Cardiac glycosides stimulate Ca2+increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells

Cancer Research

Volumn 60, Issue 14, 2000, Pages 3807-3812

  McConkey, David J ^a   Lin, Yun ^a   Nutt, Leta K ^a   Ozel, Huseyin Z ^b   Newman, Robert A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Ozelle Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM ION; CARDIAC GLYCOSIDE; CASPASE 3; CASPASE 8; CYTOCHROME C; DIGOXIN; OLEANDRIN; OUABAIN; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; POTASSIUM ION; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA;

ADENOCARCINOMA; APOPTOSIS; CALCIUM; CARDENOLIDES; CARDIAC GLYCOSIDES; CARDIOTONIC AGENTS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELL SEPARATION; CYTOCHROME C GROUP; DIGOXIN; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; MALE; MYOCARDIUM; OUABAIN; POLY(ADP-RIBOSE) POLYMERASES; PROSTATIC NEOPLASMS; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0034660878     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Cardiac glycosides in the next millennium
2. Understanding the sodium pump and its relevance to disease
3. Regulation of intracellular potassium in mesangial cells: A fluorescence analysis using the dye, PBFI
4. Is digitalis a therapy for breast carcinoma?
5. The role of calcium in the regulation of apoptosis
6. Deletion of cells by apoptosis during castration-induced involution of the rat prostate
7. Role of calcium in the programmed cell death of rat ventral prostatic glandular cells
8. 2+-dependent endonuclease as an early event in castration-induced prostatic cell death
9. Activation of programmed cell death in the rat ventral prostate after castration
10. The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin
11. Metastatic behavior of human tumor cell lines grown in the nude mouse
12. Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice
13. In vitro model for intrinsic drug resistance: Effects of protein kinase C activators on the chemosensitivity of cultured human colon cancer cells
14. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
15. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
16. Fluorometric and colorimetric detection of caspase activity associated with apoptosis
17. Prevention of apoptosis by bcl-2: Release of cytochrome c from mitochondria blocked
18. Characterization of caspase processing and activation in HL-60 cell cytosol under cell-free conditions. Nucleotide requirement and inhibitor profile
19. Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes
20. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
21. The biology of hormone refractory prostate cancer. Why does it develop?
22. +efflux in the activation of apoptosis
23. +suppresses the activation of apoptosis in lymphocytes
24. 2-terminal kinase
25. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NFκB
26. +ratio blocks apoptosis in vascular smooth muscle at a site upstream of caspase-3
27. Caspases: Enemies within
28. Induction of the apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
29. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
30. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
31. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis