Protein kinase C inhibitor and irradiation-induced apoptosis: Relevance of the cytochrome c-mediated caspase-9 death pathway

Cell Growth and Differentiation

Volumn 11, Issue 9, 2000, Pages 491-499

  Rocha, S ^a   Soengas, M S ^a   Lowe, S W ^a   Glanzmann, C ^a   Fabbro, D ^a   Winterhalter, K ^a   Bodis, S ^a   Pruschy, M ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CYTOCHROME C OXIDASE; PROTEIN KINASE C INHIBITOR; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; ENZYME INHIBITION; IRRADIATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMAL; APOPTOSIS; CASPASES; CYTOCHROME C; ENZYME INHIBITORS; HUMAN; NEOPLASMS; PROTEIN KINASE C; PROTEIN P53; RADIATION TOLERANCE; STAUROSPORINE; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0033800260     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
2. Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis
3. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
4. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
5. Radiation-induced signal transduction and stress response
6. p53 Status and the efficacy of cancer therapy in vivo
7. The complexity of p53 modulation: Emerging patterns from divergent signals
8. p53 Induces apoptosis by caspase activation through mitochondrial cytochrome c release
9. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
10. p90RSK blocks Bad-mediated cell death via a protein kinase C-dependent pathway
11. Protein kinase CβII activation by 1-β-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2α down-regulation
12. Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231
13. Inhibition of protein kinases sensitizes human tumor cells to ionizing radiation
14. BCL-2 family members and the mitochondria in apoptosis
15. Analogs of staurosporine: Potential anticancer drugs?
16. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
17. p53 Is required for radiation-induced apoptosis in mouse thymocytes
18. Bid, a Bcl2-interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
19. Two CD95 (APO-1/Fas) signaling pathways
20. Procaspase-3 is a major physiologic target of caspase-8
21. Oncogene-dependent regulation of caspase activation by p53 protein in a cell-free system
22. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
23. C-Myc-induced sensitization to apoptosis is mediated through cytochrome c release
24. Protein kinase C-α overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal
25. Akt phosphorylation of Bad couples survival signals to the cell-intrinsic death machinery
26. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
27. Ceramide induces caspase-independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis
28. The role of the sphingomyelin pathway and protein kinase C in radiation-induced cell kill
29. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
30. Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells
31. Ceramide induces cytochrome c release from isolated mitochondria. Importance of mitochondrial redox state
32. p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents
33. Differential requirement for caspase 9 in apoptotic pathways in vivo
34. Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity
35. Production of high-titer helper-free retroviruses by transient transfection