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Volumn 4, Issue 4, 2003, Pages 443-461

Pharmacogenomic considerations in drug delivery

Author keywords

Drug delivery; Enzymes; Interindividual variability; Pharmacodynamics; Pharmacogenomics; Pharmacokinetics; Receptors; Transporters

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; ANTIARRHYTHMIC AGENT; ANTIDEPRESSANT AGENT; ANTIEMETIC AGENT; AZATHIOPRINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYTOCHROME P450; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 4A; DEBRISOQUINE; DEXTROMETHORPHAN; DIMETHYLANILINE MONOOXYGENASE; DNA TOPOISOMERASE INHIBITOR; DRUG METABOLIZING ENZYME; EPIPODOPHYLLOTOXIN; IMIPRAMINE; IRINOTECAN; MERCAPTOPURINE; NEUROLEPTIC AGENT; PROPRANOLOL; PROSTAGLANDIN SYNTHASE; PROTON PUMP INHIBITOR; SIMVASTATIN; SULFONAMIDE; THIOPURINE METHYLTRANSFERASE; TIOGUANINE; TROPISETRON; UNINDEXED DRUG;

EID: 0038445929     PISSN: 14622416     EISSN: None     Source Type: Journal    
DOI: 10.1517/phgs.4.4.443.22749     Document Type: Review
Times cited : (8)

References (79)
  • 1
    • 0034638766 scopus 로고    scopus 로고
    • Pharmacogenetics and adverse drug reactions
    • Meyer UA: Pharmacogenetics and adverse drug reactions. Lancet 356,1667-1671 (2000).
    • (2000) Lancet , vol.356 , pp. 1667-1671
    • Meyer, U.A.1
  • 2
    • 0036596857 scopus 로고    scopus 로고
    • The impact of pharmacogenetics and pharmacogenomics on drug discovery
    • Lindpaintner K: The impact of pharmacogenetics and pharmacogenomics on drug discovery. Nat. Rev. Drug Discov. 1, 463-469 (2002).
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 463-469
    • Lindpaintner, K.1
  • 3
    • 0035105777 scopus 로고    scopus 로고
    • Pharmacogenetic applications of the Human Genome project
    • Liggett SB: Pharmacogenetic applications of the Human Genome project. Nat. Med. 7, 281-283 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 281-283
    • Liggett, S.B.1
  • 4
    • 0002485410 scopus 로고    scopus 로고
    • Pharmacokinetics. The dynamics of drug absorption, distribution and elimination
    • Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York
    • Wilkinson GR: Pharmacokinetics. The dynamics of drug absorption, distribution and elimination. In: Goodman and Gilman's: The pharmacological basis of therapeutics. Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York 3-30 (2001).
    • (2001) Goodman and Gilman's: The Pharmacological Basis of Therapeutics , pp. 3-30
    • Wilkinson, G.R.1
  • 5
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE, Relling MV: Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286, 487-491 (1999).
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 6
    • 0038305826 scopus 로고    scopus 로고
    • Pharmacogenetics and drug metabolism
    • Ball S, Borman N: Pharmacogenetics and drug metabolism. Nat. Biotech. 16, 4-5 (1998).
    • (1998) Nat. Biotech. , vol.16 , pp. 4-5
    • Ball, S.1    Borman, N.2
  • 7
    • 0035721949 scopus 로고    scopus 로고
    • Pharmacogenetics: An opportunity for a safer and more efficient pharmacotherapy
    • Ingelman-Sundberg M: Pharmacogenetics: an opportunity for a safer and more efficient pharmacotherapy. J. Intern. Med. 250, 186-200 (2001).
    • (2001) J. Intern. Med. , vol.250 , pp. 186-200
    • Ingelman-Sundberg, M.1
  • 8
    • 0346942394 scopus 로고    scopus 로고
    • Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays
    • Gerhold D, Lu M, Xu J, Austin C, Caskey CT, Rushmore T: Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays. Physiol. Genomics 5, 161-170 (2001).
