Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA

Cancer Research

Volumn 56, Issue 9, 1996, Pages 2033-2038

  Marchetti, Philippe ^a   Susin, Santos A ^a   Decaudin, Didier ^a   Gamen, Susana ^b   Castedo, Maria ^a   Hirsch, Tamara ^a   Zamzami, Naoufal ^a   Naval, Javier ^b   Senik, Anna ^a   Kroemer, Guido ^a  

^a CNRS   (France)

^b UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMYCIN A1; CYCLOHEXIMIDE; MENADIONE; MITOCHONDRIAL DNA;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; DNA CLEAVAGE; DRUG RESISTANCE; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

APOPTOSIS; CELL LINE; CELL-FREE SYSTEM; DNA, MITOCHONDRIAL; FLOW CYTOMETRY; HELA CELLS; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MICROSCOPY, CONFOCAL; MITOCHONDRIA;

EID: 9244237035     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Jacobson, M. D., Burne, J. F , and Raff, M. C. Programmed cell death and Bcl-2 protection in the absence of a nucleus. EMBO J , 13: 1899-1910, 1994.
2. Schulze-Osthoff, K., Walczak, H., Dröge, W., and Krammer, P. H. Cell nucleus and DNA fragmentation are not required for apoptosis. J. Cell Biol., 127: 15-20, 1994.
3. Deckwerth, T. L., and Johnson, E. M. Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J. Cell Biol., 123: 1207-1222, 1993.
4. Vayssiere, J-L., Petit, P. X., Risler, Y., and Mignotte, B. Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40. Proc. Natl. Acad. Sci. USA, 91. 11752-11756, 1994.
5. Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssiere, J-L , Petit, P. X., and Kroemer, G. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med., 181. 1661-1672, 1995.
6. Petit, P. X., LeCouer, H., Zorn, E , Dauguet, C., Mignotte, B., and Gougeon, M. L. Alterations of mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. J. Cell Biol., 130: 157-167, 1995.
7. Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S. A., Petit, P. X., Mignone, B., and Kroemer, G. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp. Med., 182: 367-377, 1995.
8. Cossarizza, A., Franceschi, C., Monti, D., Salvioli, S., Bellesia, E., Rivabene, R., Biondo, L., Rainaldi, G., Tinari, A., and Malomi, W. Protective effect of N-acetylcysteine in tumor necrosis factor-α-induced apoptosis in U937 cells: the role of mitochondria. Exp. Cell Res., 220, 232-240, 1995
9. Macho, A , Castedo, M., Marchetti, P., Aguilar, J. J., Decaudin, D. Zamzami, N., Girard, P M, Uriel, J., and Kroemer, G. Mitochondrial dysfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers Blood, 86: 2481-2487, 1995.
10. Castedo, M., Macho, A., Zamzami, N., Hirsch, T., Marchetti, P., Uriel, J., and Kroemer, G Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo. Eur. J Immunol., 25: 3277-3284, 1995.
11. Kroemer, G., Petit, P. X., Zamzami, N., Vayssière, J-L., and Mignotte, B. The biochemistry of apoptosis. FASEB J., 9: 1277-1287, 1995.
12. Newmeyer, D. D., Farschon, D. M., and Reed, J C Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Cell, 79: 353-364, 1994
13. Zamzami, Z., Susin, S. A., Marchem, P., Hirsch, T., Gómez-Monterrey, I., Castedo, M., and Kroemer, G. Mitochondrial control of nuclear apoptosis, J. Exp. Med., in press, 1996.
14. Jacobson, M. D., Burne, J. F., King, M P., Miyashita, T., Reed, J. C., and Raff, M. C. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA Nature (Lond.), 361: 365-369, 1993.
15. Gamen, S., Anel, A., Montoya, J., Marzo, I., Piñeiro, A , and Naval, J. mtDNA-depleted U937 cells are sensitive to TNF and Fas-mediated cytotoxicity. FEBS Lett., 376, 15-18, 1995.
16. Halicka, H. D., Ardelt, B., Li, X., Melamed, M. M., and Darzynkiewicz, Z. 2-Deoxy-D-glucose enhances sensitivity of human histiocytic lymphoma U937 cells to apoptosis induced by tumor necrosis factor. Cancer Res , 55: 444-449, 1995.
17. Gonzalo, J. A., Moreno de Alborán, I, Alés-Martínez, J. E., Alés-Martínez, C., and Kroemer, G Expansion and clonal deletion of peripheral T cells induced by bacterial superantigen is independent of the interleukin 2 pathway. Eur. J. Immunol., 22: 1007-1011, 1992.
18. Nicoletti, L. Migliorati, G., Pagliacci, M. C., and Riccardi, C. A rapid simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods. 139, 271-280, 1991
19. Boutry, M., and Briquet, M. Mitochondrial modifications associated with the cytoplasmic male sterility in faba beans, Eur. J Biochem., 127: 129-135, 1982.
