Hydroxyurea induces site-specific DNA damage via formation of hydrogen peroxide and nitric oxide

Japanese Journal of Cancer Research

Volumn 92, Issue 11, 2001, Pages 1166-1174

  Sakano, Katsuhisa ^a   Oikawa, Shinji ^a   Hasegawa, Keishi ^a,b   Kawanishi, Shosuke ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Mie Prefectural Science and Technology Promotion Center   (Japan)

Author keywords

Copper; DNA damage; Hydrogen peroxide; Hydroxyurea; Nitric oxide

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CARCINOGEN; CATALASE; CHELATING AGENT; COPPER; CYTOSINE; DNA FRAGMENT; ENDONUCLEASE; FORMAMIDE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; HYDROXYUREA; NITRIC OXIDE; ONCOPROTEIN; PHOSPHORUS 32; PROTEIN P16; PROTEIN P53; REAGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SARCOSINE; SCAVENGER; THYMINE;

ARTICLE; CANCER CHEMOTHERAPY; CARCINOGENIC ACTIVITY; DNA CLEAVAGE; DNA DAMAGE; DNA MODIFICATION; ELECTRON SPIN RESONANCE; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LEUKEMIA; MASS SPECTROMETRY; MUTAGENIC ACTIVITY; ONCOGENE C H RAS; OXIDATION; PRIORITY JOURNAL; SPECTROSCOPY; TUMOR SUPPRESSOR GENE;

ANIMALS; CATALASE; CATIONS, DIVALENT; CATTLE; COPPER; DNA; DNA DAMAGE; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENES, P16; GENES, P53; GENES, RAS; HUMANS; HYDROGEN PEROXIDE; HYDROXYUREA; NAD; NITRIC OXIDE; PHENANTHROLINES; SUBSTRATE SPECIFICITY;

EID: 0035206628     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb02136.x     Document Type: Article

References (65)

1. Hydroxyurea-induced leg ulceration in 14 patients
2. Hydroxyurea: An overview
3. Chronic leukemias
4. Rationale for the use of hydroxyurea as an anti-human immunodeficiency virus drug
5. Hydroxyurea to inhibit human immunodeficiency virus-1 replication
6. Differential effects of hydroxyurea upon deoxyribonucleoside triphosphate pools, analyzed with vaccinia virus ribonucleotide reductase
7. Induction by adozelesin and hydroxyurea of origin recognition complex-dependent DNA damage and DNA replication checkpoints in Saccharomyces cerevisiae
8. Acute myeloid leukemia and myelodysplastic syndromes following essential thrombocythemia treated with hydroxyurea: High proportion of cases with 17p deletion
9. From efficacy to safety: A Polycythemia Vera Study group report on hydroxyurea in patients with polycythemia vera
10. 32P alone or in combination with maintenance therapy using hydroxyurea in 461 patients greater than 65 years of age
11. Multiple squamous cell carcinomas of the skin during long-term treatment with hydroxyurea
12. Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing
13. Hydroxyurea as a reference standard in teratological screening. Comparison of the embryotoxic and teratogenic effects following single intraperitoneal or repeated oral administrations to pregnant rats
14. Microsome- and hepatocyte-mediated mutagenicity of hydroxyurea and related aliphatic hydroxamic acids in V79 Chinese hamster cells
15. Acquired DNA mutations associated with in vivo hydroxyurea exposure
16. Progressive formation of DNA lesions in cultured Ehrlich ascites tumor cells treated with hydroxyurea
17. Hydroxyurea
18. Hydroxyurea
19. Detection of nitrosyl hemoglobin in venous blood in the treatment of sickle cell anemia with hydroxyurea
20. Nitric oxide generation from hydroxyurea via copper-catalyzed peroxidation and implications for pharmacological actions of hydroxyurea
21. In vivo production of nitric oxide in rats after administration of hydroxyurea
22. Superoxide formation and DNA damage induced by a fragrant furanone in the presence of copper (II)
23. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
24. Site specificity and mechanism of oxidative DNA damage induced by carcinogenic catechol
25. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue
26. Hydroxyl free radical is not the main active species in site-specific DNA damage induced by copper (II) ion and hydrogen peroxide
27. Human DNA damage induced by 1,2,4-benzenetriol, a benzene metabolite
28. Sequencing end-labeled DNA with base-specific chemical cleavages
29. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair
30. 8-Hydroxydeoxyguanosine formation at the 5′ site of 5′-GG-3′ sequences in double-stranded DNA by UV radiation with riboflavin
31. Nitric oxide trapping efficiencies of water-soluble iron (III) complexes with dithiocarbamate derivatives
32. The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events
33. Oxygen species in paraquat toxicity: The crypto-OH radical
34. Structure of the DNA repair enzyme endonuclease IV and its DNA complex: Double-nucleotide flipping at abasic sites and three-metal-ion catalysis
35. Escherichia coli double-strand uracil-DNA glycosylase: Involvement in uracil-mediated DNA base excision repair and stimulation of activity by endonuclease IV
36. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
37. Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis
38. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
39. Mechanism of DNA cleavage induced by sodium chromate (VI) in the presence of hydrogen peroxide
40. Iron (II)-ethylenediamine-tetraacetic acid catalyzed cleavage of RNA and DNA oligonucleotides: Similar reactivity toward single- and double-stranded forms
41. Modification of bases in DNA by copper ion-1,10-phenanthroline complexes
42. Nitric oxide and oxygen radicals in infection, inflammation, and cancer
43. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors
44. DNA damage and mutation in human cells exposed to nitric oxide in vitro
45. Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: Measurement, mechanism and the effects of nutrition
46. -) in the presence of hydrogen peroxide. Implications for various pathophysiological conditions
47. Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide
48. Peroxynitrite-induced DNA damage in the supF gene: Correlation with the mutational spectrum
49. Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination
50. 1-DNA adduct
51. Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: The role of apurinic sites
52. Metal-mediated DNA damage induced by diabetogenic alloxan in the presence of NADH
53. Copper-mediated DNA damage by metabolites of p-dichlorobenzene
54. Structural integrity of the nuclear matrix: Differential effects of thiol agents and metal chelators
55. Effects of ionic strength on endogenous nuclease activity in chelated and nonchelated chromatin
56. Copper in human mammary carcinogenesis: A case-cohort study
57. Clastogenic effects of copper sulphate on the bone marrow chromosomes of mice in vivo
58. Oxygen radical formation and site-specific DNA damage by metal and carcinogen
59. Oxidative mechanisms in carcinogenesis
60. Reactive oxygen-dependent DNA damage resulting from the oxidation of phenolic compounds by a copper-redox cycle mechanism
61. Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging
62. Hydroxyurea-induced fever in cervical carcinoma: Case report and review of the literature
63. Cutaneous ulcers associated with hydroxyurea therapy in myeloproliferative disorders
64. The role of deoxynucleoside triphosphate pools in the inhibition of DNA-excision repair and replication in human cells by hydroxyurea