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Volumn 4, Issue 9, 2003, Pages 679-689

The development and regulation of gene repair

Author keywords

[No Author keywords available]

Indexed keywords

ACETOLACTATE SYNTHASE; ALKALINE PHOSPHATASE; ALPHA GALACTOSIDASE; ALPHA GLUCOSIDASE; APOLIPOPROTEIN E2; BETA GALACTOSIDASE; BETA GLOBIN; BLOOD CLOTTING FACTOR 9; CARBONATE DEHYDRATASE II; DYSTROPHIN; GAMMA GLOBIN; GENE PRODUCT; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; HYGROMYCIN; KANAMYCIN; MONOPHENOL MONOOXYGENASE; TETRACYCLINE; UNCLASSIFIED DRUG;

EID: 0042881052     PISSN: 14710056     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrg1156     Document Type: Review
Times cited : (58)

References (104)
  • 1
    • 0038745599 scopus 로고    scopus 로고
    • Progress and problems with the use of viral vectors for gene therapy
    • Thomas, C. E., Ehrhardt, A. & Kay, M. A. Progress and problems with the use of viral vectors for gene therapy. Nature Rev. Genet. 4, 346-358 (2003).
    • (2003) Nature Rev. Genet. , vol.4 , pp. 346-358
    • Thomas, C.E.1    Ehrhardt, A.2    Kay, M.A.3
  • 2
    • 0033996420 scopus 로고    scopus 로고
    • Long-term survival of ex-thalassemic patients with persistent mixed chimerism after bone marrow transplantation
    • Andreani, M. et al. Long-term survival of ex-thalassemic patients with persistent mixed chimerism after bone marrow transplantation. Bone Marrow Transplant 25, 401-404 (2000).
    • (2000) Bone Marrow Transplant , vol.25 , pp. 401-404
    • Andreani, M.1
  • 3
    • 0037314854 scopus 로고    scopus 로고
    • Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy
    • Hayashi, S. et al. Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy. Exp. Hematol. 31, 176-184 (2003).
    • (2003) Exp. Hematol. , vol.31 , pp. 176-184
    • Hayashi, S.1
  • 5
    • 0028023427 scopus 로고
    • Genetic recombination of nucleosomal templates is mediated by transcription
    • Kotani, H., Sekiguchi, J. M., Dutta, S. & Kmiec, E. B. Genetic recombination of nucleosomal templates is mediated by transcription. Mol. Gen. Genet. 244, 410-419 (1994). This paper describes the initial observations that led to the design of the chimaera.
    • (1994) Mol. Gen. Genet. , vol.244 , pp. 410-419
    • Kotani, H.1    Sekiguchi, J.M.2    Dutta, S.3    Kmiec, E.B.4
  • 6
    • 0028242846 scopus 로고
    • DNA cruciforms facilitate in vitro strand transfer on nucleosomal templates
    • Kotani, H. & Kmiec. E. B. DNA cruciforms facilitate in vitro strand transfer on nucleosomal templates. Mol. Gen. Genet 243, 681-690 (1994).
    • (1994) Mol. Gen. Genet. , vol.243 , pp. 681-690
    • Kotani, H.1    Kmiec, E.B.2
  • 7
    • 0038799991 scopus 로고    scopus 로고
    • Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
    • Paques, F. & Haber, J. E. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63, 349-404 (1999).
    • (1999) Microbiol. Mol. Biol. Rev. , vol.63 , pp. 349-404
    • Paques, F.1    Haber, J.E.2
  • 8
    • 0023709918 scopus 로고
    • Transformation of yeast with synthetic oligonucleotides
    • Moerschell, R. P., Tsunasawa, S. & Sherman, F. Transformation of yeast with synthetic oligonucleotides. Proc. Natl Acad. Sci. USA 85, 524-528 (1988). A pioneering paper that describes the use of oligonucleotides in yeast targeting.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 524-528
    • Moerschell, R.P.1    Tsunasawa, S.2    Sherman, F.3
  • 9
    • 0026704096 scopus 로고
    • Strand-specificity in the transformation of yeast with synthetic oligonucleotides
    • Yamamoto, T., Moerschell, R. P., Wakem, L. P., Komar-Panicucci, S. & Sherman, F. Strand-specificity in the transformation of yeast with synthetic oligonucleotides. Genetics 131, 811-819 (1992).
    • (1992) Genetics , vol.131 , pp. 811-819
    • Yamamoto, T.1    Moerschell, R.P.2    Wakem, L.P.3    Komar-Panicucci, S.4    Sherman, F.5
  • 10
    • 0026445689 scopus 로고
    • Parameters affecting the frequencies of transformation and co-transformation with synthetic oligonucleotides in yeast
    • Yamamoto, T., Moerschell, R. P., Wakem, L. P., Ferguson, D. & Sherman, F. Parameters affecting the frequencies of transformation and co-transformation with synthetic oligonucleotides in yeast. Yeast 8, 935-948 (1992).
    • (1992) Yeast , vol.8 , pp. 935-948
    • Yamamoto, T.1    Moerschell, R.P.2    Wakem, L.P.3    Ferguson, D.4    Sherman, F.5
  • 11
    • 0024769286 scopus 로고
    • Homologous recombination involving small single-stranded oligonucleotides in human cells
    • Campbell, C. R., Keown, W., Lowe, L., Kirschling, D. & Kucherlapati, R. Homologous recombination involving small single-stranded oligonucleotides in human cells. New Biol. 1, 223-227 (1989).
    • (1989) New Biol. , vol.1 , pp. 223-227
    • Campbell, C.R.1    Keown, W.2    Lowe, L.3    Kirschling, D.4    Kucherlapati, R.5
  • 12
    • 0034327613 scopus 로고    scopus 로고
    • The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts
    • Gamper, H. B. et al. The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts. Nucleic Acids Res. 28, 4332-4339 (2000). This article reports that gene repair using single-stranded oligonucleotides is as active as the chimaera and easier to synthesize.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 4332-4339
    • Gamper, H.B.1
  • 13
    • 0032921514 scopus 로고    scopus 로고
    • Targeted gene repair
    • Kmiec, E. B. Targeted gene repair. Gene Ther. 6, 1-3 (1999).
