Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2

Journal of Biological Chemistry

Volumn 278, Issue 13, 2003, Pages 11489-11494

  Cilenti, Lucia ^a   Lee, Younghee ^a   Hess, Sibylle ^b   Srinivasula, Srinivasa ^c   Park, Kwon Moo ^d   Junqueira, Daniela ^a   Davis, Hedvika ^a   Bonventre, Joseph V ^d   Alnemri, Emad S ^c   Zervos, Antonis S ^a  

^a UNIVERSITY OF CENTRAL FLORIDA   (United States)

^b Biovertis AG   (Germany)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CELLS; FLUORESCENCE; PROTEINS; SUBSTRATES;

PROTEOLYTIC ACTIVITY;

BIOCHEMISTRY;

CASPASE; CHAPERONE; PROTEIN INHIBITOR; SERINE PROTEINASE; SERINE PROTEINASE OMI; UNCLASSIFIED DRUG; FLUORESCEIN ISOTHIOCYANATE; MITOCHONDRIAL PROTEIN; RECOMBINANT PROTEIN; SERINE PROTEINASE INHIBITOR;

ARTICLE; CELL DEATH; CHEMICAL STRUCTURE; COMBINATORIAL LIBRARY; ENZYME ACTIVITY; ENZYME SUBSTRATE; FIBROBLAST; FLUORESCENCE; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN SECRETION; APOPTOSIS; DRUG ANTAGONISM; DRUG EFFECT; HYDROLYSIS; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS;

BACTERIA (MICROORGANISMS); MAMMALIA;

APOPTOSIS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCEIN-5-ISOTHIOCYANATE; HYDROLYSIS; MITOCHONDRIAL PROTEINS; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS;

EID: 0037562009     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212819200     Document Type: Article

References (21)

1. Faccio, L., Fusco, C., Chen, A., Martinotti, S., Bonventre, J. V., and Zervos, A. S. (2000) J. Biol. Chem. 275, 2581-2588
2. Gray, C. W., Ward, R. V., Karran, E., Turconi, S., Rowles, A., Viglienghi, D., Southan, C., Barton, A., Fantom, K. G., West, A., Savopoulos, J., Hassan, N. J., Clinkenbeard, H., Hanning, C., Amegadzie, B., Davis, J. B., Dingwall, C., Livi, G. P., and Creasy, C. L. (2000) Eur. J. Biochem. 267, 5699-5710
3. Pallen, M. J., and Wren, B. W. (1997) Mol. Microbiol. 26, 209-221
4. Spiess, C., Beil, A., and Ehrmann, M. (1999) Cell 97, 339-347
5. Faccio, L., Fusco, C., Viel, A., and Zervos, A. S. (2000) Genomics 68, 343-347
6. Suzuki, Y., Imai, Y., Nakayama, H., Takahashi, K., Takio, K., and Takahashi, R. (2001) Mol. Cell. 8, 613-621
7. Hegde, R., Srinivasula, S. M., Zhang, Z., Wassell, R., Mukattash, R., Cilenti, L., DuBois, G., Lazebnik, Y., Zervos, A. S., Fernandes-Alnemri, T., and Alnemri, E. S. (2002) J. Biol. Chem. 277, 432-438
8. Martins, L. M., Iaccarino, I., Tenev, T., Gschmeissner, S., Totty, N. F., Lemoine, N. R., Savopoulos, J., Gray, C. W., Creasy, C. L., Dingwall, C., and Downward, J. (2002) J. Biol. Chem. 277, 439-444
9. Verhagen, A. M., Silke, J., Ekert, P. G., Pakusch, M., Kaufmann, H., Connolly, L. M., Day, C. L., Tikoo, A., Burke, R., Wrobel, C., Moritz, R. L., Simpson, R. J., and Vaux, D. L. (2002) J. Biol. Chem. 277, 445-454
10. van Loo, G., van Gurp, M., Depuydt, B., Srinivasula, S. M., Rodriguez, I., Alnemri, E. S., Gevaert, K., Vandekerckhove, J., Declercq, W., and Vandenabeele, P. (2002) Cell Death Differ. 9, 20-26
11. Du, C., Fang, M., Li, Y., Li, L., and Wang, X. (2000) Cell 102, 33-42
12. Verhagen, A. M., Ekert, P. G., Pakusch, M., Silke, J., Connolly, L. M., Reid, G. E., Moritz, R. L., Simpson, R. J., and Vaux, D. L. (2000) Cell 102, 43-53
13. Chen, P., Nordstrom, W., Gish, B., and Abrams, J. M. (1996) Genes Dev. 10, 1773-1782
14. Vucic, D., Kaiser, W. J., Harvey, A. J., and Miller, L. K. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 10183-10188
15. Vucic, D., Kaiser, W. J., and Miller, L. K. (1998) Mol. Cell. Biol. 18, 3300-3309
16. Srinivasula, S. M., Datta, P., Kobayashi, M., Wu, J. W., Fujioka, M., Hegde, R., Zhang, Z., Mukattash, R., Fernandes-Alnemri, T., Shi, Y., Jaynes, J. B., and Alnemri, E. S. (2002) Curr. Biol. 12, 125-130
17. Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kagi, D., Khoo, W., Potter, J., Yoshida, R., Kaufman, S. A., Lowe, S. W., Penninger, J. M., and Mak, T. W. (1998) Cell 94, 339-352
18. Li, W., Srinivasula, S. M., Chai, J., Li, P., Wu, J. W., Zhang, Z., Alnemri, E. S., and Shi, Y. (2002) Nat. Struct. Biol. 22, 436-441
19. Hu, S. I., Carozza, M., Klein, M., Nantermet, P., Luk, D., and Crowl, R. M. (1998) J. Biol. Chem. 273, 34406-34412
20. Kitanaka, C., and Kuchino, Y. (1999) Cell Death Differ. 6, 508-515
21. Sperandio, S., de Belle, I., and Bredesen, D. E. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 14376-14381