메뉴 건너뛰기




Volumn 111, Issue 1-2, 2004, Pages 107-123

Apoptosis induced by molecular targeting therapy in hematological malignancies

Author keywords

Anti CD20; Anti CD33; Apoptosis; Arsenic trioxide; Etodolac; FLT3 inhibitor; Imatinib mesylate; Molecular targeting therapy

Indexed keywords

4 [6 METHOXY 7 [3 (1 PIPERIDINYL)PROPOXY] 4 QUINAZOLINYL] 1 PIPERAZINECARBOXYLIC ACID (4 ISOPROPOXYPHENYL)AMIDE; ACETYLSALICYLIC ACID; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; BENDAMUSTINE; CARBAZOLE DERIVATIVE; CD20 ANTIGEN; CEP 701; CYTARABINE; ETODOLAC; FLT3 LIGAND INHIBITOR; FLUDARABINE; GEMTUZUMAB OZOGAMICIN; IMATINIB; MIDOSTAURIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOXANTRONE; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN KINASE B; QUINAZOLINE DERIVATIVE; RAS PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; RITUXIMAB; SDX 101; SEMAXANIB; STAT5 PROTEIN; STAUROSPORINE DERIVATIVE; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 0345059960     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000074490     Document Type: Review
Times cited : (20)

References (141)
  • 1
    • 0034670036 scopus 로고    scopus 로고
    • The molecular biology of chronic myeloid leukemia
    • Deninger MWN, Goldman JM, Melo JV: The molecular biology of chronic myeloid leukemia. Blood 2000;96:3343-3356.
    • (2000) Blood , vol.96 , pp. 3343-3356
    • Deninger, M.W.N.1    Goldman, J.M.2    Melo, J.V.3
  • 3
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the Bcr-Abl tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, Talpaz M: Activity of a specific inhibitor of the Bcr-Abl tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001;344:1038-1042.
    • (2001) N Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3    Resta, D.J.4    Reese, S.F.5    Ford, J.M.6    Capdeville, R.7    Talpaz, M.8
  • 4
    • 0001338423 scopus 로고    scopus 로고
    • Phase II study of STI571, a tyrosine kinase inhibitor, in patients with resistant or refractory Philadelphia chromosome positive chronic myeloid leukemia
    • Kantarjian H, Sawyers CL, Hochhaus A, Guilhot F, Schiffer C, Resta D, Capdeville R, Druker B: Phase II study of STI571, a tyrosine kinase inhibitor, in patients with resistant or refractory Philadelphia chromosome positive chronic myeloid leukemia (abstract). Blood 2000;96:470.
    • (2000) Blood , vol.96 , pp. 470
    • Kantarjian, H.1    Sawyers, C.L.2    Hochhaus, A.3    Guilhot, F.4    Schiffer, C.5    Resta, D.6    Capdeville, R.7    Druker, B.8
  • 5
    • 0000869570 scopus 로고    scopus 로고
    • A phase II study to determine the safety and anti-leukemic effects of STI571 in patients with Philadelphia chromosome positive chronic myeloid leukemia in myeloid blast crisis
    • Sawyers CL, Hochhaus A, Feldman E, Goldman JM, Miller C, Ben-Am M, Capdeville R, Druker B: A phase II study to determine the safety and anti-leukemic effects of STI571 in patients with Philadelphia chromosome positive chronic myeloid leukemia in myeloid blast crisis (abstract). Blood 2000;96:503.
    • (2000) Blood , vol.96 , pp. 503
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3    Goldman, J.M.4    Miller, C.5    Ben-Am, M.6    Capdeville, R.7    Druker, B.8
  • 6
    • 0001566710 scopus 로고    scopus 로고
    • A phase II study of STI571 in adults patients with Philadelphia chromosome-positive chronic myeloid leukemia in accelerated phase
    • Talpaz M, Silver RT, Druker B, Paquette R, Goldman JM, Reese SF, Capdeville R: A phase II study of STI571 in adults patients with Philadelphia chromosome-positive chronic myeloid leukemia in accelerated phase (abstract). Blood 2000;96:469.
    • (2000) Blood , vol.96 , pp. 469
    • Talpaz, M.1    Silver, R.T.2    Druker, B.3    Paquette, R.4    Goldman, J.M.5    Reese, S.F.6    Capdeville, R.7
  • 10
    • 0023270373 scopus 로고
    • Altered adhesive interactions with marrow stroma of haematopoitic progenitor cells in chronic myeloid leukemia
    • Gordon MY, Dowding CR, Riley GP, Goldman JM, Greaves MF: Altered adhesive interactions with marrow stroma of haematopoitic progenitor cells in chronic myeloid leukemia. Nature 1987;328:342-344.
    • (1987) Nature , vol.328 , pp. 342-344
    • Gordon, M.Y.1    Dowding, C.R.2    Riley, G.P.3    Goldman, J.M.4    Greaves, M.F.5
  • 12
  • 13
    • 0028178976 scopus 로고
    • Interferon-α restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired β1 integrin receptor function
    • Bhatia R, Wayner EA, McGlave PB, Verfaillie CM: Interferon-α restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired β1 integrin receptor function. J Clin Invest 1994;94:384-391.