    • (2001) Physiol. Genomics , vol.5 , pp. 161-170
    • Gerhold, D.1    Lu, M.2    Xu, J.3    Austin, C.4    Caskey, C.T.5    Rushmore, T.6
  • 9
    • 0031794361 scopus 로고    scopus 로고
    • Inhibition and induction of cytochrome P450 and the clinical implications
    • Lin JH, Lu AY: Inhibition and induction of cytochrome P450 and the clinical implications. Clin. Pharmacokinet. 35, 361-390 (1998).
    • (1998) Clin. Pharmacokinet. , vol.35 , pp. 361-390
    • Lin, J.H.1    Lu, A.Y.2
  • 10
    • 0030022629 scopus 로고    scopus 로고
    • An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials
    • Parkinson A: An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials. Toxicol. Pathol. 24, 48-57 (1996).
    • (1996) Toxicol. Pathol. , vol.24 , pp. 48-57
    • Parkinson, A.1
  • 11
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse C, Brockmoller J, Bauer S, Roots I: Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am. J. Hum. Genet. 60, 284-295 (1997).
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 12
    • 0031472588 scopus 로고    scopus 로고
    • Role of pharmacokinetics and metabolism in drug discovery and development
    • Lin JH, Lu AY: Role of pharmacokinetics and metabolism in drug discovery and development. Pharmacol. Rev. 49, 403-449 (1997).
    • (1997) Pharmacol. Rev. , vol.49 , pp. 403-449
    • Lin, J.H.1    Lu, A.Y.2
  • 13
    • 85137893152 scopus 로고    scopus 로고
    • Pharmacogenetics
    • Woolf TF (Ed.), Marcel Dekker, Inc., New York
    • Daly AK: Pharmacogenetics. In: Handbook of Drug Metabolism. Woolf TF (Ed.), Marcel Dekker, Inc., New York, 175-202 (1999).
    • (1999) Handbook of Drug Metabolism , pp. 175-202
    • Daly, A.K.1
  • 15
    • 0030995879 scopus 로고    scopus 로고
    • Molecular mechanisms of genetic polymorphisms of drug metabolism
    • Meyer UA, Zanger UM: Molecular mechanisms of genetic polymorphisms of drug metabolism. Ann. Rev. Pharmacol. Toxicol. 37, 269-296 (1997).
    • (1997) Ann. Rev. Pharmacol. Toxicol. , vol.37 , pp. 269-296
    • Meyer, U.A.1    Zanger, U.M.2
  • 16
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjoqvist F, Ingelman-Sundberg M: Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc. Natl. Acad. Sci. USA 90, 11825-11829 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11825-11829
    • Johansson, I.1    Lundqvist, E.2    Bertilsson, L.3    Dahl, M.L.4    Sjoqvist, F.5    Ingelman-Sundberg, M.6
  • 17
    • 0034790063 scopus 로고    scopus 로고
    • Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6
    • Zanger UM, Fischer J, Raimundo S et al: Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6. Pharmacogenetics 11, 573-585 (2001).
    • (2001) Pharmacogenetics , vol.11 , pp. 573-585
    • Zanger, U.M.1    Fischer, J.2    Raimundo, S.3
  • 18
    • 0037600622 scopus 로고    scopus 로고
    • Metabolism, pharmacokinetics and excretion of a highly selective N-methyl-D-aspartate receptor antagonist, traxoprodil, in human cytochrome P450 2D6 extensive and poor metabolizers
    • Johnson K, Shah A, Jaw-Tsai S, Baxter J, Prakash C: Metabolism, pharmacokinetics and excretion of a highly selective N-methyl-D-aspartate receptor antagonist, traxoprodil, in human cytochrome P450 2D6 extensive and poor metabolizers. Drug Metab. Dispos. 31, 76-87 (2003).
