
-
-
Tornell, J.1
Snaith, M.2
-
13
-
-
0000577984
-
The "one-bead-one-compound" combinatorial library method
-
Lam K.S., Lebl M., Krchnak V. The "one-bead-one-compound" combinatorial library method. Chem. Rev. 97:1997;411-448.
-
(1997)
Chem. Rev.
, vol.97
, pp. 411-448
-
-
Lam, K.S.1
Lebl, M.2
Krchnak, V.3
-
14
-
-
84955072980
-
Combinatorial chemistry
-
Jung G, editor Weinheim: Wiley-VCH
-
Tiebes D. Combinatorial chemistry. In: Jung G, editor. Combinatorial chemistry. Weinheim: Wiley-VCH; 1999. p. 1-34.
-
(1999)
Combinatorial Chemistry
, pp. 1-34
-
-
Tiebes, D.1
-
16
-
-
0742272229
-
Developments in combinatorial chemistry
-
Weber L. Developments in combinatorial chemistry. Pharm Manuf Int 2000;45-6,48,50.
-
(2000)
Pharm Manuf Int
, vol.45
, Issue.6
, pp. 48
-
-
Weber, L.1
-
17
-
-
79959571835
-
Combinatorial chemistry and high-throughput screening in drug discovery and development
-
San Diego, CA, USA. Sep Sci Technol
-
Appell K, Baldwin JJ, Egan WJ. Combinatorial chemistry and high-throughput screening in drug discovery and development. Handbook of modern pharmaceutical analysis, San Diego, CA, USA. Sep Sci Technol 2001;3:23-56.
-
(2001)
Handbook of modern pharmaceutical analysis
, vol.3
, pp. 23-56
-
-
Appell, K.1
Baldwin, J.J.2
Egan, W.J.3
-
19
-
-
0036510961
-
Identification and mapping of small-molecule binding sites in proteins: Computational tools for structure-based drug design
-
Sotriffer C., Klebe G. Identification and mapping of small-molecule binding sites in proteins: computational tools for structure-based drug design. Farmaco. 57:2002;243-251.
-
(2002)
Farmaco
, vol.57
, pp. 243-251
-
-
Sotriffer, C.1
Klebe, G.2
-
20
-
-
0036589881
-
Structural genomics: Bridging functional genomics and structure-based drug design
-
Buchanan S.G. Structural genomics: bridging functional genomics and structure-based drug design. Curr. Opin. Drug Discov. Dev. 5:2002;367-381.
-
(2002)
Curr. Opin. Drug Discov. Dev.
, vol.5
, pp. 367-381
-
-
Buchanan, S.G.1
-
21
-
-
0742307009
-
HIV-1 protease: Structure-based drug design using the free energy perturbation approach
-
Reddy MR, Appelt K. HIV-1 protease: structure-based drug design using the free energy perturbation approach. Free Energy Calc Rational Drug Design 2001;1:317-34.
-
(2001)
Free Energy Calc Rational Drug Design
, vol.1
, pp. 317-334
-
-
Reddy, M.R.1
Appelt, K.2
-
22
-
-
0036066481
-
Affinity NMR: A powerful method for drug discovery
-
Shapiro M.J. Affinity NMR: a powerful method for drug discovery. Am. Pharm. Rev. 5:2002;96-97.
-
(2002)
Am. Pharm. Rev.
, vol.5
, pp. 96-97
-
-
Shapiro, M.J.1
-
23
-
-
0036138731
-
Strategic use of affinity-based mass spectrometry techniques in the drug discovery process
-
Kelly M.A., McLellan T.J., Rosner P.J. Strategic use of affinity-based mass spectrometry techniques in the drug discovery process. Anal Chem. 74:2002;1-9.
-
(2002)
Anal Chem.
, vol.74
, pp. 1-9
-
-
Kelly, M.A.1
McLellan, T.J.2
Rosner, P.J.3
-
24
-
-
0028806048
-
Quantitative monitoring of gene expression patterns with a complementary DNA microarray
-
Schena M., Shalon D., Davis R.W., Brown P.O. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science. 270:1995;467-470.