    • (1994) J Clin Invest , vol.94 , pp. 384-391
    • Bhatia, R.1    Wayner, E.A.2    McGlave, P.B.3    Verfaillie, C.M.4
  • 14
    • 0034032012 scopus 로고    scopus 로고
    • BCR-ABL tyrosine kinase activity regulates the expression of multiple genes implicated in the pathogenesis of chronic myeloid leukemia
    • Deininger MW, Vieira S, Mendiola R, Schultheis B, Goldman JM, Melo JV: BCR-ABL tyrosine kinase activity regulates the expression of multiple genes implicated in the pathogenesis of chronic myeloid leukemia. Cancer Res 2000;60:2049-2055.
    • (2000) Cancer Res , vol.60 , pp. 2049-2055
    • Deininger, M.W.1    Vieira, S.2    Mendiola, R.3    Schultheis, B.4    Goldman, J.M.5    Melo, J.V.6
  • 16
    • 0029131231 scopus 로고
    • BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents
    • Bedi A, Barber JP, Bedi GC, El-Deiry WS, Sidransky D, Vala MS, Akhtar AJ, Hilton J, Jones RJ: BCR-ABL-mediated inhibition of apoptosis with delay of G2/ M transition after DNA damage: A mechanism of resistance to multiple anticancer agents. Blood 1995;86: 1148-1158.
    • (1995) Blood , vol.86 , pp. 1148-1158
    • Bedi, A.1    Barber, J.P.2    Bedi, G.C.3    El-Deiry, W.S.4    Sidransky, D.5    Vala, M.S.6    Akhtar, A.J.7    Hilton, J.8    Jones, R.J.9
  • 18
    • 0032032270 scopus 로고    scopus 로고
    • Bcr-Abl exerts its anti-apoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
    • Amarante-Mendes GP, Kim CN, Liu L, Huang Y, Perkins CL, Green DR, Bhalla K: Bcr-Abl exerts its anti-apoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3. Blood 1998;91:1700-1705.
    • (1998) Blood , vol.91 , pp. 1700-1705
    • Amarante-Mendes, G.P.1    Kim, C.N.2    Liu, L.3    Huang, Y.4    Perkins, C.L.5    Green, D.R.6    Bhalla, K.7
  • 19
    • 0031588956 scopus 로고    scopus 로고
    • Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras
    • Sanchez Garcia I, Martin Zanca D: Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras. J Mol Biol 1997;267:225-228.
    • (1997) J Mol Biol , vol.267 , pp. 225-228
    • Sanchez Garcia, I.1    Martin Zanca, D.2
  • 21
    • 0034689031 scopus 로고    scopus 로고
    • Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL
    • Horita M, Andreu EJ, Benito A: Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL. J Exp Med 2000;191:977-984.
    • (2000) J Exp Med , vol.191 , pp. 977-984
    • Horita, M.1    Andreu, E.J.2    Benito, A.3
  • 22
    • 0034653929 scopus 로고    scopus 로고
    • STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells
    • Sillaber C, Gesbert F, Frank DA, Sattler M, Griffin JD: STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells. Blood 2000;95:2118-2125.
    • (2000) Blood , vol.95 , pp. 2118-2125
    • Sillaber, C.1    Gesbert, F.2    Frank, D.A.3    Sattler, M.4    Griffin, J.D.5
  • 23
    • 0030853063 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells
    • Deininger MW, Goldman JM, Lydon N, Melo JV: The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood 1997;90:3691-3698.
    • (1997) Blood , vol.90 , pp. 3691-3698
    • Deininger, M.W.1    Goldman, J.M.2    Lydon, N.3    Melo, J.V.4
  • 24
    • 15444350807 scopus 로고    scopus 로고
    • Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148)
    • Beran M, Cao X, Estrov Z, Jeha S, Jin G, O'Brien S, Talpaz M, Arlinghaus RB, Lydon NB, Kantarjian H: Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148). Clin Cancer Res 1998;4:1661-1672.
    • (1998) Clin Cancer Res , vol.4 , pp. 1661-1672
    • Beran, M.1    Cao, X.2    Estrov, Z.3    Jeha, S.4    Jin, G.5    O'Brien, S.6    Talpaz, M.7    Arlinghaus, R.B.8    Lydon, N.B.9    Kantarjian, H.10
  • 26
    • 0031869466 scopus 로고    scopus 로고
    • Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR-ABL tyrosine kinase, CGP 57148
    • Dan S, Naito M, Tsuruo T: Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR-ABL tyrosine kinase, CGP 57148. Cell Death Differ 1998;5:710-715.
    • (1998) Cell Death Differ , vol.5 , pp. 710-715
    • Dan, S.1    Naito, M.2    Tsuruo, T.3
  • 27
    • 0034665903 scopus 로고    scopus 로고
    • CGP571448B (STI571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to anti-leukemic drugs
    • Fang G, Kim CN, Perkins CL, Ramadevl N, Winton E, Wittmann S, Bhala KN: CGP571448B (STI571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to anti-leukemic drugs. Blood 2000;96:2246-2253.
    • (2000) Blood , vol.96 , pp. 2246-2253
    • Fang, G.1    Kim, C.N.2    Perkins, C.L.3    Ramadevl, N.4    Winton, E.5    Wittmann, S.6    Bhala, K.N.7
  • 38
    • 0037049766 scopus 로고    scopus 로고
    • Novel targeted therapies for Bcr-Abl positive acute leukemias: Beyond STI571
    • Nimmanapalli R, Bhalla K: Novel targeted therapies for Bcr-Abl positive acute leukemias: Beyond STI571. Oncogene 2002;21:8584-8590.
