Resistance to HIV protease inhibitors: A comparison of enzyme inhibition and antiviral potency

Biochemistry

Volumn 37, Issue 24, 1998, Pages 8735-8742

  Klabe, Ronald M ^a   Bacheler, Lee T ^a   Ala, Paul J ^a   Erickson Viitanen, Susan ^a   Meek, James L ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; INDINAVIR; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG MECHANISM; DRUG POTENCY; DRUG RESISTANCE; ENZYME INHIBITION; ESCHERICHIA COLI; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

DRUG RESISTANCE, MICROBIAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

ESCHERICHIA COLI; FELIS CATUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032537482     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972555l     Document Type: Article

References (34)

1. Debouck, C., Gorniak, J. G., Strickler, J. E., Meek, T. D., Metcalf, B. W., and Rosenberg, M. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 8903-8906.
2. Henderson, L. E., Benveniste, R. E., Sowder, R., Copeland, T. D., Schultz, A. M., and Oroszlan, S. (1988) J. Virol. 62, 2587-2595.
3. Kohl, N. E., Emini, E. A., Schleif, W. A., Davis, L. J., Heimbach, J. C., Dixon, R. A. F., Scolnik, E. M., and Sigal, I. S. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 4686-4690.
4. Peng, C., Ho, B. K., Chang, T. W., and Chang, N. T. (1989) J. Virol. 63, 2550-2555.
5. Otto, M. J. Garber, S., Winslow, D. L., Reid, C. D., Aldrich, P., Jadhav, P. K., Patterson, C. E., Hodge, C. N. and Cheng, Y.-S. E. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 7543-7547.
6. Condra, J. H., Schleif, W. A., Blahy, O. M. Gabryelski, L. J., Graham, D. J., Quintero, J. C., Rhodes, A., Robbins, H. L., Roth, E., Shivaprakash, M., Titus, D., Yang, T. Teppler, H., Squires, K. E., Deutsch, P. J., and Emini, E. A. (1995) Nature 374, 569-571.
7. King, R. W., Garber, S., Winslow, D. L., Reid, C., Bacheler, L. T. Anton, E., and Otto, M. J. (1995) Antiviral Chem. Chemother. 6, 80-88.
8. Markowitz, M., Mo, H., Kempf, D. J., Norbeck, D. W., Bhat, T. N., Erickson, J. W., and Ho, D. D. (1995) J. Virol. 69, 701-706.
9. Molla, A., Korneyeva, M., Gao, Q., Vasavanonda, S., Schipper, P. J., Mo H, Markowitz, M., Chemyavskiy, T., Niu, P., Lyons, N., Hsu, A., Granneman, G. R., Ho, D. D., Boucher, C. A. B., Leonard, J. M., Norbeck, D. W., and Kempf, D., J. (1996) Nat. Med. 2, 760-766.
10. Chen, Z., Li, Y., Schock, H. B., Chen, E., and Kuo, L. C. (1995) J. Biol. Chem. 270, 21433-21436.
11. Ala, P. J., Huston, E. E., Klabe, R. M., McCabe, D. D., Duke, J. L., Rizzo, C. J., Korant, B. D., DeLoskey, R. J., Lam, P. Y. S, Hodge, C. N., and Chang, C.-H. (1997) Biochemistry 36, 1573-1580.
12. Richman, D. D. (1995) Nature 374, 494.
13. Tritch, R. J., Cheng, Y.-S. E., Yin, F. H., and Erickson-Viitanen, S. (1991) J. Vrol. 65, 922-930.
14. Kaplan, A. H., Manchester, M., and Swanstrom, R. (1994) J. Virol. 68, 6782-6786.
15. Doyon, L., Croteau, G., Thibeault, D., Poulin, F., Pilote, L., and Lamarre, D. (1996) J. Virol. 70, 3763-3769
16. Maschera, B., Graham, D., Palú, G., Wright, L. L., Tisdale, M., Myers, R., Blair, E. D., and Furfine, E. S. (1996) J. Biol. Chem. 271, 33231-33235.
17. Nijhuis, M., Schuurman, R., de Jong, D., Schipper, P., Danner S., and Boucher, C. (1997) in Abstracts of the International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication, p 61, St. Petersburg, FL, June 25-28
