IκB kinase-α and -β genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes

Gene

Volumn 222, Issue 1, 1998, Pages 31-40

  Hu, Mickey C T ^a   Wang, You Ping ^a  

^a AMGEN INC   (United States)

Author keywords

Chromosome mapping; Gene expression; I B; NF B; Protein kinase

Indexed keywords

COMPLEMENTARY DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; PROTEIN SERINE THREONINE KINASE; CHUK PROTEIN, HUMAN; CHUK PROTEIN, MOUSE; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKB PROTEIN, MOUSE; IKBKE PROTEIN, HUMAN; IKBKE PROTEIN, MOUSE; ISOENZYME;

ADOLESCENT; ADULT; ANIMAL TISSUE; ARTICLE; CHROMOSOME 10Q; CHROMOSOME 8P; CHROMOSOME MAP; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONAL TISSUE; GENE EXPRESSION; GENE LOCATION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; CHROMOSOME 10; CHROMOSOME 8; COMPARATIVE STUDY; DNA SEQUENCE; ENZYMOLOGY; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MOUSE; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 10; CHROMOSOMES, HUMAN, PAIR 8; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA, COMPLEMENTARY; EMBRYO; EVOLUTION, MOLECULAR; GENE EXPRESSION; HUMANS; I-KAPPA B KINASE; IN SITU HYBRIDIZATION, FLUORESCENCE; ISOENZYMES; MICE; MOLECULAR SEQUENCE DATA; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE ANALYSIS, DNA; TISSUE DISTRIBUTION;

EID: 0032487672     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(98)00462-4     Document Type: Article

References (36)

