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Volumn 28, Issue 4, 2003, Pages 196-201

RNAi: An ever-growing puzzle

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; NUCLEIC ACID; RNA;

EID: 0037396027     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(03)00058-6     Document Type: Review
Times cited : (258)

References (57)
  • 1
    • 0036366576 scopus 로고    scopus 로고
    • Homology-dependent gene silencing and host defense in plants
    • Matzke M.A., et al. Homology-dependent gene silencing and host defense in plants. Adv. Genet. 46:2002;235-275.
    • (2002) Adv. Genet. , vol.46 , pp. 235-275
    • Matzke, M.A.1
  • 2
    • 0029024475 scopus 로고
    • Par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
    • Guo S., Kemphues K.J. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 81:1995;611-620.
    • (1995) Cell , vol.81 , pp. 611-620
    • Guo, S.1    Kemphues, K.J.2
  • 3
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 391:1998;806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1
  • 4
    • 0033615491 scopus 로고    scopus 로고
    • A species of small antisense RNA in posttranscriptional gene silencing in plants
    • Hamilton A.J., Baulcombe D.C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science. 286:1999;950-952.
    • (1999) Science , vol.286 , pp. 950-952
    • Hamilton, A.J.1    Baulcombe, D.C.2
  • 5
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore P.D., et al. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 101:2000;25-33.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1
  • 6
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond S.M., et al. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature. 404:2000;293-296.
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1
  • 7
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein E., et al. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature. 409:2001;363-366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1
  • 8
    • 0035662491 scopus 로고    scopus 로고
    • Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage
    • Blaszczyk J., et al. Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage. Structure. 9:2001;1225-1236.
    • (2001) Structure , vol.9 , pp. 1225-1236
    • Blaszczyk, J.1
  • 9
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon G.J. RNA interference. Nature. 418:2002;244-251.
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 10
    • 0036845374 scopus 로고    scopus 로고
    • Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
    • Zhang H., et al. Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 21:2002;5875-5885.
    • (2002) EMBO J. , vol.21 , pp. 5875-5885
    • Zhang, H.1
  • 11
    • 0037009520 scopus 로고    scopus 로고
    • Two classes of short interfering RNA in RNA silencing
    • Hamilton A., et al. Two classes of short interfering RNA in RNA silencing. EMBO J. 21:2002;4671-4679.
    • (2002) EMBO J. , vol.21 , pp. 4671-4679
    • Hamilton, A.1
  • 12
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • Grishok A., et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 106:2001;23-34.
    • (2001) Cell , vol.106 , pp. 23-34
    • Grishok, A.1
  • 13
    • 0035929322 scopus 로고    scopus 로고
    • A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans
    • Knight S.W., Bass B.L. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science. 293:2001;2269-2271.
    • (2001) Science , vol.293 , pp. 2269-2271
    • Knight, S.W.1    Bass, B.L.2
  • 14
    • 0035887005 scopus 로고    scopus 로고
    • Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
    • Ketting R.F., et al. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15:2001;2654-2659.
    • (2001) Genes Dev. , vol.15 , pp. 2654-2659
    • Ketting, R.F.1
  • 15
    • 0037009364 scopus 로고    scopus 로고
    • MicroRNA maturation: Stepwise processing and subcellular localization
    • Lee Y., et al. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 21:2002;4663-4670.
    • (2002) EMBO J. , vol.21 , pp. 4663-4670
    • Lee, Y.1
  • 16
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvagner G., et al. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 293:2001;834-838.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvagner, G.1
  • 17
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • Lee R.C., Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science. 294:2001;862-864.
    • (2001) Science , vol.294 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 18
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • Lau N.C., et al. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science. 294:2001;858-862.
    • (2001) Science , vol.294 , pp. 858-862
    • Lau, N.C.1
  • 19
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana M., et al. Identification of novel genes coding for small expressed RNAs. Science. 294:2001;853-858.
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1
  • 20
    • 0037144457 scopus 로고    scopus 로고
    • Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA
    • Llave C., et al. Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA. Science. 297:2002;2053-2056.
