Mitochondria isolated from liver contain the essential factors required for RNA/DNA oligonucleotide-targeted gene repair

Biochemical and Biophysical Research Communications

Volumn 285, Issue 2, 2001, Pages 188-194

  Chen, Zongyu ^a   Felsheim, Rod ^a   Wong, Phillip ^a   Augustin, Lance B ^a   Kren, Betsy T ^a   Metz, Richard ^a   Steer, Clifford J ^b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b ValiGen Corporation   (United States)

Author keywords

Allele specific PCR; Cell free bacterial assay; Gene therapy; Mismatch repair; Mitochondria; Nuclear extract; Plasmid; RNA DNA oligonucleotide; Single point mutation; Site directed conversion

Indexed keywords

ANTIBIOTIC AGENT; DNA; KANAMYCIN; OLIGONUCLEOTIDE; RNA; TETRACYCLINE;

ALLELE; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; CHIMERA; DNA REPAIR; ESCHERICHIA COLI; GENE THERAPY; GENOME; LIVER MITOCHONDRION; NONHUMAN; PLASMID; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT;

EID: 0034816091     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5156     Document Type: Article

References (32)

1. Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide
2. In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides
3. Correction of the UDP-glucuronosyltransferase gene defect in the Gunn rat model of Crigler-Najjar syndrome type I with a chimeric oligonucleotide
4. Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide
5. Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides
6. In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotide
7. Gene correction of the apolipoprotein (Apo) E2 phenotype to wild-type ApoE3 by in situ chimeraplasty
8. Mitochondrial mutagenesis in human cells and tissues
9. Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract
10. Repair of mtDNA in vertebrates
11. Gene repair using chimeric RNA/DNA oligonucleotides
12. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
13. Mammalian mitochondria possess homologous DNA recombination activity
14. Cloning of the cDNA encoding rat homologue of the mismatch repair gene MSH2 and its expression during spermatogenesis
15. A plausible mechanism for gene correction by chimeric oligonucleotides
16. Failure to achieve gene conversion with chimeric circular oligonucleotides: Potentially misleading PCR artifacts observed
17. Repair of alkylated purines in the hepatic DNA of mitochondria and nuclei in the rat
18. Purification and characterization of MSH1, a yeast mitochondrial protein that binds to DNA mismatches
19. Purification and characterization of a mammalian homolog of Escherichia coli MutY mismatch repair protein from calf liver mitochondria
20. Mammalian mitochondrial extracts possess DNA end-binding activity
21. Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells
22. Eukaryotic DNA mismatch repair
23. Cell cycle regulation of the human DNA mismatch repair genes hMSH2, hMLH1, and hPMS2
24. Molecular regulation of liver regeneration
25. Elevated levels of homologous DNA recombination activity in the regenerating rat liver
26. Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes
27. Proliferating cell antigen (PCNA) expression in regenerating rat liver after partial hepatectomy
28. A sequence-specific gene correction by an RNA-DNA oligonuclectide in mammalian cells characterized by transfection and nuclear extract using a lacZ shuttle system
29. Strand interruptions confer strand preference during intracellular correction of a plasmid-borne mismatch in Saccharomyces cerevisiae
30. Peptide nucleic acid delivery to human mitochondria
31. Mitochondrial genetics and disease