-
(1995)
Science
, vol.270
, pp. 467-470
-
-
Schena, M.1
Shalon, D.2
Davis, R.W.3
Brown, P.O.4
-
25
-
-
0033542378
-
Identification and temporal expression pattern of genes modulated during irreversible growth arrest and terminal differentiation in human melanoma cells
-
Huang F., Adelman J., Jiang H., Goldstein N.I., Fisher P.B. Identification and temporal expression pattern of genes modulated during irreversible growth arrest and terminal differentiation in human melanoma cells. Oncogene. 18:1999;3546-3552.
-
(1999)
Oncogene
, vol.18
, pp. 3546-3552
-
-
Huang, F.1
Adelman, J.2
Jiang, H.3
Goldstein, N.I.4
Fisher, P.B.5
-
26
-
-
0031800106
-
Microarrays: Biotechnology's discovery platform for functional genomics
-
Schena M., Heller R.A., Theriault T.P., Konrad K., Lachenmeier E., Davis R.W. Microarrays: biotechnology's discovery platform for functional genomics. Trends Biotechnol. 16:1998;301-306.
-
(1998)
Trends Biotechnol.
, vol.16
, pp. 301-306
-
-
Schena, M.1
Heller, R.A.2
Theriault, T.P.3
Konrad, K.4
Lachenmeier, E.5
Davis, R.W.6
-
27
-
-
0026674886
-
Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction
-
Liang P., Pardee A.B. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science. 257:1992;967-971.
-
(1992)
Science
, vol.257
, pp. 967-971
-
-
Liang, P.1
Pardee, A.B.2
-
28
-
-
0029148619
-
Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display
-
Shen R., Su Z.Z., Olsson C.A., Fisher P.B. Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display. Proc. Natl. Acad. Sci. U.S.A. 92:1995;6778-6782.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 6778-6782
-
-
Shen, R.1
Su, Z.Z.2
Olsson, C.A.3
Fisher, P.B.4
-
29
-
-
0032506148
-
Reciprocal subtraction differential RNA display: An efficient and rapid procedure for isolating differentially expressed gene sequences
-
Kang D.C., LaFrance R., Su Z.Z., Fisher P.B. Reciprocal subtraction differential RNA display: an efficient and rapid procedure for isolating differentially expressed gene sequences. Proc. Natl. Acad. Sci. U.S.A. 95:1998;13788-13793.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 13788-13793
-
-
Kang, D.C.1
Lafrance, R.2
Su, Z.Z.3
Fisher, P.B.4
-
30
-
-
0030962307
-
Gene expression profiles in normal and cancer cells
-
Zhang L., Zhou W., Velculescu V.E., Kern S.E., Hruban R.H., Hamilton S.R.et al. Gene expression profiles in normal and cancer cells. Science. 276:1997;1268-1272.
-
(1997)
Science
, vol.276
, pp. 1268-1272
-
-
Zhang, L.1
Zhou, W.2
Velculescu, V.E.3
Kern, S.E.4
Hruban, R.H.5
Hamilton, S.R.6
-
31
-
-
0033748034
-
RaSH, a rapid subtraction hybridization approach for identifying and cloning differentially expressed genes
-
Jiang H., Kang D.C., Alexandre D., Fisher P.B. RaSH, a rapid subtraction hybridization approach for identifying and cloning differentially expressed genes. Proc. Natl. Acad. Sci. U.S.A. 97:2000;12684-12689.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 12684-12689
-
-
Jiang, H.1
Kang, D.C.2
Alexandre, D.3
Fisher, P.B.4
-
33
-
-
0035798433
-
Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization
-
Stassar M.J., Devitt G., Brosius M., Rinnab L., Prang J., Schradin T.et al. Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization. Br. J. Cancer. 85:2001;1372-1382.
-
(2001)
Br. J. Cancer
, vol.85
, pp. 1372-1382
-
-
Stassar, M.J.1
Devitt, G.2
Brosius, M.3
Rinnab, L.4
Prang, J.5
Schradin, T.6
-
34
-
-
0028939263
-
Comparative genomic analysis of tumors: Detection of DNA losses and amplification
-
Lisitsyn N.A., Lisitsina N.M., Dalbagni G., Barker P., Sanchez C.A., Gnarra J.et al. Comparative genomic analysis of tumors: detection of DNA losses and amplification. Proc. Natl. Acad. Sci. U.S.A. 92:1995;151-155.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 151-155
-
-
Lisitsyn, N.A.1
Lisitsina, N.M.2
Dalbagni, G.3
Barker, P.4
Sanchez, C.A.5
Gnarra, J.6
-
35
-
-
0028577898
-
Identifying differences in mRNA expression by representational difference analysis of cDNA
-
Hubank M., Schatz D.G. Identifying differences in mRNA expression by representational difference analysis of cDNA. Nucleic Acids Res. 22:1994;5640-5648.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 5640-5648
-
-
Hubank, M.1
Schatz, D.G.2
-
36
-
-
0034622925
-
Printing proteins as microarrays for high-throughput function determination
-
MacBeath G., Schreiber S.L. Printing proteins as microarrays for high-throughput function determination. Science. 289:2000;1760-1763.
-
(2000)
Science
, vol.289
, pp. 1760-1763
-
-
MacBeath, G.1
Schreiber, S.L.2
-
37
-
-
0041663988
-
In vitro protein microarrays for detecting protein-protein interactions: Application of a new method for fluorescence labeling of proteins
-
Kawahashi Y., Doi N., Takashima H., Tsuda C., Oishi Y., Oyama R.et al. In vitro protein microarrays for detecting protein-protein interactions: application of a new method for fluorescence labeling of proteins. Proteomics. 3:2003;1236-1243.
-
(2003)
Proteomics
, vol.3
, pp. 1236-1243
-
-
Kawahashi, Y.1
Doi, N.2
Takashima, H.3
Tsuda, C.4
Oishi, Y.5
Oyama, R.6
-
38
-
-
0036603953
-
From combinatorial chemistry to chemical microarray
-
Lam K.S., Renil M. From combinatorial chemistry to chemical microarray. Curr. Opin. Chem. Biol. 6:2002;353-358.
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 353-358
-
-
Lam, K.S.1
Renil, M.2
-
39
-
-
0037294003
-
Affinity purification-mass spectrometry. Powerful tools for the characterization of protein complexes
-
Bauer A., Kuster B. Affinity purification-mass spectrometry. Powerful tools for the characterization of protein complexes. Eur. J. Biochem. 70:2003;570-578.
-
(2003)
Eur. J. Biochem.
, vol.70
, pp. 570-578
-
-
Bauer, A.1
Kuster, B.2
-
40
-
-
0034737298
-
RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
-
Zamore P.D., Tuschl T., Sharp P.A., Bartel D.P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 101:2000;25-33.
-
(2000)
Cell
, vol.101
, pp. 25-33
-
-
Zamore, P.D.1
Tuschl, T.2
Sharp, P.A.3
Bartel, D.P.4
-
41
-
-
0035863097
-
RNA interference is mediated by 21- and 22-nucleotide RNAs
-
Elbashir S.M., Lendeckel W., Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15:2001;188-200.
-
(2001)
Genes Dev.
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
42
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
43
-
-
18644382388
-
The polycomb group protein EZH2 is involved in progression of prostate cancer
-
Varambally S., Dhanasekaran S.M., Zhou M., Barrette T.R., Kumar-Sinha C., Sanda M.G.et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature. 419:2002;624-629.
-
(2002)
Nature
, vol.419
, pp. 624-629
-
-
Varambally, S.1
Dhanasekaran, S.M.2
Zhou, M.3
Barrette, T.R.4
Kumar-Sinha, C.5
Sanda, M.G.6
-
44
-
-
0032499252
-
Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells
-
Zambrowicz B.P., Friedrich G.A., Buxton E.C., Lilleberg S.L., Person C., Sands A.T. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 392:1998;608-611.
-
(1998)
Nature
, vol.392
, pp. 608-611
-
-
Zambrowicz, B.P.1
Friedrich, G.A.2
Buxton, E.C.3
Lilleberg, S.L.4
Person, C.5
Sands, A.T.6
-
45
-
-
0036727416
-
Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
-
Lewis D.L., Hagstrom J.E., Loomis A.G., Wolff J.A., Herweijer H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat. Genet. 32:2002;107-108.