    • (1999) Gene Ther. , vol.6 , pp. 1-3
    • Kmiec, E.B.1
  • 15
    • 0028296997 scopus 로고
    • Transcription activates RecA-promoted homologous pairing of nucleosomal DNA
    • Kotani, H. & Kmiec, E. B. Transcription activates RecA-promoted homologous pairing of nucleosomal DNA. Mol. Cell Biol. 14, 1949-1955 (1994).
    • (1994) Mol. Cell Biol. , vol.14 , pp. 1949-1955
    • Kotani, H.1    Kmiec, E.B.2
  • 16
    • 0029993658 scopus 로고    scopus 로고
    • RNA facilitates RecA-mediated DNA pairing and strand transfer between molecules bearing limited regions of homology
    • Kotani, H. et al. RNA facilitates RecA-mediated DNA pairing and strand transfer between molecules bearing limited regions of homology. Mol. Gen Genet. 250, 626-634 (1996). This was one of the first studies to show that RNA can reduce the level of homology that is required for strand exchange.
    • (1996) Mol. Gen. Genet. , vol.250 , pp. 626-634
    • Kotani, H.1
  • 17
    • 0033104162 scopus 로고    scopus 로고
    • Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract
    • Cole-Strauss, A. et al. Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract. Nucleic Acids Res. 27, 1323-1330 (1999).
    • (1999) Nucleic Acids Res. , vol.27 , pp. 1323-1330
    • Cole-Strauss, A.1
  • 18
    • 0035077792 scopus 로고    scopus 로고
    • Targeted gene correction by small single-stranded oligonucleotides in mammalian cells
    • Igoucheva, O., Alexeev, V. & Yoon, K. Targeted gene correction by small single-stranded oligonucleotides in mammalian cells. Gene Ther. 8, 391-399 (2001). A careful study of the effects of single-stranded oligonucleotides in mammalian cells.
    • (2001) Gene Ther. , vol.8 , pp. 391-399
    • Igoucheva, O.1    Alexeev, V.2    Yoon, K.3
  • 19
    • 0034329384 scopus 로고    scopus 로고
    • Targeted single-base correction by RNA-DNA oligonucleotides. Hum
    • Igoucheva, O. & Yoon, K. Targeted single-base correction by RNA-DNA oligonucleotides. Hum. Gene Ther. 11, 2307-2312 (2000).
    • (2000) Gene Ther. , vol.11 , pp. 2307-2312
    • Igoucheva, O.1    Yoon, K.2
  • 20
    • 0033392739 scopus 로고    scopus 로고
    • A sequence-specific gene correction by an RNA-DNA oligonucleotide in mammalian cells characterized by transfection and nuclear extract using a lacZ shuttle system
    • Igoucheva, O., Peritz, A. E., Levy, D. & Yoon, K. A sequence-specific gene correction by an RNA-DNA oligonucleotide in mammalian cells characterized by transfection and nuclear extract using a lacZ shuttle system. Gene Ther. 6, 1960-1971 (1999).
    • (1999) Gene Ther. , vol.6 , pp. 1960-1971
    • Igoucheva, O.1    Peritz, A.E.2    Levy, D.3    Yoon, K.4
  • 21
    • 0037432326 scopus 로고    scopus 로고
    • The synaptic complex of RecA protein participates in hybridization and inverse strand exchange reactions
    • Gamper, H. B., Nulf, C. J., Corey, D. R. & Kmiec, E. B. The synaptic complex of RecA protein participates in hybridization and inverse strand exchange reactions. Biochemistry 42, 2643-2655 (2003).
    • (2003) Biochemistry , vol.42 , pp. 2643-2655
    • Gamper, H.B.1    Nulf, C.J.2    Corey, D.R.3    Kmiec, E.B.4
  • 22
    • 0035886376 scopus 로고    scopus 로고
    • In vivo gene repair of point and frameshift mutations directed by chimeric RNA/DNA oligonucleotides and modified single-stranded oligonucleotides
    • Liu, L., Rice, M. C. & Kmiec, E. B. In vivo gene repair of point and frameshift mutations directed by chimeric RNA/DNA oligonucleotides and modified single-stranded oligonucleotides. Nucleic Acids Res. 29, 4238-4250 (2001).
    • (2001) Nucleic Acids Res. , vol.29 , pp. 4238-4250
    • Liu, L.1    Rice, M.C.2    Kmiec, E.B.3
  • 23
    • 0036640365 scopus 로고    scopus 로고
    • Rad51p and Rad54p, but not Rad52p, elevate gene repair in Saccharomyces cerevisiae directed by modified single-stranded oligonucleotide vectors
    • Liu, L., Cheng, S., van Brabant, A. J. & Kmiec, E B. Rad51p and Rad54p, but not Rad52p, elevate gene repair in Saccharomyces cerevisiae directed by modified single-stranded oligonucleotide vectors. Nucleic Acids Res. 31, 2742-2750 (2002). This study was the first to show that Rad51 stimulates gene repair in yeast.
    • (2002) Nucleic Acids Res. , vol.31 , pp. 2742-2750
    • Liu, L.1    Cheng, S.2    Van Brabant, A.J.3    Kmiec, E.B.4
  • 24
    • 0036097061 scopus 로고    scopus 로고
    • Strand bias in targeted gene repair is influenced by transcriptional activity
    • Liu, L. et al. Strand bias in targeted gene repair is influenced by transcriptional activity. Mol. Cell Biol. 22, 3852-3863 (2002).
    • (2002) Mol. Cell Biol. , vol.22 , pp. 3852-3863
    • Liu, L.1
  • 25
    • 0037297322 scopus 로고    scopus 로고
    • Targeted gene repair of cyc1 mutations in Saccharomyces cerevisiae directed by modified single-stranded DNA oligonucleotides
    • Brachman, E. E. & Kmiec, E. B. Targeted gene repair of cyc1 mutations in Saccharomyces cerevisiae directed by modified single-stranded DNA oligonucleotides. Genetics 163, 527-538 (2003).