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 76-87
    • Johnson, K.1    Shah, A.2    Jaw-Tsai, S.3    Baxter, J.4    Prakash, C.5
  • 19
    • 0035657076 scopus 로고    scopus 로고
    • Association of polymorphism in the cytochrome cYP2D6 and the efficacy and tolerability of simvastatin
    • Mulder AB, van Lijf HJ, Bon MA et al.: Association of polymorphism in the cytochrome cYP2D6 and the efficacy and tolerability of simvastatin. Clin. Pharmacol. Ther. 70, 546-551 (2001).
    • (2001) Clin. Pharmacol. Ther. , vol.70 , pp. 546-551
    • Mulder, A.B.1    van Lijf, H.J.2    Bon, M.A.3
  • 20
    • 0037096821 scopus 로고    scopus 로고
    • Patient-tailored antiemetic treatment with 5-hydroxytryptamine Type 3 receptor antagonists according to cytochrome P450 2D6 genotypes
    • Kaiser R, Sezer O, A Papies et al.: Patient-tailored antiemetic treatment with 5-hydroxytryptamine Type 3 receptor antagonists according to cytochrome P450 2D6 genotypes. J. Clin. Oncol. 20, 2805-2811 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2805-2811
    • Kaiser, R.1    Sezer, O.2    Papies, A.3
  • 21
    • 0026816971 scopus 로고
    • Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects
    • Andersson T, Regardh CG, Lou YC, Zhang Y, Dahl ML, Bertilsson L: Polymorphic hydroxylation of S-mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects. Pharmacogenetics 2, 25-31 (1992).
    • (1992) Pharmacogenetics , vol.2 , pp. 25-31
    • Andersson, T.1    Regardh, C.G.2    Lou, Y.C.3    Zhang, Y.4    Dahl, M.L.5    Bertilsson, L.6
  • 22
    • 0032586730 scopus 로고    scopus 로고
    • CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans
    • Furuta T, Ohashi K, Kosuge K et al.: CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans. Clin. Pharmacol. Ther. 65, 552-561 (1999).
    • (1999) Clin. Pharmacol. Ther. , vol.65 , pp. 552-561
    • Furuta, T.1    Ohashi, K.2    Kosuge, K.3
  • 23
    • 0033771689 scopus 로고    scopus 로고
    • 5-hydroxylation of omeprazole by human liver microsomal fractions from Chinese populations related to CYP2C19 gene dose and individual ethnicity
    • Shu Y, Wang LS, Xu ZH et al.: 5-hydroxylation of omeprazole by human liver microsomal fractions from Chinese populations related to CYP2C19 gene dose and individual ethnicity. J. Pharmacol. Exp. Ther. 295, 844-851 (2000).
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 844-851
    • Shu, Y.1    Wang, L.S.2    Xu, Z.H.3
  • 24
    • 0037184794 scopus 로고    scopus 로고
    • Polymorphism of cytochrome P450 and xenobiotic toxicity
    • Ingelman-Sundberg M: Polymorphism of cytochrome P450 and xenobiotic toxicity. Toxicology 181-182, 447-452 (2002).
    • (2002) Toxicology , vol.181-182 , pp. 447-452
    • Ingelman-Sundberg, M.1
  • 25
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP: Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther. 270, 414-423 (1994).
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 26
    • 0002939033 scopus 로고    scopus 로고
    • CYP3A
    • Levy KE, Thummel KE, Trager WF, Hansten PD, M Eichelbaum (Eds), Lippincott Williams & Wilkins, Philadelphia
    • Wrighton SA, Thummel RH: CYP3A. In: Metabolic Drug Interactions. Levy KE, Thummel KE, Trager WF, Hansten PD, M Eichelbaum (Eds), Lippincott Williams & Wilkins, Philadelphia 115-133 (2000).
    • (2000) Metabolic Drug Interactions , pp. 115-133
    • Wrighton, S.A.1    Thummel, R.H.2
  • 27
    • 0032547341 scopus 로고    scopus 로고
    • Modification of clinical presentation of prostate tumours by a novel genetic variant in CYP3A4
    • Rebbeck TR, Jaffe JM, Walker AH, Wein AJ, Malkowicz SB: Modification of clinical presentation of prostate tumours by a novel genetic variant in CYP3A4. J. Natl. Cancer Inst. 90, 1225-1229 (1998).
    • (1998) J. Natl. Cancer Inst. , vol.90 , pp. 1225-1229
    • Rebbeck, T.R.1    Jaffe, J.M.2    Walker, A.H.3    Wein, A.J.4    Malkowicz, S.B.5
  • 28
    • 0033632228 scopus 로고    scopus 로고
    • CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12, evidence for an allelic variant with altered catalytic activity
    • Sata F, Sapone A, Elizondo G et al.: CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12, evidence for an allelic variant with altered catalytic activity. Clin. Pharmacol. Ther. 67, 48-56 (2000).
    • (2000) Clin. Pharmacol. Ther. , vol.67 , pp. 48-56
    • Sata, F.1    Sapone, A.2    Elizondo, G.3
  • 29
    • 13144282667 scopus 로고    scopus 로고
    • Association of CYP3A4 genotype with treatment-related leukaemia
    • Felix CA, Walker AH, Lange BJ et al.: Association of CYP3A4 genotype with treatment-related leukaemia, Proc. Natl. Acad. Sci. USA 95, 13176-13181 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13176-13181
    • Felix, C.A.1    Walker, A.H.2    Lange, B.J.3
  • 30
    • 0032825907 scopus 로고    scopus 로고
    • Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4
    • Ball SE, Scatina J, Kao J et al.: Population distribution and effects on drug metabolism of a genetic variant in the 5′ promoter region of CYP3A4. Clin. Pharmacol. Ther. 66, 288-294 (1999).
    • (1999) Clin. Pharmacol. Ther. , vol.66 , pp. 288-294
    • Ball, S.E.1    Scatina, J.2    Kao, J.3
  • 33
    • 0027462628 scopus 로고
    • Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases
    • DM Ziegler: Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases. Ann. Rev. Pharmacol. Toxicol. 33, 179-199 (1993).
    • (1993) Ann. Rev. Pharmacol. Toxicol. , vol.33 , pp. 179-199
    • Ziegler, D.M.1
  • 34
    • 0028945438 scopus 로고
    • Structural and catalytic properties of the mammalian flavin-containing monooxygenase
    • Cashman JR: Structural and catalytic properties of the mammalian flavin-containing monooxygenase. Chem. Res. Toxicol. 8, 166-181 (1995).
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 166-181
    • Cashman, J.R.1
  • 35
    • 0036786378 scopus 로고    scopus 로고
    • Interindividual differences of human flavin-containing monooxygenase 3, genetic polymorphisms and functional variation
    • Cashman JR, Zhang J: Interindividual differences of human flavin-containing monooxygenase 3, genetic polymorphisms and functional variation. Drug Metab. Dispos. 30, 1043-1052 (2002).
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 1043-1052
    • Cashman, J.R.1    Zhang, J.2
  • 36
    • 0035201442 scopus 로고    scopus 로고
    • Population distribution of human flavin-containing monooxygenase form 3, gene polymorphisms
    • Cashman JR, Zhang J, Leushner J, Braun A: Population distribution of human flavin-containing monooxygenase form 3, gene polymorphisms. Drug Metab. Dispos. 29, 1629-1637 (2001).
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 1629-1637
    • Cashman, J.R.1    Zhang, J.2    Leushner, J.3    Braun, A.4
  • 37
    • 0036265797 scopus 로고    scopus 로고
    • Human flavin-containing monooxygenase (form 3): Polymorphisms and variations in chemical metabolism
    • JR Cashman: Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism. Pharmacogenomics 3, 325-339 (2002).
