-
1
-
-
0035496899
-
Chronic myeloid leukemia: current treatment options
-
JM Goldman BJ Druker Chronic myeloid leukemia: current treatment options Blood 98 2001 2039 2042
-
(2001)
Blood
, vol.98
, pp. 2039-2042
-
-
Goldman, JM1
Druker, BJ2
-
2
-
-
0030031766
-
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylamino-pyrimidine derivative
-
E Buchdunger J Zimmermann H Mett Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylamino-pyrimidine derivative Cancer Res 56 1996 100 104
-
(1996)
Cancer Res
, vol.56
, pp. 100-104
-
-
Buchdunger, E1
Zimmermann, J2
Mett, H3
-
3
-
-
0031026055
-
Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives
-
J Zimmermann E Buchdunger H Mett Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives Bioorg Med Chem Lett 7 1997 187 192
-
(1997)
Bioorg Med Chem Lett
, vol.7
, pp. 187-192
-
-
Zimmermann, J1
Buchdunger, E2
Mett, H3
-
4
-
-
0035871874
-
ARG tyrosine kinase activity is inhibited by STI571
-
K Okuda E Weisberg DG Gilliland JD Griffin ARG tyrosine kinase activity is inhibited by STI571 Blood 97 2001 2440 2448
-
(2001)
Blood
, vol.97
, pp. 2440-2448
-
-
Okuda, K1
Weisberg, E2
Gilliland, DG3
Griffin, JD4
-
5
-
-
0021674862
-
An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity
-
J Konopa S Watanabe O Witte An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity Cell 37 1984 1035 1042
-
(1984)
Cell
, vol.37
, pp. 1035-1042
-
-
Konopa, J1
Watanabe, S2
Witte, O3
-
7
-
-
0002200308
-
Chronic myelogenous leukemia: disease biology and current and future therapeutic strategies
-
H Kantarjian JV Melo S Tura Chronic myelogenous leukemia: disease biology and current and future therapeutic strategies Hematology (Am Soc Hematol Educ Program) 2000 90 109
-
(2000)
Hematology (Am Soc Hematol Educ Program)
, pp. 90-109
-
-
Kantarjian, H1
Melo, JV2
Tura, S3
-
8
-
-
0036139993
-
STI571: a paradigm of new agents for cancer therapeutics
-
MJ Mauro M O'Dwyer MC Heinrich BJ Druker STI571: a paradigm of new agents for cancer therapeutics J Clin Oncol 20 2002 325 334
-
(2002)
J Clin Oncol
, vol.20
, pp. 325-334
-
-
Mauro, MJ1
O'Dwyer, M2
Heinrich, MC3
Druker, BJ4
-
9
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
BJ Druker S Tamura E Buchdunger Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells Nat Med 2 1996 561 566
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, BJ1
Tamura, S2
Buchdunger, E3
-
10
-
-
0031409736
-
Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis
-
C Gambacorti-Passerini P le Coutre L Mologni Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL+ leukemic cells and induces apoptosis Blood Cells Mol Dis 23 1997 380 394
-
(1997)
Blood Cells Mol Dis
, vol.23
, pp. 380-394
-
-
Gambacorti-Passerini, C1
le Coutre, P2
Mologni, L3
-
11
-
-
0030853063
-
The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells
-
MW Deininger JM Goldman N Lydon JV Melo The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells Blood 90 1997 3691 3698
-
(1997)
Blood
, vol.90
, pp. 3691-3698
-
-
Deininger, MW1
Goldman, JM2
Lydon, N3
Melo, JV4
-
12
-
-
0033585504
-
In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor
-
P le Coutre L Mologni L Cleris In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor J Natl Cancer Inst 91 1999 163 168
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 163-168
-
-
le Coutre, P1
Mologni, L2
Cleris, L3
-
13
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
-
T Schindler W Bornmann P Pellicena Structural mechanism for STI-571 inhibition of abelson tyrosine kinase Science 289 2000 1938 1942
-
(2000)
Science
, vol.289
, pp. 1938-1942
-
-
Schindler, T1
Bornmann, W2
Pellicena, P3
-
14
-
-
0037105560
-
A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias
-
OG Ottmann BJ Druker CL Sawyers A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias Blood 100 2002 1965 1971
-
(2002)
Blood
, vol.100
, pp. 1965-1971
-
-
Ottmann, OG1
Druker, BJ2
Sawyers, CL3
-
15
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study
-
CL Sawyers A Hochhaus E Feldman Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study Blood 99 2002 3530 3539