    • (2003) Genetics , vol.163 , pp. 527-538
    • Brachman, E.E.1    Kmiec, E.B.2
  • 26
    • 0036129569 scopus 로고    scopus 로고
    • Mode of action of RNA/DNA oligonucleotides: Progress in the development of gene repair as a therapy for α(1)-antitrypsin deficiency
    • Metz, R. et al. Mode of action of RNA/DNA oligonucleotides: progress in the development of gene repair as a therapy for α(1)-antitrypsin deficiency. Chest 121, 91-97 (2002).
    • (2002) Chest , vol.121 , pp. 91-97
    • Metz, R.1
  • 27
    • 0027314983 scopus 로고
    • Complement-stabilized D-loop. RecA-catalyzed stable pairing of linear DNA molecules at internal sites
    • Jayasena, V. K. & Johnston, B. H. Complement-stabilized D-loop. RecA-catalyzed stable pairing of linear DNA molecules at internal sites J. Mol. Biol. 230, 1015-1024 (1993).
    • (1993) J. Mol. Biol. , vol.230 , pp. 1015-1024
    • Jayasena, V.K.1    Johnston, B.H.2
  • 29
    • 0037133544 scopus 로고    scopus 로고
    • Peptide nucleic acid (PNA) facilitates multistranded hybrid formation between linear double-stranded DNA targets and RecA protein-coated complementary single-stranded DNA probes
    • Belotserkovskii, B. P. & Zarling, D. A. Peptide nucleic acid (PNA) facilitates multistranded hybrid formation between linear double-stranded DNA targets and RecA protein-coated complementary single-stranded DNA probes. Biochemistry 41, 3686-3692 (2002).
    • (2002) Biochemistry , vol.41 , pp. 3686-3692
    • Belotserkovskii, B.P.1    Zarling, D.A.2
  • 30
    • 0036773706 scopus 로고    scopus 로고
    • Targeted nucleotide exchange in Saccharomyces cerevisiae directed by short oligonucleotides containing locked nucleic acids
    • Parekh-Olmedo, H., Drury, M. & Kmiec, E. B. Targeted nucleotide exchange in Saccharomyces cerevisiae directed by short oligonucleotides containing locked nucleic acids. Chem. Biol. 9, 1073-1084 (2002).
    • (2002) Chem. Biol. , vol.9 , pp. 1073-1084
    • Parekh-Olmedo, H.1    Drury, M.2    Kmiec, E.B.3
  • 31
    • 0037326888 scopus 로고    scopus 로고
    • DNA pairing is an important step in the process of targeted nucleotide exchange
    • Drury, M. & Kmiec, E. B. DNA pairing is an important step in the process of targeted nucleotide exchange. Nucleic Acids Res. 31, 899-910 (2003).
    • (2003) Nucleic Acids Res. , vol.31 , pp. 899-910
    • Drury, M.1    Kmiec, E.B.2
  • 32
    • 0032844859 scopus 로고    scopus 로고
    • Opportunities and challenges in targeting genes for therapy
    • Gruenert, D. C. Opportunities and challenges in targeting genes for therapy. Gene Ther. 6, 1347-1348 (1999).
    • (1999) Gene Ther. , vol.6 , pp. 1347-1348
    • Gruenert, D.C.1
  • 33
    • 0042368424 scopus 로고    scopus 로고
    • In vitro correction of cystic fibrosis epithelial cell lines by small fragment homologous replacement (SFHR) technique
    • Sangiuolo, F. et al. In vitro correction of cystic fibrosis epithelial cell lines by small fragment homologous replacement (SFHR) technique. BMC Med. Genet. 3, 8 (2002).
    • (2002) BMC Med. Genet. , vol.3 , pp. 8
    • Sangiuolo, F.1
  • 34
    • 0035831649 scopus 로고    scopus 로고
    • In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement
    • Kapsa, R. et al. In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement. Hum. Gene Ther. 12, 629-642 (2001).
    • (2001) Hum. Gene Ther. , vol.12 , pp. 629-642
    • Kapsa, R.1
  • 35
    • 0041867498 scopus 로고    scopus 로고
    • Targeted correction of genomic single base-pair mutations using adeno-associated virus under non-selective conditions
    • Liu, X. M. et al. Targeted correction of genomic single base-pair mutations using adeno-associated virus under non-selective conditions. Mol. Ther. 7, 159-160 (2003).
    • (2003) Mol. Ther. , vol.7 , pp. 159-160
    • Liu, X.M.1
  • 36
    • 0037497338 scopus 로고    scopus 로고
    • Harmful potential of viral vectors fuels doubts over gene therapy
    • Check, E. Harmful potential of viral vectors fuels doubts over gene therapy. Nature 423, 573-574 (2003).
    • (2003) Nature , vol.423 , pp. 573-574
    • Check, E.1
  • 37
    • 0035997963 scopus 로고    scopus 로고
    • The 'biased' evolution of targeted gene repair
    • Brachman, E. E. & Kmiec, E B. The 'biased' evolution of targeted gene repair. Curr. Opin. Mol. Ther. 4, 171-176 (2002).
    • (2002) Curr. Opin. Mol. Ther. , vol.4 , pp. 171-176
    • Brachman, E.E.1    Kmiec, E.B.2
  • 38
    • 0036460362 scopus 로고    scopus 로고
    • Mechanisms underlying targeted gene correction using chimeric RNA/DNA and single-stranded DNA oligonucleotides
    • Andersen, M. S., Sorensen, C. B., Bolund, L. & Jensen, T. G. Mechanisms underlying targeted gene correction using chimeric RNA/DNA and single-stranded DNA oligonucleotides. J. Mol. Med. 80, 770-781 (2002). This is a good review of the field of oligonucleotide targeting, with an emphasis on the mechanism.