    • (2002) Oncogene , vol.21 , pp. 8584-8590
    • Nimmanapalli, R.1    Bhalla, K.2
  • 39
    • 0034771555 scopus 로고    scopus 로고
    • The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy
    • Blagosklonny MV, Fojo T, Bhalla KN, Kim JS, Trepel JB, Figg WD, Rivera Y, Neckers L: The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy. Leukemia 2001;15: 1537-1543
    • (2001) Leukemia , vol.15 , pp. 1537-1543
    • Blagosklonny, M.V.1    Fojo, T.2    Bhalla, K.N.3    Kim, J.S.4    Trepel, J.B.5    Figg, W.D.6    Rivera, Y.7    Neckers, L.8
  • 40
    • 0034142368 scopus 로고    scopus 로고
    • Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L)
    • Perkins C, Kim CN, Fang G, Bhalla KN: Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). Blood 2000;95:1014-1022.
    • (2000) Blood , vol.95 , pp. 1014-1022
    • Perkins, C.1    Kim, C.N.2    Fang, G.3    Bhalla, K.N.4
  • 41
    • 0034330931 scopus 로고    scopus 로고
    • Efficacy of STI571, an Abl tyrosine kinase inhibitor, in conjunction with other antileukemic agants against Bcr-Abl-positive cells
    • Thiesing JT, Ohno-Jones S, Kolibaba KS, Druker BJ: Efficacy of STI571, an Abl tyrosine kinase inhibitor, in conjunction with other antileukemic agants against Bcr-Abl-positive cells. Blood 2000;96:3195-3199.
    • (2000) Blood , vol.96 , pp. 3195-3199
    • Thiesing, J.T.1    Ohno-Jones, S.2    Kolibaba, K.S.3    Druker, B.J.4
  • 42
    • 0036142963 scopus 로고    scopus 로고
    • Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells
    • Yu C, Krystal G, Varticovksi L, McKinstry R, Rahmani M, Dent P, Grant S: Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells. Cancer Res 2002;62:188-199.
    • (2002) Cancer Res , vol.62 , pp. 188-199
    • Yu, C.1    Krystal, G.2    Varticovksi, L.3    McKinstry, R.4    Rahmani, M.5    Dent, P.6    Grant, S.7
  • 43
    • 0010765587 scopus 로고    scopus 로고
    • Efficacy of SCH66336, the farnesyl transferase inhibitor, against Gleevec-resistant BCR-ABL-positive cells (abstract)
    • Nakajima A, Tauchi T, Sumi M, Bishop RW, Ohyashiki K: Efficacy of SCH66336, the farnesyl transferase inhibitor, against Gleevec-resistant BCR-ABL-positive cells (abstract). Proc Am Assoc Cancer Res 2002;43:855.
    • (2002) Proc Am Assoc Cancer Res , vol.43 , pp. 855
    • Nakajima, A.1    Tauchi, T.2    Sumi, M.3    Bishop, R.W.4    Ohyashiki, K.5
  • 55
    • 0036200042 scopus 로고    scopus 로고
    • Bendamustine, mitoxantrone and rituximab (BMR): A new effective regimen for refractory or relapsed indolent lymphomas
    • Weide R, Heymanns J, Gores A, Koppler H: Bendamustine, mitoxantrone and rituximab (BMR): A new effective regimen for refractory or relapsed indolent lymphomas. Leuk Lymph 2002;43:327-331.
    • (2002) Leuk Lymph , vol.43 , pp. 327-331
    • Weide, R.1    Heymanns, J.2    Gores, A.3    Koppler, H.4
  • 56
    • 0036177919 scopus 로고    scopus 로고
    • Rituximab: Mechanism of action and resistance
    • Maloney DG, Smith B, Rose A: Rituximab: Mechanism of action and resistance. Semin Oncol 2002;2:2-9.
    • (2002) Semin Oncol , vol.2 , pp. 2-9
    • Maloney, D.G.1    Smith, B.2    Rose, A.3
  • 57
    • 0032030699 scopus 로고    scopus 로고
    • Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies
    • Shan D, Ledbetter JA, Press OW: Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies. Blood 1998;91: 1644-1652.
    • (1998) Blood , vol.91 , pp. 1644-1652
    • Shan, D.1    Ledbetter, J.A.2    Press, O.W.3
  • 59
    • 0033774970 scopus 로고    scopus 로고
    • Mechanism of cytotoxicity induced by chimeric mouse human monoclonal antibody IDEC-C2B8 in CD20-expressing lymphoma cell lines
    • Flieger D, Renoth S, Beier I, Sauerbruch T, Schmidt-Wolf I: Mechanism of cytotoxicity induced by chimeric mouse human monoclonal antibody IDEC-C2B8 in CD20-expressing lymphoma cell lines. Cell Immunol 2000;204: 55-63.
    • (2000) Cell Immunol , vol.204 , pp. 55-63
    • Flieger, D.1    Renoth, S.2    Beier, I.3    Sauerbruch, T.4    Schmidt-Wolf, I.5
  • 60
    • 0034671315 scopus 로고    scopus 로고
    • Anti-CD20- and B-cell receptor-mediated apoptosis: Evidence for shared intracellular signaling pathways
    • Mathas S, Rickers A, Bommert K, Dorken B, Mapara MY: Anti-CD20- and B-cell receptor-mediated apoptosis: Evidence for shared intracellular signaling pathways. Cancer Res 2000; 60:7170-7176.