18. Hodge, C. N., Aldrich, P. E., Bacheler, L. T., Chang, C.-H., Eyermann, C. J., Garber, S., Grubb, M., Jackson, D. A., Jadhav, P. K., Korant, B., Lam, P. Y. S., Maurin, M. B., Meek, J. L., Otto, M. J., Rayner, M. M., Reid, C., Sharps, T. R., Shum, L., Winslow, L., and Erickson-Viitanen, S. (1996) Chem. Biol. 3, 301-314.
19. Gulnik, S. V., Suvorov, L. I., Liu, B., Yu, B., Anderson, B., Mitsuya, H., and Erickson, J. W. (1995) Biochemistry 34, 9282-9287.
20. Pazhanisamy, S., Stuver, C. M., Cullinan, A. B., Margolin, N., Rao, B. G., and Livingston, D. J. (1996) J. Biol. Chem. 271, 17979-17985.
21. Wilson, S. I., Phylip, L. H., Mills, J. S., Gulnik, S. V., Erickson, J. W., Dunn, B. M., and Kay, J. (1997) Biochim. Biophys. Acta 1339, 113-125.
22. Lam, P. Y. S., Jadhav, P. K., Eyermann, C. J., Hodge, C. N., Ru, V. Bacheler, L. T., Meek, J. L., Otto, M. J., Rayner, M. M., Wong, N., Chang, C.-H., Weber, P. C., Jackson, D. A., Sharpe, T. R., and Erickson-Viitanen, S. (1994) Science 263, 380-384.
23. Lam, P. Y. S., Ru, Y., Jadhav, P. K., Aldrich, P. E., Delucca, G. V., Eyermann, C. J., Chang, C.-H., Emmett, G., Holler, E. R., Daneker, W. F., Li, L., Confalone, P. N., McHugh, R. J., Han, Q., Markwalder, J. A., Seitz, S. P., Bacheler, L. T., Rayner, M. M., Klabe, R. M., Shum, L., Winslow, D. L., Kornhauser, D. M., Jackson, D. A., Erickson-Viitanen, S., Sharpe, T. R., and Hodge, C. N. (1996) J. Med. Chem. 39, 3514-3525.
24. Wilkerson, W. W., Hollis, A. Y., Cheatham, W. W., Lam, G. N., Erickson-Viitanen, S., Bacheler, L., Cordova, B. C., Klabe, R. M., and Meek, J. L. (1995) Bioorg. Med. Chem. Lett. 5, 3027-3032.
25. Rodgers, J. D., Johnson, B. L., Wang, H., Greenberg, R. A., Erickson-Viitanen, S., Klabe, R. M., Cordova, B. C., Rayner, M. M., Lam, G. N., and Chang, C.-H. (1996) Bioorg. Med. Chem. Lett. 6, 2919-2924.
26. Jadhav, P. K., Ala, P., Woerner, F. J., Chang, C.-H., Garber, S. S., Anton, E. D., and Bacheler, L. T. (1997) J. Med. Chem. 40, 181-191.
27. Cheng, Y.-S. E., Yin, F. H., Foundling, S., Blomstrom, D., and Kettner, C. A. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 9660-9664.
28. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
29. Erickson-Viitanen, S., Klabe, R. M., Cawood, P. G., O'Neal, P. L., and Meek, J. L. (1994) Antimicrob. Agents Chemother. 38, 1628-1634.
30. Winslow, D. L., Horlick, R. A., Anton, E. A., Tritch, R. J., Zagursky, R. J., and Bacheler, L. T. (1994) Biochem. Biophys. Res. Commun. 205, 1651-1657.
31. Nugiel, D. A., Jacobs, K., Worley, T., Patel, M., Kaltenbach, R. F., III, Meyer, D. T., Jadhav, P. K., De Lucca, G. V., Smyser, T. E., Klabe, R. M., Bacheler, L. T., Rayner, M. M., and Seitz, S. P. (1996) J. Med. Chem. 39, 2156-2169.
32. Schock, H. B., Garsky, V. M., and Kuo, L. C. (1996) J. Biol. Chem. 271, 31957-31963.
33. Vacca, P. J., Dorsey, B. D., Schleif, W. A., Levin, R. B., McDaniel, S. L., Darke, P. L., Zugay, J., Quintero, J. C., Blahy, O. M., Roth, E., Sardana, V. V., Schlabach, A. J., Graham, P. I., Condra, J. H., Gotlib, L., Holloway, M. K., Lin, J., Chen, I.-W., Vastag, K., Ostovic, D., Anderson, P. S., Emini, E. A., and Huff, J. R. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 4096-4100.
34. Reich, S. H., Melnick, M., Davies, J. F., II, Appelt, K., Lewis, K. K., Fuhry, M. A., Pino, M., Trippe, A. J., Nguyen, D., Dawson, H., Wu, B.-W., Musick, L., Kosa, M., Kahil, D., Webber, S., Gehlhaar, D. K., Andrada, D., and Shetty, B. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 3298-3302.