    • (2002) J. Mol. Med. , vol.80 , pp. 770-781
    • Andersen, M.S.1    Sorensen, C.B.2    Bolund, L.3    Jensen, T.G.4
  • 39
    • 0036272395 scopus 로고    scopus 로고
    • Optimising gene repair strategies in cell culture
    • Thorpe, P., Stevenson, B. J. & Porteous, D. J. Optimising gene repair strategies in cell culture. Gene Ther. 9, 700-702 (2002).
    • (2002) Gene Ther. , vol.9 , pp. 700-702
    • Thorpe, P.1    Stevenson, B.J.2    Porteous, D.J.3
  • 40
    • 0036512266 scopus 로고    scopus 로고
    • Functional correction of episomal mutations with short DNA fragments and RNA-DNA oligonucleotides
    • Thorpe, P. H., Stevenson, B. J. & Porteous, D. J. Functional correction of episomal mutations with short DNA fragments and RNA-DNA oligonucleotides. J. Gene Med. 4, 195-204 (2002).
    • (2002) J. Gene Med. , vol.4 , pp. 195-204
    • Thorpe, P.H.1    Stevenson, B.J.2    Porteous, D.J.3
  • 41
    • 0345711460 scopus 로고    scopus 로고
    • Gene targeting is enhanced in human cells overexpressing hRAD51
    • Yanez, R. J. & Porter, A. C. Gene targeting is enhanced in human cells overexpressing hRAD51. Gene Ther. 6, 1282-1290 (1999).
    • (1999) Gene Ther. , vol.6 , pp. 1282-1290
    • Yanez, R.J.1    Porter, A.C.2
  • 42
    • 0033914550 scopus 로고    scopus 로고
    • Influence of DNA delivery method on gene targeting frequencies in human cells
    • Yanez, R. J. & Porter, A. C. Influence of DNA delivery method on gene targeting frequencies in human cells. Somat. Cell Mol. Genet. 25, 27-31 (1999).
    • (1999) Somat. Cell Mol. Genet. , vol.25 , pp. 27-31
    • Yanez, R.J.1    Porter, A.C.2
  • 43
  • 44
    • 0034161571 scopus 로고    scopus 로고
    • Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing
    • Mazin, A. V., Zaitseva, E., Sung, P. & Kowalczykowski, S. C. Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing. EMBO J. 19, 1148-1156 (2000)
    • (2000) EMBO J. , vol.19 , pp. 1148-1156
    • Mazin, A.V.1    Zaitseva, E.2    Sung, P.3    Kowalczykowski, S.C.4
  • 45
    • 0030584084 scopus 로고    scopus 로고
    • Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro
    • Baumann, P., Benson, F. E. & West, S. C. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 87, 757-766 (1996).
    • (1996) Cell , vol.87 , pp. 757-766
    • Baumann, P.1    Benson, F.E.2    West, S.C.3
  • 46
    • 0037705453 scopus 로고    scopus 로고
    • Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration
    • Igoucheva, O., Alexeev, V., Pryce, M. & Yoon, K Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration. Nucleic Acids Res. 31, 2659-2670 (2003).
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2659-2670
    • Igoucheva, O.1    Alexeev, V.2    Pryce, M.3    Yoon, K.4
  • 47
    • 0024396565 scopus 로고
    • DNA mismatch correction in a defined system
    • Lahue, R. S., Au, K G. & Modrich, P. DNA mismatch correction in a defined system. Science 245, 160-164 (1989).
    • (1989) Science , vol.245 , pp. 160-164
    • Lahue, R.S.1    Au, K.G.2    Modrich, P.3
  • 50
    • 0034995488 scopus 로고    scopus 로고
    • In vitro and in vivo nucleotide exchange directed by chimeric RNA/DNA oligonucleotides in Saccharomyces cerevisiae
    • Rice, M. C., Bruner, M., Czymmek, K. & Kmiec, E. B. In vitro and in vivo nucleotide exchange directed by chimeric RNA/DNA oligonucleotides in Saccharomyces cerevisiae. Mol. Microbiol. 40, 857-868 (2001).
    • (2001) Mol. Microbiol. , vol.40 , pp. 857-868
    • Rice, M.C.1    Bruner, M.2    Czymmek, K.3    Kmiec, E.B.4
  • 51
    • 0033988552 scopus 로고    scopus 로고
    • Damage recognition in nucleotide excision repair of DNA
    • Batty, D. P. & Wood, R D. Damage recognition in nucleotide excision repair of DNA. Gene 241, 193-204 (2000).
    • (2000) Gene , vol.241 , pp. 193-204
    • Batty, D.P.1    Wood, R.D.2
  • 52
    • 0030768038 scopus 로고    scopus 로고
    • Nucleotide excision repair in mammalian cells
    • Wood, R. D. Nucleotide excision repair in mammalian cells. J. Biol. Chem. 272, 23465-23468 (1997)
    • (1997) J. Biol. Chem. , vol.272 , pp. 23465-23468
    • Wood, R.D.1
  • 53
    • 0035810938 scopus 로고    scopus 로고
    • High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides
    • Ellis, H. M., Yu, D., DiTizio, T. & Court, D. L. High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides. Proc. Natl Acad. Sci. USA 98, 6742-6746 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6742-6746
    • Ellis, H.M.1    Yu, D.2    DiTizio, T.3    Court, D.L.4
  • 54
    • 0029817766 scopus 로고    scopus 로고
    • Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide
    • Cole-Strauss, A. et al. Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide. Science 273, 1386-1389 (1996).
    • (1996) Science , vol.273 , pp. 1386-1389
    • Cole-Strauss, A.1
  • 55
    • 0030772320 scopus 로고    scopus 로고
    • Targeted gene conversion in a mammalian CD34-enriched cell population using a chimeric RNA/DNA oligonucleotide
    • Xiang, Y., Cole-Strauss, A., Yoon, K., Gryn, J. & Kmiec, E. B. Targeted gene conversion in a mammalian CD34-enriched cell population using a chimeric RNA/DNA oligonucleotide. J. Mol. Med. 75, 829-835 (1997).
