-
1
-
-
0034638766
-
Pharmacogenetics and adverse drug reactions
-
Meyer UA: Pharmacogenetics and adverse drug reactions. Lancet 356,1667-1671 (2000).
-
(2000)
Lancet
, vol.356
, pp. 1667-1671
-
-
Meyer, U.A.1
-
2
-
-
0036596857
-
The impact of pharmacogenetics and pharmacogenomics on drug discovery
-
Lindpaintner K: The impact of pharmacogenetics and pharmacogenomics on drug discovery. Nat. Rev. Drug Discov. 1, 463-469 (2002).
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 463-469
-
-
Lindpaintner, K.1
-
3
-
-
0035105777
-
Pharmacogenetic applications of the Human Genome project
-
Liggett SB: Pharmacogenetic applications of the Human Genome project. Nat. Med. 7, 281-283 (2001).
-
(2001)
Nat. Med.
, vol.7
, pp. 281-283
-
-
Liggett, S.B.1
-
4
-
-
0002485410
-
Pharmacokinetics. The dynamics of drug absorption, distribution and elimination
-
Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York
-
Wilkinson GR: Pharmacokinetics. The dynamics of drug absorption, distribution and elimination. In: Goodman and Gilman's: The pharmacological basis of therapeutics. Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York 3-30 (2001).
-
(2001)
Goodman and Gilman's: The Pharmacological Basis of Therapeutics
, pp. 3-30
-
-
Wilkinson, G.R.1
-
5
-
-
0033569516
-
Pharmacogenomics: Translating functional genomics into rational therapeutics
-
Evans WE, Relling MV: Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286, 487-491 (1999).
-
(1999)
Science
, vol.286
, pp. 487-491
-
-
Evans, W.E.1
Relling, M.V.2
-
6
-
-
0038305826
-
Pharmacogenetics and drug metabolism
-
Ball S, Borman N: Pharmacogenetics and drug metabolism. Nat. Biotech. 16, 4-5 (1998).
-
(1998)
Nat. Biotech.
, vol.16
, pp. 4-5
-
-
Ball, S.1
Borman, N.2
-
7
-
-
0035721949
-
Pharmacogenetics: An opportunity for a safer and more efficient pharmacotherapy
-
Ingelman-Sundberg M: Pharmacogenetics: an opportunity for a safer and more efficient pharmacotherapy. J. Intern. Med. 250, 186-200 (2001).
-
(2001)
J. Intern. Med.
, vol.250
, pp. 186-200
-
-
Ingelman-Sundberg, M.1
-
8
-
-
0346942394
-
Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays
-
Gerhold D, Lu M, Xu J, Austin C, Caskey CT, Rushmore T: Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays. Physiol. Genomics 5, 161-170 (2001).
-
(2001)
Physiol. Genomics
, vol.5
, pp. 161-170
-
-
Gerhold, D.1
Lu, M.2
Xu, J.3
Austin, C.4
Caskey, C.T.5
Rushmore, T.6
-
9
-
-
0031794361
-
Inhibition and induction of cytochrome P450 and the clinical implications
-
Lin JH, Lu AY: Inhibition and induction of cytochrome P450 and the clinical implications. Clin. Pharmacokinet. 35, 361-390 (1998).
-
(1998)
Clin. Pharmacokinet.
, vol.35
, pp. 361-390
-
-
Lin, J.H.1
Lu, A.Y.2
-
10
-
-
0030022629
-
An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials
-
Parkinson A: An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials. Toxicol. Pathol. 24, 48-57 (1996).
-
(1996)
Toxicol. Pathol.
, vol.24
, pp. 48-57
-
-
Parkinson, A.1
-
11
-
-
0031038038
-
Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
-
Sachse C, Brockmoller J, Bauer S, Roots I: Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am. J. Hum. Genet. 60, 284-295 (1997).
-
(1997)
Am. J. Hum. Genet.
