The novel binding mode of N-alkyl-N′-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis

Biochemistry

Volumn 41, Issue 47, 2002, Pages 13868-13875

  Li, Huiying ^a   Shimizu, Hideaki ^a   Flinspach, Mack ^a   Jamal, Joumana ^a   Yang, Weiping ^a   Xian, Ming ^b   Cai, Tingwei ^b   Wen, Edward Zhong ^b   Jia, Qiang ^b   Wang, Peng George ^b   Poulos, Thomas L ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING MODES;

BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; NITROGEN; SUBSTRATES;

BIOCHEMISTRY;

GUANIDINE DERIVATIVE; NITRIC OXIDE SYNTHASE;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; ENZYME PURIFICATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

ALKYLATION; ANIMALS; BINDING SITES; CLONING, MOLECULAR; GUANIDINES; ISOENZYMES; MODELS, MOLECULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PROTEIN CONFORMATION; RATS; RECOMBINANT PROTEINS;

EID: 18744415136     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020417c     Document Type: Article

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