-
(2002)
Blood
, vol.99
, pp. 3530-3539
-
-
Sawyers, CL1
Hochhaus, A2
Feldman, E3
-
16
-
-
0037085785
-
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study
-
M Talpaz RT Silver BJ Druker Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study Blood 99 2002 1928 1937
-
(2002)
Blood
, vol.99
, pp. 1928-1937
-
-
Talpaz, M1
Silver, RT2
Druker, BJ3
-
17
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
H Kantarjian C Sawyers A Hochhaus Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia N Engl J Med 346 2002 645 652
-
(2002)
N Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H1
Sawyers, C2
Hochhaus, A3
-
18
-
-
0002694995
-
STI571 (Gleevec/Glivec, imatinib) versus interferon (IFN) + cytarabine as initial therapy for patients with CML: results of a randomized study
-
B Druker STI571 (Gleevec/Glivec, imatinib) versus interferon (IFN) + cytarabine as initial therapy for patients with CML: results of a randomized study Proc Am Soc Clin Oncol 20 2002 (abstr 1)
-
(2002)
Proc Am Soc Clin Oncol
, vol.20
-
-
Druker, B1
-
19
-
-
0036682958
-
Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene
-
MK Magnusson KE Meade R Nakamura Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene Blood 100 2002 1088 1091
-
(2002)
Blood
, vol.100
, pp. 1088-1091
-
-
Magnusson, MK1
Meade, KE2
Nakamura, R3
-
20
-
-
0037103624
-
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
-
JF Apperley M Gardembas JV Melo Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta N Engl J Med 347 2002 481 487
-
(2002)
N Engl J Med
, vol.347
, pp. 481-487
-
-
Apperley, JF1
Gardembas, M2
Melo, JV3
-
21
-
-
0035960428
-
Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study
-
AT van Oosterom I Judson J Verweij Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study Lancet 358 2001 1421 1423
-
(2001)
Lancet
, vol.358
, pp. 1421-1423
-
-
van Oosterom, AT1
Judson, I2
Verweij, J3
-
22
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
GD Demetri M von Mehren CD Blanke Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors N Eng J Med 347 2002 472 480
-
(2002)
N Eng J Med
, vol.347
, pp. 472-480
-
-
Demetri, GD1
von Mehren, M2
Blanke, CD3
-
23
-
-
0037087531
-
Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies
-
MC Heinrich CD Blanke BJ Druker CL Corless Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies J Clin Oncol 20 2002 1692 1703
-
(2002)
J Clin Oncol
, vol.20
, pp. 1692-1703
-
-
Heinrich, MC1
Blanke, CD2
Druker, BJ3
Corless, CL4
-
24
-
-
0035823530
-
Case report: rapid and complete control of idiopathic hypereosinophilia with imatinib mesylate
-
JL Schaller GA Burkland Case report: rapid and complete control of idiopathic hypereosinophilia with imatinib mesylate Med Gen Med 3 2001 9
-
(2001)
Med Gen Med
, vol.3
, pp. 9
-
-
Schaller, JL1
Burkland, GA2
-
25
-
-
0037018763
-
Treatment of hypereosinophilic syndrome with imatinib mesilate
-
GJ Gleich KM Leiferman A Pardanani Treatment of hypereosinophilic syndrome with imatinib mesilate Lancet 359 2002 1577 1578
-
(2002)
Lancet
, vol.359
, pp. 1577-1578
-
-
Gleich, GJ1
Leiferman, KM2
Pardanani, A3
-
26
-
-
0037143794
-
Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans
-
RG Maki RA Awan RH Dixon Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans Int J Cancer 100 2002 623 626
-
(2002)
Int J Cancer
, vol.100
, pp. 623-626
-
-
Maki, RG1
Awan, RA2
Dixon, RH3
-
27
-
-
0036727124
-
Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
-
BP Rubin SM Schuetze JF Eary Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans J Clin Oncol 20 2002 3586 3591
-
(2002)
J Clin Oncol
, vol.20
, pp. 3586-3591
-
-
Rubin, BP1
Schuetze, SM2
Eary, JF3
-
28
-
-
31344468209
-
BCR-ABL gene amplification causes reversible cytogenetic relapse and resistance to imatinib (STI571) in a chronic phase CML patients
-
C Gambacorti-Passerini S Bungaro G Cazzaniga BCR-ABL gene amplification causes reversible cytogenetic relapse and resistance to imatinib (STI571) in a chronic phase CML patients Blood 100 2002 216a (abstr 4376).