    • (2002) Science , vol.297 , pp. 2053-2056
    • Llave, C.1
  • 21
    • 0037087780 scopus 로고    scopus 로고
    • MiRNPs: A novel class of ribonucleoproteins containing numerous microRNAs
    • Mourelatos Z., et al. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev. 16:2002;720-728.
    • (2002) Genes Dev. , vol.16 , pp. 720-728
    • Mourelatos, Z.1
  • 22
    • 0032717319 scopus 로고    scopus 로고
    • The rde-1 gene, RNA interference, and transposon silencing in C. elegans
    • Tabara H., et al. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell. 99:1999;123-132.
    • (1999) Cell , vol.99 , pp. 123-132
    • Tabara, H.1
  • 23
    • 0036828639 scopus 로고    scopus 로고
    • The Argonaute family: Tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis
    • Carmell M.A., et al. The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 16:2002;2733-2742.
    • (2002) Genes Dev. , vol.16 , pp. 2733-2742
    • Carmell, M.A.1
  • 24
    • 0036792769 scopus 로고    scopus 로고
    • Fragile X-related protein and VIG associate with the RNA interference machinery
    • Caudy A.A., et al. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev. 16:2002;2491-2496.
    • (2002) Genes Dev. , vol.16 , pp. 2491-2496
    • Caudy, A.A.1
  • 25
    • 0036791671 scopus 로고    scopus 로고
    • A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins
    • Ishizuka A., et al. A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev. 16:2002;2497-2508.
    • (2002) Genes Dev. , vol.16 , pp. 2497-2508
    • Ishizuka, A.1
  • 26
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez J., et al. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell. 110:2002;563-574.
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1
  • 27
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • Hutvagner G., Zamore P.D. A microRNA in a multiple-turnover RNAi enzyme complex. Science. 297:2002;2056-2060.
    • (2002) Science , vol.297 , pp. 2056-2060
    • Hutvagner, G.1    Zamore, P.D.2
  • 28
    • 0034716924 scopus 로고    scopus 로고
    • An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus
    • Dalmay T., et al. An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus. Cell. 101:2000;543-553.
    • (2000) Cell , vol.101 , pp. 543-553
    • Dalmay, T.1
  • 29
    • 0033551328 scopus 로고    scopus 로고
    • Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
    • Cogoni C., Macino G. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase. Nature. 399:1999;166-169.
    • (1999) Nature , vol.399 , pp. 166-169
    • Cogoni, C.1    Macino, G.2
  • 30
    • 0034708215 scopus 로고    scopus 로고
    • EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans
    • Smardon A., et al. EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans. Curr. Biol. 10:2000;169-178.
    • (2000) Curr. Biol. , vol.10 , pp. 169-178
    • Smardon, A.1
  • 31
    • 0035900651 scopus 로고    scopus 로고
    • On the role of RNA amplification in dsRNA-triggered gene silencing
    • Sijen T., et al. On the role of RNA amplification in dsRNA-triggered gene silencing. Cell. 107:2001;465-476.
    • (2001) Cell , vol.107 , pp. 465-476
    • Sijen, T.1
  • 32
    • 0035999373 scopus 로고    scopus 로고
    • Spreading of RNA targeting and DNA methylation in RNA silencing requires transcription of the target gene and a putative RNA-dependent RNA polymerase
    • Vaistij F.E., et al. Spreading of RNA targeting and DNA methylation in RNA silencing requires transcription of the target gene and a putative RNA-dependent RNA polymerase. Plant Cell. 14:2002;857-867.
    • (2002) Plant Cell , vol.14 , pp. 857-867
    • Vaistij, F.E.1
  • 33
    • 0035798399 scopus 로고    scopus 로고
    • RNAi as random degradative PCR: SiRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs
    • Lipardi C., et al. RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs. Cell. 107:2001;297-307.
    • (2001) Cell , vol.107 , pp. 297-307
    • Lipardi, C.1
  • 34
    • 0036752955 scopus 로고    scopus 로고
    • Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways
    • Schwarz D.S., et al. Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol. Cell. 10:2002;537-548.
