-
1
-
-
0028568315
-
Cell cycle control and cancer
-
Hartwell LH, Kastan MB. Cell cycle control and cancer. Science 1994; 266: 1821-28.
-
(1994)
Science
, vol.266
, pp. 1821-1828
-
-
Hartwell, L.H.1
Kastan, M.B.2
-
2
-
-
0003418645
-
A restricition point for control of normal animal cell proliferation
-
Pardee A. A restricition point for control of normal animal cell proliferation. Proc Natl Acad Sci USA 1974; 71: 1286-1290.
-
(1974)
Proc. Natl. Acad. Sci. USA
, vol.71
, pp. 1286-1290
-
-
Pardee, A.1
-
3
-
-
0037337879
-
Reappraisal of serum starvation, the restriction point, G0 and G1 phase arrest points
-
Cooper S. Reappraisal of serum starvation, the restriction point, G0 and G1 phase arrest points. FASEB J 2003; 17: 333-40.
-
(2003)
FASEB J.
, vol.17
, pp. 333-340
-
-
Cooper, S.1
-
4
-
-
0029587551
-
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
-
Quelle DE, Zindy F, Ashmun RA, Sherr CJ. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995; 83: 993-1000.
-
(1995)
Cell
, vol.83
, pp. 993-1000
-
-
Quelle, D.E.1
Zindy, F.2
Ashmun, R.A.3
Sherr, C.J.4
-
5
-
-
0030728468
-
Tumour suppression at the mouse INK4a locus mediated by the alternative reading frame product of p19ARF
-
Kamijo T, Zindy F, Roussel MF, et al. Tumour suppression at the mouse INK4a locus mediated by the alternative reading frame product of p19ARF. Cell 1997; 91: 649-59.
-
(1997)
Cell
, vol.91
, pp. 649-659
-
-
Kamijo, T.1
Zindy, F.2
Roussel, M.F.3
-
6
-
-
0035817687
-
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
-
Krimpenfort P, Quon KC, Mooi WJ, Loonstra A, Berns A. Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature 2001; 413: 83-86.
-
(2001)
Nature
, vol.413
, pp. 83-86
-
-
Krimpenfort, P.1
Quon, K.C.2
Mooi, W.J.3
Loonstra, A.4
Berns, A.5
-
7
-
-
0035817688
-
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumourigenesis
-
Sharpless NE, Bardeesy N, Lee K-H, et al. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumourigenesis. Nature 2001; 413: 86-91.
-
(2001)
Nature
, vol.413
, pp. 86-91
-
-
Sharpless, N.E.1
Bardeesy, N.2
Lee, K.-H.3
-
8
-
-
0029054399
-
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
-
Lukas J, Parry D, Aagaard L, et al. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 1995; 375: 503-06.
-
(1995)
Nature
, vol.375
, pp. 503-506
-
-
Lukas, J.1
Parry, D.2
Aagaard, L.3
-
9
-
-
0028978274
-
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
-
Wolfel T, Hauer M, Schneider J, et al. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 1995; 269: 1281-84.
-
(1995)
Science
, vol.269
, pp. 1281-1284
-
-
Wolfel, T.1
Hauer, M.2
Schneider, J.3
-
10
-
-
0032517341
-
p16ink4a/CDKN2A tumour suppressor and its relatives
-
Ruas M, Peters G. p16ink4a/CDKN2A tumour suppressor and its relatives. BBA Rev Cancer 1998; 1378/2: F115-17.
-
(1998)
BBA Rev. Cancer
, vol.1378
, Issue.2
-
-
Ruas, M.1
Peters, G.2
-
11
-
-
0030973878
-
New functional activities for the p21 family of cdk inhibitors
-
LaBaer J, Garrett MD, Stevenson LF, et al. New functional activities for the p21 family of cdk inhibitors. Genes Dev 1997; 11: 847-62.
-
(1997)
Genes Dev.
, vol.11
, pp. 847-862
-
-
LaBaer, J.1
Garrett, M.D.2
Stevenson, L.F.3
-
12
-
-
0034660618
-
Crystal structure of a gamma-herpesvirus cyclin-cdk complex
-
Card GL, Knowles P, Laman H, et al. Crystal structure of a gamma-herpesvirus cyclin-cdk complex. EMBO J 2000; 19: 2877-88.
-
(2000)
EMBO J.
, vol.19
, pp. 2877-2888
-
-
Card, G.L.1
Knowles, P.2
Laman, H.3
-
13
-
-
0030697223
-
Viral cyclin/cdk6 complexes evade inhibition by cdk inhibitory proteins
-
Swanton C, Mann DJ, Fleckenstein B, et al. Viral cyclin/cdk6 complexes evade inhibition by cdk inhibitory proteins. Nature 1997; 390: 184-87.
-
(1997)
Nature
, vol.390
, pp. 184-187
-
-
Swanton, C.1
Mann, D.J.2
Fleckenstein, B.3
-
14
-
-
0033551066
-
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
-
Chen Y-N, Sharma S, Ramsey T, et al. Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists. Proc Natl Acad Sci USA 1999; 96: 4325-29.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4325-4329
-
-
Chen, Y.-N.1
Sharma, S.2
Ramsey, T.3
-
16
-
-
0031048716
-
Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
-
Porter PL, Malone KE, Heagerty PJ, et al. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat Med 1997; 3: 222-25.
-
(1997)
Nat. Med.
, vol.3
, pp. 222-225
-
-
Porter, P.L.1
Malone, K.E.2
Heagerty, P.J.3
-
17
-
-
0031048236
-
Increased proteosome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
-
Loda M, Cukor B, Tam S, et al. Increased proteosome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 1997; 3: 231-34.
-
(1997)
Nat. Med.
, vol.3
, pp. 231-234
-
-
Loda, M.1
Cukor, B.2
Tam, S.3
-
18
-
-
16944363001
-
Decreased levels of the cell-cycle inhibitor p27kip1 protein: Prognostic implications in primary breast cancer
-
Catzavelos C, Bhattacharya N, Ung YC, et al. Decreased levels of the cell-cycle inhibitor p27kip1 protein: prognostic implications in primary breast cancer. Nat Med 1997; 3: 227-30.
-
(1997)
Nat. Med.
, vol.3
, pp. 227-230
-
-
Catzavelos, C.1
Bhattacharya, N.2
Ung, Y.C.3
-
19
-
-
18644376449
-
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
-
Liang J, Zubovitz J, Petrocelli T, et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 2002; 8: 1153-60.
-
(2002)
Nat. Med.
, vol.8
, pp. 1153-1160
-
-
Liang, J.1
Zubovitz, J.2
Petrocelli, T.3
-
20
-
-
0036799377
-
PKB/Akt mediates cell-cycle progression by phosphorylation of p27kip1 at threonine 157 and modulation of its cellular localization
-
Shin I, Yakes M, Rojo F, et al. PKB/Akt mediates cell-cycle progression by phosphorylation of p27kip1 at threonine 157 and modulation of its cellular localization. Nat Med 2002; 8: 1145-52.
-
(2002)
Nat. Med.
, vol.8
, pp. 1145-1152
-
-
Shin, I.1
Yakes, M.2
Rojo, F.3
-
21
-
-
18644370396
-
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
-
Viglietto G, Motti ML, Bruni P, et al. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med 2002; 8: 1136-44.
-
(2002)
Nat. Med.
, vol.8
, pp. 1136-1144
-
-
Viglietto, G.1
Motti, M.L.2
Bruni, P.3
-
22
-
-
0034745353
-
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neuoverexpressing cells
-
Zhou BP, Liao Y, Xia W, et al. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neuoverexpressing cells. Nat Cell Biol 2001; 3: 245-52.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 245-252
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
-
23
-
-
0042197268
-
Are p27 and p21 cytoplasmic oncoproteins?
-
Blagosklonny MV. Are p27 and p21 cytoplasmic oncoproteins? Cell Cycle 2002; 1: 391-93.
-
(2002)
Cell Cycle
, vol.1
, pp. 391-393
-
-
Blagosklonny, M.V.1
-
24
-
-
0035754080
-
To cycle or not to cycle: A critical decision in cancer
-
Malumbres M, Barbacid M. To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 2001; 1: 222-31.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 222-231
-
-
Malumbres, M.1
Barbacid, M.2
-
25
-
-
0031951182
-
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
-
Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 1998; 18: 753-61.
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 753-761
-
-
Lundberg, A.S.1
Weinberg, R.A.2
-
26
-
-
0033578816
-
cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
-
Harbour JW, Luo RX, Del Santi A, et al. cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 1999; 98: 859-69.
-
(1999)
Cell
, vol.98
, pp. 859-869
-
-
Harbour, J.W.1
Luo, R.X.2
Del Santi, A.3
-
27
-
-
0034948814
-
Differential regulation of retinoblastoma tumor suppressor protein by G1 cyclin-dependent kinase complexes in vivo
-
Ezhevsky SA, Ho A, Becker-Hapak M, et al. Differential regulation of retinoblastoma tumor suppressor protein by G1 cyclin-dependent kinase complexes in vivo. Mol Cell Biol 2001; 21: 4773-84.
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 4773-4784
-
-
Ezhevsky, S.A.1
Ho, A.2
Becker-Hapak, M.3
-
28
-
-
0033119801
-
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
-
Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999; 398: 422-26.
-
(1999)
Nature
, vol.398
, pp. 422-426
-
-
Tetsu, O.1
McCormick, F.2
-
29
-
-
0032533225
-
Glycogen synthase kinase-3 beta regulates cyclin D1 proteolysis and subcellular localisation
-
Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-3 beta regulates cyclin D1 proteolysis and subcellular localisation. Genes Dev 1998; 12: 3499-11.
-
(1998)
Genes Dev.
, vol.12
, pp. 3499-3511
-
-
Diehl, J.A.1
Cheng, M.2
Roussel, M.F.3
Sherr, C.J.4
-
30
-
-
0033830522
-
SSeCKS, a major protein kinase C substrate with tumour suppressor activity, regulates G1-S progression by controlling the expression and cellular compartmentalization of cyclin D
-
Lin X, Nelson P, Gelman IH. SSeCKS, a major protein kinase C substrate with tumour suppressor activity, regulates G1-S progression by controlling the expression and cellular compartmentalization of cyclin D. Mol Cell Biol 2000; 20: 7259-72.
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 7259-7272
-
-
Lin, X.1
Nelson, P.2
Gelman, I.H.3
-
31
-
-
0033559264
-
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
-
Cheng M, Olivier P, Diehl JA, et al. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 1999; 18: 1571-83.
-
(1999)
EMBO J.
, vol.18
, pp. 1571-1583
-
-
Cheng, M.1
Olivier, P.2
Diehl, J.A.3
-
32
-
-
0037153424
-
Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1)
-
Sugimoto M, Martin N, Wilks DP, et al. Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1). Oncogene 2002; 21: 8067-74.
-
(2002)
Oncogene
, vol.21
, pp. 8067-8074
-
-
Sugimoto, M.1
Martin, N.2
Wilks, D.P.3
-
33
-
-
0032709473
-
Regulation of CDK4 activity by a novel CDK4-binding protein, p34SEI-1
-
Sugimoto M, Nakamura T, Ohtani N, et al. Regulation of CDK4 activity by a novel CDK4-binding protein, p34SEI-1. Genes Dev 1999; 13: 3027-33.
-
(1999)
Genes Dev.
, vol.13
, pp. 3027-3033
-
-
Sugimoto, M.1
Nakamura, T.2
Ohtani, N.3
-
35
-
-
0028836031
-
Chromosome 11q13 markers and D-type cyclins in breast cancer
-
Peters G, Fantl V, Smith R, et al. Chromosome 11q13 markers and D-type cyclins in breast cancer. Breast Cancer Res Treat 1995; 33: 125-35.
-
(1995)
Breast Cancer Res. Treat.
, vol.33
, pp. 125-135
-
-
Peters, G.1
Fantl, V.2
Smith, R.3
-
36
-
-
0028243879
-
Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
-
Wang TC, Cardiff RD, Zukerberg L, et al. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 1994; 369: 669-71.
-
(1994)
Nature
, vol.369
, pp. 669-671
-
-
Wang, T.C.1
Cardiff, R.D.2
Zukerberg, L.3
-
37
-
-
0037050256
-
Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E
-
Bowe DB, Kenney NJ, Adereth Y, Maroulakou IG. Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E. Oncogene 2002; 21: 291-98.
-
(2002)
Oncogene
, vol.21
, pp. 291-298
-
-
Bowe, D.B.1
Kenney, N.J.2
Adereth, Y.3
Maroulakou, I.G.4
-
38
-
-
0035921849
-
Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
-
Strohmaier H, Spruck CH, Kaiser P, et al. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 2001; 413: 268-69.
-
(2001)
Nature
, vol.413
, pp. 268-269
-
-
Strohmaier, H.1
Spruck, C.H.2
Kaiser, P.3
-
40
-
-
0037137519
-
A gene-expression signature as a predictor of survival in breast cancer
-
van de Vijver MJ, Yudong DH, van't Veer LJ, et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002; 347: 1999-2068.
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 1999-2068
-
-
van de Vijver, M.J.1
Yudong, D.H.2
van't Veer, L.J.3
-
41
-
-
0031670668
-
Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms
-
Senderowicz AM, Headlee D, Stinson SF, et al. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J Clin Oncol 1998; 16: 2986-99.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 2986-2999
-
-
Senderowicz, A.M.1
Headlee, D.2
Stinson, S.F.3
-
42
-
-
0001114216
-
Phase I clinical and pharmacokinetic trial of flavopiridol
-
(abstr)
-
Thomas J, Cleary J, Tutsch K, et al. Phase I clinical and pharmacokinetic trial of flavopiridol. Proc Am Assoc Cancer Res 1997; 38: 222 (abstr).
-
(1997)
Proc. Am. Assoc. Cancer Res.
, vol.38
, pp. 222
-
-
Thomas, J.1
Cleary, J.2
Tutsch, K.3
-
43
-
-
0033955395
-
Flavopiridol, a novel cyclin-dependent kinase inhibitor in metastatic renal cancer: A University of Chicago Phase II Consortium study
-
Stadler WM, Vogelzang NJ, Amato R, et al. Flavopiridol, a novel cyclin-dependent kinase inhibitor in metastatic renal cancer: a University of Chicago Phase II Consortium study. J Clin Oncol 2000; 18: 371-75.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 371-375
-
-
Stadler, W.M.1
Vogelzang, N.J.2
Amato, R.3
-
44
-
-
0034900178
-
A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer
-
Shapiro GI, Supko JG, Patterson A, et al. A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer. Clin Cancer Res 2001; 7: 1590-99.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1590-1599
-
-
Shapiro, G.I.1
Supko, J.G.2
Patterson, A.3
-
45
-
-
0035300684
-
Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma
-
Schwartz GK, Ilson D, Saltz L, et al. Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma. J Clin Oncol 2001; 19: 1985-92.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 1985-1992
-
-
Schwartz, G.K.1
Ilson, D.2
Saltz, L.3
-
46
-
-
0036789539
-
Phase I clinical and pharmacokinetic study of Flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms
-
Tan AR, Headlee D, Messmann R, et al. Phase I clinical and pharmacokinetic study of Flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms. J Clin Oncol 2002; 20: 4074-82.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 4074-4082
-
-
Tan, A.R.1
Headlee, D.2
Messmann, R.3
-
47
-
-
0030812207
-
Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: The importance of sequence of administration
-
Bible KC, Kaufmann SH. Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: the importance of sequence of administration. Cancer Res 1997; 57: 3375-80.
-
(1997)
Cancer Res.
, vol.57
, pp. 3375-3380
-
-
Bible, K.C.1
Kaufmann, S.H.2
-
48
-
-
0037089691
-
Phase I study of the cyclin-dependent kinase inhibitor flavopiridol in combination with paclitaxel in patients with advanced solid tumours
-
Schwartz GK, O'Reilly E, Ilson D, et al. Phase I study of the cyclin-dependent kinase inhibitor flavopiridol in combination with paclitaxel in patients with advanced solid tumours. J Clin Oncol 2002; 20: 2157-70.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2157-2170
-
-
Schwartz, G.K.1
O'Reilly, E.2
Ilson, D.3
-
49
-
-
0005779480
-
A phase I/pharmacological study of weekly sequential irinotecan and flavopiridol
-
(abstr)
-
Shah MA, Kortmansky J, Gonen M, et al. A phase I/pharmacological study of weekly sequential irinotecan and flavopiridol. Proc Am Soc Clin Oncl 2002: 373 (abstr).
-
(2002)
Proc. Am. Soc. Clin. Oncl.
, pp. 373
-
-
Shah, M.A.1
Kortmansky, J.2
Gonen, M.3
-
50
-
-
0348017547
-
Phase I study of HMR1275 (flavopiridol) in non-small cell lung cancer (NSCLC) patients after 24hr IV administration in combination with paclitaxel and carboplatin
-
(abstr)
-
Gries J-M, Kasimis B, Schwarzenberger P, et al. Phase I study of HMR1275 (flavopiridol) in non-small cell lung cancer (NSCLC) patients after 24hr IV administration in combination with paclitaxel and carboplatin. Proc Am Soc Clin Oncl 2002: 372 (abstr).
-
(2002)
Proc. Am. Soc. Clin. Oncl.
, pp. 372
-
-
Gries, J.-M.1
Kasimis, B.2
Schwarzenberger, P.3
-
51
-
-
0033533741
-
UCN-01 mediated G1 arrest in normal but not tumor breast cells is pRb-dependent and p53-independent
-
Chen X, Lowe M, Keyomarsi K. UCN-01 mediated G1 arrest in normal but not tumor breast cells is pRb-dependent and p53-independent. Oncogene 1999; 18: 5691-702.
-
(1999)
Oncogene
, vol.18
, pp. 5691-5702
-
-
Chen, X.1
Lowe, M.2
Keyomarsi, K.3
-
52
-
-
0032852874
-
RB status as a determinant of response to UCN-01 in non-small cell lung carcinoma
-
Mack PC, Gandara DR, Bowen C, et al. RB status as a determinant of response to UCN-01 in non-small cell lung carcinoma. Clin Cancer Res 1999; 5: 2596-604.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 2596-2604
-
-
Mack, P.C.1
Gandara, D.R.2
Bowen, C.3
-
53
-
-
0036847699
-
Antitumour activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(kip1)
-
Patel V, Lahusen T, Leethanakul C, et al. Antitumour activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(kip1). Clin Cancer Res 2002; 8: 3549-60.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 3549-3560
-
-
Patel, V.1
Lahusen, T.2
Leethanakul, C.3
-
54
-
-
0034655281
-
The radiosensitising agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
-
Busby EC, Leistritz DF, Abraham RT, et al. The radiosensitising agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res 2000; 60: 2108-12.
-
(2000)
Cancer Res.
, vol.60
, pp. 2108-2112
-
-
Busby, E.C.1
Leistritz, D.F.2
Abraham, R.T.3
-
55
-
-
0034053130
-
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
-
Graves PR, Yu L, Schwarz JK, et al. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem 2000; 275: 5600-05.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 5600-5605
-
-
Graves, P.R.1
Yu, L.2
Schwarz, J.K.3
-
56
-
-
2242421834
-
Structural basis for Chk1 inhibition by UCN-01
-
Zhao B, Bower MJ, McDevitt PJ, et al. Structural basis for Chk1 inhibition by UCN-01. J Biol Chem 2002; 277: 46609-15.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 46609-46615
-
-
Zhao, B.1
Bower, M.J.2
McDevitt, P.J.3
-
57
-
-
0037034928
-
Interference with PDK1-Akt survival pathway by UCN-01 (7-hydroxystaurosporine)
-
Sato S, Fujita N, Tsuruo T. Interference with PDK1-Akt survival pathway by UCN-01 (7-hydroxystaurosporine). Oncogene 2002; 21: 1727-38.
