Effect of proteasome inhibitors on monocytic IκB-α and -β depletion, NF-κB activation, and cytokine production

Journal of Leukocyte Biology

Volumn 63, Issue 3, 1998, Pages 395-404

  Haas, Monika ^a   Page, Sharon ^a   Page, Michael ^a   Neumann, Franz Josef ^a   Marx, Nikolaus ^a   Adam, Michaela ^b   Ziegler Heitbrock, H W Löms ^c   Neumeier, Dieter ^a   Brand, Korbinian ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Interleukin 1 ; Interleukin 8; Lipopolysaccharide; Transcription factors; Tumor necrosis factor

Indexed keywords

CALPASTATIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PROTEINASE INHIBITOR; TUMOR NECROSIS FACTOR;

ARTICLE; GENE ACTIVATION; GENE REPRESSION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

EID: 0031931132     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.63.3.395     Document Type: Article

References (65)

1. Ziegler-Heitbrock, H. W. L. (1989) The biology of the monocyte system. Eur. J. Cell. Biol. 49, 1-12.
2. Müller, J. M., Ziegler-Heitbrock, H. W. L., Baeuerle, P. A. (1993) Nuclear factor kappa B, a mediator of lipopolysaccharicle effects. Immunobiol. 187, 233-256.
3. Bazzoni, F., Beutler, B. (1996) The tumor necrosis factor ligand and receptor families. N. Engl. J. Med. 334, 1717-1725.
4. Baeuerle, P. A., Henkel, T. (1994) Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-179.
5. Siebenlist, U., Franzoso, G., Brown, K. (1994) Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10, 405-455.
6. Goldfeld, A. E., Doyle, C., Maniatis, T. (1990) Human tumor necrosis factor α gene regulation by virus and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 87, 9769-9773.
7. Ziegler-Heitbrock, H. W. L., Sternsdorf, T., Liese, J., Belohradsky, B., Weber, C., Wedel, A., Schreck, R., Baeuerle, P. A., Stroebel, M. (1993) Pyrrolidine dithiocarbamate inhibits NF-κB mobilization and TNF production in human monocytes. J. Immunol. 151, 6986-6993.
8. Trede, N. S., Tsytsykova, A. L. Chatila, T., Goldfeld, A., Geha, R. S. (1995) Transcriptional activation of the human TNF-α promoter by superantigen in human monocytic cells: Role of NF-κB. J. Immunol. 155, 902-908.
9. Brand, K., Fowler, T. S., Mackman, N. (1991) Tissue factor mRNA in THP-1 monocytic cells is regulated at both transcriptional and posttranscriptional levels in response to lipopolysaccharide. Mol. Cell. Biol. 11, 4732-4738.
10. Mackman, N., Brand, K., Edgington, T. S. (1991) Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor κB binding sites. J. Exp. Med. 174, 1517-1526.
11. Stein, B., Baldwin, A. S. (1993) Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB. Mol. Cell. Biol. 13, 7191-7198.
12. Kunsch, C., Rosen, C. A. (1993). NF-κB subunit-specific regulation of the interleukin-8 promoter. Mol. Cell. Biol. 13, 6146-6173.
13. Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T., Akira, S. (1993) Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci. USA 90, 10193-10197.
14. Okamoto, S., Mukaida, N., Yasumoto, K., Rice, N., Ishikawa, Y., Horiguchi, H., Murakami, S., Matsushima, K. (1994) The interleukin-8, AP-1, and κB-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. J. Biol. Chem. 269, 8582-8589.
15. Kerr, L. D., Ransone, L. J., Wamsley, P., Schmitt, M. J., Boyer, T. G., Zhou, Q., Berk, A. J., Verma, I. M. (1993) Association between protooncoproteins rel and TATA-binding protein mediates transcriptional activation by NF-κB. Nature 365, 412-419.
16. Rhoades, K., Golub, S. H., Economou, J. S. (1992) The regulation of the human tumor necrosis factor a promoter region in macrophage, T cell, and B cell lines. J. Biol. Chem. 267, 22102-22107.
17. Leitman, D. C., Mackow, E. R., Williams, T., Baxter, J. D., West, B. L. (1992) The core promoter region of the tumor necrosis factor a gene confers phorbol ester responsiveness to upstream transcriptional activators. Mol. Cell Biol. 12, 1352-1356.
18. Goldfeld, A. E., McCaffrey, P. G., Strominger, J. L., Rao, A. (1993) Identification of a novel cyclosporin-sensitive element in the human tumor necrosis α gene promoter. J. Exp. Med. 178, 1365-1379.
19. Galdiero, M., Cippolaro-de-L'ero, G., Donnarumma, G., Marcatili, A., Galdiero, F. (1995) Interleukin-1 and interleukin-6 gene expression in human monocytes stimulated with Salmonella typhimurium porins. Immunol. 86, 612-619.