    • (2002) Mol. Cell , vol.10 , pp. 537-548
    • Schwarz, D.S.1
  • 35
    • 0035425379 scopus 로고    scopus 로고
    • RNA silencing as a plant immune system against viruses
    • Voinnet O. RNA silencing as a plant immune system against viruses. Trends Genet. 17:2001;449-459.
    • (2001) Trends Genet. , vol.17 , pp. 449-459
    • Voinnet, O.1
  • 36
    • 3643145804 scopus 로고    scopus 로고
    • Initiation and maintenance of virus-induced gene silencing
    • Ruiz M.T., et al. Initiation and maintenance of virus-induced gene silencing. Plant Cell. 10:1998;937-946.
    • (1998) Plant Cell , vol.10 , pp. 937-946
    • Ruiz, M.T.1
  • 37
    • 0035313137 scopus 로고    scopus 로고
    • Viral suppressors of RNA silencing
    • Li W.X., Ding S.W. Viral suppressors of RNA silencing. Curr. Opin. Biotechnol. 12:2001;150-154.
    • (2001) Curr. Opin. Biotechnol. , vol.12 , pp. 150-154
    • Li, W.X.1    Ding, S.W.2
  • 38
    • 0037123630 scopus 로고    scopus 로고
    • Induction and suppression of RNA silencing by an animal virus
    • Li H., et al. Induction and suppression of RNA silencing by an animal virus. Science. 296:2002;1319-1321.
    • (2002) Science , vol.296 , pp. 1319-1321
    • Li, H.1
  • 39
    • 0001359591 scopus 로고
    • Introduction of a chimeric chalcone synthase gene into Petunia results in reversible co-Suppression of homologous genes in trans
    • Napoli C., et al. Introduction of a chimeric chalcone synthase gene into Petunia results in reversible co-Suppression of homologous genes in trans. Plant Cell. 2:1990;279-289.
    • (1990) Plant Cell , vol.2 , pp. 279-289
    • Napoli, C.1
  • 40
    • 0025413459 scopus 로고
    • Inhibition of flower pigmentation by antisense CHS genes: Promoter and minimal sequence requirements for the antisense effect
    • van der Krol A.R., et al. Inhibition of flower pigmentation by antisense CHS genes: promoter and minimal sequence requirements for the antisense effect. Plant Mol. Biol. 14:1990;457-466.
    • (1990) Plant Mol. Biol. , vol.14 , pp. 457-466
    • Van der Krol, A.R.1
  • 41
    • 0035169953 scopus 로고    scopus 로고
    • The rest is silence
    • Bernstein E., et al. The rest is silence. RNA. 7:2001;1509-1521.
    • (2001) RNA , vol.7 , pp. 1509-1521
    • Bernstein, E.1
  • 42
    • 0032739015 scopus 로고    scopus 로고
    • Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
    • Ketting R.F., et al. Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD. Cell. 99:1999;133-141.
    • (1999) Cell , vol.99 , pp. 133-141
    • Ketting, R.F.1
  • 43
    • 0028031830 scopus 로고
    • RNA-directed de novo methylation of genomic sequences in plants
    • Wassenegger M., et al. RNA-directed de novo methylation of genomic sequences in plants. Cell. 76:1994;567-576.
    • (1994) Cell , vol.76 , pp. 567-576
    • Wassenegger, M.1
  • 44
    • 0034596989 scopus 로고    scopus 로고
    • Transcriptional silencing and promoter methylation triggered by double-stranded RNA
    • Mette M.F., et al. Transcriptional silencing and promoter methylation triggered by double-stranded RNA. EMBO J. 19:2000;5194-5201.
    • (2000) EMBO J. , vol.19 , pp. 5194-5201
    • Mette, M.F.1
  • 45
    • 0035873992 scopus 로고    scopus 로고
    • RNA-directed transcriptional gene silencing in plants can be inherited independently of the RNA trigger and requires Met1 for maintenance
    • Jones L., et al. RNA-directed transcriptional gene silencing in plants can be inherited independently of the RNA trigger and requires Met1 for maintenance. Curr. Biol. 11:2001;747-757.