    • (1997) J. Mol. Med. , vol.75 , pp. 829-835
    • Xiang, Y.1    Cole-Strauss, A.2    Yoon, K.3    Gryn, J.4    Kmiec, E.B.5
  • 56
    • 85047696977 scopus 로고    scopus 로고
    • Targeted β-globin gene conversion in human hematopoietic CD34(+) and Lin(-)CD38(-)cells
    • Liu, H., Agarwal, S., Kmiec, E. & Davis, B. R. Targeted β-globin gene conversion in human hematopoietic CD34(+) and Lin(-)CD38(-)cells. Gene Ther. 9, 118-126 (2002).
    • (2002) Gene Ther. , vol.9 , pp. 118-126
    • Liu, H.1    Agarwal, S.2    Kmiec, E.3    Davis, B.R.4
  • 57
    • 0031734471 scopus 로고    scopus 로고
    • Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide
    • Alexeev, V. & Yoon, K. Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide. Nature Biotechnol. 16, 1343-1346 (1998).
    • (1998) Nature Biotechnol. , vol.16 , pp. 1343-1346
    • Alexeev, V.1    Yoon, K.2
  • 58
    • 0033989521 scopus 로고    scopus 로고
    • Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide
    • Alexeev, V., Igoucheva, O., Domashenko, A., Cotsarelis, G. & Yoon, K. Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide. Nature Biotechnol. 18, 43-47 (2000).
    • (2000) Nature Biotechnol. , vol.18 , pp. 43-47
    • Alexeev, V.1    Igoucheva, O.2    Domashenko, A.3    Cotsarelis, G.4    Yoon, K.5
  • 59
    • 0029892249 scopus 로고    scopus 로고
    • Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA/DNA oligonucleotide
    • Yoon, K., Cole-Strauss, A. & Kmiec, E. B. Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA/DNA oligonucleotide. Proc. Natl Acad. Sci. USA 93, 2071-2076 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2071-2076
    • Yoon, K.1    Cole-Strauss, A.2    Kmiec, E.B.3
  • 60
    • 0030913556 scopus 로고    scopus 로고
    • Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide
    • Kren, B. T., Cole-Strauss, A., Kmiec, E. B. & Steer, C. J. Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide. Hepatology 25, 1462-1468 (1997).
    • (1997) Hepatology , vol.25 , pp. 1462-1468
    • Kren, B.T.1    Cole-Strauss, A.2    Kmiec, E.B.3    Steer, C.J.4
  • 61
    • 0032457288 scopus 로고    scopus 로고
    • Different frequency of gene targeting events by the RNA-DNA oligonucleotide among epithelial cells
    • Santana, E., Peritz, A. E., Lyer, S., Uitto, J. & Yoon, K. Different frequency of gene targeting events by the RNA-DNA oligonucleotide among epithelial cells. J. Invest. Dermatol. 111, 1172-1177 (1998).
    • (1998) J. Invest. Dermatol. , vol.111 , pp. 1172-1177
    • Santana, E.1    Peritz, A.E.2    Lyer, S.3    Uitto, J.4    Yoon, K.5
  • 62
    • 0031953132 scopus 로고    scopus 로고
    • In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides
    • Kren, B. T, Bandyopadhyay, P. & Steer, C. J. In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides. Nature Med. 4, 285-290 (1998). This study presents in vivo evidence of chimeric oligonucleotide activity in animals, which is supported by strong genotypic and phenotypic data.
    • (1998) Nature Med. , vol.4 , pp. 285-290
    • Kren, B.T.1    Bandyopadhyay, P.2    Steer, C.J.3
  • 63
    • 0033537836 scopus 로고    scopus 로고
    • Nucleotide exchange in genomic DNA of rat hepatocytes using RNA/DNA oligonucleotides. Targeted delivery of liposomes and polyethleneimine to the asialoglycoprotein receptor
    • Bandyopadhyay, P., Ma, X., Linehan-Stieers, C., Kren, B. T. & Steer, C. J. Nucleotide exchange in genomic DNA of rat hepatocytes using RNA/DNA oligonucleotides. Targeted delivery of liposomes and polyethleneimine to the asialoglycoprotein receptor. J. Biol. Chem. 274, 10163-10172 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 10163-10172
    • Bandyopadhyay, P.1    Ma, X.2    Linehan-Stieers, C.3    Kren, B.T.4    Steer, C.J.5
  • 64
    • 0035918314 scopus 로고    scopus 로고
    • Gene correction of the apolipoprotein (Apc) E2 phenotype to wild-type ApoE 3 by in situ chimeraplasty
    • Tagalakis, A. D., Graham, I. R., Riddell, D. R., Dickson, J. G. & Owen, J. S. Gene correction of the apolipoprotein (Apc) E2 phenotype to wild-type ApoE3 by in situ chimeraplasty. J. Biol. Chem. 276, 13226-13230 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 13226-13230
    • Tagalakis, A.D.1    Graham, I.R.2    Riddell, D.R.3    Dickson, J.G.4    Owen, J.S.5
  • 65
    • 0032931129 scopus 로고    scopus 로고
    • Homologous recombination based gene therapy
    • Lai, L.-W. & Lien, Y. H. Homologous recombination based gene therapy. Expt. Nephrol. 7, 11-14 (1999).
    • (1999) Expt. Nephrol. , vol.7 , pp. 11-14
    • Lai, L.-W.1    Lien, Y.H.2
  • 66
    • 0036174938 scopus 로고    scopus 로고
    • Chimeric RNA/DNA oligonucleotide-based gene therapy
    • Lai, L. W. & Lien, Y. H. Chimeric RNA/DNA oligonucleotide-based gene therapy. Kidney Int. 61 (Suppl.), 47-51 (2002).
    • (2002) Kidney Int. , vol.61 , Issue.SUPPL. , pp. 47-51
    • Lai, L.W.1    Lien, Y.H.2
  • 67
    • 0034086776 scopus 로고    scopus 로고
    • In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotide
    • Bartlett, R. J. et al. In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotide. Nature Biotechnol. 18, 615-622 (2000). This article describes gene repair in a dog model for muscular dystrophy, along with an excellent discussion of what each assay shows.