20. Kramer, B., Wiegmann, K., Krönke, M. (1995) Regulation of the human TNF promoter by the transcription factor Ets. J. Biol. Chem. 270, 6577-6583.
21. Kramer, B., Machleidt, T., Wiegmann, K., Krönke, M. (1995) Superantigen-induced transcriptional activation of the human TNF gene promoter in T cells. J. Inflamm. 45, 183-192.
22. Luo, C., Burgeon, E., Carew, J. A., McCaffrey, P. G., Badalian, T. M., Lane, W. S., Hogan, P. G., Rao, A. (1996) Recombinant NFATl (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol. Cell. Biol. 16, 3955-3966.
23. Lenardo, M. J., Baltimore, D. (1989) NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 58, 227-229.
24. Grilli, M., Chiu, J. J.-S., Lenardo, M. J. (1993) NF-κB and Rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143, 1-62.
25. Baldwin, A. S. (1996) The NF-κB and IκB proteins: New discoveries and insights. Annu. Rev. Immunol. 14, 649-681.
26. Palombella, V. J., Rando, O. J., Goldberg, A. L., Maniatis, T. (1994) The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78, 773-785.
27. Thanos, D., Maniatis, T. (1995) NF-κB: a lesson in family values. Cell 80, 529-532.
28. Thompson, J. E., Phillips, R. J., Erdjument-Bromage, H., Tempst, P., Ghosh, S. (1995) IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell 80, 573-582.
29. Whiteside, S. T., Epinat, J.-C., Rice, N. R., Israel, A. (1997) I kappa B epsilon, a novel member of the IκB family, controls RelA and cRel NF-κB activity. EMBO J. 16, 1413-1426.
30. Ulevitch, R. J., Tobias, P. S. (1995) Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol. 13, 437-457.
31. Henkel, T., Machleidt, T., Alkalay, I., Krönke, M., Ben-Neriah, Y., Baeuerle, P. A. (1993) Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature 365, 182-185.
32. Traenckner, E. B.-M., Wilk, S., Baeuerle, P. A. (1994) A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J. 13, 5433-5441.
33. Alkalay, I., Yaron, A., Hatzubai, A., Orian, A., Ciechanover, A., Ben-Neriah, Y. (1995) Stimulation-dependent IκB-α phosphorylation marks the NF-κB inhibitor for degradation via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 92, 10599-10603.
34. Lin, Y., Brown, K., Siebenlist, U. (1995) Activation of NF-κB requires proteolysis of the inhibitor IκB-α: signal-induced phosphorylation of IκB-α alone does not release active NF-κB. Proc. Natl. Acad. Sci. USA 92, 552-556.
35. Liu, Z.-Q., Kunimatsu, M., Yang, J.-P., Ozaki, Y., Sasaki, M., Okamoto, T. (1996) Proteolytic processing of nuclear factor-κB by calpain in vitro. FEBS Lett. 385, 109-113.
36. Imbert, V., Rupec, R. A., Livolsi, A., Pahl, H. L., Traenckner, B.-M., Mueller-Dieckmann, C., Farahifar, D., Rossi, B., Auberger, P., Baeuerle, P. A., Peyron, J.-F. (1996) Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB-α. Cell 86, 787-798.
37. Baeuerle, P. A., Baltimore, D. (1996) NF-κB: Ten years after. Cell 87, 13-20.
38. Cobb, R. R., Felts, K. A., Parry, G. C. N., Mackman, N. (1996) Proteasome inhibitors block VCAM-1 and ICAM-1 gene expression in endothelial cells without affecting nuclear translocation of nuclear factor-κB. Eur. J. Immunol. 26, 839-845.
39. Donald, R., Ballard, D. W., Hawiger, J. (1995) Proteolytic processing of NF-κB/IκB in human monocytes. J. Biol. Chem. 270, 9-12.
40. Schow, S. R., Joly, A. (1997) N-Acetyl-leucinyl-leucinyl-norleucinal inhibits lipopolysaccharide-induced NF-κB activation and prevents TNF and IL-6 synthesis in vivo. Cell Immunol. 175, 199-202.
41. Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., Goldberg, D. (1994) Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761-771.
42. Fox, J. E. B., Austin, C. D., Reynolds, C. C., Steffen, P. K. (1991) Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets. J. Biol. Chem. 20, 13289-13295.
43. McGowan, E. B., Becker, E., Detweiler, T. C. (1989) Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d. Biochem. Biophys. Res. Commun. 158, 432-435.
44. Wilcox, D., Mason, R. W. (1992) Inhibition of cysteine proteinases in lysosomes and whole cells. Biochem. J. 285, 495-502.