    • (2000) Cancer Res , vol.60 , pp. 7170-7176
    • Mathas, S.1    Rickers, A.2    Bommert, K.3    Dorken, B.4    Mapara, M.Y.5
  • 61
    • 0033855194 scopus 로고    scopus 로고
    • Clustered CD20 induced apoptosis: src-family kinase, the proximal regulator of tyrosine phos-phorylation, calcium influx, and caspase 3-dependent apoptosis
    • Hofmeister JK, Cooney D, Coggeshall KM: Clustered CD20 induced apoptosis: src-family kinase, the proximal regulator of tyrosine phos-phorylation, calcium influx, and caspase 3-dependent apoptosis. Blood Cells Mol Dis 2000;26:133-143.
    • (2000) Blood Cells Mol Dis , vol.26 , pp. 133-143
    • Hofmeister, J.K.1    Cooney, D.2    Coggeshall, K.M.3
  • 62
    • 0035282930 scopus 로고    scopus 로고
    • Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin
    • Ghetie MA, Bright H, Vitetta ES: Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin. Blood 2001;97: 1392-1398.
    • (2001) Blood , vol.97 , pp. 1392-1398
    • Ghetie, M.A.1    Bright, H.2    Vitetta, E.S.3
  • 64
    • 0037082469 scopus 로고    scopus 로고
    • The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cell lines through a p38 mitogen activated protein-kinase-dependent mechanism
    • Pedersen IM, Buhl AM, Klausen P, Geisler CH, Jurlander J: The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cell lines through a p38 mitogen activated protein-kinase-dependent mechanism. Blood 2002;99: 1314-1319.
    • (2002) Blood , vol.99 , pp. 1314-1319
    • Pedersen, I.M.1    Buhl, A.M.2    Klausen, P.3    Geisler, C.H.4    Jurlander, J.5
  • 65
    • 0036464611 scopus 로고    scopus 로고
    • The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction
    • Byrd JC, Kitada S, Flinn IW, Aron JL, Pearson M, Lucas D, Reed JC: The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction. Blood 2002;99:1038-1043.
    • (2002) Blood , vol.99 , pp. 1038-1043
    • Byrd, J.C.1    Kitada, S.2    Flinn, I.W.3    Aron, J.L.4    Pearson, M.5    Lucas, D.6    Reed, J.C.7
  • 66
    • 0027379720 scopus 로고
    • Association of tyrosine and serine kinases with the B cell surface antigen CD20. Induction via CD20 of tyrosine phosphorylation and activation of phospholipase C-γ 1 and PLC phospholipase C-γ 2
    • Deans JP, Schieven GL, Shu GL, Valentine MA, Gilliland LA, Aruffo A, Clark EA, Ledbetter JA: Association of tyrosine and serine kinases with the B cell surface antigen CD20. Induction via CD20 of tyrosine phosphorylation and activation of phospholipase C-γ 1 and PLC phospholipase C-γ 2. J Immunol 1993; 151:4494-4504.
    • (1993) J Immunol , vol.151 , pp. 4494-4504
    • Deans, J.P.1    Schieven, G.L.2    Shu, G.L.3    Valentine, M.A.4    Gilliland, L.A.5    Aruffo, A.6    Clark, E.A.7    Ledbetter, J.A.8
  • 67
    • 0034104375 scopus 로고    scopus 로고
    • Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells
    • Shan D, Ledbetter JA, Press OW: Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells. Cancer Immunol Immunother 2000;48:673-683.
    • (2000) Cancer Immunol Immunother , vol.48 , pp. 673-683
    • Shan, D.1    Ledbetter, J.A.2    Press, O.W.3
  • 68
    • 0029115799 scopus 로고
    • Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn and Lck with the B-cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20
    • Deans JP, Kalt L, Ledbetter JA, Schieven GL, Bolen JB, Johnson P: Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn and Lck with the B-cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20. J Biol Chem 1995;270: 22632-22638.
    • (1995) J Biol Chem , vol.270 , pp. 22632-22638
    • Deans, J.P.1    Kalt, L.2    Ledbetter, J.A.3    Schieven, G.L.4    Bolen, J.B.5    Johnson, P.6
  • 69
    • 0036408912 scopus 로고    scopus 로고
    • CD20-mediated apoptosis: Signaling through lipid rafts
    • Deans JP, Li H, Polyak MJ: CD20-mediated apoptosis: Signaling through lipid rafts. Immunology 2002;107:176-182.
    • (2002) Immunology , vol.107 , pp. 176-182
    • Deans, J.P.1    Li, H.2    Polyak, M.J.3
  • 71
    • 0035282930 scopus 로고    scopus 로고
    • Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin
    • Ghetie MA, Bright H, Vitetta ES: Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin. Blood 2001;97: 1392-1398.
