NMDA induces apoptosis and necrosis in neuronal cultures. Increased APP immunoreactivity is linked to apoptotic cells

Neuroscience Letters

Volumn 221, Issue 2-3, 1997, Pages 213-216

  Lesort, M ^a   Esclaire, F ^a   Yardin, C ^a   Hugon, J ^a  

^a UNIVERSITY OF LIMOGES   (France)

Author keywords

amyloid precursor protein; apoptosis; extracellular deposits; immunoreactivity; N methyl D aspartate; necrosis; rat neuronal cultures

Indexed keywords

AMYLOID PRECURSOR PROTEIN; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CORTEX; CELL CULTURE; CONTROLLED STUDY; EMBRYO; IMMUNOCYTOCHEMISTRY; NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOPTOSIS; CELLS, CULTURED; EXCITATORY AMINO ACID AGONISTS; EXTRACELLULAR SPACE; IMMUNOHISTOCHEMISTRY; N-METHYLASPARTATE; NECROSIS; NEURONS; RATS; RATS, WISTAR;

EID: 0031015255     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13310-3     Document Type: Article

References (23)

1. Ankarcrona, M., Dypbukt, J.M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S.A. and Nicotera, P., Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function, Neuron, 15 (1995) 961-973.
2. Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P. and Lipton, S.A., Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures, Proc. Natl. Acad. Sci. USA, 92 (1995) 7162-7166.
3. Chartier-Harlin, M.C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., Goate, A., Rossor, M., Roques, P., Hardy, J. and Mullan, M., Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene, Nature, 353 (1991) 844-846.
4. Cotman, C.W. and Anderson, A.J., A potential role for apoptosis in neurodegeneration and Alzheimer's disease, Mol. Neurobiol., 10 (1995) 19-45.
5. Esch, F.S., Keim, P.S., Beattie, E.C., Blacher, R.W., Culwell, A.R., Oltersdorf, T., McClure, D. and Ward, P.J., Cleavage of amyloid β peptide during constitutive processing of its precursor, Science, 248 (1990) 1122-1124.
6. Fesus, L., Thomazy, V. and Falus, A., Induction and activation of tissue transglutaminase during programmed cell death, FEBS Lett., 224 (1987) 104-108.
7. Haass, C., Koo, E.H., Mellon, A., Hung, A.Y. and Selkoe, D.J., Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments, Nature, 357 (1992) 500-503.
8. Hugon, J., Hugon, F., Esclaire, F., Diop, A.G. and Lesort, M., The presence of calbinding in neuronal cultures protects from oxidative stress, Brain Res., 707 (1996) 288-292.
9. Kang, J., Lemaire, H.G., Unterbeck, A., Salbaum, J.M., Masters, C.L., Grzeschik, K.H. and Multhaup, G., Beyreuther, K and Müller-Hill, B., The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor, Nature, 325 (1987) 733-736.
10. Lassmann, H., Bancher, C., Breitschopf, H., Wegiel, J., Bobinski, M., Jellinger, K. and Wisniewski, H., Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ, Acta Neuropathol., 89 (1995) 35-41.
11. Le Blanc, A., Increased production of 4 kDa amyloid β peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis, J. Neurosci., 15 (1995) 7837-7846.
12. Lesort, M., Yardin, C., Esclaire, F. and Hugon, J., NMDA toxicity induces membrane blebbings accumulating APP derivates in human and rat neuronal cultures, Soc. Neurosci. Abstr., 3 (1995) 208.
13. Lo, A.C., Houenou, L.J. and Oppenheim, R.W., Apoptosis in the nervous system: morphological features, methods, pathology, and prevention, Arch. Histol. Cytol., 58 (1995) 139-149.
14. Mossman, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays, J. Immunol. Methods, 65 (1983) 55-63.
15. Murrell, J., Farlow, M., Ghetti, B. and Benson, M.D., A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease, Science, 254 (1991) 97-99.
16. Nitsch, R.M., Slack, B.E., Wurtman, R.J. and Growdon, J.H., Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors, Science, 258 (1992) 304-307.
17. Nixon, R.A. and Cataldo, A.M., The endosomal-lysosomal system of neurons: new roles, Trends Neurosci., 18 (1995) 489-496.
18. Schubert, D., Jin, L.W., Saitoh, T. and Cole, G., The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion, Neuron, 3 (1989) 689-694.
19. Slack, B.E., Breu, J., Petryniak, M.A., Srivastava, K.S. and Wurtman, R.J., Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor, J. Biol. Chem., 270 (1995) 8337-8344.
20. Smale, G., Nichols, N.R., Brady, D.R., Finch, C.E. and Horton, W.E., Evidence for apoptotic cell death in Alzheimer's disease, Exp. Neurol., 133 (1995) 225-230.
21. Tornusciolo, D.R.Z., Schmidt, R.E. and Roth, K.A., Simultaneous detection of TDT-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells and multiple immunohistochemical markers in single tissue sections, Biotechniques, 19 (1995) 800-805.
22. Wyllie, A.H., Kerr, J.F.R. and Currie, A.R., Cell death the significance of apoptosis, Int. Rev. Cytol., 68 (1980) 252-306.
23. Wyllie, A.H. and Duvall, D., Cell injury and death. In J.O'D. McGee, P.G. Isaacson and N.A. Wright (Eds.), Oxford Textbook of Pathology, Principles of pathology, Vol. 1, Oxford University Press, Oxford, 1992, pp. 141-193.