-
(2002)
Nat. Genet.
, vol.32
, pp. 107-108
-
-
Lewis, D.L.1
Hagstrom, J.E.2
Loomis, A.G.3
Wolff, J.A.4
Herweijer, H.5
-
46
-
-
0037019339
-
Gene expression: RNA interference in adult mice
-
McCaffrey A.P., Meuse L., Pham T.T., Conklin D.S., Hannon G.J., Kay M.A. Gene expression: RNA interference in adult mice. Nature. 418:2002;38-39.
-
(2002)
Nature
, vol.418
, pp. 38-39
-
-
McCaffrey, A.P.1
Meuse, L.2
Pham, T.T.3
Conklin, D.S.4
Hannon, G.J.5
Kay, M.A.6
-
48
-
-
0038380750
-
High-content assays for ligand regulation of G-protein-coupled receptors
-
Milligan G. High-content assays for ligand regulation of G-protein-coupled receptors. Drug Discov. Today. 8:2003;579-585.
-
(2003)
Drug Discov. Today
, vol.8
, pp. 579-585
-
-
Milligan, G.1
-
49
-
-
0000951677
-
Use of peptide synthesis to pobe viral antigens for epitopes to a resolution of a single amino acid
-
Geysen H.M., Meloen R.H., Barteling S.J. Use of peptide synthesis to pobe viral antigens for epitopes to a resolution of a single amino acid. Proc. Natl. Acad. Sci. U.S.A. 81:1984;3998-4002.
-
(1984)
Proc. Natl. Acad. Sci. U.S.A.
, vol.81
, pp. 3998-4002
-
-
Geysen, H.M.1
Meloen, R.H.2
Barteling, S.J.3
-
50
-
-
0034699864
-
Efficient solid-phase synthesis of quinazoline-2-thioxo-4-ones with SynPhase lanterns
-
Makino S., Suzuki N., Nakanishi E., Tsuji T. Efficient solid-phase synthesis of quinazoline-2-thioxo-4-ones with SynPhase lanterns. Tetrahedron Lett. 41:2000;8333-8337.
-
(2000)
Tetrahedron Lett.
, vol.41
, pp. 8333-8337
-
-
Makino, S.1
Suzuki, N.2
Nakanishi, E.3
Tsuji, T.4
-
51
-
-
0141546762
-
Traceless synthesis of urea, semicarbazide and carbamate derivatives using bromo-Wang resin and bromo-Wang SynPhase Lantern
-
Phoon C.W., Sim M.M. Traceless synthesis of urea, semicarbazide and carbamate derivatives using bromo-Wang resin and bromo-Wang SynPhase Lantern. Synlett. 5:2001;697-699.
-
(2001)
Synlett
, vol.5
, pp. 697-699
-
-
Phoon, C.W.1
Sim, M.M.2
-
52
-
-
0026656122
-
Spot-synthesis - An easy technique for the positionally addressable, parallel chemical synthesis on a membrane support
-
Frank R. Spot-synthesis - an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron. 48:1992;9217-9232.
-
(1992)
Tetrahedron
, vol.48
, pp. 9217-9232
-
-
Frank, R.1
-
53
-
-
33748243831
-
Radiofrequency encoded combinatorial chemistry
-
Nicolaou K.C., Xiao X.Y., Parandoosh Z., Senyei A., Nova M.P. Radiofrequency encoded combinatorial chemistry. Angew. Chem. Int. Ed. 34:1995;2289-2291.
-
(1995)
Angew. Chem. Int. Ed.