    • (2001) Blood , vol.97 , pp. 1392-1398
    • Ghetie, M.A.1    Bright, H.2    Vitetta, E.S.3
  • 72
    • 0030800131 scopus 로고    scopus 로고
    • Chimeric anti-CD20 (IDEC-C2B8) monoclonal antibody sensitizes a B-cell lymphoma cell line to cell killing by cytotoxic drugs
    • Demidem A, Lam T, Alas S, Hariharan K, Hanna N, Bonavida B: Chimeric anti-CD20 (IDEC-C2B8) monoclonal antibody sensitizes a B-cell lymphoma cell line to cell killing by cytotoxic drugs. Cancer Biother Radiopharm 1997;12:177-186.
    • (1997) Cancer Biother Radiopharm , vol.12 , pp. 177-186
    • Demidem, A.1    Lam, T.2    Alas, S.3    Hariharan, K.4    Hanna, N.5    Bonavida, B.6
  • 73
    • 0033794618 scopus 로고    scopus 로고
    • Potentiation of fludarabine cytotoxicity on non-Hodgkin's lymphoma by pentoxifylline and rituximab
    • Alas S, Bonavida B, Emmanouilides C: Potentiation of fludarabine cytotoxicity on non-Hodgkin's lymphoma by pentoxifylline and ri-tuximab. Anticancer Res 2000;20:2961-2966.
    • (2000) Anticancer Res , vol.20 , pp. 2961-2966
    • Alas, S.1    Bonavida, B.2    Emmanouilides, C.3
  • 74
    • 0034894958 scopus 로고    scopus 로고
    • Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis
    • Alas S, Emmanouillides C, Bonavida B: Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis. Clin Cancer Res 2001;7:709-723.
    • (2001) Clin Cancer Res , vol.7 , pp. 709-723
    • Alas, S.1    Emmanouillides, C.2    Bonavida, B.3
  • 75
    • 0035393595 scopus 로고    scopus 로고
    • Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin-10 autocrine/paracrine loop and results in down-regulation of Bcl-2 and sensitization to cytotoxic drugs
    • Alas S, Bonavida B: Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin-10 autocrine/paracrine loop and results in down-regulation of Bcl-2 and sensitization to cytotoxic drugs. Cancer Res 2001;61:5137-5144.
    • (2001) Cancer Res , vol.61 , pp. 5137-5144
    • Alas, S.1    Bonavida, B.2
  • 76
    • 0036154263 scopus 로고    scopus 로고
    • Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: Role of cytokines, complement and caspases
    • Chow KU, Sommerlad WD, Boehrer S, Schneider B, Seipelt G, Rummel MJ, Hoelzer D, Mitrou PS, Weidmann E: Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: Role of cytokines, complement and caspases. Haematologica 2002;87:33-43.
    • (2002) Haematologica , vol.87 , pp. 33-43
    • Chow, K.U.1    Sommerlad, W.D.2    Boehrer, S.3    Schneider, B.4    Seipelt, G.5    Rummel, M.J.6    Hoelzer, D.7    Mitrou, P.S.8    Weidmann, E.9
  • 77
    • 0036307780 scopus 로고    scopus 로고
    • Rituximab modifies the cisplatin-mitochondrial signaling pathway, resulting in apoptosis in cisplatin-resistant non-Hodgkin's lymphoma
    • Alas S, Ng CP, Bonavida B: Rituximab modifies the cisplatin- mitochondrial signaling pathway, resulting in apoptosis in cisplatin-resistant non-Hodgkin's lymphoma. Clin Cancer Res 2002;8:836-845.
    • (2002) Clin Cancer Res , vol.8 , pp. 836-845
    • Alas, S.1    Ng, C.P.2    Bonavida, B.3
  • 80
    • 0021222051 scopus 로고
    • A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells
    • Griffin JD, Linch D, Sabbath K, Larcom P, Schlossman SF: A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells. Leuk Res 1984;8:521-534.
    • (1984) Leuk Res , vol.8 , pp. 521-534
    • Griffin, J.D.1    Linch, D.2    Sabbath, K.3    Larcom, P.4    Schlossman, S.F.5
  • 81
    • 0023712557 scopus 로고
    • Molecular cloning, expression and chromosomal localization of a human gene encoding the CD33 myeloid differentiation antigen
    • Peiper SC, Ashmun RA, Look AT: Molecular cloning, expression and chromosomal localization of a human gene encoding the CD33 myeloid differentiation antigen. Blood 1988;72: 314-321.
    • (1988) Blood , vol.72 , pp. 314-321
    • Peiper, S.C.1    Ashmun, R.A.2    Look, A.T.3
  • 82
    • 0035874504 scopus 로고    scopus 로고
    • Targeting of the CD33-calicheamicin immunoconjugate Mylotarg 8CMA-676) in acute myeloid leukemia: In vivo and in vitro saturation and internalization by leukemic and normal myeloid cells
    • Van der Velden VHJ, te Marvelde JG, Hoogeveen PG, Bernstein ID, Houtsmuller AB, Berger MS, van Dongen JJM: Targeting of the CD33-calicheamicin immunoconjugate Mylotarg 8CMA-676) in acute myeloid leukemia: In vivo and in vitro saturation and internalization by leukemic and normal myeloid cells. Blood 2001;97:3197-3204.