1. Arakane, F., King, S.R., Du, Y., Kallen, C.B., Walsh, L.P., Watari, H., Stocco, D.M., Strauss III, J.F., 1997. Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity. J. Biol. Chem. 272, 32656-32662.
2. Baeuerle, P.A., Baltimore, D., 1996. NF-κB: ten years after. Cell 87, 13-20.
3. Baldwin Jr., A.S., 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-681.
4. Beg, A.A., Baltimore, D., 1996. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274, 782-784.
5. Bose, H.S., Sugawara, T., Strauss III, J.F., Miller, W.L., 1996. The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. New Engl. J. Med. 335, 1870-1878.
6. Chen, Z.J., Parent, L., Maniatis, T., 1996. Site-specific phosphorylation of IκBa by a novel ubiquitination-dependent protein kinase activity. Cell 84, 853-862.
7. Connelly, M.A., Marcu, K.B., 1995. CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain. Cell. Mol. Biol. Res. 41, 537-549.
8. DiDonato, J.A., Hayakawa, M., Rothwarf, D.M., Zandi, E., Karin, M., 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388, 548-554.
9. Dube, I.D., Raimondi, S.C., Pi, D., Kalousek, D.K., 1986. A new translocation, t(10;14)(q24;q11), in T cell neoplasia. Blood 67, 1181-1184.
10. Hanspal, M., Yoon, S.-H., Yu, H., Hanspal, J.S., Lambert, S., Palek, J., Prchal, J.T., 1991. Molecular basis of spectrin and ankyrin deficiencies in severe hereditary spherocytosis: evidence implicating a primary defect of ankyrin. Blood 77, 165-173.
11. Heng, H.H.Q., Squire, J., Tsui, L.-C., 1992. High resolution mapping of mammalian genes by in situ hybridization to free chromatin. Proc. Natl. Acad. Sci. USA 89, 9509-9513.
12. Heng, H.H.Q., Tsui, L.-C., 1993. Modes of DAPI banding and simultaneous in situ hybridization. Chromosoma 102, 325-332.
13. Kanda, S., Hodgkin, M.N., Woodfield, R.J., Wakelam, M.J., Thomas, G., Claesson-Welsh, L., 1997. Phosphatidylinositol 3′-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells. J. Biol. Chem. 272, 23347-23353.
14. Liptay, S., Schmid, R.M., Perkins, N.D., Meltzer, P., Altherr, M.R., McPherson, J.D., Wasmuth, J.J., Nabel, G.J., 1992. Related subunits of NF-kappa-β map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2. Genomics 13, 287-292.
15. Liu, Z.-G., Hu, H., Goeddel, D.V., Karin, M., 1996. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis, while NF-κB activation prevents cell death. Cell 87, 565-576.
16. Machnicki, J.L., Bloomfield, C.D., 1990. Clinical significance of the cytogenetics of acute leukemias. Oncology 4, 23-30.
17. Mathew, S., Murty, V.V.V.S., Dalla-Favera, R., Chaganti, R.S.K., 1993. Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa-Bp50, NF-kappa-Bp65, and lyt-10 by fluorescence in situ hybridization. Oncogene 8, 191-193.
18. McKusick, V. A., 1997. Mendelian Inheritance in Man, 12th ed. Johns Hopkins University Press, Baltimore.
19. Mercurio, F., Zhu, H., Murray, B.W., Shevchenko, A., Bennett, B.L., Li, J.W., Young, D.B., Barbosa, M., Mann, M., Manning, A., Rao, A., 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278, 860-866.
20. Miyamoto, S., Verma, I.M., 1995. Rel/NF-κB/IκB story. Adv. Cancer Res. 66, 255-292.
21. Mock, B.A., Connelly, M.A., McBride, O.W., Kozak, C.A., Marcu, K.B., 1995. CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19. Genomics 27, 348-351.
22. Muenke, M., Schell, U., Hehr, A., Robin, N.H., Losken, H.W., Schinzel, A., Pulleyn, L.J., Rutland, P., Reardon, W., Malcolm, S., Winter, R.M., 1994. A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Nat. Genet. 8, 269-274.
23. Neri, A., Chang, C.-C., Lombardi, L., Salina, M., Corradini, P., Maiolo, A.T., Chaganti, R.S.K., Dalla-Favera, R., 1991. B Cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa-B p50. Cell 67, 1075-1087.
24. Offit, K., Jhanwar, S.C., Ladanyi, M., Filippa, D.A., Chaganti, R.S., 1991a. Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment. Genes Chromosomes Cancer 3, 189-201.
25. Offit, K., Wong, G., Filippa, D.A., Tao, Y., Chaganti, R.S., 1991b. Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: clinical correlations. Blood 77, 1508-1515.
26. Raimondi, S.C., Behm, F.G., Roberson, P.K., Pui, C.H., Rivera, G.K., Murphy, S.B., Williams, D.L., 1988. Cytogenetics of childhood T-cell leukemia. Blood 72, 1560-1566.
27. Regnier, C.H., Yeong Song, H., Gao, X., Goeddel, D.V., Cao, Z., Rothe, M., 1997. Identification and characterization of an IκB kinase. Cell 90, 373-383.
28. Sambrook, J., Fritsch, E.F., Maniatis, T., 1989. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
29. Siebenlist, U., Franzoso, G., Brown, K., 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell. Biol. 10, 405-455.
30. Stancovski, I., Baltimore, D., 1997. NF-κB activation: the IκB kinase revealed? Cell 91, 299-302.
31. Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R., Verma, I.M., 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274, 787-789.
32. Verma, I.M., Stevenson, J., 1997. IκB kinase: beginning, not the end. Proc. Natl. Acad. Sci. USA 94, 11758-11760.
33. Verma, I.M., Stevenson, J.K., Schwarz, E.M., Van Antwerp, D., Miyamoto, S., 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9, 2723-2735.
34. Wang, C.-Y., Mayo, M.W., Baldwin Jr., A.S., 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274, 784-787.
35. Woronicz, J.D., Gao, X., Cao, Z., Rothe, M., Goeddel, D.V., 1997. IκB kinase-β: NF-KB activation and complex formation with IκB kinase-α and NIK. Science 281, 866-870.
36. Zandi, E., Rothwarf, D.M., Delhase, M., Hayakawa, M., Karin, M., 1997. The IκB kinase complex (IKK) contains two kinase subunits, IKK-α and IKK-β, necessary for IκB phosphorylation and NF-κB activation. Cell 91, 243-252.