Vβ CDR3 motifs associated with BP recognition are enriched in OX-40+ spinal cord T cells of Lewis rats with EAE

Journal of Neuroscience Research

Volumn 44, Issue 6, 1996, Pages 562-567

  Buenafe, A C ^a,b   Weinberg, A D ^a,b   Culbertson, N E ^a   Vandenbark, A A ^a,b   Offner, H ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

autoimmunity; MS; TCR V

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; CELL MARKER; MYELIN BASIC PROTEIN; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CELL SELECTION; FEMALE; INFLAMMATION; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEQUENCE ANALYSIS; SPINAL CORD; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, SURFACE; AUTOANTIGENS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; MEMBRANE GLYCOPROTEINS; MYELIN BASIC PROTEINS; RATS; RATS, INBRED LEW; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, TUMOR NECROSIS FACTOR; SEQUENCE ANALYSIS, DNA; SPINAL CORD; T-LYMPHOCYTES; TUMOR NECROSIS FACTORS;

EID: 0029904390     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960615)44:6<562::AID-JNR6>3.0.CO;2-9     Document Type: Article

References (25)

1. Baum PR, Gayle RB, Ramsdell F, Srinivasan S, Sorensen RA, Watson ML, Seldin MF, Baker E, Sutherland GR, Clifford KN, Alderson MR, Goodwin RG, Fanslow WC (1994): Molecular characterization of murine and human OX-40/OX-40 ligand systems: Identification of a human OX-40 ligand as the HTLV-1-regulated protein gp34. EMBO J 13:3992.
2. Bentley GA, Boulot G, Karjalainen K, Mariuzza RA (1995): Crystal structure of the β chain of a T cell antigen receptor. Science 267:1984-1987.
3. Bourdette DN, Vainiene M, Morrison WJ, Jones R, Turner J, Hashim GA, Vandenbark AA, Offner H (1991): Myelin basic protein specific T cell lines and clones derived from the central nervous system of rats with experimental autoimmune encephalomyelitis only recognize encephalitogenic epitopes. J Neurosci Res 30:308.
4. Buenafe AC, Vainiene M, Celnik B, Vandenbark AA, Offner H (1994): Analysis of Vβ8-CDR3 sequences derived from the CNS of Lewis rats with experimental autoimmune encephalomyelitis. J Immunol 153:386-394.
5. Buenafe AC, Vainiene M, Celnik B, Vandenbark AA, Offner H (1995): Analysis of Vβ8.2-CDR3 sequences from spinal cord T cells of Lewis rats vaccinated or treated with TCR Vβ8.2-39-59 peptide. J Immunol 155:1556-1564.
6. Burns FR, Li X, Shen N, Offner H, Chou Y, Vandenbark AA, Heber-Katz E (1989): Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J Exp Med 169:27-39.
7. Calderhead DM, Buhlmann JE, van den Eertwegh AJM, Claassen E, Noelle RJ, Fell HP (1993): Cloning of mouse Ox40: A T cell activation marker that may mediate T-B cell interactions. J Immunol 151:5261-5271.
8. Chluba J, Steeg C, Becker S, Wekerle H, Epplen JT (1989): T cell receptor β chain usage in myelin basic protein-specific rat T lymphocytes. Eur J Immunol 19:279.
9. Chothia C, Boswell DR, Lesk AM (1988): The outline structure of the T-cell αβ receptor. EMBO J 7:3745.
10. Davis MM, Bjorkman PJ (1988): T-cell antigen receptor genes and T-cell recognition. Nature 334:395.
11. + T cells with homology to tumor necrosis factor. J Exp Med 180:757.
12. Gold DP, Offner H, Sun D, Wilery S, Vandenbark AA, Wilson DB (1991): Analysis of T cell receptor β chains in Lewis rats with experimental allergic encephalomyelitis: Conserved complementary determining region 3. J Exp Med 174:1476.
13. Gold DP, Vainiene M, Celnik B, Wiley S, Gibbs C, Hashim GA, Vandenbark AA, Offner H (1992): Characterization of the immune response to a secondary encephalitogenic epitope of basic protein in Lewis rats. II. Biased T cell receptor Vβ expression predominates in spinal cord infiltrating T cells. J Immunol 148:1712.
14. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C (1991): "Sequences of Proteins of Immunologic Interest." 5th ed. NIH Publication No. 91-3242. Bethesda, MD: U. S. Department of Health and Human Services, Public Health Service.
15. Latza U, Durkop H, Schnittger S, Ringeling J, Eitelbach F, Hummel M, Fonatsch C, Stein H (1994): The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen. Eur J Immunol 24:677-683.
16. Mallett S, Barclay AN (1991): A new superfamily of cell surface proteins related to the nerve growth factor receptor. Immunol Today 12:220-223.
17. Offner H, Buenafe AC, Vainiene M, Celnik B, Weinberg AD, Gold DP, Hashim G, Vandenbark AA (1993): Where, when, and how to detect biased expression of disease-relevant Vβ genes in rats with experimental autoimmune encephalomyelitis. J Immunol 151:506.
18. Oksenberg JR, Panzara MA, Begovich AB, Mitchell D, Erlich HA, Murray RS, Shimonkevitz R, Sherritt M, Rothbard J, Bernard CCA, Steinman L (1993): Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature 362:68.
19. Paterson DJ, Jefferies WA, Green JR, Brandon MR, Corthesy P, Puklavec M, Williams AF (1987): Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol Immunol 24:1281.
20. Smith CA, Farrah T, Goodwin RG (1994): The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death. Cell 76:959-962.
21. Vandenbark AA, Vainiene M, Celnik B, Hashim G, Offner H (1992): TCR peptide therapy decreases the frequency of encephalitogenic T cells in the periphery and the central nervous system. J Neuroimmunol 39:251.
22. Weinberg AD, Wallin JJ, Jones RE, Sullivan TJ, Bourdette DN, Vandenbark AA, Offner H (1994): Target organ specific upregulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis. J Immunol 152:4712.
23. + T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis. J Neurosc Res 43:42.
24. Weinberg AD, Bourdette DN, Sullivan TJ, Lemon M, Wallin JJ, Maziarz R, Davey M, Palida F, Godfrey W, Engleman E, Fulton RJ, Offner H, Vandenbark AA (1996b): Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis. Nature Med 2: 183-189.
25. Zhang X-M, Heber-Katz E (1992): T cell receptor sequences from encephalitogenic T cells in adult Lewis rats suggest an early ontogenic origin. J Immunol 148:746.