Affinity NMR: A powerful method for drug discovery

American Pharmaceutical Review

Volumn 5, Issue 2, 2002, Pages 94-97

  Shapiro, Michael J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; EPITOPE; LIGAND; PROTEIN;

ARTICLE; BINDING AFFINITY; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIFFUSION; DRUG DESIGN; DRUG SCREENING; DRUG TARGETING; EPITOPE MAPPING; LIGAND BINDING; MACROMOLECULE; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTEIN INTERACTION; PROTEIN STRUCTURE; SENSITIVITY ANALYSIS;

EID: 0036066481     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Nuclear Magnetic Resonance-Based Approaches for Lead Generation in Drug Discovery
2. One-Dimensional Relaxation- and Diffusion-Edited NMR Methods for Screening Compounds that Bind to Macromolecules
3. Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution
4. Characterization of ligand binding by saturation transfer difference NMR spectroscopy
5. Transferred 13C T1 Relaxation at natural isotopic abundance: A practical method for determining site-specific changes in ligand flexibility upon binding to a macromolecule
6. Spin Label Enhanced NMR Screening
7. Diffusion-Edited NMR-Affinity NMR for Direct Observation of Molecular Interactions
8. NOE Pumping: A Novel NMR Technique for Identification of Compounds with Binding Affinity to Macromolecules
9. NOE Pumping. 2. A High-Throughput Method To Determine Compounds with Binding Affinity to Macromolecules by NMR
10. Group Epitope Mapping by Saturation Transfer Difference NMR to Identify Segments of a Ligand in Direct Contact with a Protein Receptor
11. Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water