, vol.60
, pp. 284-295
-
-
Sachse, C.1
Brockmoller, J.2
Bauer, S.3
Roots, I.4
-
12
-
-
0031472588
-
Role of pharmacokinetics and metabolism in drug discovery and development
-
Lin JH, Lu AY: Role of pharmacokinetics and metabolism in drug discovery and development. Pharmacol. Rev. 49, 403-449 (1997).
-
(1997)
Pharmacol. Rev.
, vol.49
, pp. 403-449
-
-
Lin, J.H.1
Lu, A.Y.2
-
13
-
-
85137893152
-
Pharmacogenetics
-
Woolf TF (Ed.), Marcel Dekker, Inc., New York
-
Daly AK: Pharmacogenetics. In: Handbook of Drug Metabolism. Woolf TF (Ed.), Marcel Dekker, Inc., New York, 175-202 (1999).
-
(1999)
Handbook of Drug Metabolism
, pp. 175-202
-
-
Daly, A.K.1
-
14
-
-
0017695082
-
Polymorphic hydroxylation of Debrisoquine in man
-
Mahgoub A, Idle JR, Dring LG, Lancaster R, Smith RL: Polymorphic hydroxylation of Debrisoquine in man. Lancet 2, 584-586 (1977).
-
(1977)
Lancet
, vol.2
, pp. 584-586
-
-
Mahgoub, A.1
Idle, J.R.2
Dring, L.G.3
Lancaster, R.4
Smith, R.L.5
-
15
-
-
0030995879
-
Molecular mechanisms of genetic polymorphisms of drug metabolism
-
Meyer UA, Zanger UM: Molecular mechanisms of genetic polymorphisms of drug metabolism. Ann. Rev. Pharmacol. Toxicol. 37, 269-296 (1997).
-
(1997)
Ann. Rev. Pharmacol. Toxicol.
, vol.37
, pp. 269-296
-
-
Meyer, U.A.1
Zanger, U.M.2
-
16
-
-
0027136288
-
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
-
Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjoqvist F, Ingelman-Sundberg M: Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc. Natl. Acad. Sci. USA 90, 11825-11829 (1993).
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 11825-11829
-
-
Johansson, I.1
Lundqvist, E.2
Bertilsson, L.3
Dahl, M.L.4
Sjoqvist, F.5
Ingelman-Sundberg, M.6
-
17
-
-
0034790063
-
Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6
-
Zanger UM, Fischer J, Raimundo S et al: Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6. Pharmacogenetics 11, 573-585 (2001).
-
(2001)
Pharmacogenetics
, vol.11
, pp. 573-585
-
-
Zanger, U.M.1
Fischer, J.2
Raimundo, S.3
-
18
-
-
0037600622
-
Metabolism, pharmacokinetics and excretion of a highly selective N-methyl-D-aspartate receptor antagonist, traxoprodil, in human cytochrome P450 2D6 extensive and poor metabolizers
-
Johnson K, Shah A, Jaw-Tsai S, Baxter J, Prakash C: Metabolism, pharmacokinetics and excretion of a highly selective N-methyl-D-aspartate receptor antagonist, traxoprodil, in human cytochrome P450 2D6 extensive and poor metabolizers. Drug Metab. Dispos. 31, 76-87 (2003).
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 76-87
-
-
Johnson, K.1
Shah, A.2
Jaw-Tsai, S.3
Baxter, J.4
Prakash, C.5
-
19
-
-
0035657076
-
Association of polymorphism in the cytochrome cYP2D6 and the efficacy and tolerability of simvastatin
-
Mulder AB, van Lijf HJ, Bon MA et al.: Association of polymorphism in the cytochrome cYP2D6 and the efficacy and tolerability of simvastatin. Clin. Pharmacol. Ther. 70, 546-551 (2001).
-
(2001)
Clin. Pharmacol. Ther.