    • (2002) Pharmacogenomics , vol.3 , pp. 325-339
    • Cashman, J.R.1
  • 38
    • 0028333611 scopus 로고
    • Expression cloning of a mammalian proton-coupled oligopeptide transporter
    • Fei YJ, Kanai Y, Nussberger S et al.: Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368, 563-566 (1994).
    • (1994) Nature , vol.368 , pp. 563-566
    • Fei, Y.J.1    Kanai, Y.2    Nussberger, S.3
  • 39
    • 0036009619 scopus 로고    scopus 로고
    • The thiopurine S-methyltransferase gene locus - Implications for clinical pharmacogenomics
    • McLeod HL, Siva C: The thiopurine S-methyltransferase gene locus - implications for clinical pharmacogenomics. Pharmacogenomics. 3, 89-98 (2002).
    • (2002) Pharmacogenomics , vol.3 , pp. 89-98
    • McLeod, H.L.1    Siva, C.2
  • 41
    • 0029919807 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase deficiency: Two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians
    • Tai HL, Krynetski EY, Yates CR et al.: Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians. Am. J. Hum. Genet. 58, 694-702 (1996).
    • (1996) Am. J. Hum. Genet. , vol.58 , pp. 694-702
    • Tai, H.L.1    Krynetski, E.Y.2    Yates, C.R.3
  • 42
    • 0031820555 scopus 로고    scopus 로고
    • Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans
    • Loennechen T, Yates CR, Fessing MY, Relling MV, Krynetski EY, Evans WE: Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans. Clin. Pharmacol. Ther. 64, 46-51 (1998).
    • (1998) Clin. Pharmacol. Ther. , vol.64 , pp. 46-51
    • Loennechen, T.1    Yates, C.R.2    Fessing, M.Y.3    Relling, M.V.4    Krynetski, E.Y.5    Evans, W.E.6
  • 43
    • 0035871560 scopus 로고    scopus 로고
    • Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
    • Evans WE, Hon YY, Bomgaars L et al.: Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J. Clin. Oncol. 19, 2293-2301 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2293-2301
    • Evans, W.E.1    Hon, Y.Y.2    Bomgaars, L.3
  • 44
    • 0035478335 scopus 로고    scopus 로고
    • Pharmacogenomics of drug transporters: The next drug delivery challenge
    • Lee VH, Sporty JL, Fandy TE: Pharmacogenomics of drug transporters: the next drug delivery challenge. Adv. Drug Deliv. Rev. 50(Suppl. 1), S33-S40 (2001).
    • (2001) Adv. Drug Deliv. Rev. , vol.50 , Issue.SUPPL. 1
    • Lee, V.H.1    Sporty, J.L.2    Fandy, T.E.3
  • 46
    • 17644445622 scopus 로고    scopus 로고
    • Transporters and xenobiotic disposition
    • RB Kim: Transporters and xenobiotic disposition. Toxicology 181-182, 291-297 (2002).
    • (2002) Toxicology , vol.181-182 , pp. 291-297
    • Kim, R.B.1
  • 47
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multi-drug resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • Hoffmeyer S, Burk O, von Richter O et al.: Functional polymorphisms of the human multi-drug resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc. Natl. Acad. Sci. USA 97, 3473-3478 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3473-3478
    • Hoffmeyer, S.1    Burk, O.2    von Richter, O.3
  • 48
    • 0037431040 scopus 로고    scopus 로고
    • Association of multi-drug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
    • Siddiqui A, Kerb R, Weale ME et al.: Association of multi-drug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N. Engl. J. Med. 348, 1442-1448 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1442-1448
    • Siddiqui, A.1    Kerb, R.2    Weale, M.E.3
  • 49
    • 0034997034 scopus 로고    scopus 로고
    • Expression of P-glycoprotein in human placenta: Relation to genetic polymorphism of the multi-drug resistance (MDR)-1 gene
    • Tanabe M, Ieiri I, Nagata N et al.: Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multi-drug resistance (MDR)-1 gene. J. Pharmacol. Exp. Ther. 297, 1137-1143 (2001).