, vol.34
, pp. 2289-2291
-
-
Nicolaou, K.C.1
Xiao, X.Y.2
Parandoosh, Z.3
Senyei, A.4
Nova, M.P.5
-
54
-
-
0028815228
-
Radio frequency tag encoded combinatorial library method for the discovery of tripeptide-substituted cinnamic acid inhibitors of the protein tyrosine phosphatase Ptp1b
-
Moran E.J., Sarshar S., Cargill J.F., Shahbaz M.M., Lio A., Mjalli A.M.M.et al. Radio frequency tag encoded combinatorial library method for the discovery of tripeptide-substituted cinnamic acid inhibitors of the protein tyrosine phosphatase Ptp1b. J. Am. Chem. Soc. 117:1995;10787-10788.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 10787-10788
-
-
Moran, E.J.1
Sarshar, S.2
Cargill, J.F.3
Shahbaz, M.M.4
Lio, A.5
Mjalli, A.M.M.6
-
55
-
-
0037238058
-
Combinatorial peptide library methods for immunobiology research
-
Liu R., Enstrom A.M., Lam K.S. Combinatorial peptide library methods for immunobiology research. Exp. Hematol. 31:2003;11-30.
-
(2003)
Exp. Hematol.
, vol.31
, pp. 11-30
-
-
Liu, R.1
Enstrom, A.M.2
Lam, K.S.3
-
56
-
-
0030904387
-
Application of combinatorial library methods in cancer research and drug discovery
-
Lam K.S. Application of combinatorial library methods in cancer research and drug discovery. Anti-Cancer Drug Design. 12:1997;145-167.
-
(1997)
Anti-Cancer Drug Design
, vol.12
, pp. 145-167
-
-
Lam, K.S.1
-
57
-
-
0031310605
-
High throughput analysis and purification in support of automated parallel synthesis
-
Weller H.N., Young M.G., Michalczyk S.J., Reitnauer G.H., Cooley R.S., Rahn P.C.et al. High throughput analysis and purification in support of automated parallel synthesis. Mol. Diversity. 3:1997;61-70.
-
(1997)
Mol. Diversity
, vol.3
, pp. 61-70
-
-
Weller, H.N.1
Young, M.G.2
Michalczyk, S.J.3
Reitnauer, G.H.4
Cooley, R.S.5
Rahn, P.C.6
-
58
-
-
0026419328
-
A new type of synthetic peptide library for identifying ligand-binding activity
-
Lam K.S., Salmon S.E., Hersh E.M., Hruby V.J., Kazmierski W.M., Knapp R.J. A new type of synthetic peptide library for identifying ligand-binding activity. Nature. 354:1991;82-84.
-
(1991)
Nature
, vol.354
, pp. 82-84
-
-
Lam, K.S.1
Salmon, S.E.2
Hersh, E.M.3
Hruby, V.J.4
Kazmierski, W.M.5
Knapp, R.J.6
-
59
-
-
0031151959
-
Encoding methods for combinatorial chemistry
-
Czarnik A.W. Encoding methods for combinatorial chemistry. Curr. Opin. Chem. Biol. 1:1997;60-66.
-
(1997)
Curr. Opin. Chem. Biol.
, vol.1
, pp. 60-66
-
-
Czarnik, A.W.1
-
60
-
-
0034115097
-
Recent developments in the encoding and deconvolution of combinatorial libraries
-
Barnes C., Balasubramanian S. Recent developments in the encoding and deconvolution of combinatorial libraries. Curr. Opin. Chem. Biol. 4:2000;346-350.
-
(2000)
Curr. Opin. Chem. Biol.
, vol.4
, pp. 346-350
-
-
Barnes, C.1
Balasubramanian, S.2
-
61
-
-
0035358555
-
Solutions for library encoding to create collections of discrete compounds
-
Affleck R.L. Solutions for library encoding to create collections of discrete compounds. Curr. Opin. Chem. Biol. 5:2001;257-263.
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 257-263
-
-
Affleck, R.L.1
-
62
-
-
0037014692
-
A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries
-
Liu R., Marik J., Lam K.S. A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries. J. Am. Chem. Soc. 124:2002;7678-7680.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 7678-7680
-
-
Liu, R.1
Marik, J.2
Lam, K.S.3
-
63
-
-
0037951325
-
A novel and rapid encoding method based on mass spectrometry for "one-bead-one-compound" small molecule combinatorial libraries
-
Song A., Zhang J., Lebrilla C.B., Lam K.S. A novel and rapid encoding method based on mass spectrometry for "one-bead-one-compound" small molecule combinatorial libraries. J. Am. Chem. Soc. 125:2003;6180-6188.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 6180-6188
-
-
Song, A.1
Zhang, J.2
Lebrilla, C.B.3
Lam, K.S.4
-
64
-
-
0035903710
-
Decoding products of diversity pathways from stock solutions derived from single polymeric macrobeads
-
Blackwell H.E., Perez L., Schreiber S.L. Decoding products of diversity pathways from stock solutions derived from single polymeric macrobeads. Angew. Chem. Intl. Ed. 40:2001;3421-3425.