, vol.70
, pp. 546-551
-
-
Mulder, A.B.1
van Lijf, H.J.2
Bon, M.A.3
-
20
-
-
0037096821
-
Patient-tailored antiemetic treatment with 5-hydroxytryptamine Type 3 receptor antagonists according to cytochrome P450 2D6 genotypes
-
Kaiser R, Sezer O, A Papies et al.: Patient-tailored antiemetic treatment with 5-hydroxytryptamine Type 3 receptor antagonists according to cytochrome P450 2D6 genotypes. J. Clin. Oncol. 20, 2805-2811 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2805-2811
-
-
Kaiser, R.1
Sezer, O.2
Papies, A.3
-
21
-
-
0026816971
-
Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects
-
Andersson T, Regardh CG, Lou YC, Zhang Y, Dahl ML, Bertilsson L: Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects. Pharmacogenetics 2, 25-31 (1992).
-
(1992)
Pharmacogenetics
, vol.2
, pp. 25-31
-
-
Andersson, T.1
Regardh, C.G.2
Lou, Y.C.3
Zhang, Y.4
Dahl, M.L.5
Bertilsson, L.6
-
22
-
-
0032586730
-
CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans
-
Furuta T, Ohashi K, Kosuge K et al.: CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans. Clin. Pharmacol. Ther. 65, 552-561 (1999).
-
(1999)
Clin. Pharmacol. Ther.
, vol.65
, pp. 552-561
-
-
Furuta, T.1
Ohashi, K.2
Kosuge, K.3
-
23
-
-
0033771689
-
5-hydroxylation of omeprazole by human liver microsomal fractions from Chinese populations related to CYP2C19 gene dose and individual ethnicity
-
Shu Y, Wang LS, Xu ZH et al.: 5-hydroxylation of omeprazole by human liver microsomal fractions from Chinese populations related to CYP2C19 gene dose and individual ethnicity. J. Pharmacol. Exp. Ther. 295, 844-851 (2000).
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 844-851
-
-
Shu, Y.1
Wang, L.S.2
Xu, Z.H.3
-
24
-
-
0037184794
-
Polymorphism of cytochrome P450 and xenobiotic toxicity
-
Ingelman-Sundberg M: Polymorphism of cytochrome P450 and xenobiotic toxicity. Toxicology 181-182, 447-452 (2002).
-
(2002)
Toxicology
, vol.181-182
, pp. 447-452
-
-
Ingelman-Sundberg, M.1
-
25
-
-
0028237729
-
Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
-
Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP: Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther. 270, 414-423 (1994).
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.270
, pp. 414-423
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Inui, Y.4
Guengerich, F.P.5
-
26
-
-
0002939033
-
CYP3A
-
Levy KE, Thummel KE, Trager WF, Hansten PD, M Eichelbaum (Eds), Lippincott Williams & Wilkins, Philadelphia
-
Wrighton SA, Thummel RH: CYP3A. In: Metabolic Drug Interactions. Levy KE, Thummel KE, Trager WF, Hansten PD, M Eichelbaum (Eds), Lippincott Williams & Wilkins, Philadelphia 115-133 (2000).
-
(2000)
Metabolic Drug Interactions
, pp. 115-133
-
-
Wrighton, S.A.1
Thummel, R.H.2
-
27
-
-
0032547341
-
Modification of clinical presentation of prostate tumours by a novel genetic variant in CYP3A4
-
Rebbeck TR, Jaffe JM, Walker AH, Wein AJ, Malkowicz SB: Modification of clinical presentation of prostate tumours by a novel genetic variant in CYP3A4. J. Natl. Cancer Inst. 90, 1225-1229 (1998).
-
(1998)
J. Natl. Cancer Inst.
, vol.90
, pp. 1225-1229
-
-
Rebbeck, T.R.1
Jaffe, J.M.2
Walker, A.H.3
Wein, A.J.4
Malkowicz, S.B.5
-
28
-
-
0033632228
-
CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12, evidence for an allelic variant with altered catalytic activity
-
Sata F, Sapone A, Elizondo G et al.: CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12, evidence for an allelic variant with altered catalytic activity. Clin. Pharmacol. Ther. 67, 48-56 (2000).