-
(2002)
Blood
, vol.100
, pp. 216a
-
-
Gambacorti-Passerini, C1
Bungaro, S2
Cazzaniga, G3
-
29
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
BJ Druker M Talpaz DJ Resta Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia N Engl J Med 344 2001 1031 1037
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, BJ1
Talpaz, M2
Resta, DJ3
-
30
-
-
0036431559
-
Differences between in vivo and in vitro sensitivity to imatinib of Bcr/Abl+ cells obtained from leukemic patients
-
C Gambacorti-Passerini F Rossi M Verga Differences between in vivo and in vitro sensitivity to imatinib of Bcr/Abl+ cells obtained from leukemic patients Blood Cells Mol Dis 28 2002 361 372
-
(2002)
Blood Cells Mol Dis
, vol.28
, pp. 361-372
-
-
Gambacorti-Passerini, C1
Rossi, F2
Verga, M3
-
31
-
-
0035929673
-
Roots of clinical resistance to STI-571 cancer therapy
-
ME Gorre NP Shah K Ellwood Roots of clinical resistance to STI-571 cancer therapy Science 293 2001 2163 (abstr).
-
(2001)
Science
, vol.293
, pp. 2163
-
-
Gorre, ME1
Shah, NP2
Ellwood, K3
-
32
-
-
0034161460
-
Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification
-
P le Coutre E Tassi M Varella-Garcia Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification Blood 95 2000 1758 1766
-
(2000)
Blood
, vol.95
, pp. 1758-1766
-
-
le Coutre, P1
Tassi, E2
Varella-Garcia, M3
-
33
-
-
0034210577
-
Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines
-
E Weisberg JD Griffin Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines Blood 95 2000 3498 3505
-
(2000)
Blood
, vol.95
, pp. 3498-3505
-
-
Weisberg, E1
Griffin, JD2
-
34
-
-
0034254368
-
Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance
-
FX Mahon MW Deininger B Schultheis Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance Blood 96 2000 1070 1079
-
(2000)
Blood
, vol.96
, pp. 1070-1079
-
-
Mahon, FX1
Deininger, MW2
Schultheis, B3
-
35
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
ME Gorre M Mohammed K Ellwood Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification Science 293 2001 876 880
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, ME1
Mohammed, M2
Ellwood, K3
-
36
-
-
0036566540
-
High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
-
S Branford Z Rudzki S Walsh High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance Blood 99 2002 3472 3475
-
(2002)
Blood
, vol.99
, pp. 3472-3475
-
-
Branford, S1
Rudzki, Z2
Walsh, S3
-
37
-
-
0037045589
-
Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study
-
WK Hofmann S de Vos D Elashoff Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study Lancet 359 2002 481 486
-
(2002)
Lancet
, vol.359
, pp. 481-486
-
-
Hofmann, WK1
de Vos, S2
Elashoff, D3
-
38
-
-
0001275121
-
Molecular and chromosomal mechanisms of resistance in CML patients after STI571 (Glivec) therapy
-
S Kreil C Muller T Lahaye Molecular and chromosomal mechanisms of resistance in CML patients after STI571 (Glivec) therapy Blood 98 2001 435a (abstr 1823).