    • (2001) Curr. Biol. , vol.11 , pp. 747-757
    • Jones, L.1
  • 46
    • 0036184188 scopus 로고    scopus 로고
    • RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila
    • Pal-Bhadra M., et al. RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol. Cell. 9:2002;315-327.
    • (2002) Mol. Cell , vol.9 , pp. 315-327
    • Pal-Bhadra, M.1
  • 47
    • 0037072661 scopus 로고    scopus 로고
    • Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi
    • Volpe T.A., et al. Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science. 297:2002;1833-1837.
    • (2002) Science , vol.297 , pp. 1833-1837
    • Volpe, T.A.1
  • 48
    • 0037072660 scopus 로고    scopus 로고
    • Small RNAs correspond to centromere heterochromatic repeats
    • Reinhart B.J., Bartel D.P. Small RNAs correspond to centromere heterochromatic repeats. Science. 297:2002;1831.
    • (2002) Science , vol.297 , pp. 1831
    • Reinhart, B.J.1    Bartel, D.P.2
  • 49
    • 0037183856 scopus 로고    scopus 로고
    • Establishment and maintenance of a heterochromatin domain
    • Hall I.M., et al. Establishment and maintenance of a heterochromatin domain. Science. 297:2002;2232-2237.
    • (2002) Science , vol.297 , pp. 2232-2237
    • Hall, I.M.1
  • 50
    • 0037145031 scopus 로고    scopus 로고
    • Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena
    • Mochizuki K., et al. Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell. 110:2002;689-699.
    • (2002) Cell , vol.110 , pp. 689-699
    • Mochizuki, K.1
  • 51
    • 0037145016 scopus 로고    scopus 로고
    • Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena
    • Taverna S.D., et al. Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena. Cell. 110:2002;701-711.
    • (2002) Cell , vol.110 , pp. 701-711
    • Taverna, S.D.1
  • 52
    • 0033579344 scopus 로고    scopus 로고
    • Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase
    • Cogoni C., Macino G. Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase. Science. 286:1999;2342-2344.
    • (1999) Science , vol.286 , pp. 2342-2344
    • Cogoni, C.1    Macino, G.2
  • 53
    • 0037188904 scopus 로고    scopus 로고
    • The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans
    • Tabara H., et al. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell. 109:2002;861-871.
    • (2002) Cell , vol.109 , pp. 861-871
    • Tabara, H.1
  • 54
    • 0034716907 scopus 로고    scopus 로고
    • Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance
    • Mourrain P., et al. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell. 101:2000;533-542.
    • (2000) Cell , vol.101 , pp. 533-542
    • Mourrain, P.1
  • 55
    • 0037007007 scopus 로고    scopus 로고
    • Using RNA interference to identify genes required for RNA interference
    • Dudley N.R., et al. Using RNA interference to identify genes required for RNA interference. Proc. Natl. Acad. Sci. U. S. A. 99:2002;4191-4196.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 4191-4196
    • Dudley, N.R.1
  • 56
    • 0035798415 scopus 로고    scopus 로고
    • ATP requirements and small interfering RNA structure in the RNA interference pathway
    • Nykanen A., et al. ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell. 107:2001;309-321.
    • (2001) Cell , vol.107 , pp. 309-321
    • Nykanen, A.1
  • 57
    • 0036953376 scopus 로고    scopus 로고
    • The genetics of RNA silencing
    • Glossary Co-suppression: A term that refers to silencing of endogenous loci following the introduction of transgenes. It can also refer to silencing of transgenic loci in a copy-number-dependent fashion. Dicer: An RNase III family member that produces siRNAs. PTGS: Post-transcriptional gene silencing
    • Tijsterman M., et al. The genetics of RNA silencing. Annu. Rev. Genet. 36:2002;489-519.
    • (2002) Annu. Rev. Genet. , vol.36 , pp. 489-519
    • Tijsterman, M.1


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