-
(2000)
Clin. Pharmacol. Ther.
, vol.67
, pp. 48-56
-
-
Sata, F.1
Sapone, A.2
Elizondo, G.3
-
29
-
-
13144282667
-
Association of CYP3A4 genotype with treatment-related leukaemia
-
Felix CA, Walker AH, Lange BJ et al.: Association of CYP3A4 genotype with treatment-related leukaemia, Proc. Natl. Acad. Sci. USA 95, 13176-13181 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13176-13181
-
-
Felix, C.A.1
Walker, A.H.2
Lange, B.J.3
-
30
-
-
0032825907
-
Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4
-
Ball SE, Scatina J, Kao J et al.: Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4. Clin. Pharmacol. Ther. 66, 288-294 (1999).
-
(1999)
Clin. Pharmacol. Ther.
, vol.66
, pp. 288-294
-
-
Ball, S.E.1
Scatina, J.2
Kao, J.3
-
31
-
-
0033030842
-
Molecular genetics and epidemiology of prostate carcinoma
-
Ruijter E, van de Kaa KC, Miller G, Ruiter D, Debruyne F, Schalken J: Molecular genetics and epidemiology of prostate carcinoma. Endocr. Rev. 20, 22-45 (1999).
-
(1999)
Endocr. Rev.
, vol.20
, pp. 22-45
-
-
Ruijter, E.1
van de Kaa, K.C.2
Miller, G.3
Ruiter, D.4
Debruyne, F.5
Schalken, J.6
-
33
-
-
0027462628
-
Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases
-
DM Ziegler: Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases. Ann. Rev. Pharmacol. Toxicol. 33, 179-199 (1993).
-
(1993)
Ann. Rev. Pharmacol. Toxicol.
, vol.33
, pp. 179-199
-
-
Ziegler, D.M.1
-
34
-
-
0028945438
-
Structural and catalytic properties of the mammalian flavin-containing monooxygenase
-
Cashman JR: Structural and catalytic properties of the mammalian flavin-containing monooxygenase. Chem. Res. Toxicol. 8, 166-181 (1995).
-
(1995)
Chem. Res. Toxicol.
, vol.8
, pp. 166-181
-
-
Cashman, J.R.1
-
35
-
-
0036786378
-
Interindividual differences of human flavin-containing monooxygenase 3, genetic polymorphisms and functional variation
-
Cashman JR, Zhang J: Interindividual differences of human flavin-containing monooxygenase 3, genetic polymorphisms and functional variation. Drug Metab. Dispos. 30, 1043-1052 (2002).
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 1043-1052
-
-
Cashman, J.R.1
Zhang, J.2
-
36
-
-
0035201442
-
Population distribution of human flavin-containing monooxygenase form 3, gene polymorphisms
-
Cashman JR, Zhang J, Leushner J, Braun A: Population distribution of human flavin-containing monooxygenase form 3, gene polymorphisms. Drug Metab. Dispos. 29, 1629-1637 (2001).
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 1629-1637
-
-
Cashman, J.R.1
Zhang, J.2
Leushner, J.3
Braun, A.4
-
37
-
-
0036265797
-
Human flavin-containing monooxygenase (form 3): Polymorphisms and variations in chemical metabolism
-
JR Cashman: Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism. Pharmacogenomics 3, 325-339 (2002).
-
(2002)
Pharmacogenomics
, vol.3
, pp. 325-339
-
-
Cashman, J.R.1
-
38
-
-
0028333611
-
Expression cloning of a mammalian proton-coupled oligopeptide transporter
-
Fei YJ, Kanai Y, Nussberger S et al.: Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368, 563-566 (1994).
-
(1994)
Nature
, vol.368
, pp. 563-566
-
-
Fei, Y.J.1
Kanai, Y.2
Nussberger, S.3
-
39
-
-
0036009619
-
The thiopurine S-methyltransferase gene locus - Implications for clinical pharmacogenomics
-
McLeod HL, Siva C: The thiopurine S-methyltransferase gene locus - implications for clinical pharmacogenomics. Pharmacogenomics. 3, 89-98 (2002).
