IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosis

EMBO Reports

Volumn 4, Issue 2, 2003, Pages 189-194

  Elliott, James I ^a   Higgins, Christopher F ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CHARYBDOTOXIN; CLOTRIMAZOLE; IBERIOTOXIN; ION CHANNEL; LIDOCAINE; PHOSPHATIDYLSERINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; QUININE; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL 1; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURFACE; CELL VOLUME; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; T LYMPHOCYTE; THYMOCYTE; ADULT; CELL DEATH; CELL STRUCTURE; LYMPH NODE CELL; MESENTERY LYMPH NODE; MOLECULAR BIOLOGY; MOUSE; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT, ACTIVE; CALCIMYCIN; CALCIUM; CD4-POSITIVE T-LYMPHOCYTES; CELL SIZE; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; KINETICS; LYMPH NODES; MICE; PHOSPHATIDYLSERINES; POTASSIUM CHANNELS;

ANIMALIA; CINCHONA PUBESCENS;

EID: 0037298183     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.embor722     Document Type: Article

References (30)

1. Benzaquen, L.R., Brugnara, C., Byers, H.R., Gatton-Celli, S. & Halperin, J.A. (1995) Clotrimazole inhibits cell proliferation in vitro and in vivo. Nature Med., 1, 534-540.
2. Bortner, C.D. & Cidlowski, J.A. (1999) Caspase independent/dependent regulation of K(+), cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis. J. Biol. Chem., 274, 21953-21962.
3. Czirjak, G., Petheo, G.L., Spat, A. & Enyedi, P. (2001) Inhibition of TASK-1 potassium channel by phospholipase C. Am. J. Physiol. Cell. Physiol., 281, C700-C708.
4. Dallaporta, B. et al. (1999) Plasma membrane potential in thymocyte apoptosis. J. Immunol., 162, 6534-6542.
5. 2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization. J. Biol. Chem., 275, 39954-39963.
6. Dick, G.M., Rossow, C.F, Smirnov, S., Horowitz, B. & Sanders, K.M. (2001) Tamoxifen activates smooth muscle BK channels through the regulatory beta 1 subunit. J. Biol. Chem., 276, 34594-34599.
7. Doerfler, P., Forbush, K.A. & Perlmutter, R.M. (2000) Caspase enzyme activity is not essential for apoptosis during thymocyte development. J. Immunol., 164, 4071-4079.
8. Fanger, C.M. et al. (2001) Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J. Biol. Chem., 276, 12249-12256.
9. Gribkoff, V.K. et al. (1996) Effects of channel modulators on cloned large-conductance calcium-activated potassium channels. Mol. Pharmacol., 50, 206-217.
10. Hamon, Y. et al. (2000) ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nature Cell Biol., 2, 399-406.
11. Hoffmann, E.K. (2000) Intracellular signalling involved in volume regulatory decrease. Cell. Physiol. Biochem., 10, 273-288.
12. Khanna, R., Chang, M.C., Joiner, W.J., Kaczmarek, L.K. & Schlichter, L.C. (1999) hSK4/hIK1, a calmodulin-binding KCa channel in human T lymphocytes. Roles in proliferation and volume regulation. J. Biol. Chem., 274, 14838-14849.
13. + channel family. J. Biol. Chem., 275, 9340-9347.
14. + channels regulating chloride secretion in murine airway and colonic epithelium. Mol. Pharmacol., 60, 753-760.
15. Maeno, E., Ishizaki,Y., Kanaseki, T, Hazama, A. & Okada, Y. (2000) Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc. Natl Acad. Sci. USA, 97, 9487-9492.
16. Mariathasan, S. et al. (2001) Duration and strength of extracellular signal-regulated kinase signals are altered during positive versus negative thymocyte selection. J. Immunol., 167, 4966-4973.
17. 2+ entry in the regulation of phosphatidylserine expression at the surface of stimulated cells. Biochemistry, 38, 10092-10098.
18. + channel TASK-2 (KCNK5) by changes in cell volume. J. Biol. Chem., 276, 43166-43174.
19. Ormerod, M.G., Paul, F., Cheetham, M. & Sun, X.M. (1995) Discrimination of apoptotic thymocytes by forward light scatter. Cytometry, 21, 300-304.
20. Petronilli, V., Penzo, D., Scorrano, L., Bernardi, P. & Di Lisa, F. (2001) The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ. J. Biol. Chem., 276, 12030-12034.
21. Savill, J. and Fadok,V. (2000) Corpse clearance defines the meaning of cell death. Nature, 407, 784-788.
22. Schanne, F.A., Kane, A.B., Young, E.E. & Farber, J.L. (1979) Calcium dependence of toxic cell death: a final common pathway. Science, 206, 700-702.
23. Schlegel, R.A., Callahan, M.K. & Williamson, P. (2000) The central role of phosphatidylserine in the phagocytosis of apoptotic thymocytes. Ann. N. Y. Acad. Sci., 926, 217-225.
24. Sims, P.J. & Wiedmer, T. (2001) Unraveling the mysteries of phospholipid scrambling. Thromb. Haemost., 86, 266-275.
25. Trimarchi, J.R., Liu, L., Smith, P.J. & Keefe, D.L. (2002) Apoptosis recruits two-pore domain potassium channels used for homeostatic volume regulation. Am. J. Physiol. Cell. Physiol., 282, C588-C594.
26. 2+-dependent potassium channels. Proc. Natl Acad. Sci. USA, 98, 5329-5334.
27. Vermes, I., Haanen, C. & Reutelingsperger, C. (2000) Flow cytometry of apoptotic cell death. J. Immunol. Methods, 243, 167-190.
28. + channels in the regulatory volume decrease in human osteoblast-like cells. J. Membr. Biol., 178, 11-20.
29. Yu, S.P., Canzoniero, L.M. & Choi, D.W. (2001) Ion homeostasis and apoptosis. Curr. Opin. Cell. Biol., 13, 405-411.
30. Yu, S.P. et al. (1997) Mediation of neuronal apoptosis by enhancement of outward potassium current. Science, 278, 114-117.