In vivo targeted repair of a point mutation in the canine dystrophin gene by a chimeric RNA/DNA oligonucleotide

Nature Biotechnology

Volumn 18, Issue 6, 2000, Pages 615-622

  Bartlett, Richard J ^a,b,f   Stockinger, Sabine ^b   Denis, Melvin M ^b,c   Bartlett, William T ^a,b   Inverardi, Luca ^b   Le, T T ^c,d   Man, Nguyen Thi ^e   Morris, Glenn E ^e   Bogan, Daniel J ^a   Metcalf Bogan, Janet ^a   Kornegay, Joe N ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d 363 Hamilton Hall ^*  (United States)

^e GLYNDWR UNIVERSITY   (United Kingdom)

^f NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

Author keywords

Canine; Chimeric RNA DNA oligonucleotide; Dystrophin; In situ RT PCR; Invivo gene repair; Quantitative RT PCR

Indexed keywords

DNA; DYSTROPHIN; OLIGONUCLEOTIDE; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASE MISPAIRING; CHIMERA; CONTROLLED STUDY; DNA REPAIR; DOG; DUCHENNE MUSCULAR DYSTROPHY; EXON; FRAMESHIFT MUTATION; GENE DELETION; GENE LOCATION; GENE TARGETING; MALE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RNA TRANSLATION;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; DNA; DNA REPAIR; DOGS; DYSTROPHIN; EPITOPE MAPPING; EXONS; FRAMESHIFT MUTATION; IMMUNOHISTOCHEMISTRY; INTRONS; MALE; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, DUCHENNE; OLIGONUCLEOTIDES; POINT MUTATION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SARCOLEMMA; SEQUENCE HOMOLOGY, NUCLEIC ACID; TEMPERATURE;

ANIMALIA; CANIS FAMILIARIS;

EID: 0034086776     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/76448     Document Type: Article

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