-
(2002)
Pharmacogenomics
, vol.3
, pp. 89-98
-
-
McLeod, H.L.1
Siva, C.2
-
40
-
-
0028861745
-
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase
-
Krynetski EY, Schuetz JD, Galpin AJ, Pui CH, Relling MV, Evans WE: A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase. Proc. Natl. Acad. Sci. USA 92, 949-953 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 949-953
-
-
Krynetski, E.Y.1
Schuetz, J.D.2
Galpin, A.J.3
Pui, C.H.4
Relling, M.V.5
Evans, W.E.6
-
41
-
-
0029919807
-
Thiopurine S-methyltransferase deficiency: Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
-
Tai HL, Krynetski EY, Yates CR et al.: Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians. Am. J. Hum. Genet. 58, 694-702 (1996).
-
(1996)
Am. J. Hum. Genet.
, vol.58
, pp. 694-702
-
-
Tai, H.L.1
Krynetski, E.Y.2
Yates, C.R.3
-
42
-
-
0031820555
-
Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans
-
Loennechen T, Yates CR, Fessing MY, Relling MV, Krynetski EY, Evans WE: Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans. Clin. Pharmacol. Ther. 64, 46-51 (1998).
-
(1998)
Clin. Pharmacol. Ther.
, vol.64
, pp. 46-51
-
-
Loennechen, T.1
Yates, C.R.2
Fessing, M.Y.3
Relling, M.V.4
Krynetski, E.Y.5
Evans, W.E.6
-
43
-
-
0035871560
-
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
-
Evans WE, Hon YY, Bomgaars L et al.: Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J. Clin. Oncol. 19, 2293-2301 (2001).
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 2293-2301
-
-
Evans, W.E.1
Hon, Y.Y.2
Bomgaars, L.3
-
44
-
-
0035478335
-
Pharmacogenomics of drug transporters: The next drug delivery challenge
-
Lee VH, Sporty JL, Fandy TE: Pharmacogenomics of drug transporters: the next drug delivery challenge. Adv. Drug Deliv. Rev. 50(Suppl. 1), S33-S40 (2001).
-
(2001)
Adv. Drug Deliv. Rev.
, vol.50
, Issue.SUPPL. 1
-
-
Lee, V.H.1
Sporty, J.L.2
Fandy, T.E.3
-
46
-
-
17644445622
-
Transporters and xenobiotic disposition
-
RB Kim: Transporters and xenobiotic disposition. Toxicology 181-182, 291-297 (2002).
-
(2002)
Toxicology
, vol.181-182
, pp. 291-297
-
-
Kim, R.B.1
-
47
-
-
0034724324
-
Functional polymorphisms of the human multi-drug resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
-
Hoffmeyer S, Burk O, von Richter O et al.: Functional polymorphisms of the human multi-drug resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc. Natl. Acad. Sci. USA 97, 3473-3478 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 3473-3478
-
-
Hoffmeyer, S.1
Burk, O.2
von Richter, O.3
-
48
-
-
0037431040
-
Association of multi-drug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
-
Siddiqui A, Kerb R, Weale ME et al.: Association of multi-drug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N. Engl. J. Med. 348, 1442-1448 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1442-1448
-
-
Siddiqui, A.1
Kerb, R.2
Weale, M.E.3
-
49
-
-
0034997034
-
Expression of P-glycoprotein in human placenta: Relation to genetic polymorphism of the multi-drug resistance (MDR)-1 gene
-
Tanabe M, Ieiri I, Nagata N et al.: Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multi-drug resistance (MDR)-1 gene. J. Pharmacol. Exp. Ther. 297, 1137-1143 (2001).
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.297
, pp. 1137-1143
-
-
Tanabe, M.1
Ieiri, I.2
Nagata, N.3
-
50
-
-
0037183584
-
Neurotoxicity induced by tacrolimus after liver transplantation: Relation to genetic polymorphisms of the ABCB1 (MDR1) gene
-
Yamauchi A, Ieiri I, Kataoka Y et al.: Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene. Transplantation 74, 571-572 (2002).
-
(2002)
Transplantation
, vol.74
, pp. 571-572
-
-
Yamauchi, A.1
Ieiri, I.2
Kataoka, Y.3
-
51
-
-
0036073404
-
Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): Allele frequencies in the Japanese population and functional analysis
-
Nozawa T, Nakajima M, Tamai I et al.: Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. J. Pharmacol. Exp. Ther. 302, 804-813 (2002).
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.302
, pp. 804-813
-
-
Nozawa, T.1
Nakajima, M.2
Tamai, I.3
-
52
-
-
0037733365
-
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
-
Konig J, Cui Y, Nies AT, Keppler D: A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. Gastrointest. Liver Physiol. 278, G156-G164 (2000).
-
(2000)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.278
-
-
Konig, J.1
Cui, Y.2
Nies, A.T.3
Keppler, D.4
-
53
-
-
0035929574
-
Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European-and African-Americans
-
Tirona RG, Leake BF. Merino G, Kim RB: Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European-and African-Americans. J. Biol. Chem. 276, 35669-35675 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 35669-35675
-
-
Tirona, R.G.1
Leake, B.F.2
Merino, G.3
Kim, R.B.4
-
54
-
-
0034709561
-
Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
-
Tamai I, Nezu J, Uchino H et al.: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem. Biophys. Res. Commun. 273, 251-260 (2000).
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 251-260
-
-
Tamai, I.1
Nezu, J.2
Uchino, H.3
-
55
-
-
0036020986
-
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function
-
Leabman MK, Huang CC, Kawamoto M et al.: Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics 12, 395-405 (2002).
-
(2002)
Pharmacogenetics
, vol.12
, pp. 395-405
-
-
Leabman, M.K.1
Huang, C.C.2
Kawamoto, M.3
-
56
-
-
0035066252
-
Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
-
Dresser MJ, Leabman MK, Giacomini KM: Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J. Pharm. Sci. 90, 397-421 (2001).
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 397-421
-
-
Dresser, M.J.1
Leabman, M.K.2
Giacomini, K.M.3
-
57
-
-
0030605375
-
Seminars in medicine of the Beth Israel Hospital, Boston: Adrenergic receptors-evolving concepts and clinical implications
-
Insel PA: Seminars in medicine of the Beth Israel Hospital, Boston: Adrenergic receptors-evolving concepts and clinical implications. N. Engl. J. Med. 334, 580-585 (1996).
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 580-585
-
-
Insel, P.A.1
-
58
-
-
0000658715
-
Neurotransmission. The autonomic and somatic motor nervous systems
-
Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York
-
Hoffman BB, Taylor JG: Neurotransmission. The autonomic and somatic motor nervous systems. In: Goodman and Gilman's: The Pharmacological Basis of Therapeutics. Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York, 115-153 (2001).
-
(2001)
Goodman and Gilman's: The Pharmacological Basis of Therapeutics
, pp. 115-153
-
-
Hoffman, B.B.1
Taylor, J.G.2
-
59
-
-
0034641736
-
Complex promoter and coding region β2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness
-
Drysdale CM, McGraw DW, Stack CB et al.: Complex promoter and coding region β2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc. Natl. Acad. Sci. USA 97, 10483-10488 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 10483-10488
-
-
Drysdale, C.M.1
McGraw, D.W.2
Stack, C.B.3
-
60
-
-
0035807591
-
The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization
-
Dishy V, Sofowora GG, Xie HG et al.: The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N. Engl. J. Med. 345, 1030-1035 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 1030-1035
-
-
Dishy, V.1
Sofowora, G.G.2
Xie, H.G.3
-
61
-
-
0000495137
-
Catecholamine, sympathomimetic drugs and adrenergic receptor antagonists
-
Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York
-
Hoffman BB: Catecholamine, sympathomimetic drugs and adrenergic receptor antagonists. In: Goodman and Gilman's: The Pharmacological Basis of Therapeutics. Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York, 269-290 (2001).