20. Perronilli, V., Cola, C., Massari, S., Colonna, R. and Bernardi, P. Physiological effectors modify voltage-sensing by the cyclosporin A-sensitive mitochondrial permeability transition pore. J. Biol. Chem., 268: 21939-21945, 1993.
21. Wood, E. R., and Earnshaw, W. C. Mitotic chromatin condensation in vitro using somatic cell extracts and nuclei with variable levels of endogenous topoisomerase II J. Cell Biol., 111: 2839-2850, 1990.
22. Lazebnik, Y. A., Cole, S , Cooke, C. A., Nelson, W. G , and Earnshaw, W. C. Nuclear events of apoptosis in vitro in cell-free mitotic extracts, a model system for analysis of the active phase of apoptosis. J. Cell Biol., 1993: 7-22, 1993.
23. Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., and Earnshaw, W. C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (Lond), 371: 346-347, 1994.
24. Petit, P. X., O'Connor, J E., Grunwald, D , and Brown, S. C. Analysis of the membrane potential of rat- and mouse-liver mitochondria by flow cytometry and possible applications. Eur. J. Biochem , 220: 389-397, 1990.
25. 2+: their relationship to apoptosis and oncogenesis. FEBS Lett., 325: 104-107, 1993.
26. Schulze-Osthoff, K., Bakker, A. C., Vanhaesbroeck, B., Beyaert, R., Jacob, W A., and Fiers, W. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. J. Biol. Chem., 267: 5317-5323, 1992.
27. Schulze-Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G., and Fiers, W. Depletion of the mitochondrial electron transport abrogates the cytotoxic and geneinductive effects of TNF. EMBO J., 12: 3095-3104, 1993.
28. Wright, S. C., Kumar, P., Tam, A. W., Shen, N, Varma, M., and Larrick, J. W. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. J. Cell. Biochem., 48, 344-355, 1992.
29. Wolvetang, E. J., Johnson, K. L., Krauer, K , Ralph, S. J., and Linnane, A. W. Mitochondrial respiratory chain inhibitors induce apoptosis. FEBS Lett., 339: 40-44, 1994.
30. Bernardi, P., Broekemeier, K. M , and Pfeiffer, D. R. Recent progress on regulation of the mitochondrial permeability transition pore: a cyclosporin-sensitive pore in the inner mitochondrial membrane. J. Bioenerg. Biomembr., 26: 509-517, 1994.
31. Zorani, M., and Szabò, I. The mitochondrial permeability transition. Biochem. Biophys. Acta Rev. Biomembr., 1241: 139-176, 1995.
32. Brandohn, G., Le-Saux, A., Trezeguet, V., Lauquinn, G. J., and Vignais, P. V. Chemical, immunological, enzymatic, and genetic approaches to studying the arrangement of the peptide chain of the ADP/ATP carrier in the mitochondrial membrane. J. Bioenerg. Biomembr., 25: 493-501, 1993.
33. 2+ uniporter by pure and impure ruthenium red. Mol. Cell. Biochem., 139: 33-40, 1994.
34. Schulze-Osthoff, K., Krammer, P. H., and Droge, W Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death. EMBO J., 13: 4587-4596, 1994.
35. Jacobson, M. D., and Raff, M. C Programmed cell death and Bcl-2 protection in very low oxygen. Nature (Lond.), 374: 814-816, 1995.
36. Krajeuski, S , Tanaka, S., Takayama, S., Schibler, M. J , Fenton, W., and Reed, J. C. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res., 55: 4701-4714, 1993.
37. Krajewski, S., Krajewska, M., Shabaik, A , Wang, H. G., Ine, S., Pong, L., and Reed, J. C. Immunohistochemical analysis of in vivo patterns of bcl-x expression. Cancer Res., 54: 5501-5507, 1994.
38. McEnery, M. W., Snowman, A. M., Trifiletti, R. R., and Snyder, S. H. Isolation of the mitochondrial benzodiazepine receptor association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc. Natl. Acad. Sci. USA, 89: 3170-3174, 1992
39. Kinnally, K. W , Zorov, D. B., Antonenko, Y. N., Snyder, S. H., McEnery, M. W., and Tedeschi, H. Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands. Proc. Natl Acad. Sci. USA, 90: 1374-1378, 1993.
40. Tanaka, S., Saito, K. and Reed, J C. Structure-function analysis of the Bcl-2 oncoprotein Addition of a heterologous transmembrane domain to portions of the Bcl-2β protein restores function as a regulator of cell survival. J. Biol. Chem., 268: 10920-10926, 1993.
41. Nguyen, M , Branton, P. E., Walton, P A , Oltvai, Z. N., Korsmeyer, S. J., and Shore, G. C. Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus. J. Biol. Chem., 269: 16521-16524, 1994.