In vivo gene repair of point and frameshift mutations directed by chimeric RNA/DNA oligonucleotides and modified single-stranded oligonucleotides

Nucleic Acids Research

Volumn 29, Issue 20, 2001, Pages 4238-4250

  Liu, L ^a   Rice, M C ^a   Kmiec, E B ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HYGROMYCIN; NUCLEASE; NUCLEIC ACID BASE; OLIGONUCLEOTIDE; RNA; SINGLE STRANDED DNA;

ARTICLE; CHEMICAL STRUCTURE; CHIMERA; CHROMOSOME; CONTROLLED STUDY; DNA REPAIR; DNA RNA HYBRIDIZATION; DNA VECTOR; EPISOME; FRAMESHIFT MUTATION; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENE MUTATION; GENE TARGETING; GENETIC CODE; GENETIC TRANSCRIPTION; GENETICS; GROWTH; IN VIVO STUDY; MACHINE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; POINT MUTATION; PRIORITY JOURNAL; REPORTER GENE; SACCHAROMYCES CEREVISIAE;

EID: 0035886376     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.20.4238     Document Type: Article

References (39)

1. Targeted gene repair
2. Progress toward functional genomics applications using RNA/DNA oligonucleotides
3. Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA.DNA oligonucleotide
4. Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide
5. Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide
6. Gene correction by RNA-DNA oligonucleotide
7. In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotides
8. Different frequency of gene targeting events by the RNA-DNA oligonucleotide among epithelial cells
9. Gene correction of the apolipoprotein (Apo) E2 phenotype to wild-type ApoE3 by in situ chimeraplasty
10. Targeted gene repair directed by a chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract
11. A plausible mechanism for gene correction by chimeric oligonucleotides
12. The DNA strand of chimeric.RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts
13. Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides
14. Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide
15. Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of Crigler-Najjar syndrome type I with a chimeric oligonucleotide
16. A tool for functional plant genomics: Chimeric RNA/DNA oligonucleotides cause in vivo gene-specific mutations
17. Targeted manipulation of maize genes in vivo using chimeric RNA/DNA oligonucleotides
18. Engineering herbicide-resistant maize using chimeric RNA/DNA oligonucleotides
19. Genetic repair of mutations in plant cell-free extracts directed by specific chimeric oligonucleotides
20. Evidence for four-stranded exchange by RecA protein
21. Targeted correction of an episomal gene in mammalian cells by a short DNA fragment tethered to a triplex-forming oligonucleotide
22. Correction of chromosomal point mutations in human cells with bifunctional oligonucleotides
23. Regulation of targeted gene repair in Saccharomyces cerevisiae
24. Transformation of yeast with synthetic oligonucleotides
25. Strand-specificity in the transformation of yeast with synthetic oligonucleotides
26. Targeted gene correction by small single-stranded oligonucleotides in mammalian cells
27. Targeted replacement of normal and mutant CFTR sequences in human airway epithelial cells using DNA fragments
28. Targeted gene repair in mammalian cells using chimeric RNA/DNA oligonucleotides and modified single-stranded vectors
29. Oligodeoxynucleotide-directed mutagenesis of Escherichia coli and yeast by simple cotransformation of the primer and template
30. Oligodeoxynucleotide-directed mutagenesis using the yeast transformation system
31. Oligonucleotide-directed double-strand break repair in plasmids of Escherichia coli: A method for site-specific mutagenesis
32. Naturally occurring antisense RNA control-a brief review
33. Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene
34. Effect of excision repair by diploid human fibroblasts on the kinds and location of mutations induced by (±)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenz(a)pyrene in the coding region of the HPRT gene
35. Transcription-coupled repair of DNA damage: Unanticipated players, unexpected complexities
36. Detection and determination of oligonucleotide triplex formation-mediated transcription-coupled DNA repair in HeLa nuclear extracts
37. Parameters affecting the frequencies of transformation and co-transformation with synthetic oligonucleotides in yeast
38. Oligonucleotide-based gene-specific transcription inhibitors that target the open complex
39. Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: Sequence-specific suicide transportation