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 1137-1143
    • Tanabe, M.1    Ieiri, I.2    Nagata, N.3
  • 50
    • 0037183584 scopus 로고    scopus 로고
    • Neurotoxicity induced by tacrolimus after liver transplantation: Relation to genetic polymorphisms of the ABCB1 (MDR1) gene
    • Yamauchi A, Ieiri I, Kataoka Y et al.: Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene. Transplantation 74, 571-572 (2002).
    • (2002) Transplantation , vol.74 , pp. 571-572
    • Yamauchi, A.1    Ieiri, I.2    Kataoka, Y.3
  • 51
    • 0036073404 scopus 로고    scopus 로고
    • Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): Allele frequencies in the Japanese population and functional analysis
    • Nozawa T, Nakajima M, Tamai I et al.: Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. J. Pharmacol. Exp. Ther. 302, 804-813 (2002).
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 804-813
    • Nozawa, T.1    Nakajima, M.2    Tamai, I.3
  • 52
    • 0037733365 scopus 로고    scopus 로고
    • A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
    • Konig J, Cui Y, Nies AT, Keppler D: A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. Gastrointest. Liver Physiol. 278, G156-G164 (2000).
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.278
    • Konig, J.1    Cui, Y.2    Nies, A.T.3    Keppler, D.4
  • 53
    • 0035929574 scopus 로고    scopus 로고
    • Polymorphisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European-and African-Americans
    • Tirona RG, Leake BF. Merino G, Kim RB: Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European-and African-Americans. J. Biol. Chem. 276, 35669-35675 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 35669-35675
    • Tirona, R.G.1    Leake, B.F.2    Merino, G.3    Kim, R.B.4
  • 54
    • 0034709561 scopus 로고    scopus 로고
    • Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
    • Tamai I, Nezu J, Uchino H et al.: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem. Biophys. Res. Commun. 273, 251-260 (2000).
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , pp. 251-260
    • Tamai, I.1    Nezu, J.2    Uchino, H.3
  • 55
    • 0036020986 scopus 로고    scopus 로고
    • Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function
    • Leabman MK, Huang CC, Kawamoto M et al.: Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics 12, 395-405 (2002).
    • (2002) Pharmacogenetics , vol.12 , pp. 395-405
    • Leabman, M.K.1    Huang, C.C.2    Kawamoto, M.3
  • 56
    • 0035066252 scopus 로고    scopus 로고
    • Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
    • Dresser MJ, Leabman MK, Giacomini KM: Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J. Pharm. Sci. 90, 397-421 (2001).
    • (2001) J. Pharm. Sci. , vol.90 , pp. 397-421
    • Dresser, M.J.1    Leabman, M.K.2    Giacomini, K.M.3
  • 57
    • 0030605375 scopus 로고    scopus 로고
    • Seminars in medicine of the Beth Israel Hospital, Boston: Adrenergic receptors-evolving concepts and clinical implications
    • Insel PA: Seminars in medicine of the Beth Israel Hospital, Boston: Adrenergic receptors-evolving concepts and clinical implications. N. Engl. J. Med. 334, 580-585 (1996).
    • (1996) N. Engl. J. Med. , vol.334 , pp. 580-585
    • Insel, P.A.1
  • 58
    • 0000658715 scopus 로고    scopus 로고
    • Neurotransmission. The autonomic and somatic motor nervous systems
    • Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York
    • Hoffman BB, Taylor JG: Neurotransmission. The autonomic and somatic motor nervous systems. In: Goodman and Gilman's: The Pharmacological Basis of Therapeutics. Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York, 115-153 (2001).
