Design of adenosine kinase inhibitors from the NMR-based screening of fragments

Journal of Medicinal Chemistry

Volumn 43, Issue 25, 2000, Pages 4781-4786

  Hajduk, P J ^a   Gomtsyan, A ^a   Didomenico, S ^a   Cowart, M ^a   Bayburt, E K ^a   Solomon, L ^a   Severin, J ^a   Smith, R ^a   Walter, K ^a   Holzman, T F ^a   Stewart, A ^a   McGaraughty, S ^a   Jarvis, M F ^a   Kowaluk, E A ^a   Fesik, S W ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE KINASE INHIBITOR;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE;

ADENOSINE KINASE; ANALGESICS; ANIMALS; CELL LINE; DATABASES, FACTUAL; ENZYME INHIBITORS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034649553     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000373a     Document Type: Article

References (18)

1. New assay technologies for high-throughput screening
2. Technological advances in high-throughput screening
3. Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors
4. Successful virtual screening of a chemical database for farnesyltransferase inhibitor leads
5. Drug discovery: Filtering out failures early in the game
6. Discovering high-affinity ligands for proteins: SAR by NMR
7. Discovering high-affinity ligands for proteins
8. Emerging molecular approaches to pain therapy
9. Characterization of the effects of adenosine kinase inhibitors on acute thermal nociception in mice
10. Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy
11. NMR-based screening in drug discovery
12. ABT-702, (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyridine ), a novel orally effective adenosine kinase (ak) inhibitor with analgesic and antiinflammatory properties: I. In vitro characterization and acute antinociceptive effects in mice
13. ABT-702, (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido- [2,3-d]pyridine), A novel orally effective adenosine kinase (ak) inhibitor with analgesic and antiinflammatory properties: II. Antinociceptive and antiinflammatory effects in rat models of persistent, inflammatory, and neuropathic pain
14. Cloning and expression of the adenosine kinase gene from rat and human tissues
15. 1H HSQC spectra of proteins
16. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
17. A synthesis method of indole-3-methanamine and/or gramine from indole-3-carboxaldehyde, and its application for the synthesis of brassinin, its 4-substituted analogues, and 1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline