Computer Modeling of Selective Regions in the Active Site of Nitric Oxide Synthases: Implication for the Design of Isoform-Selective Inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 26, 2003, Pages 5700-5711

  Ji, Haitao ^a   Li, Huiying ^b   Flinspach, Mack ^b   Poulos, Thomas L ^b   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; CALCULATION; COMPUTER MODEL; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR INTERACTION; PRINCIPAL COMPONENT ANALYSIS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; COMPUTER SIMULATION; DIPEPTIDES; DRUG DESIGN; ENZYME INHIBITORS; IMINES; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITRIC OXIDE SYNTHASE; NITROARGININE; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0347626255     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030301u     Document Type: Article

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