    • (2001) Goodman and Gilman's: The Pharmacological Basis of Therapeutics , pp. 115-153
    • Hoffman, B.B.1    Taylor, J.G.2
  • 59
    • 0034641736 scopus 로고    scopus 로고
    • Complex promoter and coding region β2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness
    • Drysdale CM, McGraw DW, Stack CB et al.: Complex promoter and coding region β2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc. Natl. Acad. Sci. USA 97, 10483-10488 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10483-10488
    • Drysdale, C.M.1    McGraw, D.W.2    Stack, C.B.3
  • 60
    • 0035807591 scopus 로고    scopus 로고
    • The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization
    • Dishy V, Sofowora GG, Xie HG et al.: The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N. Engl. J. Med. 345, 1030-1035 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 1030-1035
    • Dishy, V.1    Sofowora, G.G.2    Xie, H.G.3
  • 61
    • 0000495137 scopus 로고    scopus 로고
    • Catecholamine, sympathomimetic drugs and adrenergic receptor antagonists
    • Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York
    • Hoffman BB: Catecholamine, sympathomimetic drugs and adrenergic receptor antagonists. In: Goodman and Gilman's: The Pharmacological Basis of Therapeutics. Hardman AJG, Limbird LE (Eds), McGraw-Hill, New York, 269-290 (2001).
    • (2001) Goodman and Gilman's: The Pharmacological Basis of Therapeutics , pp. 269-290
    • Hoffman, B.B.1
  • 62
    • 0030848812 scopus 로고    scopus 로고
    • Decreased blood pressure response in mice deficient of the α1b-adrenergic receptor
    • Cavalli A, Lattion AL, Hummler E et al.: Decreased blood pressure response in mice deficient of the α1b-adrenergic receptor. Proc. Natl. Acad. Sci. USA 94, 11589-11594 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 11589-11594
    • Cavalli, A.1    Lattion, A.L.2    Hummler, E.3
  • 64
    • 0345426348 scopus 로고    scopus 로고
    • Variability in phenylephrine response and essential hypertension: A search for human α(1b)-adrenergic receptor polymorphisms
    • Buscher R, Herrmann V, Ring KM et al.: Variability in phenylephrine response and essential hypertension: a search for human α(1b)-adrenergic receptor polymorphisms. J. Pharmacol. Exp. Ther. 291, 793-798 (1999).
    • (1999) J. Pharmacol. Exp. Ther. , vol.291 , pp. 793-798
    • Buscher, R.1    Herrmann, V.2    Ring, K.M.3
  • 67
    • 0032537482 scopus 로고    scopus 로고
    • Resistance to HIV protease inhibitors: A comparison of enzyme inhibition and antiviral potency
    • Klabe RM, Bacheler LT, Ala PJ, Erickson-Viitanen S, Meek JL: Resistance to HIV protease inhibitors: a comparison of enzyme inhibition and antiviral potency. Biochemistry 37, 8735-8742 (1998).
    • (1998) Biochemistry , vol.37 , pp. 8735-8742
    • Klabe, R.M.1    Bacheler, L.T.2    Ala, P.J.3    Erickson-Viitanen, S.4    Meek, J.L.5
  • 68
    • 0035933060 scopus 로고    scopus 로고
    • Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes
    • Velazquez-Campoy A, Todd MJ, Vega S, Freire E: Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes. Proc. Natl. Acad. Sci. USA 98, 6062-6067 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6062-6067
    • Velazquez-Campoy, A.1    Todd, M.J.2    Vega, S.3    Freire, E.4
  • 69
    • 0037047028 scopus 로고    scopus 로고
    • Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes
    • Velazquez-Campoy A, Vega S, Freire E: Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes. Biochemistry 41, 8613-8619 (2002).
    • (2002) Biochemistry , vol.41 , pp. 8613-8619
    • Velazquez-Campoy, A.1    Vega, S.2    Freire, E.3
  • 70
    • 0029821703 scopus 로고    scopus 로고
    • Evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein
    • Herve F, Duche JC, d'Athis P et al.: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein. Pharmacogenetics 6, 403-415 (1996).
