Delineation of the Clotrimazole/TRAM-34 Binding Site on the Intermediate Conductance Calcium-activated Potassium Channel, IKCa1

Journal of Biological Chemistry

Volumn 276, Issue 34, 2001, Pages 32040-32045

  Wulff, Heike ^a   Gutman, George A ^a,b   Cahalan, Michael D ^a   Chandy, K George ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CALCIUM; CELLS; DISEASES; DRUG PRODUCTS; HYDROPHOBICITY;

BINDING SITES;

BIOCHEMISTRY;

[1 (2 CHLOROPHENYL)DIPHENYL METHYL] 1H PYRAZOLE; ACETONITRILE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CHARYBDOTOXIN; CLOTRIMAZOLE; ECONAZOLE; KETOCONAZOLE; NIFEDIPINE; PYRAZOLE DERIVATIVE; TETRAZOLE DERIVATIVE; TETRYLAMMONIUM; UNCLASSIFIED DRUG; CALCIUM; CALCIUM CHANNEL; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; KCNN4 PROTEIN, HUMAN; POTASSIUM CHANNEL; TRAM 34;

AMINO ACID SUBSTITUTION; ARTICLE; CHIMERA; DIARRHEA; DRUG BINDING SITE; HYDROPHOBICITY; IMMUNOSUPPRESSIVE TREATMENT; LIPOPHILICITY; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SICKLE CELL ANEMIA; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOPLASM; DRUG ANTAGONISM; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BINDING SITES; CALCIUM; CALCIUM CHANNELS; CLOTRIMAZOLE; CYTOPLASM; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNELS; PROTEIN CONFORMATION; PYRAZOLES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035943601     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105231200     Document Type: Article

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