-
(2002)
Oncogene
, vol.21
, pp. 1727-1738
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
58
-
-
0035871444
-
Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms
-
Sausville EA, Arbuck SG, Messmann R, et al. Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms. J Clin Oncol 2001; 19: 2319-33.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 2319-2333
-
-
Sausville, E.A.1
Arbuck, S.G.2
Messmann, R.3
-
59
-
-
0031034160
-
Activation of the cell death program by inhibition ofproteosome function
-
Drexler HCA. Activation of the cell death program by inhibition ofproteosome function. Proc Natl Acad Sci USA 1997; 94: 855-60.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 855-860
-
-
Drexler, H.C.A.1
-
60
-
-
0037111832
-
Phase I trial of the proteosome inhibitor PS-341 in patients with refractory hematological malignancies
-
Orlowski RZ, Stinchcombe TE, Mitchell BS, et al. Phase I trial of the proteosome inhibitor PS-341 in patients with refractory hematological malignancies. J Clin Oncol 2002; 20: 4420-27.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 4420-4427
-
-
Orlowski, R.Z.1
Stinchcombe, T.E.2
Mitchell, B.S.3
-
61
-
-
0003216241
-
Phase II trial of PS-341, a novel proteosome inhibitor, alone or in combination with dexamethasone, in patients with multiple myeloma who have relapsed following front-line therapy and are refractory to their most recent therapy
-
(abstr)
-
Richardson PG, Berenson J, Irwin D. Phase II trial of PS-341, a novel proteosome inhibitor, alone or in combination with dexamethasone, in patients with multiple myeloma who have relapsed following front-line therapy and are refractory to their most recent therapy. Blood 2001; 98: 774 (abstr).
-
(2001)
Blood
, vol.98
, pp. 774
-
-
Richardson, P.G.1
Berenson, J.2
Irwin, D.3
-
62
-
-
0033920566
-
Protease inhibitor-induced apoptosis: Accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteosome inhibition
-
An WG, Hwang SG, Trepel JB, Blagosklonny MV. Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteosome inhibition. Leukemia 2000; 14: 1276-83.
-
(2000)
Leukemia
, vol.14
, pp. 1276-1283
-
-
An, W.G.1
Hwang, S.G.2
Trepel, J.B.3
Blagosklonny, M.V.4
-
63
-
-
0033598320
-
Discovery of novel antitumour sulfonamides targeting G1 phase of the cell cycle
-
Owa T, Yoshino H, Okauchi T, et al. Discovery of novel antitumour sulfonamides targeting G1 phase of the cell cycle. J Med Chem 1999; 42: 3789-99.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 3789-3799
-
-
Owa, T.1
Yoshino, H.2
Okauchi, T.3
-
64
-
-
0034773165
-
E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo
-
Ozawa Y, Sugi NH, Nagasu T, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer 2001; 38: 2275-82.
-
(2001)
Eur. J. Cancer
, vol.38
, pp. 2275-2282
-
-
Ozawa, Y.1
Sugi, N.H.2
Nagasu, T.3
-
65
-
-
4243296525
-
Phase I and pharmacokinetic study of E7070, a novel chlorindoyl-sulfonamide inhibiting the activation of cdk2 and cyclin E
-
(abstr)
-
Dittrich C, Dumez H, Calvert H et al. Phase I and pharmacokinetic study of E7070, a novel chlorindoyl-sulfonamide inhibiting the activation of cdk2 and cyclin E. Clin Cancer Res 2000; 6: 4529s (abstr).
-
(2000)
Clin. Cancer Res.
, vol.6
-
-
Dittrich, C.1
Dumez, H.2
Calvert, H.3
-
66
-
-
0000287733
-
Phase I trial of five-days continuous infusion E7070 (N(3-chloro-7-indoly)-1,4-benzene-disulfonamide) in patients with solid tumors
-
(abstr)
-
Droz JP, Roch H, Zanetta Sea. Phase I trial of five-days continuous infusion E7070 (N(3-chloro-7-indoly)-1,4-benzene-disulfonamide) in patients with solid tumors. Proc Am Assoc Cancer Res 2000; 41: 609 (abstr).
-
(2000)
Proc. Am. Assoc. Cancer Res.
