Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with Immunosuppressant properties

Biochemistry

Volumn 41, Issue 24, 2002, Pages 7781-7794

  Schmalhofer, William A ^a   Bao, Jianming ^a   McManus, Owen B ^a   Green, Brian ^a   Matyskiela, Mary ^a   Wunderler, Denise ^a   Bugianesi, Randal M ^a   Felix, John P ^a   Hanner, Markus ^a,b   Linde Arias, Ana Rosa ^a   Ponte, Cristiano G ^a   Velasco, Lucia ^a   Koo, Gloria ^a   Staruch, Mary Jo ^a   Miao, Shouwu ^a   Parsons, William H ^a   Rupprecht, Kathleen ^a   Slaughter, Robert S ^a   Kaczorowski, Gregory J ^a   Garcia, Maria L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b INTERCEL   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSANTS;

ASSAYS; DISEASES; ENZYMES; ISOMERS; POTASSIUM;

BIOCHEMISTRY;

4 PHENYL 4 [3 (2 METHOXYPHENYL) 3 OXO 2 AZAPROP 1 YL]CYCLOHEXANONE; IMMUNOSUPPRESSIVE AGENT; KV1.3 CHANNEL INHIBITOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; HUMAN; HUMAN CELL; ISOMERISM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE ACTIVATION; VOLTAGE CLAMP;

ALANINE; ANIMALS; BINDING SITES; CELL LINE; CHO CELLS; CRICETINAE; CYCLOHEXANONES; GUINEA PIGS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTRACELLULAR FLUID; KV1.3 POTASSIUM CHANNEL; LYMPHOCYTE ACTIVATION; MONOIODOTYROSINE; PATCH-CLAMP TECHNIQUES; PHENYLALANINE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; SCORPION VENOMS; T-LYMPHOCYTES; TRANSFECTION; TRITERPENES; TYROSINE;

EID: 18444373237     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi025722c     Document Type: Article

References (37)