Adrenergic receptors - Evolving concepts and clinical implications

New England Journal of Medicine

Volumn 334, Issue 9, 1996, Pages 580-585

  Insel, Paul A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ADRENERGIC RECEPTOR BLOCKING AGENT; ADRENERGIC RECEPTOR STIMULATING AGENT;

ADRENALIN RELEASE; ADRENERGIC SYSTEM; ADRENERGIC TRANSMISSION; ASTHMA; CONGESTIVE HEART FAILURE; HYPERTENSION; NORADRENALIN RELEASE; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; CARDIOVASCULAR DISEASE; CHEMISTRY; CLASSIFICATION; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADRENERGIC AGONISTS; ADRENERGIC ANTAGONISTS; ASTHMA; CARDIOVASCULAR DISEASES; GTP-BINDING PROTEINS; HUMANS; OBESITY; RECEPTORS, ADRENERGIC; SIGNAL TRANSDUCTION;

EID: 0030605375     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199602293340907     Document Type: Review

References (47)

1. Bylund DB, Eikenberg DC, Hieble JP, et al. International Union of Pharmacology nomenclature of adrenoceptors Pharmacol Rev 1994,46 121-36.
2. Perkins JP, ed. The beta-adrenergic receptors Clifton, N J.: Humana Press, 1991.
3. 1-Adrenergic receptor subtypes. Annu Rev Pharmacol Toxicol 1994;34:117-33.
4. Ruffolo RR Jr, Nichols AJ, Stadel JM, Hieble JP. Structure and function of alpha-adrenoceptors. Pharmacol Rev 1991;43 475-505
5. Jasper JR, Insel PA. Evolving concepts of partial agonism. the beta-adrenergic receptor as a paradigm. Biochem Pharmacol 1992;43:119-30
6. Caron MG, Lefkowitz RJ. Catecholamine receptors: structure, function, and regulation. Recent Prog Horm Res 1993;48.277-90.
7. Ahlquist RP. A study of the adrenotropic responses. Am J Physiol 1948;153: 586-600
8. Lands AM, Arnold A, McAuliff JP, Luduena FP, Brown TG Jr. Differentiation of receptor systems activated by sympathomimetic amines Nature 1967; 214:597-8.
9. Berthelsen S, Pettinger WA. A functional basis for classification of α-adrenergic receptors. Life Sci 1977;21:595-606.
10. Ariens EG, Simonis AM. Physiological and pharmacological aspects of adrenergic classification. Biochem Pharmacol 1983;32:1539-45
11. Motulsky HJ, Insel PA. Adrenergic receptors in man: direct identification, physiologic regulation, and clinical alterations. N Engl J Med 1982;307:18-29.
12. Lefkowitz RJ, Caron MG, Stiles GL. Mechanisms of membrane-receptor regulation, biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors. N Engl J Med 1984;310:1570-9.
13. Dixon RA, Kobilka BK, Strader DJ, et al. Cloning of the gene and cDNA tor mammalian beta-adrenergic receptor and homology with rhodopsin. Nature 1986;321:75-9.
14. 1-adrenoceptor classification: sharpening Occam's razor Trends Pharmacol Sci 1994;15:167-70
15. 1-antagonists Life Sci 1994,54 1845-54.
16. 3-adrenoceplor. the search for a physiological function. Trends Pharmacol Sci 1994;15:3-7
17. 3-adrenoceptor in man. J Clin Invest 1995;95 2239-45.
18. 2-adrenergic receptor Science 1994;264 582-6.
19. IB-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proc Natl Acad Sci U S A 1994,91.10109-13.
20. Bertin B, Manster P, Makeh I, et al Specific atrial overexpression of G protein coupled human beta I adrenoceptors in transgenic mice. Cardiovasc Res 1993;27:1606-12
21. Simon MI, Strathmann MP, Gautam N. Diversity of G proteins in signal transduction. Science 1991;252:802-8
22. Hescheler J, Schultz G. Heterotrimeric G proteins involved in the modulation of voltage-dependent calcium channels of neuroendocrine cells Ann N Y Acad Sci 1994;733:306-12
