Di-substituted cyclohexyl derivatives bind to two identical sites with positive cooperativity on the voltage-gated potassium channel, Kv1.3

Biochemistry

Volumn 42, Issue 16, 2003, Pages 4733-4743

  Schmalhofer, William A ^a   Slaughter, Robert S ^a   Matyskiela, Mary ^a   Felix, John P ^a   Tang, Yui S ^a   Rupprecht, Kathleen ^a   Kaczorowski, Gregory J ^a   Garcia, Maria L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; ISOTHERMS; POTASSIUM; PROTEINS;

HILL COEFFICIENTS;

ENZYME INHIBITION;

1 (N PROPYLCARBAMOYLOXY) 4 PHENYL 4 [3 (2 METHOXYPHENYL) 3 OXO 2 AZAPROP 1 YL]CYCLOHEXANE; CYCLOHEXYL DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; POTASSIUM CHANNEL; TRITIUM; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CHANNEL GATING; CORRELATION ANALYSIS; DRUG SYNTHESIS; ISOTOPE LABELING; PRIORITY JOURNAL; PROTEIN CONFORMATION;

AZA COMPOUNDS; BINDING SITES; BINDING, COMPETITIVE; CYCLOHEXANES; ISOMERISM; KINETICS; KV1.3 POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN BINDING;

TRITIUM;

EID: 0037472141     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034122q     Document Type: Article

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