    • (2001) Blood , vol.97 , pp. 3197-3204
    • Van Der Velden, V.H.J.1    Te Marvelde, J.G.2    Hoogeveen, P.G.3    Bernstein, I.D.4    Houtsmuller, A.B.5    Berger, M.S.6    Van Dongen, J.J.M.7
  • 86
    • 0023820894 scopus 로고
    • Calicheamicin γ 1:An antitumor antibiotic that cleaves double-stranded DNA site specificity
    • Zein N, Sinha AM, McGahren WJ, Ellestad GA: Calicheamicin γ 1:An antitumor antibiotic that cleaves double-stranded DNA site specificity. Science 1988;240:1198-1201.
    • (1988) Science , vol.240 , pp. 1198-1201
    • Zein, N.1    Sinha, A.M.2    McGahren, W.J.3    Ellestad, G.A.4
  • 87
    • 0027319406 scopus 로고
    • Chemistry and biology of natural and designed enediynes
    • Nicolaou KC, Smith AL, Yue EW: Chemistry and biology of natural and designed enediynes. Proc Natl Acad Sci USA 1993;90:5881-5888.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5881-5888
    • Nicolaou, K.C.1    Smith, A.L.2    Yue, E.W.3
  • 88
    • 0037804758 scopus 로고    scopus 로고
    • Differential response of human acute myeloid leukemia cells to gemtuzumab ozogamicin (Mylotarg) in vitro. Role of chk1 and chk2 phosphorylation and caspase 3
    • Epub Feb 6, 2003
    • Amico D, Barbui AM, Erba E, Rambaldi A, Introna M, Golay J: Differential response of human acute myeloid leukemia cells to gemtuzumab ozogamicin (Mylotarg) in vitro. Role of chk1 and chk2 phosphorylation and caspase 3. Blood 2003;101:4589-4597/Epub Feb 6, 2003.
    • (2003) Blood , vol.101 , pp. 4589-4597
    • Amico, D.1    Barbui, A.M.2    Erba, E.3    Rambaldi, A.4    Introna, M.5    Golay, J.6
  • 92
    • 0033563119 scopus 로고    scopus 로고
    • Sustained in vivo regression of Dunning H rat prostate cancers treated combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555)
    • George DJ, Dionne CA, Jani J, Angeles T, Murakata C, Lamb J, Isaacs JT: Sustained in vivo regression of Dunning H rat prostate cancers treated combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555). Cancer Res 1999;59:2395-2401.
    • (1999) Cancer Res , vol.59 , pp. 2395-2401
    • George, D.J.1    Dionne, C.A.2    Jani, J.3    Angeles, T.4    Murakata, C.5    Lamb, J.6    Isaacs, J.T.7
  • 95
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong TA, Shawver LK, Sun L, Tang C, App H, Powell TJ, Kim YH, Schreck R, Wang X, Risau W, Ullrich A, Hirth KP, McMahon G: SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 1999;59: 99-106.
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6    Kim, Y.H.7    Schreck, R.8    Wang, X.9    Risau, W.10    Ullrich, A.11    Hirth, K.P.12    McMahon, G.13
  • 98
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, Naoe T: Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 2000;19:624-631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3    Tanimoto, M.4    Kitamura, T.5    Saito, H.6    Naoe, T.7
  • 100
    • 0035889243 scopus 로고    scopus 로고
    • The phosphatidylinositide 3′;-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C
    • Tenzer A, Zingg D, Rocha S, Hemmings B, Fabbro D, Glanzmann C, Schubiger PA, Bodis S, Pruschy M: The phosphatidylinositide 3′-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer Res 2001;61:8203-8210.
    • (2001) Cancer Res , vol.61 , pp. 8203-8210
    • Tenzer, A.1    Zingg, D.2    Rocha, S.3    Hemmings, B.4    Fabbro, D.5    Glanzmann, C.6    Schubiger, P.A.7    Bodis, S.8    Pruschy, M.9
  • 102
    • 0037441745 scopus 로고    scopus 로고
    • The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3
    • Spiekermann K, Dirschinger RJ, Schwab R, Bagrintseva K, Faber F, Buske C, Schnittger S, Kelly LM, Gilliland DG, Hiddemann W: The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood 2003;101:1494-1504.
    • (2003) Blood , vol.101 , pp. 1494-1504
    • Spiekermann, K.1    Dirschinger, R.J.2    Schwab, R.3    Bagrintseva, K.4    Faber, F.5    Buske, C.6    Schnittger, S.7    Kelly, L.M.8    Gilliland, D.G.9    Hiddemann, W.10
  • 104
    • 0025089467 scopus 로고
    • Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17
    • Borrow J, Goddard AD, Sheer D, Solomon E: Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 1990;249:1577-1580.
    • (1990) Science , vol.249 , pp. 1577-1580
    • Borrow, J.1    Goddard, A.D.2    Sheer, D.3    Solomon, E.4
  • 105
    • 0030738403 scopus 로고    scopus 로고
    • All-trans-retinoic acid significantly increases 5-year survival in patients with acute promyelocytic leukemia: Long-term follow-up of the New York study
    • Soignet S, Fleischauer A, Polyak T, Heller G, Warrell RP Jr: All-trans-retinoic acid significantly increases 5-year survival in patients with acute promyelocytic leukemia: Long-term follow-up of the New York study. Cancer Chemother Pharmacol 1997;40(suppl): 25-29.
    • (1997) Cancer Chemother Pharmacol , vol.40 , Issue.SUPPL. , pp. 25-29
    • Soignet, S.1    Fleischauer, A.2    Polyak, T.3    Heller, G.4    Warrell Jr., R.P.5
  • 107
    • 0025201879 scopus 로고
    • All-trans-retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results
    • Castaigne S, Chomienne C, Daniel MT, Ballerini P, Berger R, Fenaux P, Degos L: All-trans-retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood1990;76:1704-1709.