-
(2001)
Angew. Chem. Intl. Ed.
, vol.40
, pp. 3421-3425
-
-
Blackwell, H.E.1
Perez, L.2
Schreiber, S.L.3
-
67
-
-
0035937468
-
Dynamic combinatorial chemistry
-
Lehn J.M., Eliseev A.V. Dynamic combinatorial chemistry. Science. 291:2001;2331-2332.
-
(2001)
Science
, vol.291
, pp. 2331-2332
-
-
Lehn, J.M.1
Eliseev, A.V.2
-
68
-
-
0037337035
-
In situ assembly of enzyme inhibitors using extended tethering
-
Erlanson D.A., Lam J.W., Wiesmann C., Luong T.N., Simmons R.L., DeLano W.L.et al. In situ assembly of enzyme inhibitors using extended tethering. Nat. Biotechnol. 21:2003;308-314.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 308-314
-
-
Erlanson, D.A.1
Lam, J.W.2
Wiesmann, C.3
Luong, T.N.4
Simmons, R.L.5
Delano, W.L.6
-
69
-
-
0036047069
-
Drug discovery by dynamic combinatorial libraries
-
Ramstrom O., Lehn J.-M. Drug discovery by dynamic combinatorial libraries. Nat. Rev. Drug Discov. 1:2002;26-36.
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 26-36
-
-
Ramstrom, O.1
Lehn, J.-M.2
-
70
-
-
0026108692
-
Light-directed, spatially addressable parallel chemical synthesis
-
Fodor S.P.A., Read J.L., Pirrung M.C., Stryer L., Lu A.T., Solas D. Light-directed, spatially addressable parallel chemical synthesis. Science. 251:1991;767-773.
-
(1991)
Science
, vol.251
, pp. 767-773
-
-
Fodor, S.P.A.1
Read, J.L.2
Pirrung, M.C.3
Stryer, L.4
Lu, A.T.5
Solas, D.6
-
71
-
-
0035017737
-
Peptide and small molecule microarray for high throughput cell adhesion and functional assays
-
Falsey J.R., Renil M., Park S., Li S., Lam K.S. Peptide and small molecule microarray for high throughput cell adhesion and functional assays. Bioconjugate Chem. 12:2001;346-353.
-
(2001)
Bioconjugate Chem.
, vol.12
, pp. 346-353
-
-
Falsey, J.R.1
Renil, M.2
Park, S.3
Li, S.4
Lam, K.S.5
-
72
-
-
0038679485
-
Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research
-
Lam K.S., Liu R., Miyamoto S., Lehman A.L., Tuscano J.M. Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research. Acc. Chem. Res. 36:2003;370-377.
-
(2003)
Acc. Chem. Res.
, vol.36
, pp. 370-377
-
-
Lam, K.S.1
Liu, R.2
Miyamoto, S.3
Lehman, A.L.4
Tuscano, J.M.5
-
73
-
-
0036603953
-
From combinatorial chemistry to chemical microarray
-
Lam K.S., Renil M. From combinatorial chemistry to chemical microarray. Curr. Opin. Chem. Biol. 6:2002;353-358.
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 353-358
-
-
Lam, K.S.1
Renil, M.2
-
74
-
-
0037674681
-
Developments in microarray technologies
-
Howbrook D.N., van der Valk A.M., O'Shaughnessy M.C., Sarker D.K., Baker S.C., Lloyd A.W. Developments in microarray technologies. Drug Discov. Today. 8:2003;642-651.
