A tool for functional plant genomics: Chimeric RNA/DNA oligonucleotides cause in vivo gene-specific mutations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 15, 1999, Pages 8774-8778

  Beetham, Peter R ^a   Kipp, Peter B ^a   Sawycky, Xenia L ^a   Arntzen, Charles J ^a   May, Gregory D ^a,b  

^a School of Integrative Plant Science   (United States)

^b PLANT BIOLOGY DIVISION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOLACTATE SYNTHASE; DNA; GREEN FLUORESCENT PROTEIN; HERBICIDE; OLIGONUCLEOTIDE; PROLINE; RIBONUCLEOTIDE; RNA;

ALLELE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CHIMERA; DNA SEQUENCE; FRAMESHIFT MUTATION; GENOME; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PLANT; PLANT CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; TOBACCO; TRANSGENE;

ACETOLACTATE SYNTHASE; CELLS, CULTURED; DNA, PLANT; DRUG RESISTANCE; FRAMESHIFT MUTATION; GENE EXPRESSION REGULATION; GENE TARGETING; GENES, PLANT; GREEN FLUORESCENT PROTEINS; HERBICIDES; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MUTAGENESIS, SITE-DIRECTED; OLIGONUCLEOTIDES; PHENOTYPE; PLANTS, TOXIC; RNA, PLANT; SULFONAMIDES; TOBACCO; TRANSFORMATION, GENETIC; TRANSGENES; TRIAZINES;

EMBRYOPHYTA; NICOTIANA TABACUM;

EID: 0033587679     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.15.8774     Document Type: Article

References (14)

1. Fink, G. R. (1998) Genetics 149, 473-477.
2. Yoon, K., Cole-Strauss, A. & Kmiec, E. B. (1996) Proc. Natl. Acad. Sci. USA 93, 2071-2076.
3. Cole-Strauss, A., Yoon, K., Xiang, Y., Byrne, B. C., Rice. M. C., Cryn, J. & Kmiec, E. B. (1996) Science 273, 1386-1389.
4. Kren, B. T., Bandyopadhyay, P. & Steer, C. J. (1998) Nat. Med. 4, 285-290.
5. Alexeev, V. & Yoon, K. (1998) Nat. Biotechnol. 16, 1343-1346.
6. Cole-Strauss, A., Gamper, H., Holloman, W. K., Muñoz, M., Cheng, N. & Kmiec, E. B. (1999) Nucleic Acids Res. 27(5), 1323-1330.
7. Chalef, R. S. & Ray, T. B. (1984) Science 223, 1148-1151.
8. Chalef, R. S. & Mauvais, C. J. (1984) Science 224, 1443-1445.
9. Lee, K. Y., Townsend, J., Tepperman, J., Black, M., Chui, C. F., Mazur, B., Dunsmuir, O. & Bedbrook, J. (1988) EMBO J. 7, 1241-1248.
10. Bedbrook, J. R., Chalef, R. S., Falco, S. C., Mazur, B. J., Somerville, C. R. & Yadav, N. S. (1991) U.S. Patent 5, 013,659.
11. Horsch R. B., Fry J. B., Hoffmann N. L., Wallroth M., Eichholtz D., Rodgers S. B. & Fraley R. T. (1985) Science 227, 1229-1231.
12. Chiu, W. L., Niwa, Y., Zeng, W., Hirano, T., Kobayashi, H. & Sheen, J. (1996) Curr. Biol. 6(3), 325-330.
13. Bishop, R. E., Pauly, G. T. & Moschel, R. C. (1996) Carcinogenesis 17, 849-856.
14. Kamiya, H., Suzuki, M. & Ohtsuka, E. (1993) FEBS Lett. 328, 125-129.