23. Dixon RA, Sigal IS, Rands E, et al Ligand binding to the beta-adrenergic receptor involves its rhodopsin-like core. Nature 1987,326 73-7.
24. Clapham DE, Neer EJ New roles for G-protein beta gamma-dimers in transmembrane signalling. Nature 1993;365:403-6.
25. s-adenylate cyclase interactions. FASEB J 1991;5:2300-3.
26. Post SR, Hilal-Dandan R, Urasawa K, et al. Quantification of signaling components and amplification in the β-adrenergic receptor-adenylyl cyclase pathway in isolated adult rat ventricular myocytes. Biochem J 1995,311:75-80.
27. s protein in native membranes. J Biol Chem 1988;263: 17239-42.
28. Brandt DR, Ross EM. Catecholamine-stimulated GTPase cycle: multiple sites of regulation by beta-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesicles. J Biol Chem 1986;261:1656-64
29. Fung BK, Hurley JB, Stryer L Flow of information in the light-triggered cyclic nucleotide cascade of vision Proc Natl Acad Sci U S A 1981;78.152-6.
30. Keefer JR, Limbird LE. The alpha 2A-adrenergic receptor is targeted directly to the basolateral membrane domain of Madin-Darby canine kidney cells independent of coupling to pertussis toxin-sensitive GTP-binding proteins. J Biol Chem 1993;268:11340-7
31. Sakaue M, Hoffman BB. Glucocorticoids induce transcription and expression of the alpha 1B adrenergic receptor gene in DTT1 MF-2 smooth muscle cells. J Clin Invest 1991;88:385-9.
32. Insel PA. Beta-adrenergic receptors in pathophysiologic states and in clinical medicine. In: Perkins JP, ed. The beta-adrenergic receptors. Clifton, N.J.: Humana Press, 1991:295-344
33. Shih M, Malbon CC Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase re-veal distinctive cell-type-specific roles in agonist-induced desensitization. Proc Natl Acad Sci U S A 1994;91:12193-7.
34. Premont RT, Inglese J, Lefkowitz RJ. Protein kinases that phosphorylate activated G protein-coupled receptors. FASEB J 1995;9:175-82.
35. De Blasi A, Parruti G, Sallese M. Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes: selective increase of beta-adrenergic receptor kinase 1 and 2. J Clin Invest 1995,95:203-10.
36. 1-adrenergic receptors in the failing human heart. Circulation 1993,87:454-63.
37. Bristow MR, Minobe WA, Raynolds MV, et al. Reduced beta 1 receptor messenger RNA abundance in the failing human heart J Clin Invest 1993; 92:2737-45.
38. Bristow MR, Hershberger RE, Port JD, et al Beta-adrenergic pathways in nonfailing and failing human ventricular myocardium. Circulation 1990;82: Suppl I:I-12-I-25.
39. Ungerer M, Parruti G, Bohm M, et al. Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. Circ Res 1994, 74:206-13.
40. Ping P, Gelzer-Bell R, Roth DA, Kiel D, Insel PA, Hammond HK. Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. J Clin Invest 1995, 95:1271-80
41. 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993;8 334-9.
42. 2-adrenergic receptor in nocturnal and nonnocturnal asthma: evidence that Gly16 correlates with the nocturnal phenotype J Clin Invest 1995,95:1635-41.
43. 2-adrenergic receptor impart distinct agonist-promoted regulatory properties Biochemistry 1994;33:9414-9. [Erratum, Biochemistry 1994;33.14368.]
44. 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 1995;345:1213-4
45. 3-adrenergic-receptor gene. N Engl J Med 1995,333:343-7.
46. 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns N Engl J Med 1995;333: 348-51.
47. 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 1995;333.352-4.