A sequence-specific gene correction by an RNA-DNA oligonucleotide in mammalian cells characterized by transfection and nuclear extract using a lacZ shuttle system

Gene Therapy

Volumn 6, Issue 12, 1999, Pages 1960-1971

  Igoucheva, O ^a   Peritz, A E ^a   Levy, D ^a   Yoon, K ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Gene therapy; Homologous recombination; Point mutation; Site specific gene conversion

Indexed keywords

BETA GALACTOSIDASE; CELL EXTRACT; DNA HYBRID; OLIGONUCLEOTIDE; PROTEIN P53; RNA DERIVATIVE;

ANIMAL CELL; ARTICLE; BACTERIAL GENE; BACTERIUM TRANSFORMATION; CELL NUCLEUS; CELL TYPE; CONTROLLED STUDY; DNA REPAIR; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; FIBROBLAST; GENE CONVERSION; GENE SEQUENCE; GENE TARGETING; GENETIC RECOMBINATION; GENETIC TRANSFECTION; HISTOCHEMISTRY; HUMAN; HUMAN CELL; LACTOSE OPERON; MAMMAL CELL; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SHUTTLE VECTOR;

ANIMALS; BETA-GALACTOSIDASE; CELLS, CULTURED; CHO CELLS; CRICETINAE; DNA PROBES; ENZYME ACTIVATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC ENGINEERING; GENETIC VECTORS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RNA PROBES;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA;

EID: 0033392739     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301042     Document Type: Article

References (42)