-
(2001)
Goodman and Gilman's: The Pharmacological Basis of Therapeutics
, pp. 269-290
-
-
Hoffman, B.B.1
-
62
-
-
0030848812
-
Decreased blood pressure response in mice deficient of the α1b-adrenergic receptor
-
Cavalli A, Lattion AL, Hummler E et al.: Decreased blood pressure response in mice deficient of the α1b-adrenergic receptor. Proc. Natl. Acad. Sci. USA 94, 11589-11594 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 11589-11594
-
-
Cavalli, A.1
Lattion, A.L.2
Hummler, E.3
-
63
-
-
0026786044
-
Genomic organization and expression of the human α1B-adrenergic receptor
-
Ramarao CS, Denker JM, Perez DM, Gaivin RJ, Riek RP, Graham RM: Genomic organization and expression of the human α1B-adrenergic receptor. J. Biol. Chem. 267, 21936-21945 (1992).
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 21936-21945
-
-
Ramarao, C.S.1
Denker, J.M.2
Perez, D.M.3
Gaivin, R.J.4
Riek, R.P.5
Graham, R.M.6
-
64
-
-
0345426348
-
Variability in phenylephrine response and essential hypertension: A search for human α(1b)-adrenergic receptor polymorphisms
-
Buscher R, Herrmann V, Ring KM et al.: Variability in phenylephrine response and essential hypertension: a search for human α(1b)-adrenergic receptor polymorphisms. J. Pharmacol. Exp. Ther. 291, 793-798 (1999).
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.291
, pp. 793-798
-
-
Buscher, R.1
Herrmann, V.2
Ring, K.M.3
-
66
-
-
0034764480
-
Functional characterization of cyclooxygenase-2 polymorphisms
-
Fritsche E, Baek SJ, King LM, Zeldin DC, Eling TE, Bell DA: Functional characterization of cyclooxygenase-2 polymorphisms. J. Pharmacol. Exp. Ther. 299, 468-476 (2001).
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 468-476
-
-
Fritsche, E.1
Baek, S.J.2
King, L.M.3
Zeldin, D.C.4
Eling, T.E.5
Bell, D.A.6
-
67
-
-
0032537482
-
Resistance to HIV protease inhibitors: A comparison of enzyme inhibition and antiviral potency
-
Klabe RM, Bacheler LT, Ala PJ, Erickson-Viitanen S, Meek JL: Resistance to HIV protease inhibitors: a comparison of enzyme inhibition and antiviral potency. Biochemistry 37, 8735-8742 (1998).
-
(1998)
Biochemistry
, vol.37
, pp. 8735-8742
-
-
Klabe, R.M.1
Bacheler, L.T.2
Ala, P.J.3
Erickson-Viitanen, S.4
Meek, J.L.5
-
68
-
-
0035933060
-
Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes
-
Velazquez-Campoy A, Todd MJ, Vega S, Freire E: Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes. Proc. Natl. Acad. Sci. USA 98, 6062-6067 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 6062-6067
-
-
Velazquez-Campoy, A.1
Todd, M.J.2
Vega, S.3
Freire, E.4
-
69
-
-
0037047028
-
Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes
-
Velazquez-Campoy A, Vega S, Freire E: Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes. Biochemistry 41, 8613-8619 (2002).
-
(2002)
Biochemistry
, vol.41
, pp. 8613-8619
-
-
Velazquez-Campoy, A.1
Vega, S.2
Freire, E.3
-
70
-
-
0029821703
-
Evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein
-
Herve F, Duche JC, d'Athis P et al.: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein. Pharmacogenetics 6, 403-415 (1996).
