UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line

Biochemical and Biophysical Research Communications

Volumn 219, Issue 3, 1996, Pages 778-783

  Kawakami, Kimihiro ^a   Futami, Hitoyasu ^a   Takahara, Jiro ^b   Yamaguchi, Ken ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; CYCLIN DEPENDENT KINASE; GENE PRODUCT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; LUNG CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE;

ALKALOIDS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL CYCLE; CELL LINE; CYCLIN-DEPENDENT KINASES; DNA, NEOPLASM; ENZYME INHIBITORS; HISTONES; HUMANS; LUNG NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASE C; RETINOBLASTOMA PROTEIN; STAUROSPORINE; TUMOR CELLS, CULTURED;

EID: 0029871688     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1996.0310     Document Type: Article

References (22)

1. Arion, D., Meijer, L., Brizuela, L., and Beach, D. (1988) Cell 55, 371-378.
2. Elledge, S. J., Richman, R., Hall, F. L., Williams, R. T., Lodgson, N., and Harper, J. W. (1992) Proc. Natl. Acad. Sci. USA 89, 2907-2911.
3. Matsushime, H., Ewen, M. E., Strom, D. K., Kato, J. Y., Hanks, S. K., Roussel, M. F., and Sherr, C. J. (1992) Cell 71, 323-334.
4. Serrano, M., Hannon, G. J., and Beach, D. (1993) Nature 366, 704-707.
5. Meyerson, M., and Harlow, E. (1994) Mol Cell Biol 14, 2077-2086.
6. DeCaprio, J. A., Ludlow, J. W., Figge, J., Shew, J. Y., Huang, C. M., Lee, W. H., Marsilio, E., Paucha, E., and Livingston, D. M. (1988) Cell 54, 275-283.
7. Ludlow, J. W., DeCaprio, J. A., Huang, C. M., Lee, W. H., Paucha, E., and Livingston, D. M. (1989) Cell 56, 57-65.
8. Xiong, Y., Zhang, H., and Beach, D. (1992) Cell 71, 504-514.
9. Devoto, S. H., Mudryj, M., Pines, J., Hunter, T., and Nevins, J. R. (1992) Cell 68, 167-176.
10. Takahashi, I., Kobayashi, E., Asano, K., Yoshida, M., and Nakano, H. (1987) J Antibiot (Tokyo) 40, 1782-1784.
11. Akinaga, S., Gomi, K., Morimoto, M., Tamaoki, T., and Okabe, M. (1991) Cancer Res 51, 4888-4892.
12. Tamaoki, T. (1991) Methods Enzymology 201, 340-347.
13. Akinaga, S., Nomura, K., Gomi, K., and Okabe, M. (1993) Cancer Chemother Pharmacol 32, 183-189.
14. Seynaeve, C. M., Stetler, S. M., Sebers, S., Kaur, G., Sausville, E. A., and Worland, P. J. (1993) Cancer Res 53, 2081-2086.
15. Tamaki, T., Kanakura, Y., Kuriu, A., Ikeda, H., Mitsui, H., Yagura, H., Matsumura, I., Druker, B., Griffin, J. D., Kanayama, Y., and et, a. 1. (1992) Cancer Res 52, 566-570.
16. Mittnacht, S., and Weinberg, R. A. (1991) Cell 65, 381-393.
17. Cordon, C. C., and Richon, V. M. (1994) Ann J Pathol 144, 500-510.
18. Koff, A., Cross, F., Fisher, A., Schumacher, J., Leguellec, K., Philippe, M., and Roberts, J. M. (1991) Cell 66, 1217-1228.
19. Gadbois, D. M., Hamaguchi, J. R., Swank, R. A., and Bradbury, E. M. (1992) Biochem Biophys Res Commun 184, 80-85.
20. Kitagawa, M., Okabe, T., Ogino, H., Matsumoto, H., Suzuki, T. I., Kokubo, T., Higashi, H., Saitoh, S., Taya, Y., Yasuda, H., and et, a. 1. (1993) Oncogene 8, 2425-2432.
21. Feldman, S. T., and Schonthal, A. (1994) Cancer Res 54, 494-498.
22. Strickland, J. E., Dlugosz, A. A., Hennings, H., and Yuspa, S. H. (1993) Carcinogenesis 14, 205-209.