Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine

Journal of Biological Chemistry

Volumn 276, Issue 21, 2001, Pages 17914-17919

  Curman, Darko ^a   Cinel, Bruno ^a   Williams, David E ^a   Rundle, Natalie ^a   Block, Wesley D ^d   Goodarzi, Aaron A ^d   Hutchins, James R ^b   Clarke, Paul R ^b   Zhou, Bin Bing ^c   Lees Miller, Susan P ^d   Andersen, Raymond J ^a   Roberge, Michel ^a,e  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

^d UNIVERSITY OF CALGARY   (Canada)

^e 2146 Health Sciences Mall ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYME INHIBITION; MOLECULAR STRUCTURE; MUTAGENESIS; PROTEINS; TOXICITY;

CYTOTOXICITY;

BIOCHEMISTRY;

ALKALOID DERIVATIVE; ATM PROTEIN; ATM RAD 3 RELATED PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CHECKPOINT KINASE RAD3; DEBROMOHYMENIALDISINE; DNA DEPENDENT PROTEIN KINASE; PROTEIN KINASE; UNCLASSIFIED DRUG; ALKALOID; AZEPINE DERIVATIVE; ENZYME INHIBITOR; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PYRROLE DERIVATIVE;

ARTICLE; ATAXIA TELANGIECTASIA; CANCER CELL; CELL CYCLE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVATION; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPONGE (PORIFERA); WESTERN BLOTTING; ANIMAL; CELL LINE; DRUG EFFECT;

MINK CELL FOCUS-FORMING VIRUS; PORIFERA;

ALKALOIDS; ANIMALS; AZEPINES; CELL LINE; DNA DAMAGE; ENZYME INHIBITORS; G2 PHASE; PORIFERA; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PYRROLES; SIGNAL TRANSDUCTION;

EID: 0242659422     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100728200     Document Type: Article

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