Structural basis for pterin antagonism in nitric-oxide synthase: Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin

Journal of Biological Chemistry

Volumn 276, Issue 52, 2001, Pages 49133-49141

  Kotsonis, Peter ^g   Fröhlich, Lothar G ^a   Raman, C S ^b   Li, Huiying ^c   Berg, Michael ^d   Gerwig, Rainer ^d   Groehn, Viola ^d   Kang, Yonghan ^d   Al Masoudi, Najim ^d   Taghavi Moghadam, Shahriyar ^d   Mohr, Detlev ^d   Münch, Ursula ^d   Schnabel, Joachim ^d   Martásek, Pavel ^e   Masters, Bettie S S ^e   Strobel, Hartmut ^f   Poulos, Thomas ^c   Matter, Hans ^f   Pfleiderer, Wolfgang ^d   Schmidt, Harald H H W ^h  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF KONSTANZ   (Germany)

^e UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^f SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^g Novartis Inst for Medical Sciences   (United Kingdom)

^h JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROSTATICS; ENZYME INHIBITION; HYDROPHOBICITY; PATHOLOGY;

HYPOTHETICAL BINDING MODES;

NITROGEN COMPOUNDS;

4 OXOPTERIDINE DERIVATIVE; ARGININE; FOLIC ACID ANTAGONIST; METHOTREXATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OXYGENASE; PHENYL GROUP; PHENYLALANINE; PTERIDINE DERIVATIVE; PTERIN; SERINE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; 5,6,7,8-TETRAHYDROBIOPTERIN; ANTIOXIDANT; BIOPTERIN; DRUG DERIVATIVE; ISOENZYME;

ARTICLE; BINDING SITE; CRYSTALLIZATION; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROPHOBICITY; MOLECULAR INTERACTION; PHARMACOPHORE; PRIORITY JOURNAL; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; CEREBELLUM; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SWINE;

ANIMAL; ANTIOXIDANTS; BINDING SITES; BIOPTERIN; CEREBELLUM; HUMAN; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRIC-OXIDE SYNTHASE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SWINE;

EID: 0242407670     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011469200     Document Type: Article

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