1. Yoon K, Cole-Strauss A, Kmiec EB. Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA/DNA oligonucleotide. Proc Natl Acad Sci USA 1996; 93: 2071-2076.
2. Cole-Strauss A et al. Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide. Science 1996; 273: 1386-1389.
3. Kren BT, Cole-Strauss A, Kmiec EB, Steer CJ. Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide. Hepatology 1997; 25: 1462-1468.
4. +- enriched cell population using a chimeric RNA/DNA oligonucleotide. J Mol Med 1997; 75: 829-835.
5. Kren BT, Bandyopadhyay P, Steer CJ. In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides. Nature Med 1998; 4: 285-290.
6. Santana E et al. Different frequency of gene targeting events by the RNA-DNA oligonucleotide among epithelial cells. J Invest Dermatol 1998; 111: 1172-1177.
7. Alexeev V, Yoon K. Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide. Nature Biotech 1998; 16: 1343-1346.
8. Stasiak A, West SC, Egelman EH. Sickle cell anemia research and a recombinant DNA technique (letter; comment). Science 1997; 277: 460-462.
9. Strauss M. The site-specific correction of genetic defects (news; comment). Nature Med 1998; 4: 274-275.
10. Thomas KR, Capecchi MR. Recombinant DNA technique and sickle cell anemia research (letter; comment). Science 1997; 275: 1404-1405.
11. Cupples CG, Miller JH. A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions. Proc Natl Acad Sci USA 1989; 86: 5345-5349.
12. Cupples CG, Miller JH. Effects of amino acid substitutions at the active site in E. coli ß-galactosidase. Genetics 1988; 120: 637-643.
13. Zhang Z et al. Failure to achieve gene conversion with chimeric circular oligonucleotides: potentially misleading PCR artifacts observed. Antisense Nucl Acids Drug Dev 1998; 8: 531-536.
14. Sambrook J, Fritsch EF, Maniatis T (eds). Molecular Cloning. Cold Spring Harbor Laboratory Press: New York, 1989, 1.63.
15. Mekeel KL et al. Inactivation of p53 results in high rates of homologous recombination. Oncogene 1997; 14: 1847-1857.
16. Thyagarajan B et al. Characterization of homologous DNA recombination activity in normal and immortal mammalian cells. Nucleic Acids Res 1996; 24: 4084-4091.
17. Harvery M et al. In vitro growth characteristics of embryonic fibroblasts isolated from p53-deficient mice. Oncogene 1993; 8: 2457-2467.
18. Yewdell JW, Gannon JV, Lane DP. Monoclonal antibody analysis of p53 expression in normal and transformed cells. J Virol 1986; 59: 444-452.
19. Calos MP, Lebowski JS, Botchan MR. High mutation frequency in DNA transfected into mammalian cells. Proc Natl Acad Sci USA 1983; 80: 3015-3019.
20. Lebowski JS et al. Transfected DNA is mutated in monkey, mouse, and human cells. Mol Cell Biol 1984; 4: 1951-1960.
21. Miller JH, Lebowsky JS, Greisen KS, Calos MP. Specificity of mutations induced in transfected DNA by mammalian cells. EMBO J 1984; 3: 3117-3121.
22. Razzaque A, Mizusawa H, Seidman MM. Rearrangement and mutagenesis of a shuttle vector plasmid after passage in mammalian cells. Proc Natl Acad Sci USA 1983; 80: 3010-3014.
23. Razzaque A, Chakrabarti S, Joffee S, Seidman M. Mutagenesis of a shuttle vector plasmid in mammalian cells. Mol Cell Biol 1984; 4: 435-441.
24. Cole-Strauss A et al. Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract. Nucleic Acids Res 1999; 27: 1323-1330.
25. Lin FM, Sperle K, Sternberg N. Intermolecular recombination between DNAs introduced into mouse L cells is mediated by nonconservative pathway that leads to crossover products. Mol Cell Biol 1990; 10: 113-119.
26. Maryon E, Carroll D. Characterization of recombination intermediates from DNA injected into Xenopus laevis oocytes: evidence for a nonconservative mechanism of homologous recombination. Mol Cell Biol 1991; 8: 3918-3928.
27. Rouet P, Smih F, Jasin M. Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells. Proc Natl Acad Sci USA 1994; 91: 6064-6068.
28. Modrich P, Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochcem 1996; 65: 101-133.
29. Fang WH, Modrich P. Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction. J Biol Chem 1993; 268: 11838-11844.
30. Diem C, Runger TM. Processing of three different types of DNA damage in cell lines of a cutaneous squamous cell carcinoma progression model. Carcinogenesis 1997; 18: 657-662.
31. Lawrence JN, Benford DJ. Chemically-induced unscheduled DNA synthesis in cultures of adult human epidermal keratinocytes. Mut Res 1993; 291: 105-115.
32. Sturzbecher HW et al. p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction. EMBO J 1996; 15: 1992-2002.
33. Lee S, Elenbaas B, Levine A, Griffith J. p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell 1995; 81: 1013-1020.
34. Meyn MS, Strasfeld L, Allen C. Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangi-ectasia. Int J Radiat Biol 1994; 66: S141-S149.
35. Wiesmuller L, Cammenga J, Deppert WW. In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes. J Virol 1996; 70: 737-744.
36. Dudenhoffer C et al. Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination. Mol Cell Biol 1998; 18: 5332-5342.
37. Buerstedde JM, Takeda S. Increased ratio of targeted to random integration after transfection of chicken B cell lines. Cell 1991; 67: 179-188.
38. 2+ mobilization through distinct pathways. EMBO J 1994; 13: 1341-1349.
39. Yanez RJ, Porter ACG. Therapeutic gene targeting. Gene Therapy 1998; 5: 149-159.
40. Mitra R, Nickoloff B. Cultivation of human epidermal keratinocytes in serum-free growth medium. In: Leigh I, Watt FM (eds). Keratinocytes Methods. Cambridge University Press: Cambridge, 1994, pp 17-20.
41. Young DC, Kingsley SD, Ryan KA, Dutko FJ. Selective inactivation of eukaryotic β-galactosidase in assays for inhibitors of HIV-1 TAT using bacterial β-galactosidase as a reporter enzyme. Anal Biochem 1993; 215: 24-30.
42. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983; 11: 1475-1489.