    • (2000) Nature Biotechnol. , vol.18 , pp. 615-622
    • Bartlett, R.J.1
  • 68
    • 0034624974 scopus 로고    scopus 로고
    • Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides
    • Rando, T. A., Disatnik, M, H. & Zhou, L. Z. Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides. Proc. Natl Acad. Sci. USA 97, 5363-5368 (2000). An excellent article that outlines gene repair in a well-characterized animal model and provides a good phenotypic analysis.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5363-5368
    • Rando, T.A.1    Disatnik, M.H.2    Zhou, L.Z.3
  • 69
    • 0036211418 scopus 로고    scopus 로고
    • Dystrophin gene repair in mdx muscle precursor cells in vitro and in vivo mediated by RNA-DNA chimeric oligonucleotides
    • Bertoni, C. & Rando, T. A. Dystrophin gene repair in mdx muscle precursor cells in vitro and in vivo mediated by RNA-DNA chimeric oligonucleotides. Hum. Gene Ther. 13, 707-718 (2002).
    • (2002) Hum. Gene Ther. , vol.13 , pp. 707-718
    • Bertoni, C.1    Rando, T.A.2
  • 70
    • 0034966380 scopus 로고    scopus 로고
    • Targeted correction of the point mutations of β-thalassemia and targeted mutagenesis of the nucleotide associated with HPFH by RNA/DNA oligonucleotides: Potential for β-thalassemia gene therapy
    • Li, Z. H., Liu, D. P., Yin, W. X., Guo, Z. C. & Liang, C. C. Targeted correction of the point mutations of β-thalassemia and targeted mutagenesis of the nucleotide associated with HPFH by RNA/DNA oligonucleotides: potential for β-thalassemia gene therapy. Blood Cells Mol. Dis. 27, 530-538 (2001).
    • (2001) Blood Cells Mol. Dis. , vol.27 , pp. 530-538
    • Li, Z.H.1    Liu, D.P.2    Yin, W.X.3    Guo, Z.C.4    Liang, C.C.5
  • 71
    • 0035066680 scopus 로고    scopus 로고
    • Persistent failures in gene repair
    • van der Steege, G. et al. Persistent failures in gene repair. Nature Biotechnol. 19, 305-306 (2001).
    • (2001) Nature Biotechnol. , vol.19 , pp. 305-306
    • Van der Steege, G.1
  • 72
    • 0031047639 scopus 로고    scopus 로고
    • Recombinant DNA technique and sickle cell anemia research
    • Thomas, K. R. & Capecchi, M. R. Recombinant DNA technique and sickle cell anemia research. Science 275, 1404-1405 (1997).
    • (1997) Science , vol.275 , pp. 1404-1405
    • Thomas, K.R.1    Capecchi, M.R.2
  • 73
    • 85059997150 scopus 로고    scopus 로고
    • Gene repair validation
    • Graham, I. R. et al. Gene repair validation. Nature Biotechnol. 19, 507-508 (2001).
    • (2001) Nature Biotechnol. , vol.19 , pp. 507-508
    • Graham, I.R.1
  • 75
    • 0031827986 scopus 로고    scopus 로고
    • Enhanced gene transfer into HuH-7 cells and primary rat hepatocytes using targeted liposomes and polyethlenimine
    • Bandyopadhyay, P., Kren, B. T., Ma, X. & Steer, C. J. Enhanced gene transfer into HuH-7 cells and primary rat hepatocytes using targeted liposomes and polyethlenimine. Biotechniques 25, 282-292 (1998).
    • (1998) Biotechniques , vol.25 , pp. 282-292
    • Bandyopadhyay, P.1    Kren, B.T.2    Ma, X.3    Steer, C.J.4
  • 76
    • 0035937782 scopus 로고    scopus 로고
    • Analysis of the binding of p53 to DNAs containing mismatched and bulged bases
    • Degtyareva, N., Subramanian, D. & Griffith, J. D. Analysis of the binding of p53 to DNAs containing mismatched and bulged bases. J. Biol. Chem. 276, 8778-8784 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 8778-8784
    • Degtyareva, N.1    Subramanian, D.2    Griffith, J.D.3
  • 77
    • 0031865231 scopus 로고    scopus 로고
    • Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination
    • Dudenhoffer, C., Rohaly, G., Will, K., Deppert, W. & Wiesmuller, L. Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination. Mol. Cell Biol. 18, 5332-5342 (1998).
    • (1998) Mol. Cell Biol. , vol.18 , pp. 5332-5342
    • Dudenhoffer, C.1    Rohaly, G.2    Will, K.3    Deppert, W.4    Wiesmuller, L.5
  • 78
    • 0034743705 scopus 로고    scopus 로고
    • Targeted correction of a defective selectable marker gene in human epithelial cells by small DNA fragments
    • Colosimo, A., Goncz, K. K., Novelli, G., Dallapiccola, B. & Gruenert, D. C. Targeted correction of a defective selectable marker gene in human epithelial cells by small DNA fragments. Mol. Ther. 3, 178-185 (2001).
    • (2001) Mol. Ther. , vol.3 , pp. 178-185
    • Colosimo, A.1    Goncz, K.K.2    Novelli, G.3    Dallapiccola, B.4    Gruenert, D.C.5
  • 79
    • 0035137927 scopus 로고    scopus 로고
    • Molecular dissection of interactions between Rad51 and members of the recombination-repair group
    • Krejci, L., Damborsky, J., Thomsen, B., Duno, M. & Bendixen, C. Molecular dissection of interactions between Rad51 and members of the recombination-repair group. Mol. Cell Biol. 21, 966-976 (2001).