-
(2001)
Blood
, vol.98
, pp. 435a
-
-
Kreil, S1
Muller, C2
Lahaye, T3
-
39
-
-
0035895106
-
Restoration of sensitivity to STI571 in STI571-resistant chronic myeloid leukemia cells
-
AJ Tipping FX Mahon V Lagarde Restoration of sensitivity to STI571 in STI571-resistant chronic myeloid leukemia cells Blood 98 2001 3864 3867
-
(2001)
Blood
, vol.98
, pp. 3864-3867
-
-
Tipping, AJ1
Mahon, FX2
Lagarde, V3
-
40
-
-
0036682301
-
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
-
B Nagar WG Bornmann P Pellicena Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571) Cancer Res 62 2002 4236 4243
-
(2002)
Cancer Res
, vol.62
, pp. 4236-4243
-
-
Nagar, B1
Bornmann, WG2
Pellicena, P3
-
41
-
-
0037045583
-
BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study
-
N von Bubnoff F Schneller C Peschel J Duyster BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study Lancet 359 2002 487 491
-
(2002)
Lancet
, vol.359
, pp. 487-491
-
-
von Bubnoff, N1
Schneller, F2
Peschel, C3
Duyster, J4
-
42
-
-
79960970542
-
Resistance to Gleevec: sequence analysis reveals a spectrum of BCR/ABL kinase domain mutations in both acquired- and de novo- resistant cases of chronic myelogenous leukemia (CML) in myeloid blast crisis
-
NP Shah JM Nicoll ME Gorre Resistance to Gleevec: sequence analysis reveals a spectrum of BCR/ABL kinase domain mutations in both acquired- and de novo- resistant cases of chronic myelogenous leukemia (CML) in myeloid blast crisis Blood 98 2001 3205 (abstr 770).
-
(2001)
Blood
, vol.98
, pp. 3205
-
-
Shah, NP1
Nicoll, JM2
Gorre, ME3
-
43
-
-
0035929652
-
Roots of clinical resistance to STI-571 cancer therapy
-
C Barthe P Cony-Makhoul JV Melo JR Mahon Roots of clinical resistance to STI-571 cancer therapy Science 293 2001 2163
-
(2001)
Science
, vol.293
, pp. 2163
-
-
Barthe, C1
Cony-Makhoul, P2
Melo, JV3
Mahon, JR4
-
44
-
-
0035929673
-
Roots of clinical resistance to STI-571 cancer therapy
-
A Hochhaus S Kreil A Corbin Roots of clinical resistance to STI-571 cancer therapy Science 293 2001 2163
-
(2001)
Science
, vol.293
, pp. 2163
-
-
Hochhaus, A1
Kreil, S2
Corbin, A3
-
45
-
-
0036682481
-
Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
-
C Roche-Lestienne V Soenen-Cornu N Grardel-Duflos Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment Blood 100 2002 1014 1018
-
(2002)
Blood
, vol.100
, pp. 1014-1018
-
-
Roche-Lestienne, C1
Soenen-Cornu, V2
Grardel-Duflos, N3
-
46
-
-
0035976571
-
Research on resistance to cancer drug Gleevec
-
CL Sawyers Research on resistance to cancer drug Gleevec Science 294 2001 1834
-
(2001)
Science
, vol.294
, pp. 1834
-
-
Sawyers, CL1
-
47
-
-
0030766163
-
Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog
-
SR Hubbard Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog Embo J 16 1997 5572 5581
-
(1997)
Embo J
, vol.16
, pp. 5572-5581
-
-
Hubbard, SR1
-
48
-
-
0035165210
-
Mechanism-based design of a protein kinase inhibitor
-
K Parang JH Till AJ Ablooglu Mechanism-based design of a protein kinase inhibitor Nat Struct Biol 8 2001 37 41
-
(2001)
Nat Struct Biol
, vol.8
, pp. 37-41
-
-
Parang, K1
Till, JH2
Ablooglu, AJ3
-
49
-
-
0035971245
-
Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism
-
JH Till AJ Ablooglu M Frankel Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism J Biol Chem 276 2001 10049 10055
-
(2001)
J Biol Chem
, vol.276
, pp. 10049-10055
-
-
Till, JH1
Ablooglu, AJ2
Frankel, M3
-
50
-
-
0029644168
-
Adenylate kinase motions during catalysis: an energetic counterweight balancing substrate binding
-
CW Muller GJ Schlauderer J Reinstein GE Schulz Adenylate kinase motions during catalysis: an energetic counterweight balancing substrate binding Structure 4 1996 147 156
-
(1996)
Structure
, vol.4
, pp. 147-156
-
-
Muller, CW1
Schlauderer, GJ2
Reinstein, J3
Schulz, GE4
-
51
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
N Shah J Nicoll B Nagar Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia Cancer Cell 2 2002 117
-
(2002)
Cancer Cell
, vol.2
, pp. 117
-
-
Shah, N1
Nicoll, J2
Nagar, B3
-
52
-
-
0037199996
-
Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571
-
AS Corbin E Buchdunger F Pascal BJ Druker Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571 J Biol Chem 277 2002 32214 32219
-
(2002)
J Biol Chem
, vol.277
, pp. 32214-32219
-
-
Corbin, AS1
Buchdunger, E2
Pascal, F3
Druker, BJ4
-
53
-
-
0042305479
-
Alpha 1 acid glycoprotein (AGP) binds to STI571 and substantially alters its pharmacokinetics in chronic nyeloid leukemia patients
-
C Gambacorti-Passerini M Zucchetti D Russo Alpha 1 acid glycoprotein (AGP) binds to STI571 and substantially alters its pharmacokinetics in chronic nyeloid leukemia patients Clin Cancer Res 9 2003 in press.