-
(2003)
Drug Discov. Today
, vol.8
, pp. 642-651
-
-
Howbrook, D.N.1
Van Der Valk, A.M.2
O'Shaughnessy, M.C.3
Sarker, D.K.4
Baker, S.C.5
Lloyd, A.W.6
-
75
-
-
0037394124
-
Designing screens: How to make your hits a hit
-
Walters W.P., Namchuk M. Designing screens: how to make your hits a hit. Nat. Rev. Drug Discov. 2:2003;259-266.
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 259-266
-
-
Walters, W.P.1
Namchuk, M.2
-
76
-
-
0036877067
-
An automated quantitative high content sscreening assay for neurite outgrowth
-
Arden S.R., Janardhan P., Debiasio R., Arnold B., Ghosh R.N. An automated quantitative high content sscreening assay for neurite outgrowth. Chimica Oggi. 20:2002;64-67.
-
(2002)
Chimica Oggi.
, vol.20
, pp. 64-67
-
-
Arden, S.R.1
Janardhan, P.2
Debiasio, R.3
Arnold, B.4
Ghosh, R.N.5
-
77
-
-
0027362628
-
Complex synthetic chemical libraries indexed with molecular tags
-
Ohlmeyer M.H.J., Swanson R.N., Dillard L.W., Reader J.C., Asouline G., Kobayashi R.et al. Complex synthetic chemical libraries indexed with molecular tags. Proc. Natl. Acad. Sci. U.S.A. 90:1993;10922-10926.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 10922-10926
-
-
Ohlmeyer, M.H.J.1
Swanson, R.N.2
Dillard, L.W.3
Reader, J.C.4
Asouline, G.5
Kobayashi, R.6
-
78
-
-
0029873825
-
Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags
-
Ni Z.J., Maclean D., Holmes C.P., Murphy M.M., Ruhland B., Jacobs J.W.et al. Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags. J. Med. Chem. 39:1996;1601-1608.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1601-1608
-
-
Ni, Z.J.1
MacLean, D.2
Holmes, C.P.3
Murphy, M.M.4
Ruhland, B.5
Jacobs, J.W.6
-
79
-
-
0001117151
-
Improved methods for encoding and decoding dialkylamine-encoded combinatorial libraries
-
Fitch W.L., Baer T.A., Chen W., Holden F., Holmes C.P., Maclean D.et al. Improved methods for encoding and decoding dialkylamine-encoded combinatorial libraries. J. Comb. Chem. 1:1999;188-194.
-
(1999)
J. Comb. Chem.
, vol.1
, pp. 188-194
-
-
Fitch, W.L.1
Baer, T.A.2
Chen, W.3
Holden, F.4
Holmes, C.P.5
MacLean, D.6
-
80
-
-
0034697160
-
Trityl tags for encoding in combinatorial synthesis
-
Shchepinov M.S., Chalk R., Southern E.M. Trityl tags for encoding in combinatorial synthesis. Tetrahedron. 56:2000;2712-2724.
-
(2000)
Tetrahedron
, vol.56
, pp. 2712-2724
-
-
Shchepinov, M.S.1
Chalk, R.2
Southern, E.M.3
-
81
-
-
0030252966
-
High-volume cellular screening for anticancer agents with combinatorial chemical libraries - A new methodology
-
Salmon S.E., Liu-Stevens R.H., Zhao Y., Michal L., Viktor K., Ken W.et al. High-volume cellular screening for anticancer agents with combinatorial chemical libraries - a new methodology. Mol. Diversity. 2:1996;57-63.
-
(1996)
Mol. Diversity
, vol.2
, pp. 57-63
-
-
Salmon, S.E.1
Liu-Stevens, R.H.2
Zhao, Y.3
Michal, L.4
Viktor, K.5
Ken, W.6
-
82
-
-
0037523452
-
Going to the well no more: Lawn format assays for ultra-high-throughput screening
-
Marron B., Jayawickreme C.K. Going to the well no more: lawn format assays for ultra-high-throughput screening. Curr. Opin. Chem. Biol. 7:2003;395-401.
-
(2003)
Curr. Opin. Chem. Biol.
, vol.7
, pp. 395-401
-
-
Marron, B.1
Jayawickreme, C.K.2
-
83
-
-
0031127997
-
Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D
-
Kick E.K., Roe D.C., Skillman A.G., Liu G., Ewing T.J.A., Sun Y.et al. Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D. Chem. Biol. 4:1997;297-307.