, vol.41
, pp. 609
-
-
Droz, J.P.1
Roch, H.2
Zanetta, S.3
-
67
-
-
0034772246
-
Phase I and pharmacokinetic study of E7070, a novel sulfonamide, given at a daily times 5 schedule in patients with solid tumours: A study by the EORTC-Early Clinical Studies Group (ECSG)
-
Punt CJA, Fumoleau P, van de Walle B, et al. Phase I and pharmacokinetic study of E7070, a novel sulfonamide, given at a daily times 5 schedule in patients with solid tumours: a study by the EORTC-Early Clinical Studies Group (ECSG). Ann Oncol 2001; 12: 1289-93.
-
(2001)
Ann. Oncol.
, vol.12
, pp. 1289-1293
-
-
Punt, C.J.A.1
Fumoleau, P.2
van de Walle, B.3
-
68
-
-
0037102283
-
Phase I and pharmacokinetic study of E7070, a novel chloroindolyl sulfonamide cell cycle inhibitor, administered as a one-hour infusion every three weeks
-
Raymond E, ten Bokkel Huinink WW, Taieb J, et al. Phase I and pharmacokinetic study of E7070, a novel chloroindolyl sulfonamide cell cycle inhibitor, administered as a one-hour infusion every three weeks. J Clin Oncol 2002; 20: 3508-21.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3508-3521
-
-
Raymond, E.1
ten Bokkel Huinink, W.W.2
Taieb, J.3
-
69
-
-
0242421438
-
A Phase II and pharmacodynamic study of E7070 in patients with non-small cell lung cancer (NSCLC) who have failed platinum-based chemotherapy
-
(abstr)
-
Talbot D, Norbury C, Slade M, et al. A Phase II and pharmacodynamic study of E7070 in patients with non-small cell lung cancer (NSCLC) who have failed platinum-based chemotherapy. Proc Am Soc Clin Oncol 2002; 1306 (abstr).
-
(2002)
Proc. Am. Soc. Clin. Oncol.
, pp. 1306
-
-
Talbot, D.1
Norbury, C.2
Slade, M.3
-
70
-
-
0000902909
-
A multicentre randomised phase II study of E7070 in patients with colorectal cancer who have failed 5-fluorouracil-based chemotherapy
-
(abstr)
-
Mainwaring PN, Van Cutsem E, Van Laethem J-L, et al. A multicentre randomised phase II study of E7070 in patients with colorectal cancer who have failed 5-fluorouracil-based chemotherapy. Proc Am Soc Clin Oncol 2002; 611 (abstr).
-
(2002)
Proc. Am. Soc. Clin. Oncol.
, pp. 611
-
-
Mainwaring, P.N.1
Van Cutsem, E.2
Van Laethem, J.-L.3
-
71
-
-
0034596309
-
Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
-
Marks PA, Richon VM, Rifkind RA. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst 2000; 92: 1210-16.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 1210-1216
-
-
Marks, P.A.1
Richon, V.M.2
Rifkind, R.A.3
-
72
-
-
0033850625
-
FR901228 causes mitotic arrest but does not alter microtubule polymerization
-
Sandor V, Robbins AR, Robey R, et al. FR901228 causes mitotic arrest but does not alter microtubule polymerization. Anticancer Drugs 2000; 11: 445-54.
-
(2000)
Anticancer Drugs
, vol.11
, pp. 445-454
-
-
Sandor, V.1
Robbins, A.R.2
Robey, R.3
-
73
-
-
0033822112
-
P21-dependent g(1) arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228
-
Sandor V, Senderowicz A, Mertins S, et al. P21-dependent g(1) arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228. Br J Cancer 2000; 83: 817-25.
-
(2000)
Br. J. Cancer
, vol.83
, pp. 817-825
-
-
Sandor, V.1
Senderowicz, A.2
Mertins, S.3
-
74
-
-
0033551152
-
A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors
-
Saito A, Yamashita T, Mariko Y, et al. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc Natl Acad Sci USA 1999; 96: 4592-597.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4592-4597
-
-
Saito, A.1
Yamashita, T.2
Mariko, Y.3
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