-
(2003)
Clin Cancer Res
, vol.9
-
-
Gambacorti-Passerini, C1
Zucchetti, M2
Russo, D3
-
54
-
-
85120117872
-
-
J Ford STI571 investigators' brochure 2001 Novartis AG Basel
-
(2001)
-
-
Ford, J1
-
55
-
-
0035929652
-
Roots of clinical resistance to STI-571 cancer therapy
-
C Gambacorti-Passerini G Corneo M D'Incalci Roots of clinical resistance to STI-571 cancer therapy Science 293 2001 2163
-
(2001)
Science
, vol.293
, pp. 2163
-
-
Gambacorti-Passerini, C1
Corneo, G2
D'Incalci, M3
-
56
-
-
0037129575
-
Decrease of resistance to imatinib in leukaemia
-
C Gambacorti-Passerini Decrease of resistance to imatinib in leukaemia Lancet 359 2002 1776 1777
-
(2002)
Lancet
, vol.359
, pp. 1776-1777
-
-
Gambacorti-Passerini, C1
-
57
-
-
85120092255
-
Elevated 1 evels of the plasma protein alpha 1 acid glycoprotein in chronic myelogenous leukemia in blast crisis mediate pharmacological resistance to Gleevec (STI571, imatinib) in vitro and are associated with primary resistance in vivo
-
J Larghero F Mahon I Madalaine-Chambrin Elevated 1 evels of the plasma protein alpha 1 acid glycoprotein in chronic myelogenous leukemia in blast crisis mediate pharmacological resistance to Gleevec (STI571, imatinib) in vitro and are associated with primary resistance in vivo Blood 98 2001 2582 (abstr 616)
-
(2001)
Blood
, vol.98
, pp. 2582
-
-
Larghero, J1
Mahon, F2
Madalaine-Chambrin, I3
-
58
-
-
18344396578
-
Determination of -1 acid glycoprotein in patients with Ph+ chronic myeloid leukemia during the first 13 weeks of therapy with STI571
-
P le Coutre K Kreuzer I Na Determination of -1 acid glycoprotein in patients with Ph+ chronic myeloid leukemia during the first 13 weeks of therapy with STI571 Blood Cells Mol Dis 28 2002 75 85
-
(2002)
Blood Cells Mol Dis
, vol.28
, pp. 75-85
-
-
le Coutre, P1
Kreuzer, K2
Na, I3
-
59
-
-
0034684075
-
Role of alpha 1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571
-
C Gambacorti-Passerini R Barni P le Coutre Role of alpha 1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571 J Natl Cancer Inst 92 2000 1641 1650
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1641-1650
-
-
Gambacorti-Passerini, C1
Barni, R2
le Coutre, P3
-
60
-
-
0037045574
-
Resistance to targeted therapy in leukaemia
-
JD Griffin Resistance to targeted therapy in leukaemia Lancet 359 2002 458 459
-
(2002)
Lancet
, vol.359
, pp. 458-459
-
-
Griffin, JD1
-
61
-
-
0036493544
-
Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
-
WK Hofmann LC Jones NA Lemp Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation Blood 99 2002 1860 1862
-
(2002)
Blood
, vol.99
, pp. 1860-1862
-
-
Hofmann, WK1
Jones, LC2
Lemp, NA3
|