    • (1990) Blood , vol.76 , pp. 1704-1709
    • Castaigne, S.1    Chomienne, C.2    Daniel, M.T.3    Ballerini, P.4    Berger, R.5    Fenaux, P.6    Degos, L.7
  • 110
    • 0036338444 scopus 로고    scopus 로고
    • Hematologic malignancies: New developments and future treatments
    • Cheson BD: Hematologic malignancies: New developments and future treatments. Semin Oncol 2002;29(suppl 13):33-45.
    • (2002) Semin Oncol , vol.29 , Issue.13 SUPPL. , pp. 33-45
    • Cheson, B.D.1
  • 115
    • 0033974883 scopus 로고    scopus 로고
    • Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelo-cytic leukemia
    • Cai X, Shen YL, Zhu Q, Jia PM, Yu Y, Zhou L, Huang Y, Zhang JW, Xiong SM, Chen SJ, Wang ZY, Chen Z, Chen GQ: Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelo-cytic leukemia. Leukemia 2000;14:262-270.
    • (2000) Leukemia , vol.14 , pp. 262-270
    • Cai, X.1    Shen, Y.L.2    Zhu, Q.3    Jia, P.M.4    Yu, Y.5    Zhou, L.6    Huang, Y.7    Zhang, J.W.8    Xiong, S.M.9    Chen, S.J.10    Wang, Z.Y.11    Chen, Z.12    Chen, G.Q.13
  • 116
    • 0031657760 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species and caspase-3 activation in arsenite-induced apoptosis
    • Chen YH, Lin-Shiau SY, Lin JK: Involvement of reactive oxygen species and caspase-3 activation in arsenite-induced apoptosis. J Cell Physiol 1998;177:324-333.
    • (1998) J Cell Physiol , vol.177 , pp. 324-333
    • Chen, Y.H.1    Lin-Shiau, S.Y.2    Lin, J.K.3
  • 119
    • 0033121186 scopus 로고    scopus 로고
    • Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines
    • Klampfer L., Cammenga J, Wisniewski HG, Nimer SD: Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines. Blood 1999;93:2386-2394.
    • (1999) Blood , vol.93 , pp. 2386-2394
    • Klampfer, L.1    Cammenga, J.2    Wisniewski, H.G.3    Nimer, S.D.4
  • 120
    • 0029115954 scopus 로고
    • Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells
    • Shiff SJ, Qiao L, Tsai LL, Rigas B: Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells. J Clin Invest 1995;96:491-503.
    • (1995) J Clin Invest , vol.96 , pp. 491-503
    • Shiff, S.J.1    Qiao, L.2    Tsai, L.L.3    Rigas, B.4
  • 121
    • 0033575760 scopus 로고    scopus 로고
    • Malignant transformation and antineoplastic actions of non-steroidal anti-inflammatory drugs (NSAIDs) on cyclooxy-genase-null embryo fibroblasts
    • Zhang X, Morham SG, Langenbach R, Young DA: Malignant transformation and antineoplastic actions of non-steroidal anti-inflammatory drugs (NSAIDs) on cyclooxy-genase-null embryo fibroblasts. J Exp Med 1999;90:451-459.
    • (1999) J Exp Med , vol.90 , pp. 451-459
    • Zhang, X.1    Morham, S.G.2    Langenbach, R.3    Young, D.A.4
  • 122
    • 0033575796 scopus 로고    scopus 로고
    • The role of cyclooxygenase inhibition in the antineoplastic effects of non-steroidal anti-inflammatory drugs (NSAIDs)
    • Shiff SJ, Rigas B: The role of cyclooxygenase inhibition in the antineoplastic effects of non-steroidal anti-inflammatory drugs (NSAIDs). J Exp Med 1999;190:445-450.
    • (1999) J Exp Med , vol.190 , pp. 445-450
    • Shiff, S.J.1    Rigas, B.2
  • 123
    • 0032992467 scopus 로고    scopus 로고
    • Salicylates and sulfasalazine, but not glu-cocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFκB
    • Cronstein BN, Montesinos MC, Weissmann G: Salicylates and sulfasalazine, but not glu-cocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6377-6381
    • Cronstein, B.N.1    Montesinos, M.C.2    Weissmann, G.3
  • 124
    • 0022505922 scopus 로고
    • Reye's syndrome: Mitochondrial swelling and Ca(2+)release induced by Reye's plasma, allantoin and salicylate
    • Martens ME, Chang CH, Lee CP: Reye's syndrome: Mitochondrial swelling and Ca(2+)release induced by Reye's plasma, allantoin and salicylate. Arch Biochem Biophys 1986;244: 773-786.
    • (1986) Arch Biochem Biophys , vol.244 , pp. 773-786
    • Martens, M.E.1    Chang, C.H.2    Lee, C.P.3
  • 125
    • 0028347022 scopus 로고
    • Acetylsalicylate-induced mitochondrial dysfunction and its potentiation by Ca(2+)
    • Tomoda T, Takeda K, Kurashige T, Enzan H, Miyahara M: Acetylsalicylate-induced mitochondrial dysfunction and its potentiation by Ca(2+). Liver 1994;14:103-108.
