Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide

Nature Biotechnology

Volumn 18, Issue 1, 2000, Pages 43-47

  Alexeev, Vitali ^a   Igoucheva, Olga ^a   Domashenko, Alla ^b   Cotsarelis, George ^b   Yoon, Kyonggeun ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Epidermis; Gene correction; Intradermal injection; Topical application

Indexed keywords

DIHYDROXYPHENYLACETIC ACID; MELANIN; MONOPHENOL MONOOXYGENASE; OLIGONUCLEOTIDE;

ALBINISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA RNA HYBRIDIZATION; GENOTYPE; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL;

ADMINISTRATION, CUTANEOUS; ALBINISM; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHROMOSOMES; DNA; GENE CONVERSION; GENE THERAPY; HAIR COLOR; HAIR FOLLICLE; INJECTIONS, INTRADERMAL; MELANOCYTES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MONOPHENOL MONOOXYGENASE; OLIGONUCLEOTIDES; PHENOTYPE; POINT MUTATION; RNA; SKIN; TRANSFECTION;

ANIMALIA; RODENTIA;

EID: 0033989521     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/71901     Document Type: Article

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