    • (2001) Mol. Cell Biol. , vol.21 , pp. 966-976
    • Krejci, L.1    Damborsky, J.2    Thomsen, B.3    Duno, M.4    Bendixen, C.5
  • 80
    • 0035914418 scopus 로고    scopus 로고
    • DNA pairing and strand exchange by the Escherichia coli RecA and yeast Rad51 proteins without ATP hydrolysis: On the importance of not getting stuck
    • Rice, K. P., Eggler, A. L., Sung, P. & Cox, M. M. DNA pairing and strand exchange by the Escherichia coli RecA and yeast Rad51 proteins without ATP hydrolysis: on the importance of not getting stuck. J. Biol. Chem. 276, 38570-38581 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 38570-38581
    • Rice, K.P.1    Eggler, A.L.2    Sung, P.3    Cox, M.M.4
  • 81
    • 0036829783 scopus 로고    scopus 로고
    • Strand pairing by Rad54 and Rad51 is enhanced by chromatin
    • Alexiadis, V. & Kadonaga, J. T. Strand pairing by Rad54 and Rad51 is enhanced by chromatin. Genes Dev. 16, 2767-2771 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2767-2771
    • Alexiadis, V.1    Kadonaga, J.T.2
  • 82
    • 0032526320 scopus 로고    scopus 로고
    • Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation
    • Vispe, S., Cazaux, C., Lesca, C. & Defais, M. Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation. Nucleic Acids Res. 26, 2859-2864 (1998).
    • (1998) Nucleic Acids Res. , vol.26 , pp. 2859-2864
    • Vispe, S.1    Cazaux, C.2    Lesca, C.3    Defais, M.4
  • 83
    • 0023349389 scopus 로고
    • Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors
    • Burke, D. T., Carle, G. F. & Olson, M. V. Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science 236, 806-812 (1987).
    • (1987) Science , vol.236 , pp. 806-812
    • Burke, D.T.1    Carle, G.F.2    Olson, M.V.3
  • 84
    • 0021891866 scopus 로고
    • Psoralens as photoactive probes of nucleic acid structure and function: Organic chemistry, photochemistry, and biochemistry
    • Cimino, G. D., Gamper, H. B., Isaacs, S. T. & Hearst, J. E. Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry. Annu. Rev. Biochem. 54, 1151-1193 (1985).
    • (1985) Annu. Rev. Biochem. , vol.54 , pp. 1151-1193
    • Cimino, G.D.1    Gamper, H.B.2    Isaacs, S.T.3    Hearst, J.E.4
  • 85
    • 0029912788 scopus 로고    scopus 로고
    • Recombination induced by triple-helix-targeted DNA damage in mammalian cells
    • Faruqi, A. F., Seidman, M. M., Segal, D. J., Carroll, D. & Glazer, P. M. Recombination induced by triple-helix-targeted DNA damage in mammalian cells. Mol. Cell Biol. 16, 6820-6828 (1996).
    • (1996) Mol. Cell Biol. , vol.16 , pp. 6820-6828
    • Faruqi, A.F.1    Seidman, M.M.2    Segal, D.J.3    Carroll, D.4    Glazer, P.M.5
  • 86
    • 0029131864 scopus 로고
    • Triple helix directed psoralen adducts induce a low frequency of recombination in an SV40 shuttle vector
    • Sandor, Z. & Bredberg, A. Triple helix directed psoralen adducts induce a low frequency of recombination in an SV40 shuttle vector. Biochim. Biophys. Acta 1263, 235-240 (1995).
    • (1995) Biochim. Biophys. Acta , vol.1263 , pp. 235-240
    • Sandor, Z.1    Bredberg, A.2
  • 87
    • 0029007162 scopus 로고
    • High-affinity triple helix formation by synthetic oligonucleotides at a site within a selectable mammalian gene
    • Vasquez, K. M., Wensel, T. G., Hogan, M. E. & Wilson, J. H. High-affinity triple helix formation by synthetic oligonucleotides at a site within a selectable mammalian gene. Biochemistry 34, 7243-7251 (1995).
    • (1995) Biochemistry , vol.34 , pp. 7243-7251
    • Vasquez, K.M.1    Wensel, T.G.2    Hogan, M.E.3    Wilson, J.H.4
  • 88
    • 0029738829 scopus 로고    scopus 로고
    • High-efficiency triple-helix-mediated photo-cross-linking at a targeted site within a selectable mammalian gene
    • Vasquez, K. M., Wensel, T. G., Hogan, M. E. & Wilson, J. H. High-efficiency triple-helix-mediated photo-cross-linking at a targeted site within a selectable mammalian gene. Biochemistry 35, 10712-10719 (1996).
    • (1996) Biochemistry , vol.35 , pp. 10712-10719
    • Vasquez, K.M.1    Wensel, T.G.2    Hogan, M.E.3    Wilson, J.H.4
  • 89
    • 0037435422 scopus 로고    scopus 로고
    • Short, single-stranded oligonucleotides mediate targeted nucleotide conversion using extracts from isolated liver mitochondria
    • Kren, B. T., Wong, P. Y. & Steer, C. J. Short, single-stranded oligonucleotides mediate targeted nucleotide conversion using extracts from isolated liver mitochondria. DNA Repair 2, 531-546 (2003).
    • (2003) DNA Repair , vol.2 , pp. 531-546
    • Kren, B.T.1    Wong, P.Y.2    Steer, C.J.3
  • 90
    • 0037445212 scopus 로고    scopus 로고
    • Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides
    • Dekker, M., Brouwers, C. & Te, R. H. Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides. Nucleic Acids Res. 31, 27 (2003). This paper represents an important step in the use of single-stranded DNA for targeting in mouse ES cells.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 27
    • Dekker, M.1    Brouwers, C.2    Te, R.H.3
  • 91
    • 0035822999 scopus 로고    scopus 로고
    • The many faces of chromatin remodeling: Switching beyond transcription
    • Fyodorov, D. V. & Kadonaga, J. T. The many faces of chromatin remodeling: SWItching beyond transcription. Cell 106, 523-525 (2001).
    • (2001) Cell , vol.106 , pp. 523-525
    • Fyodorov, D.V.1    Kadonaga, J.T.2
  • 92
    • 0013187276 scopus 로고    scopus 로고
    • Re-engineering plant gene targeting
    • Britt, A. B. & May, G. D. Re-engineering plant gene targeting. Trends Plant Sci. 8, 90-95 (2003).
    • (2003) Trends Plant Sci. , vol.8 , pp. 90-95
    • Britt, A.B.1    May, G.D.2
  • 93
    • 0141927821 scopus 로고    scopus 로고
    • Correction/mutation of acid α-D-glucosidase gene by modified single-stranded oligonucleotides: In vitro and in vivo studies
    • in the press
    • Lu, I.-L. et al. Correction/mutation of acid α-D-glucosidase gene by modified single-stranded oligonucleotides: in vitro and in vivo studies. Gene Therapy (in the press). One of the most complete studies using single-stranded vectors, with convincing genotype and phenotype evidence of conversion.
    • Gene Therapy
    • Lu, I.-L.1
  • 94
    • 0035853251 scopus 로고    scopus 로고
    • Targeted gene repair in mammalian cells using chimeric RNA/DNA oligonucleotides and modified single-stranded vectors
    • Parekh-Olmedo, H., Czymmek, K. & Kmiec, E. B. Targeted gene repair in mammalian cells using chimeric RNA/DNA oligonucleotides and modified single-stranded vectors. Sci. STKE 2001, 1 (2001).
    • (2001) Sci. STKE , vol.2001 , pp. 1
    • Parekh-Olmedo, H.1    Czymmek, K.2    Kmiec, E.B.3
  • 95
    • 0037124355 scopus 로고    scopus 로고
    • Mutations in yeast Rad51 that partially bypass the requirement for Rad55 and Rad57 in DNA repair by increasing the stability of Rad51-DNA complexes
    • Fortin, G. S. & Symington, L. S. Mutations in yeast Rad51 that partially bypass the requirement for Rad55 and Rad57 in DNA repair by increasing the stability of Rad51-DNA complexes. EMBO J. 21, 3160-3170 (2002).
    • (2002) EMBO J. , vol.21 , pp. 3160-3170
    • Fortin, G.S.1    Symington, L.S.2
  • 96
    • 0033621041 scopus 로고    scopus 로고
    • Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of crigler-najjar syndrome type I with a chimeric oligonucleotide
    • Kren, B. T. et al. Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of crigler-najjar syndrome type I with a chimeric oligonucleotide. Proc. Natl Acad. Sci. USA 96, 10349-10354 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 10349-10354
    • Kren, B.T.1
  • 97
    • 0039594943 scopus 로고    scopus 로고
    • A plausible mechanism for gene correction by chimeric oligonucleotides
    • Gamper, H. B. et al. A plausible mechanism for gene correction by chimeric oligonucleotides. Biochemistry 39, 5808-5816 (2000).
    • (2000) Biochemistry , vol.39 , pp. 5808-5816
    • Gamper, H.B.1
  • 98
    • 0034816091 scopus 로고    scopus 로고
    • Mitochondria isolated from liver contain the essential factors required for RNA/DNA oligonucleotide-targeted gene repair
    • Chen, Z. et al. Mitochondria isolated from liver contain the essential factors required for RNA/DNA oligonucleotide-targeted gene repair. Biochem. Biophys. Res. Commun. 285, 188-194 (2001).
    • (2001) Biochem. Biophys. Res. Commun. , vol.285 , pp. 188-194
    • Chen, Z.1
  • 99
    • 0034885154 scopus 로고    scopus 로고
    • Chloroplast lysates support directed mutagenesis via modified DNA and chimeric RNA/DNA oligonucleotides
    • Kmiec, E. B., Johnson, C. & May, G. D. Chloroplast lysates support directed mutagenesis via modified DNA and chimeric RNA/DNA oligonucleotides. Plant J. 27, 267-274 (2001).
    • (2001) Plant J. , vol.27 , pp. 267-274
    • Kmiec, E.B.1    Johnson, C.2    May, G.D.3
  • 100
    • 0034045767 scopus 로고    scopus 로고
    • Genetic repair of mutations in plant cell-free extracts directed by specific chimeric oligonucleotides
    • Rice, M. C., May, G. D., Kipp, P. B., Parekh, H. & Kmiec, E. B. Genetic repair of mutations in plant cell-free extracts directed by specific chimeric oligonucleotides. Plant Physiol. 123, 427-438 (2000).
    • (2000) Plant Physiol. , vol.123 , pp. 427-438
    • Rice, M.C.1    May, G.D.2    Kipp, P.B.3    Parekh, H.4    Kmiec, E.B.5
  • 101
    • 0033587679 scopus 로고    scopus 로고
    • A tool for functional plant genomics: Chimeric RNA/DNA oligonucleotides cause in vivo gene-specific mutations
    • Beetham, P. R., Kipp, P. B., Sawycky, X. L., Arntzen, C. J. & May, G. D. A tool for functional plant genomics: chimeric RNA/DNA oligonucleotides cause in vivo gene-specific mutations. Proc. Natl Acad. Sci. USA 96, 8774-8778 (1999). The first report of gene repair in plants using chimeric RNA-DNA oligonucleotides.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8774-8778
    • Beetham, P.R.1    Kipp, P.B.2    Sawycky, X.L.3    Arntzen, C.J.4    May, G.D.5
  • 102
    • 0037648962 scopus 로고    scopus 로고
    • Chimeric RNA/DNA oligonucleotide-based site-specific modification of the tobacco acetolactate syntase gene
    • Kochevenko, A & Willmitzer, L. Chimeric RNA/DNA oligonucleotide-based site-specific modification of the tobacco acetolactate syntase gene. Plant Physiol. 132, 174-184 (2003).
    • (2003) Plant Physiol. , vol.132 , pp. 174-184
    • Kochevenko, A.1    Willmitzer, L.2
  • 103
    • 0033587695 scopus 로고    scopus 로고
    • Targeted manipulation of maize genes in vivo using chimeric RNA/DNA oligonucleotides
    • Zhu, T. et al. Targeted manipulation of maize genes in vivo using chimeric RNA/DNA oligonucleotides. Proc. Natl Acad. Sci. USA 96, 8768-8773 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8768-8773
    • Zhu, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.