-
(1996)
Pharmacogenetics
, vol.6
, pp. 403-415
-
-
Herve, F.1
Duche, J.C.2
d'Athis, P.3
-
71
-
-
0032570940
-
The genetic variant A of human α 1-acid glycoprotein limits the blood to brain transfer of drugs it binds
-
Jolliet-Riant P, Boukef MF, Duche JC, Simon N, Tillement JP: The genetic variant A of human α 1-acid glycoprotein limits the blood to brain transfer of drugs it binds. Life Sci. 62, L219-L226 (1998 ).
-
(1998)
Life Sci.
, vol.62
-
-
Jolliet-Riant, P.1
Boukef, M.F.2
Duche, J.C.3
Simon, N.4
Tillement, J.P.5
-
72
-
-
0037215586
-
Hydrophobic and ionic factors in the binding of local anesthetics to the major variant of human alpha1-acid glycoprotein
-
Taheri S, Cogswell LP, III, Gent A, Strichartz GR: Hydrophobic and ionic factors in the binding of local anesthetics to the major variant of human alpha1-acid glycoprotein. J. Pharmacol. Exp. Ther. 304, 71-80 (2003).
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.304
, pp. 71-80
-
-
Taheri, S.1
Cogswell L.P. III2
Gent, A.3
Strichartz, G.R.4
-
73
-
-
0036218554
-
Changes in plasma protein binding have little clinical relevance
-
Benet LZ, Hoener BA: Changes in plasma protein binding have little clinical relevance. Clin. Pharmacol. Ther. 71, 115-121 (2002).
-
(2002)
Clin. Pharmacol. Ther.
, vol.71
, pp. 115-121
-
-
Benet, L.Z.1
Hoener, B.A.2
-
75
-
-
0038128342
-
Constitutive androstane receptor and pregnane receptor gene expression in human liver: Interindividual variability and correlation with CYP2B6 mRNA levels
-
Chang TK, Bandiera SM, Chen JX: Constitutive androstane receptor and pregnane receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels. Drug Metab Dispos. 31, 7-10 (2003).
-
(2003)
Drug Metab Dispos.
, vol.31
, pp. 7-10
-
-
Chang, T.K.1
Bandiera, S.M.2
Chen, J.X.3
-
76
-
-
0037421590
-
Pharmacogenomics-drug disposition, drug targets and side effects
-
Evans WE, McLeod HL: Pharmacogenomics-drug disposition, drug targets and side effects. N. Engl. J. Med. 348, 538-549 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 538-549
-
-
Evans, W.E.1
McLeod, H.L.2
-
77
-
-
0035861049
-
Potential role of pharmacogenomics in reducing adverse drug reactions: A systematic review
-
A US
-
KA Phillips A US, Veenstra DL, Oren E, Lee JK, Sadee W: Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review. JAMA 286, 2270-2279 (2001).
-
(2001)
JAMA
, vol.286
, pp. 2270-2279
-
-
Phillips, K.A.1
Veenstra, D.L.2
Oren, E.3
Lee, J.K.4
Sadee, W.5
-
78
-
-
0012197737
-
The clinical relevance of routine genotyping of CYP2D6/2C19 null alleles of psychiatric patients
-
de Vries EM, Pot HJ, Conemans JMH, Uges DRA: The clinical relevance of routine genotyping of CYP2D6/2C19 null alleles of psychiatric patients. Br. J. Clin. Pharmacol. 53, 550P-551P (2002).
-
(2002)
Br. J. Clin. Pharmacol.
, vol.53
-
-
de Vries, E.M.1
Pot, H.J.2
Conemans, J.M.H.3
Uges, D.R.A.4
-
79
-
-
0036527287
-
Ethical perspectives on pharmacogenomic profiling in the drug development process
-
Issa AM: Ethical perspectives on pharmacogenomic profiling in the drug development process. Nat. Rev. Drug Discov. 1, 300-308 (2002).
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 300-308
-
-
Issa, A.M.1
|