Development and initial application of an in vitro model of apoptosis in rodent cholangiocytes

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 272, Issue 1 35-1, 1997, Pages

  Que, Florencia G ^a   Gores, Gregory J ^a   LaRusso, Nicholas F ^a,b  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

beauvericin; cysteine protease P 32; fluorogenic interleukin 1 converting enzyme protease substrates; interleukin 1 converting enzyme CED 3 homologue 1; potassium

Indexed keywords

BEAUVERICIN; CALCIUM ION; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; POTASSIUM ION; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; BILE DUCT; CALCIUM CELL LEVEL; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; RAT;

EID: 0031014749     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1997.272.1.g106     Document Type: Article

References (36)

1. Afford, S. C., S. Hubscher, A. J. Strain, D. H. Adams, and J. M. Neuberger. Apoptosis in the human liver during allograft rejection and end-stage liver disease. J. Pathol. 176: 373-380, 1995.
2. Alpini, G., J. O. Phillips, and N. F. LaRusso. The Biology of Biliary Epithelia. New York: Raven, 1994.
3. 2+ and pH. Biochem. Biophys. Res. Commun. 186: 782-789, 1992.
4. Ben-Ari, Z., A. P. Dhillon, and S. Sherlock. Autoimmune cholangiopathy: part of the spectrum of autoimmune chronic active hepatitis. Hepatology Baltimore 18: 10-15, 1993.
5. Bernuau, D., G. Feldmann, C. Dergott, and C. Gisselbrecht. Ultrastructural lesions of bile ducts in primary biliary cirrhosis. Hum. Pathol. 12: 782-793, 1981.
6. Bhathal, P. S., and J. A. M. Gall. Deletion of hyperplastic biliary epithelial cells by apoptosis following removal of the proliferative stimulus. Liver 5: 311-325, 1985.
7. Chomczynski, P., and N. Sacchi. Single step method of RNA isolation by acid guanidium thiocyanate phenol chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
8. Clavien, P.-A., R. C. Harvey, and S. M. Strasberg. Preservation and reperfusion injuries in liver allografts. Transplantation 53: 957-978, 1992.
9. Dickson, R. C., S. F. Bronk, and G. J. Gores. Glycine cytoprotection during lethal hepatocellular injury from adenosine triphosphate depletion. Gastroenterology 102: 2098-2107, 1992.
10. D'Mello, S. R., C. Galli, T. Ciotti, and P. Calissano. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. USA 90: 10989-10993, 1993.
11. Duke, R. C., R. Z. Witter, P. B. Nash, J. D.-E. Young, and D. M. Ojcius. Cytolysis mediated by ionophores and pore-forming agents: role of intracellular calcium in apoptosis. FASEB J. 8: 237-246, 1994.
12. Flaws, J. A., K. Kugu, A. M. Trbovich, A. DeSanti, K. I. Tilly, A. N. Hirschfield, and J. L. Tilly. Interleukin-1β-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle. Endocrinology 136: 5042-5053, 1995.
13. Gratiot-Deans, J., L. Ding, L. A. Turka, and G. Nunez. Bcl-2 proto-oncogene expression during human T cell development. J. Immunol. 151: 83-91, 1993.
14. Grubman, S. A., R. D. Perrone, D. W. Lee, S. L. Murray, L. C. Rogers, L. I. Wolkoff, A. E. Mulberg, V. Cherington, and D. M. Jefferson. Regulation of intracellular pH by immortalized human intrahepatic biliary epithelial cell lines. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G1060-G1070, 1994.
15. Krams, S. M., H. Egawa, M. B. Quinn, J. C. Villanueva, R. Garcia-Kennedy, and O. M. Martinez. Apoptosis as a mechanism of cell death in liver allograft rejection. Transplantation 59: 621-625, 1995.
16. Lippke, J. A., Y. Gu, G. Sarnecki, P. R. Caron, and M. S. Su. Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32. J. Biol. Chem. 271: 1825-1828, 1996.
17. Los, M., M. Van de Craen, L. C. Penning, H. Schenk, M. Westendorp, P. A. Baeuerie, W. Droge, P. H. Krammer, W. Fiers, and K. Schulze-Osthoff. Requirement of an ICE/ CED-3 protease for Fas/APO-1-mediated apoptosis. Nature Lond. 375: 81-83, 1995.
18. Martinez, O. M., J. C. Villanueva, M. E. Gershwin, and S. M. Krams. Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis. Hepatology Baltimore 21: 113-119, 1995.
19. McConkey, D. J., P. Hartzell, P. Nicotera, and S. Orrenius. Calcium-activated DNA fragmentation kills immature thymocytes. FASEB J. 3: 1843-1848, 1989.
20. + exchange by cultured renal cells. Am. J. Physiol. 255 (Cell Physiol. 24): C76-C85, 1988.
21. + exchange. J. Membr. Biol. 93: 33-42, 1986.
22. Nawaz, S., and R. H. Fennell. Apoptosis of bile duct epithelial cells in hepatic allograft rejection. Histopathology 25: 137-142, 1994.
23. Ojcius, D. M., A. Zychlinsky, L. M. Zheng, and J. D. Young, Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes. Exp. Cell Res. 197: 43-49, 1991.
24. Oltvai, Z. N., C. L. Milliman, and S. J. Korsmeyer. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619, 1993.
25. 2+-dependent mechanisms of cytotoxicity and programmed cell death. Toxicol. Lett. 64/65: 357-364, 1992.
26. Patel, T., S. Bronk, and G. J. Gores. Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes. J. Clin. Invest. 94: 2183-2192, 1994.
27. Ray, C. A., R. A. Black, S. R. Kronheim, T. A. Greenstreet, P. R. Sleath, G. S. Salvesen, and D. J. Pickup. Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1β coverting enzyme. Cell 69: 597-604, 1992.
28. Roberts, J. M., J. W. Searle, and W. G. E. Cooksley. Histological patterns of prolonged hepatitis C infection. Gastroenterol. Jpn. 28: 37-41, 1993.
29. Roberts, S. K., S. M. Kuntz, G. J. Gores, and N. F. LaRusso. Regulation of bicarbonate-dependent ductular bile secretion assessed by lumenal micropuncture of isolated rodent intrahepatic bile ducts. Proc. Natl. Acad. Sci. USA 90: 9080-9084, 1993.
30. Schlegel, J., I. Peters, S. Orrenius, D. K. Miller, N. A. Thornberry, T.-T. Yamin, and D. W. Nicholson. CPP32/ apopain is a key interleukin 1β converting enzyme-like protease involved in Fas-mediated apoptosis. J. Biol. Chem. 271: 1841-1844, 1996.
31. Searle, J., B. V. Harmon, C. J. Bishop, and J. F. R. Kerr. The significance of cell death by apoptosis in hepatobiliary disease. J. Gastroenterol. Hepatol. 2: 77-96, 1987.
32. Spivey, J. R., S. F. Bronk, and G. J. Gores. Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium. J. Clin. Invest. 92: 17-24, 1993.
33. Tietz, P. S., G. Alpini, L. D. Pham, and N. F. LaRusso. Somatostatin inhibits secretin-induced ductal hypercholeresis and exocytosis by cholangiocytes. Am. J. Physiol. 269 (Gastrointest. Liver Physiol. 32): G110-G118, 1995.
34. Vroman, B., and N. F. LaRusso. Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells. Lab. Invest. 74: 303-313, 1996.
35. Walker, N. P. C., R. V. Talanian, K. D. Brady, L. C. Dang, N. J. Bump, C. R. Ferenz, S. Franklin, T. Ghayur, M. C. Hackett, L. D. Hammill, L. Herzog, M. Hugunin, W. Houy, J. A. Mankovich, L. McGuiness, E. Oriewicz, M. Paskind, C. A. Pratt, P. Reis, A. Summani, M. Terranova, J. P. Welch, L. Xiong, A. Moller, D. E. Tracey, R. Kamen, and W. W. Wong. Crystal structure of the cysteine protease interleukin-1β-converting enzyme: a (p20/p10)2 homodimer. Cell 78: 343-352, 1994.
36. Wyllie, A. H., J. F. R. Kerr, and A. R. Currie. Cell death: the significance of apoptosis. In: International Review of Cytology. New York: Academic, 1980, p. 251-306.