-
(1997)
Chem. Biol.
, vol.4
, pp. 297-307
-
-
Kick, E.K.1
Roe, D.C.2
Skillman, A.G.3
Liu, G.4
Ewing, T.J.A.5
Sun, Y.6
-
84
-
-
0037434541
-
Absorption classification of oral drugs based on molecular surface properties
-
Bergstrom C.A.S., Strafford M., Lazorova L., Avdeef A., Luthman K., Artursson P. Absorption classification of oral drugs based on molecular surface properties. J. Med. Chem. 46:2003;558-570.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 558-570
-
-
Bergstrom, C.A.S.1
Strafford, M.2
Lazorova, L.3
Avdeef, A.4
Luthman, K.5
Artursson, P.6
-
86
-
-
0036051992
-
High-throughput crystallography for lead discovery in drug design
-
Blundell T.L., Jhoti H., Abell C. High-throughput crystallography for lead discovery in drug design. Nat. Rev. Drug. Discov. 1:2002;45-54.
-
(2002)
Nat. Rev. Drug. Discov.
, vol.1
, pp. 45-54
-
-
Blundell, T.L.1
Jhoti, H.2
Abell, C.3
-
87
-
-
0036462475
-
High-throughput crystallization and structure determination in drug discovery
-
Stewart L., Clark P., Behnke C. High-throughput crystallization and structure determination in drug discovery. Drug Discov. Today. 7:2002;187-196.
-
(2002)
Drug Discov. Today
, vol.7
, pp. 187-196
-
-
Stewart, L.1
Clark, P.2
Behnke, C.3
-
88
-
-
0001011919
-
High-throughput X-ray crystallography for structure-based drug design
-
Goodwill K.E., Tennant M.G., Stevens R.C. High-throughput X-ray crystallography for structure-based drug design. Drug Discov. Today. 6:2001;S113-S118.
-
(2001)
Drug Discov. Today
, vol.6
-
-
Goodwill, K.E.1
Tennant, M.G.2
Stevens, R.C.3
-
90
-
-
0037014686
-
High-throughput NMR-based screening with competition binding experiments
-
Dalvit C., Flocco M., Knapp S., Mostardini M., Perego R., Stockman B.J. et al. High-throughput NMR-based screening with competition binding experiments. J. Am. Chem. Soc. 124:2002;7702-7709.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 7702-7709
-
-
Dalvit, C.1
Flocco, M.2
Knapp, S.3
Mostardini, M.4
Perego, R.5
Stockman, B.J.6
-
91
-
-
0036066481
-
Affinity NMR: A powerful method for drug discovery
-
Shapiro M.J. Affinity NMR: a powerful method for drug discovery. Am. Pharma. Rev. 5:2002;9496-9497.
-
(2002)
Am. Pharma. Rev.
, vol.5
, pp. 9496-9497
-
-
Shapiro, M.J.1
-
92
-
-
0038520161
-
NMR-based screening methods for lead discovery
-
Martin V., Klaus F. NMR-based screening methods for lead discovery. EXS. 93:2003;183-202.
-
(2003)
EXS
, vol.93
, pp. 183-202
-
-
Martin, V.1
Klaus, F.2
-
93
-
-
0034649553
-
Design of adenosine kinase inhibitors from the NMR-based screening of fragments
-
Hadjuk P.J., Gomtsyan A., Didomenico S., Cowart M., Bayburt E.K., Solomon L.et al. Design of adenosine kinase inhibitors from the NMR-based screening of fragments. J. Med. Chem. 43:2000;4781-4786.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 4781-4786
-
-
Hadjuk, P.J.1
Gomtsyan, A.2
Didomenico, S.3
Cowart, M.4
Bayburt, E.K.5
Solomon, L.6
-
94
-
-
0031962612
-
Mass spectrometry and the age of the proteome
-
Yates J.R. III Mass spectrometry and the age of the proteome. J. Mass Spectrom. 33:1998;1-19.
-
(1998)
J. Mass Spectrom.
, vol.33
, pp. 1-19
-
-
Yates III, J.R.1
|