45. Tsujinaka, T., Kajiwara, Y., Kambayashi, J., Sakon, M., Higuchi, N., Tanaka, T., Mori, T. (1988) Synthesis of a new cell penetrating calpain inhibitor (calpeptin). Biochem. Biophys. Res. Commun. 153, 1201-1208.
46. Figueiredo-Pereira, M. E., Banik, N., Wilk, S. (1994) Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain. J. Neurochem. 62, 1989-1994.
47. Brand, K., Mackman, N., Curtiss, L. K. (1993) Interferon-γ inhibits macrophage apolipoprotein E production by posttranslational mechanisms. J. Clin. Invest. 91, 2031-2039.
48. Brand, K., Banca, C. L., Mackman, N., Terkeltaub, R. A., Fan, S. T., Curtiss, L. K. (1994) Oxidized low density lipoprotein enhances lipopolysaccharide-induced tissue factor expression in human adherent monocytes. Arterioscler. Thromb. 14, 790-797.
49. Kastenbauer, S., Wedel, A., Frankenberger, M., Wirth, T., Ziegler-Heitbrock, H. W. L. (1996) Analysis of promoter activity by polymerase chain reaction amplification of reporter gene mRNA. Anal. Biochem. 233, 137-139.
50. Kube, D., Platzer, C., Von Knethen, A., Straub, H., Bohlen, H., Hafner, M., Tesch, H. (1995) Isolation of the human interleukin 10 promoter, characterization of the promoter activity in Burkitt's lymphoma cell lines. Cytokine 7, 1-7.
51. Shakhov, A. N., Collart, M. A., Vassalli, P., Nedospasov, S. A., Jongeneel, C. V. (1990) κB-type enhancers are involved in lipopolysaccharidemediated transcriptional activation of the tumor necrosis factor α gene in primary macrophages. J. Exp. Med. 171, 35-47.
52. Hiscott, J., Marois, J., Garoufalis, J., D'Addarion, M., Roulston, A., Kwan, I., Pepin, N., Lacoste, J., Nguyen, H., Bensi, G., Fenton, M. (1993) Characterization of a functional NF-kappa B site in the human interleukin-1β promoter: evidence for a positive autoregulatory loop. Mol. Cell. Biol. 13, 6231-6240.
53. Han, J., Jiang, Y., Li, Z., Kravchenko, V. V., Ulevitch, R. J. (1997) Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 386, 296-299.
54. Read, M. A., Neish, A. S., Luscinskas, F. W., Palombella, V. J., Maniatis, T., Collins, T. (1995) The proteasome pathway is required for cytokine-induced endothelial leukocyte adhesion molecule expression. Immunity 2, 493-506.
55. Pouch, M.-N., Petit, F., Buri, J., Briand, Y., Schmid, H.-P. (1995) Identification and initial characterization of a specific proteasome (prosome) associated RNase activity. J. Biol. Chem. 270, 22023-22028.
56. Johnson, D. R., Douglas, I., Jahnke, A., Ghosh, S., Pober, J. S. (1996) A sustained reduction in IκB-β may contribute to persistent NF-κB activation in human endothelial cells. J. Biol. Chem. 271, 16317-16322.
57. Goldberg, A. L. (1992) The mechanism and functions of ATP-dependent proteases in bacterial and animal cells. Eur. J. Biochem. 203, 9-23.
58. Rivett, A. J. (1993) Proteasomes: multicatalytic proteinase complexes. Biochem. J. 291, 1-10.
59. Hilt, W., Wolf, D. H. (1996) Proteasomes: destruction as a programme. Trends Biol. Sci. 21, 96-102.
60. Eggers, M., Boes-Fabian, B., Ruppert, T., Kloetzel, P.-M, Koszinowski, U. H. (1995) The cleavage preference of the proteasome governs the yield of antigenic peptides. J. Exp. Med. 182, 1865-1870.
61. Kuckelkorn, U., Frentzel, S., Kraft, R., Kostka, S., Groettrup, M., Kloetzel, P.-M. (1995) Incorporation of major histocompatibility complex-encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-γ. Eur. J. Immunol. 25, 2605-2611.
62. Griscavage, J. M., Wilk, S., Ignarro, L. J. (1996) Inhibitors of the proteasome pathway interfere with the induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Proc. Natl. Acad. Sci. USA 93, 3308-3312.
63. Marok, R., Winyard, P. G., Coumbe, A., Kus, M. L., Gaffney, K., Blades, S., Mapp, P. I., Morris, C. J., Blake, D. R., Kaltschmidt, C., Baeuerle, P. A. (1996) Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue. Arthr. Rheumatism 39, 583-591.
64. Brand, K., Page, S., Rogler, G., Bartsch, A., Brandi, R., Knuechel, R., Page, M., Kaltschmidt, C., Baeuerle, P. A., Neumeier, D. (1996) Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. J. Clin. Invest. 97, 1715-1722.
65. Ulevitch, R. J., Dunn, D. L., Fink, M. P., Taylor, C. E. (1996) Endotoxin-related intracellular pathways: implications for therapeutic intervention. Shock 6, 1-2.