    • (1996) Pharmacogenetics , vol.6 , pp. 403-415
    • Herve, F.1    Duche, J.C.2    d'Athis, P.3
  • 71
    • 0032570940 scopus 로고    scopus 로고
    • The genetic variant A of human α 1-acid glycoprotein limits the blood to brain transfer of drugs it binds
    • Jolliet-Riant P, Boukef MF, Duche JC, Simon N, Tillement JP: The genetic variant A of human α 1-acid glycoprotein limits the blood to brain transfer of drugs it binds. Life Sci. 62, L219-L226 (1998 ).
    • (1998) Life Sci. , vol.62
    • Jolliet-Riant, P.1    Boukef, M.F.2    Duche, J.C.3    Simon, N.4    Tillement, J.P.5
  • 72
    • 0037215586 scopus 로고    scopus 로고
    • Hydrophobic and ionic factors in the binding of local anesthetics to the major variant of human alpha1-acid glycoprotein
    • Taheri S, Cogswell LP, III, Gent A, Strichartz GR: Hydrophobic and ionic factors in the binding of local anesthetics to the major variant of human alpha1-acid glycoprotein. J. Pharmacol. Exp. Ther. 304, 71-80 (2003).
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 71-80
    • Taheri, S.1    Cogswell L.P. III2    Gent, A.3    Strichartz, G.R.4
  • 73
    • 0036218554 scopus 로고    scopus 로고
    • Changes in plasma protein binding have little clinical relevance
    • Benet LZ, Hoener BA: Changes in plasma protein binding have little clinical relevance. Clin. Pharmacol. Ther. 71, 115-121 (2002).
    • (2002) Clin. Pharmacol. Ther. , vol.71 , pp. 115-121
    • Benet, L.Z.1    Hoener, B.A.2
  • 75
    • 0038128342 scopus 로고    scopus 로고
    • Constitutive androstane receptor and pregnane receptor gene expression in human liver: Interindividual variability and correlation with CYP2B6 mRNA levels
    • Chang TK, Bandiera SM, Chen JX: Constitutive androstane receptor and pregnane receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels. Drug Metab Dispos. 31, 7-10 (2003).
    • (2003) Drug Metab Dispos. , vol.31 , pp. 7-10
    • Chang, T.K.1    Bandiera, S.M.2    Chen, J.X.3
  • 76
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics-drug disposition, drug targets and side effects
    • Evans WE, McLeod HL: Pharmacogenomics-drug disposition, drug targets and side effects. N. Engl. J. Med. 348, 538-549 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 77
    • 0035861049 scopus 로고    scopus 로고
    • Potential role of pharmacogenomics in reducing adverse drug reactions: A systematic review
    • A US
    • KA Phillips A US, Veenstra DL, Oren E, Lee JK, Sadee W: Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review. JAMA 286, 2270-2279 (2001).
    • (2001) JAMA , vol.286 , pp. 2270-2279
    • Phillips, K.A.1    Veenstra, D.L.2    Oren, E.3    Lee, J.K.4    Sadee, W.5
  • 78
    • 0012197737 scopus 로고    scopus 로고
    • The clinical relevance of routine genotyping of CYP2D6/2C19 null alleles of psychiatric patients
    • de Vries EM, Pot HJ, Conemans JMH, Uges DRA: The clinical relevance of routine genotyping of CYP2D6/2C19 null alleles of psychiatric patients. Br. J. Clin. Pharmacol. 53, 550P-551P (2002).
    • (2002) Br. J. Clin. Pharmacol. , vol.53
    • de Vries, E.M.1    Pot, H.J.2    Conemans, J.M.H.3    Uges, D.R.A.4
  • 79
    • 0036527287 scopus 로고    scopus 로고
    • Ethical perspectives on pharmacogenomic profiling in the drug development process
    • Issa AM: Ethical perspectives on pharmacogenomic profiling in the drug development process. Nat. Rev. Drug Discov. 1, 300-308 (2002).
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 300-308
    • Issa, A.M.1


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