    • (1994) Liver , vol.14 , pp. 103-108
    • Tomoda, T.1    Takeda, K.2    Kurashige, T.3    Enzan, H.4    Miyahara, M.5
  • 126
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA: Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1997; 272:3406-3410.
    • (1997) J Biol Chem , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 128
    • 0037108708 scopus 로고    scopus 로고
    • Benzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G(2)-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cells
    • Moon EY, Lerner A: Benzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G(2)-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cells. Cancer Res 2002;62:5711-5719.
    • (2002) Cancer Res , vol.62 , pp. 5711-5719
    • Moon, E.Y.1    Lerner, A.2
  • 129
    • 0028207597 scopus 로고
    • Etodolac clinical pharmacokinetics
    • Brocks DR, Jamali F: Etodolac clinical pharmacokinetics. Clin Pharmacokinet 1994;26: 259-274.
    • (1994) Clin Pharmacokinet , vol.26 , pp. 259-274
    • Brocks, D.R.1    Jamali, F.2
  • 130
    • 0021022219 scopus 로고
    • Resolution of etodolac and anti-inflammatory and prostaglandin synthetase inhibiting properties of the enantiomers
    • Demerson CA, Humber LG, Abraham NA, Schilling G, Martel RR, Pace-Asciak C: Resolution of etodolac and anti-inflammatory and prostaglandin synthetase inhibiting properties of the enantiomers. J Med Chem 1983; 26:1778-1780.
    • (1983) J Med Chem , vol.26 , pp. 1778-1780
    • Demerson, C.A.1    Humber, L.G.2    Abraham, N.A.3    Schilling, G.4    Martel, R.R.5    Pace-Asciak, C.6
  • 131
    • 26344470693 scopus 로고    scopus 로고
    • Enhanced clearance of leukemic lymphocytes in B-cell chronic lymphocytic leukemia with etodolac
    • Nardella FA, LeFevre JA: Enhanced clearance of leukemic lymphocytes in B-cell chronic lymphocytic leukemia with etodolac. Arthritis Rheum 1999;42:S56.
    • (1999) Arthritis Rheum , vol.42
    • Nardella, F.A.1    LeFevre, J.A.2
  • 132
    • 0024556599 scopus 로고
    • Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro
    • Collins RJ, Verschuer LA, Harmon BV, Prentice RL, Pope JH, Kerr JF: Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro. Br J Haematol 1989;71:343-350.
    • (1989) Br J Haematol , vol.71 , pp. 343-350
    • Collins, R.J.1    Verschuer, L.A.2    Harmon, B.V.3    Prentice, R.L.4    Pope, J.H.5    Kerr, J.F.6
  • 134
    • 0033927332 scopus 로고    scopus 로고
    • Nitrogen cavitation for cell disruption to obtain mitochondria from cultured cells
    • Gottlieb R, Adachi S: Nitrogen cavitation for cell disruption to obtain mitochondria from cultured cells. Methods Enzymol 2000;322: 213-221.
    • (2000) Methods Enzymol , vol.322 , pp. 213-221
    • Gottlieb, R.1    Adachi, S.2
  • 135
    • 0030803271 scopus 로고    scopus 로고
    • Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis
    • Adachi S, Cross AR, Babior BM, Gottlieb RA: Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis. J Biol Chem 1997;272:21878-21882.
    • (1997) J Biol Chem , vol.272 , pp. 21878-21882
    • Adachi, S.1    Cross, A.R.2    Babior, B.M.3    Gottlieb, R.A.4
  • 138
    • 0344408361 scopus 로고    scopus 로고
    • Etodolac: A nonsteroidal anti-inflammatory drug that induces apoptosis in B-cell chronic lymphocytic leukemia cells in vitro and in vivo
    • Adachi S, Amox DG, Kitada S, Carson DA, Leoni LM: Etodolac: A nonsteroidal anti-inflammatory drug that induces apoptosis in B-cell chronic lymphocytic leukemia cells in vitro and in vivo (abstract). Proc Am Assoc Cancer Res 2000;41:739.
    • (2000) Proc Am Assoc Cancer Res , vol.41 , pp. 739
    • Adachi, S.1    Amox, D.G.2    Kitada, S.3    Carson, D.A.4    Leoni, L.M.5
  • 140
    • 0033594911 scopus 로고    scopus 로고
    • Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
    • Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR: Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc Natl Acad Sci USA 1999;96:7563-7568.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7563-7568
    • Warner, T.D.1    Giuliano, F.2    Vojnovic, I.3    Bukasa, A.4    Mitchell, J.A.5    Vane, J.R.6
  • 141
    • 0345271311 scopus 로고    scopus 로고
    • In vitro and in vivo activity of SDX-101 (R-etodolac), a pro-apoptotic compound for the treatment of chronic lymphocytic leukemia, multiple myeloma and lymphoma
    • Leoni LM, Carson DA, Scranton S, Rosenthal AS: In vitro and in vivo activity of SDX-101 (R-etodolac), a pro-apoptotic compound for the treatment of chronic lymphocytic leukemia, multiple myeloma and lymphoma (abstract). Ann Oncol 2002;13:
    • (2002) Ann Oncol , vol.13 , pp. 147
    • Leoni, L.M.1    Carson, D.A.2    Scranton, S.3    Rosenthal, A.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.